TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T63816 Histone deacetylase 4 D0E7PQ Vorinostat Approved 5311 C14H20N2O3 264.32 C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 D0L7LC Romidepsin Approved 5352062 C24H36N4O6S2 540.7 C/C=C\\1/C(=O)N[C@H](C(=O)O[C@H]\\2CC(=O)N[C@@H](C(=O)N[C@H](CSSCC/C=C2)C(=O)N1)C(C)C)C(C)C IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 D0M8FD SNDX-275 Phase 2 4261 C21H20N4O3 376.4 C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 D0GE5B RG-2833 Phase 1 56654642 C20H25N3O2 339.4 CC1=CC=C(C=C1)C(=O)NCCCCCC(=O)NC2=CC=CC=C2N IC50 ~ 180000 nM Poor binder T63816 Histone deacetylase 4 B03PZD 2-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(6-phenylhexyl)acetamide Investigative 136025984 C19H25N3O2S 359.5 CC1=CC(=O)NC(=N1)SCC(=O)NCCCCCCC2=CC=CC=C2 IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 B07VJX (1R,2R,3R)-2-(5-Chloro-2,2-dimethyl-3H-1,4-benzodioxin-7-yl)-N-hydroxy-3-phenylcyclopropane-1-carboxamide Investigative 76324876 C20H20ClNO4 373.8 CC1(COC2=C(O1)C=C(C=C2Cl)[C@@H]3[C@H]([C@H]3C(=O)NO)C4=CC=CC=C4)C IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B0GAH1 Pimelic Diphenylamide 106 Investigative 16070100 C20H25N3O2 339.4 CC1=CC=C(C=C1)NC(=O)CCCCCC(=O)NC2=CC=CC=C2N IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 B0H7FG (1R,2R,3R)-N-Hydroxy-2-phenyl-3-[3-(trifluoromethyl)quinoxalin-6-yl]cyclopropane-1-carboxamide Investigative 76313987 C19H14F3N3O2 373.3 C1=CC=C(C=C1)[C@@H]2[C@H]([C@@H]2C(=O)NO)C3=CC4=NC(=CN=C4C=C3)C(F)(F)F IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B0IP6E N-[(2S)-1-[[6-(2-Amino-4-fluoroanilino)-6-oxohexyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-4-methoxybenzamide Investigative 137657586 C31H34FN5O4 559.6 COC1=CC=C(C=C1)C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)NCCCCCC(=O)NC4=C(C=C(C=C4)F)N IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 B0LZI8 N-Hydroxy-E-3-(4''-methoxybiphenyl-4-yl)-acrylamide Investigative 15986509 C16H15NO3 269.29 COC1=CC=C(C=C1)C2=CC=C(C=C2)/C=C/C(=O)NO IC50 = 99400 nM Poor binder T63816 Histone deacetylase 4 B0OYP1 (1R,2R,3R)-N-Hydroxy-2-(1-methylpyrazol-4-yl)-3-phenylcyclopropane-1-carboxamide Investigative 60148646 C14H15N3O2 257.29 CN1C=C(C=N1)[C@@H]2[C@H]([C@H]2C(=O)NO)C3=CC=CC=C3 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B0R4TM 2-{[2-(4-Tert-butylphenyl)-2-oxoethyl]sulfanyl}-6-methyl-3,4-dihydropyrimidin-4-one Investigative 135497781 C17H20N2O2S 316.4 CC1=CC(=O)NC(=N1)SCC(=O)C2=CC=C(C=C2)C(C)(C)C IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 B0VTQ6 N-(2-Aminophenyl)-7,7-di(1H-indol-3-yl)heptanamide Investigative 45271073 C29H30N4O 450.6 C1=CC=C2C(=C1)C(=CN2)C(CCCCCC(=O)NC3=CC=CC=C3N)C4=CNC5=CC=CC=C54 IC50 = 150000 nM Poor binder T63816 Histone deacetylase 4 B0VWI8 (1R,2R,3R)-N-Hydroxy-2-phenyl-3-(4-pyrimidin-2-ylphenyl)cyclopropane-1-carboxamide Investigative 60148735 C20H17N3O2 331.4 C1=CC=C(C=C1)[C@@H]2[C@H]([C@@H]2C(=O)NO)C3=CC=C(C=C3)C4=NC=CC=N4 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B13SGM (2E,4E)-5-[4-[3-(1-Adamantyl)-4-methoxyphenyl]phenyl]-N-hydroxypenta-2,4-dienamide Investigative 90654947 C28H31NO3 429.5 COC1=C(C=C(C=C1)C2=CC=C(C=C2)/C=C/C=C/C(=O)NO)C34CC5CC(C3)CC(C5)C4 IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 B1BZ7I (1R,2R,3R)-2-[4-(3,3-Difluoropyrrolidin-1-yl)phenyl]-N-hydroxy-3-phenylcyclopropane-1-carboxamide Investigative 60148765 C20H20F2N2O2 358.4 C1CN(CC1(F)F)C2=CC=C(C=C2)[C@@H]3[C@H]([C@H]3C(=O)NO)C4=CC=CC=C4 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B1SXO5 N-[4-[2-(4-Methylpyrimidin-2-yl)sulfanylacetyl]phenyl]acetamide Investigative 56659403 C15H15N3O2S 301.4 CC1=NC(=NC=C1)SCC(=O)C2=CC=C(C=C2)NC(=O)C IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 B1TSK2 N-[(2S)-3-(1H-Indol-3-yl)-1-oxo-1-[4-(propylaminocarbamoyl)anilino]propan-2-yl]-4-methoxybenzamide Investigative 137635119 C29H31N5O4 513.6 CCCNNC(=O)C1=CC=C(C=C1)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)C4=CC=C(C=C4)OC IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B1W2BP (1S,14S,17R,23S)-23-Propan-2-yl-7,8-dithia-15,21,24,26-tetrazatricyclo[12.11.2.017,21]heptacosane-16,22,25,27-tetrone Investigative 102140473 C24H40N4O4S2 512.7 CC(C)[C@H]1C(=O)N2CCC[C@@H]2C(=O)N[C@H]3CCCCCSSCCCCC[C@@H](C(=O)N1)NC3=O IC50 = 63000 nM Poor binder T63816 Histone deacetylase 4 B2VLJ6 N-[4-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)sulfanylmethyl]phenyl]acetamide Investigative 136025842 C14H15N3O2S 289.35 CC1=CC(=O)NC(=N1)SCC2=CC=C(C=C2)NC(=O)C IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 B30QFP (1S,5S,6R,9S,15E,20R)-5-Hydroxy-6-(2-methylpropyl)-20-(2-methylsulfanylethyl)-2-oxa-11,12-dithia-7,19,22-triazabicyclo[7.7.6]docos-15-ene-3,8,18,21-tetrone Investigative 90665810 C23H37N3O6S3 547.8 CC(C)C[C@@H]1[C@H](CC(=O)O[C@H]\\2CC(=O)N[C@@H](C(=O)N[C@H](CSSCC/C=C2)C(=O)N1)CCSC)O IC50 = 58880 nM Poor binder T63816 Histone deacetylase 4 B3AGR9 (1R,2R,3S)-N-Hydroxy-2-(5-methyl-1,3-thiazol-2-yl)-3-phenylcyclopropane-1-carboxamide Investigative 76321254 C14H14N2O2S 274.34 CC1=CN=C(S1)[C@@H]2[C@H]([C@H]2C(=O)NO)C3=CC=CC=C3 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B3MS6D 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid hydroxyamide pyren-1-ylamide Investigative 57336564 C24H12F12N2O3 604.3 C1=CC2=C3C(=C1)C=CC4=C(C=CC(=C43)C=C2)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B3Q2UG (1R,2R,3R)-2-(2-Cyclopropyl-1,3-benzoxazol-5-yl)-N-hydroxy-3-phenylcyclopropane-1-carboxamide Investigative 76317533 C20H18N2O3 334.4 C1CC1C2=NC3=C(O2)C=CC(=C3)[C@@H]4[C@H]([C@H]4C(=O)NO)C5=CC=CC=C5 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B3TCW8 N-Hydroxy-2-propylpentanamide Investigative 88129 C8H17NO2 159.23 CCCC(CCC)C(=O)NO IC50 = 170000 nM Poor binder T63816 Histone deacetylase 4 B3UK0O Carbamic acid,N-[[4-[[(4-amino[1,1'-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]-,methyl ester Investigative 25032862 C22H21N3O3 375.4 COC(=O)NCC1=CC=C(C=C1)C(=O)NC2=C(C=CC(=C2)C3=CC=CC=C3)N IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B40IVW 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid biphenyl-3-ylamide hydroxyamide Investigative 57336567 C20H12F12N2O3 556.3 C1=CC=C(C=C1)C2=CC(=CC=C2)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B40XIT N-(2-Chlorophenyl)-2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N'-hydroxyoctanediamide Investigative 137657892 C14H7ClF12N2O3 514.65 C1=CC=C(C(=C1)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)Cl Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B42YAZ CID 57336568 Investigative 57336568 C18H10F12N2O3 530.3 C1=CC=C2C=C(C=CC2=C1)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B4FDZ3 CID 57521296 Investigative 57521296 C18H16ClNO4 345.8 C1COC2=C(O1)C=C(C=C2Cl)[C@@H]3[C@H]([C@H]3C(=O)NO)C4=CC=CC=C4 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B4NL8Q N-Hydroxy-3-[1-(2-phenylethyl)triazol-4-yl]benzamide Investigative 136030780 C17H16N4O2 308.33 C1=CC=C(C=C1)CCN2C=C(N=N2)C3=CC(=CC=C3)C(=O)NO IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 B4ZEY0 Thailandepsin B Investigative 56676500 C24H39N3O6S2 529.7 CCCC[C@@H]1C(=O)N[C@@H]2CSSCC/C=C/[C@H](CC(=O)N1)OC(=O)C[C@@H]([C@H](NC2=O)[C@@H](C)CC)O IC50 = 57440 nM Poor binder T63816 Histone deacetylase 4 B58CXB (1R,14S,17R,23S)-23-Benzyl-7,8-dithia-15,21,24,26-tetrazatricyclo[12.11.2.017,21]heptacosane-16,22,25,27-tetrone Investigative 118706556 C28H40N4O4S2 560.8 C1CC[C@@H]2C(=O)N[C@H](C(=O)N3CCC[C@@H]3C(=O)N[C@@H](CCCCCSSCC1)C(=O)N2)CC4=CC=CC=C4 IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 B59SUW Azumamide D Investigative 16095113 C25H35N5O5 485.6 C[C@H]1[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC1=O)C)C)CC2=CC=CC=C2)C/C=C\\CCC(=O)N IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B5HIZ3 N-[4-[2-[(4-Methyl-6-oxo-1H-pyridin-2-yl)oxy]acetyl]phenyl]acetamide Investigative 56673261 C16H16N2O4 300.31 CC1=CC(=O)NC(=C1)OCC(=O)C2=CC=C(C=C2)NC(=O)C IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 B5R4IE 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid hydroxyamide (4-iodo-phenyl)amide Investigative 57336559 C14H7F12IN2O3 606.1 C1=CC(=CC=C1NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)I Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B5YA1D 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-N-hydroxy-N'-(2-methylphenyl)octanediamide Investigative 137647616 C15H10F12N2O3 494.23 CC1=CC=CC=C1NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B67IZM 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic Acid(4-Chlorophenyl)Amide Hydroxyamide Investigative 57336555 C14H7ClF12N2O3 514.65 C1=CC(=CC=C1NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)Cl Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B67MOZ (1R,2R,3R)-2-(3-Cyclopropylquinoxalin-6-yl)-N-hydroxy-3-phenylcyclopropane-1-carboxamide Investigative 76310312 C21H19N3O2 345.4 C1CC1C2=CN=C3C=CC(=CC3=N2)[C@@H]4[C@H]([C@H]4C(=O)NO)C5=CC=CC=C5 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B6HDE3 (2R,3R)-N-Hydroxy-2,3-diphenylcyclopropane-1-carboxamide Investigative 60148997 C16H15NO2 253.29 C1=CC=C(C=C1)[C@@H]2[C@H](C2C(=O)NO)C3=CC=CC=C3 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B6K7LT Benzyl (2S)-4-[5-[(2-amino-5-phenylphenyl)carbamoyl]pyridin-2-yl]-2-methylpiperazine-1-carboxylate Investigative 16663079 C31H31N5O3 521.6 C[C@H]1CN(CCN1C(=O)OCC2=CC=CC=C2)C3=NC=C(C=C3)C(=O)NC4=C(C=CC(=C4)C5=CC=CC=C5)N IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B6O4DQ (E)-N-Hydroxy-3-[4-(trifluoromethyl)phenyl]acrylamide Investigative 53374826 C10H8F3NO2 231.17 C1=CC(=CC=C1/C=C/C(=O)NO)C(F)(F)F IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 B6W4EY (1S,5S,6R,9S,15E,20R)-20-Butyl-5-hydroxy-6-(2-methylpropyl)-2-oxa-11,12-dithia-7,19,22-triazabicyclo[7.7.6]docos-15-ene-3,8,18,21-tetrone Investigative 90665811 C24H39N3O6S2 529.7 CCCC[C@@H]1C(=O)N[C@@H]2CSSCC/C=C/[C@H](CC(=O)N1)OC(=O)C[C@@H]([C@H](NC2=O)CC(C)C)O IC50 = 132500 nM Poor binder T63816 Histone deacetylase 4 B73HIA (1R,2R,3R)-N-Hydroxy-2-[4-(1,3-oxazol-4-yl)phenyl]-3-phenylcyclopropane-1-carboxamide Investigative 76324877 C19H16N2O3 320.3 C1=CC=C(C=C1)[C@@H]2[C@H]([C@@H]2C(=O)NO)C3=CC=C(C=C3)C4=COC=N4 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B76NHE 2-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(4-phenylbutyl)acetamide Investigative 136086923 C17H21N3O2S 331.4 CC1=CC(=O)NC(=N1)SCC(=O)NCCCCC2=CC=CC=C2 IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 B7AL9E (1R,14S,17R,23S)-23-Propan-2-yl-7,8-dithia-15,21,24,26-tetrazatricyclo[12.11.2.017,21]heptacosane-16,22,25,27-tetrone Investigative 118706555 C24H40N4O4S2 512.7 CC(C)[C@H]1C(=O)N2CCC[C@@H]2C(=O)N[C@H]3CCCCCSSCCCCC[C@H](C(=O)N1)NC3=O IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 B7FPR4 (1R,2R,3R)-N-Hydroxy-2-phenyl-3-(4-pyrimidin-5-ylphenyl)cyclopropane-1-carboxamide Investigative 60148736 C20H17N3O2 331.4 C1=CC=C(C=C1)[C@@H]2[C@H]([C@@H]2C(=O)NO)C3=CC=C(C=C3)C4=CN=CN=C4 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B7HYJ6 (1S,12R,15S,18R)-15-Propan-2-yl-24,25-dithia-3,14,17,31-tetrazatetracyclo[16.12.2.03,12.05,10]dotriaconta-5,7,9-triene-2,13,16,32-tetrone Investigative 102140474 C29H42N4O4S2 574.8 CC(C)[C@H]1C(=O)N[C@@H]2CCCCCSSCCCCC[C@@H](C(=O)N3CC4=CC=CC=C4C[C@@H]3C(=O)N1)NC2=O IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 B7JEZ8 1-((4-Hydroxy-6-methylpyrimidin-2-yl)thio)propan-2-one Investigative 135462117 C8H10N2O2S 198.24 CC1=CC(=O)NC(=N1)SCC(=O)C IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 B7MV0J (2R)-2-[(1-Hydroxy-6-sulfanylidenepyridine-2-carbonyl)amino]-2-phenylacetic acid Investigative 86294747 C14H12N2O4S 304.32 C1=CC=C(C=C1)[C@H](C(=O)O)NC(=O)C2=CC=CC(=S)N2O IC50 = 64000 nM Poor binder T63816 Histone deacetylase 4 B7OGL2 N-Hydroxy-5-[1-[(4-phenylphenyl)methyl]pyrazol-3-yl]pentanamide Investigative 118714377 C21H23N3O2 349.4 C1=CC=C(C=C1)C2=CC=C(C=C2)CN3C=CC(=N3)CCCCC(=O)NO IC50 = 83100 nM Poor binder T63816 Histone deacetylase 4 B7UVK6 (1R,2R,3R)-N-Hydroxy-2-phenyl-3-pyrazolo[1,5-a]pyridin-2-ylcyclopropane-1-carboxamide Investigative 76310314 C17H15N3O2 293.32 C1=CC=C(C=C1)[C@@H]2[C@H]([C@@H]2C(=O)NO)C3=NN4C=CC=CC4=C3 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B81YTQ N-[4-[2-(3-Hydroxyphenyl)sulfanylacetyl]phenyl]acetamide Investigative 56666337 C16H15NO3S 301.4 CC(=O)NC1=CC=C(C=C1)C(=O)CSC2=CC=CC(=C2)O IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 B82VOA (1R,2R,3R)-N-Hydroxy-2-phenyl-3-[2-(trifluoromethyl)pyridin-4-yl]cyclopropane-1-carboxamide Investigative 60148672 C16H13F3N2O2 322.28 C1=CC=C(C=C1)[C@@H]2[C@H]([C@@H]2C(=O)NO)C3=CC(=NC=C3)C(F)(F)F IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B8I2PY N-Hydroxy-9H-fluorene-9-carboxamide Investigative 54030066 C14H11NO2 225.24 C1=CC=C2C(=C1)C(C3=CC=CC=C32)C(=O)NO IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B8QVI3 (1R,2R,3R)-N-Hydroxy-2-phenyl-3-(4-pyridazin-3-ylphenyl)cyclopropane-1-carboxamide Investigative 60148716 C20H17N3O2 331.4 C1=CC=C(C=C1)[C@@H]2[C@H]([C@@H]2C(=O)NO)C3=CC=C(C=C3)C4=NN=CC=C4 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B8YM4H N-[4-(Dimethylamino)phenyl]-2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N'-hydroxyoctanediamide Investigative 137631704 C16H13F12N3O3 523.27 CN(C)C1=CC=C(C=C1)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B90DNP N-Hydroxy-5-[1-[(4-indol-1-ylphenyl)methyl]pyrazol-3-yl]pentanamide Investigative 118714375 C23H24N4O2 388.5 C1=CC=C2C(=C1)C=CN2C3=CC=C(C=C3)CN4C=CC(=N4)CCCCC(=O)NO IC50 = 86400 nM Poor binder T63816 Histone deacetylase 4 B93MKY N-[4-[1-Hydroxy-2-[(4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]ethyl]phenyl]acetamide Investigative 136025843 C15H17N3O3S 319.4 CC1=CC(=O)NC(=N1)SCC(C2=CC=C(C=C2)NC(=O)C)O IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 B9GB4J Benzamide-type inhibitor, 4 Investigative 23648260 C25H22N4O3S 458.5 C1=CC(=CN=C1)COC(=O)NCC2=CC=C(C=C2)C(=O)NC3=C(C=CC(=C3)C4=CC=CS4)N IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B9H3VQ (3S,6Z,9S,12R,16S)-6-Ethylidene-16-[(E)-4-methylsulfanylbut-1-enyl]-9-(methylsulfanylmethyl)-3,12-di(propan-2-yl)-1-oxa-4,7,10-triazacyclohexadecane-2,5,8,11,14-pentone Investigative 70695508 C27H43N3O6S2 569.8 C/C=C\\1/C(=O)N[C@H](C(=O)O[C@@H](CC(=O)C[C@@H](C(=O)N[C@@H](C(=O)N1)CSC)C(C)C)/C=C/CCSC)C(C)C IC50 = 110000 nM Poor binder T63816 Histone deacetylase 4 B9N2WQ Chembl4202863 Investigative 145968675 C26H24N4O4 456.5 CC1=CC=C(C=C1)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)C4=CC=C(C=C4)C(=O)NO IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 B9N3KM (1R,2R,3R)-2-[4-(3,3-Dimethylazetidin-1-yl)phenyl]-N-hydroxy-3-phenylcyclopropane-1-carboxamide Investigative 60148766 C21H24N2O2 336.4 CC1(CN(C1)C2=CC=C(C=C2)[C@@H]3[C@H]([C@H]3C(=O)NO)C4=CC=CC=C4)C IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 B9OI5Q 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid biphenyl-2-ylamide hydroxyamide Investigative 57336569 C20H12F12N2O3 556.3 C1=CC=C(C=C1)C2=CC=CC=C2NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BAD74G N-(3-Chlorophenyl)-2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N'-hydroxyoctanediamide Investigative 137656303 C14H7ClF12N2O3 514.65 C1=CC(=CC(=C1)Cl)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BAK1J9 (E)-N-Hydroxy-5-(2-hydroxystyryl)furan-2-carboxamide Investigative 44562040 C13H11NO4 245.23 C1=CC=C(C(=C1)/C=C/C2=CC=C(O2)C(=O)NO)O IC50 = 74240 nM Poor binder T63816 Histone deacetylase 4 BAL2D3 5-[[6-Oxo-4-(4-phenylphenyl)-1H-pyrimidin-2-yl]sulfanyl]pentanehydroxamic acid Investigative 136173089 C21H21N3O3S 395.5 C1=CC=C(C=C1)C2=CC=C(C=C2)C3=CC(=O)NC(=N3)SCCCCC(=O)NO IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BB3NG0 3beta-[4-(2-Cyclopropyl-5-oxazolyl)phenyl]-2alpha-phenylcyclopropane-1alpha-carbohydroxamic acid Investigative 60148695 C22H20N2O3 360.4 C1CC1C2=NC=C(O2)C3=CC=C(C=C3)[C@@H]4[C@H]([C@H]4C(=O)NO)C5=CC=CC=C5 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BB6FT2 N-(2-Aminophenyl)-4-[(6-oxo-4-phenyl-1H-pyrimidin-2-yl)sulfanylmethyl]benzamide Investigative 135869606 C24H20N4O2S 428.5 C1=CC=C(C=C1)C2=CC(=O)NC(=N2)SCC3=CC=C(C=C3)C(=O)NC4=CC=CC=C4N IC50 = 125000 nM Poor binder T63816 Histone deacetylase 4 BBH13V (E)-3-[5-[[Benzyl-[2-(4-methylphenoxy)ethyl]amino]methyl]furan-2-yl]-N-hydroxyprop-2-enamide Investigative 71770059 C24H26N2O4 406.5 CC1=CC=C(C=C1)OCCN(CC2=CC=CC=C2)CC3=CC=C(O3)/C=C/C(=O)NO IC50 = 68110 nM Poor binder T63816 Histone deacetylase 4 BBRQ61 3beta-(2-Cyclopropyl-4-pyridyl)-2alpha-phenylcyclopropane-1alpha-carbohydroxamic acid Investigative 60148667 C18H18N2O2 294.3 C1CC1C2=NC=CC(=C2)[C@@H]3[C@H]([C@H]3C(=O)NO)C4=CC=CC=C4 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BC05YB E,E-5-(4''-Methoxybiphenyl-4-yl)-penta-2,4-dienoic acid Nhydroxyamide Investigative 42631047 C18H17NO3 295.3 COC1=CC=C(C=C1)C2=CC=C(C=C2)/C=C/C=C/C(=O)NO IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BC3G4L 5-[1-[(4-Anilinophenyl)methyl]pyrazol-3-yl]-N-hydroxypentanamide Investigative 118714376 C21H24N4O2 364.4 C1=CC=C(C=C1)NC2=CC=C(C=C2)CN3C=CC(=N3)CCCCC(=O)NO IC50 = 56300 nM Poor binder T63816 Histone deacetylase 4 BC54SO 2-[2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-oxoethyl]sulfanyl-4-methyl-1H-pyrimidin-6-one Investigative 136086920 C15H14N2O4S 318.3 CC1=CC(=O)NC(=N1)SCC(=O)C2=CC3=C(C=C2)OCCO3 IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BCA7Q1 1-(2,4-Dihydroxy-5-propan-2-ylphenyl)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-[4-(morpholin-4-ylmethyl)phenyl]triazole-4-carboxamide Investigative 90655296 C30H40N6O6 580.7 CC(C)C1=CC(=C(C=C1O)O)N2C(=C(N=N2)C(=O)NCCCCCCC(=O)NO)C3=CC=C(C=C3)CN4CCOCC4 IC50 = 71500 nM Poor binder T63816 Histone deacetylase 4 BCH09S 1-Hydroxy-6-sulfanylidene-1,6-dihydropyridine-2-carboxylic acid Investigative 59585196 C6H5NO3S 171.18 C1=CC(=S)N(C(=C1)C(=O)O)O IC50 = 71000 nM Poor binder T63816 Histone deacetylase 4 BCN8A1 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic Acid(4-Cyanophenyl)Amide Hydroxyamide Investigative 57336558 C15H7F12N3O3 505.21 C1=CC(=CC=C1C#N)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BD4E0N CID 57336565 Investigative 57336565 C22H13F12N5O3 623.4 C1=CC=C(C=C1)N2C(=CN=N2)C3=CC=C(C=C3)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BD5V4P (1R,2R,3R)-N-Hydroxy-2-phenyl-3-quinoxalin-6-ylcyclopropane-1-carboxamide Investigative 76324878 C18H15N3O2 305.3 C1=CC=C(C=C1)[C@@H]2[C@H]([C@@H]2C(=O)NO)C3=CC4=NC=CN=C4C=C3 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BD9E0Q N-Hydroxy-2-(1-methylpyrrole-2-carbonyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine-7-carboxamide Investigative 58465708 C14H16N4O3 288.3 CN1C=CC=C1C(=O)N2CCN3C=C(C=C3C2)C(=O)NO IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BDCZ86 2-[(4-Methyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-(2-phenylethyl)acetamide Investigative 135441620 C15H17N3O2S 303.4 CC1=CC(=O)NC(=N1)SCC(=O)NCCC2=CC=CC=C2 IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BE2B0Y (E)-5-(2-(Benzo[d][1,3]dioxol-5-yl)vinyl)-N-hydroxyfuran-2-carboxamide Investigative 44562076 C14H11NO5 273.24 C1OC2=C(O1)C=C(C=C2)/C=C/C3=CC=C(O3)C(=O)NO IC50 = 85600 nM Poor binder T63816 Histone deacetylase 4 BE2IR7 (1S,2S)-N-Hydroxy-2-phenylcyclopropane-1-carboxamide Investigative 76332117 C10H11NO2 177.2 C1[C@@H]([C@H]1C(=O)NO)C2=CC=CC=C2 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BE2XS4 N-Hydroxy-5-[1-[(3-phenylphenyl)methyl]pyrazol-3-yl]pentanamide Investigative 72195322 C21H23N3O2 349.4 C1=CC=C(C=C1)C2=CC=CC(=C2)CN3C=CC(=N3)CCCCC(=O)NO IC50 = 81500 nM Poor binder T63816 Histone deacetylase 4 BE5WH2 N-Hydroxy-3-[1-(2-thiophen-3-ylethyl)triazol-4-yl]benzamide Investigative 136030781 C15H14N4O2S 314.4 C1=CC(=CC(=C1)C(=O)NO)C2=CN(N=N2)CCC3=CSC=C3 IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BE5WU6 N-Hydroxy-3-[2-(phenylsulfanylmethyl)-1,3-thiazol-4-yl]benzamide Investigative 76853289 C17H14N2O2S2 342.4 C1=CC=C(C=C1)SCC2=NC(=CS2)C3=CC(=CC=C3)C(=O)NO IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BE8IS2 (1R,2R,3R)-2-(6-Cyclopropylpyridazin-4-yl)-N-hydroxy-3-phenylcyclopropane-1-carboxamide Investigative 60148836 C17H17N3O2 295.34 C1CC1C2=NN=CC(=C2)[C@@H]3[C@H]([C@H]3C(=O)NO)C4=CC=CC=C4 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BEP61I 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic Acid(3-Ethylphenyl)Amide Hydroxyamide Investigative 57336562 C16H12F12N2O3 508.26 CCC1=CC(=CC=C1)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BFC08Z 2-[2-(4-Hydroxyphenyl)-2-oxoethyl]sulfanyl-4-methyl-1H-pyrimidin-6-one Investigative 135928628 C13H12N2O3S 276.31 CC1=CC(=O)NC(=N1)SCC(=O)C2=CC=C(C=C2)O IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BFS46T (1R,2R,3R)-2-(2-Cyclopropylquinoxalin-6-yl)-N-hydroxy-3-phenylcyclopropane-1-carboxamide Investigative 76324875 C21H19N3O2 345.4 C1CC1C2=CN=C3C=C(C=CC3=N2)[C@@H]4[C@H]([C@H]4C(=O)NO)C5=CC=CC=C5 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BG09QH N-{4-[2-(4,6-Dimethyl-pyrimidin-2-ylsulfanyl)-acetyl]-phenyl}-acetamide Investigative 1108280 C16H17N3O2S 315.4 CC1=CC(=NC(=N1)SCC(=O)C2=CC=C(C=C2)NC(=O)C)C IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BG0VK9 (1R,2R,3R)-N-Hydroxy-2-[4-(5-methyl-1H-imidazol-2-yl)phenyl]-3-phenylcyclopropane-1-carboxamide Investigative 60148739 C20H19N3O2 333.4 CC1=CN=C(N1)C2=CC=C(C=C2)[C@@H]3[C@H]([C@H]3C(=O)NO)C4=CC=CC=C4 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BGN3O9 (1R,2R,3R)-N-Hydroxy-2-[3-(1,3-oxazol-5-yl)phenyl]-3-phenylcyclopropane-1-carboxamide Investigative 60148692 C19H16N2O3 320.3 C1=CC=C(C=C1)[C@@H]2[C@H]([C@@H]2C(=O)NO)C3=CC=CC(=C3)C4=CN=CO4 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BGW6O5 3beta-[4-(1-Methyl-1H-imidazole-2-yl)phenyl]-2alpha-phenylcyclopropane-1alpha-carbohydroxamic acid Investigative 60148789 C20H19N3O2 333.4 CN1C=CN=C1C2=CC=C(C=C2)[C@@H]3[C@H]([C@H]3C(=O)NO)C4=CC=CC=C4 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BGX50Z (1R,2R,3R)-N-Hydroxy-2-[4-(1,3-oxazol-2-yl)phenyl]-3-phenylcyclopropane-1-carboxamide Investigative 60148788 C19H16N2O3 320.3 C1=CC=C(C=C1)[C@@H]2[C@H]([C@@H]2C(=O)NO)C3=CC=C(C=C3)C4=NC=CO4 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BGZ0U2 (1R,2R,3R)-2-(2-Cyclopropylpyrimidin-5-yl)-N-hydroxy-3-phenylcyclopropane-1-carboxamide Investigative 60148834 C17H17N3O2 295.34 C1CC1C2=NC=C(C=N2)[C@@H]3[C@H]([C@H]3C(=O)NO)C4=CC=CC=C4 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BH4RI7 N-[(2S)-1-[[6-(2-Amino-5-thiophen-2-ylanilino)-6-oxohexyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-4-methoxybenzamide Investigative 137633138 C35H37N5O4S 623.8 COC1=CC=C(C=C1)C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)NCCCCCC(=O)NC4=C(C=CC(=C4)C5=CC=CS5)N IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BH4SW7 Chembl4167599 Investigative 145954785 C31H43ClN6O6 631.2 C1=CC2=C3C(=CC=C4C3=C1C(=O)N(C4=O)CCCCCC(=O)NO)C(=O)N(C2=O)CCCNCCCCNCCCCN.Cl IC50 = 117000 nM Poor binder T63816 Histone deacetylase 4 BHB09K 2-(2,2-Dimethylpropanoyl)-N-hydroxy-1,3-dihydroisoindole-5-carboxamide Investigative 58147224 C14H18N2O3 262.3 CC(C)(C)C(=O)N1CC2=C(C1)C=C(C=C2)C(=O)NO IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BHD6Z0 (1R,2R,3R)-2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-N-hydroxy-3-phenylcyclopropane-1-carboxamide Investigative 60148648 C18H17NO4 311.3 C1COC2=C(O1)C=CC(=C2)[C@@H]3[C@H]([C@H]3C(=O)NO)C4=CC=CC=C4 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BHGX52 6-Methyl-2-phenacylsulfanyl-1H-pyrimidin-4-one Investigative 135412194 C13H12N2O2S 260.31 CC1=CC(=O)NC(=N1)SCC(=O)C2=CC=CC=C2 IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BHVA03 (1R,2R,3S)-N-Hydroxy-2-(2-methyl-1,3-thiazol-5-yl)-3-phenylcyclopropane-1-carboxamide Investigative 60148861 C14H14N2O2S 274.34 CC1=NC=C(S1)[C@@H]2[C@H]([C@H]2C(=O)NO)C3=CC=CC=C3 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BI0PW7 (1R,2R,3R)-N-Hydroxy-2-phenyl-3-[6-(trifluoromethyl)pyridin-3-yl]cyclopropane-1-carboxamide Investigative 60148671 C16H13F3N2O2 322.28 C1=CC=C(C=C1)[C@@H]2[C@H]([C@@H]2C(=O)NO)C3=CN=C(C=C3)C(F)(F)F IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BI5YC9 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-N-hydroxy-N'-[3-(1-phenyltriazol-4-yl)phenyl]octanediamide Investigative 137632251 C22H13F12N5O3 623.4 C1=CC=C(C=C1)N2C=C(N=N2)C3=CC(=CC=C3)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BI6ZB1 N-Methyl-N-[4-[2-[(4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetyl]phenyl]acetamide Investigative 136025986 C16H17N3O3S 331.4 CC1=CC(=O)NC(=N1)SCC(=O)C2=CC=C(C=C2)N(C)C(=O)C IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BI97WY N-Hydroxy-2-(1-methylpyrrole-2-carbonyl)-1,3,4,5-tetrahydro-2-benzazepine-7-carboxamide Investigative 58147302 C17H19N3O3 313.35 CN1C=CC=C1C(=O)N2CCCC3=C(C2)C=CC(=C3)C(=O)NO IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BIH41V (1R,14S,17R,23S)-23-Benzyl-4-oxa-7,8-dithia-15,21,24,26-tetrazatricyclo[12.11.2.017,21]heptacosane-16,22,25,27-tetrone Investigative 71458560 C27H38N4O5S2 562.7 C1CC[C@H]2C(=O)N[C@H](CCOCCSSCC1)C(=O)N[C@H](C(=O)N3CCC[C@@H]3C(=O)N2)CC4=CC=CC=C4 IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BIV94E 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid (4-acetylaminophenyl)-amide hydroxyamide Investigative 57336556 C16H11F12N3O4 537.26 CC(=O)NC1=CC=C(C=C1)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BJ1OD3 2-(Tert-butylcarbonylmethylthio)-4-hydroxy-6-methylpyrimidine Investigative 135473106 C11H16N2O2S 240.32 CC1=CC(=O)NC(=N1)SCC(=O)C(C)(C)C IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BJ2Y3N 2-(4-Chlorophenacylthio)-4-hydroxy-6-methylpyrimidine Investigative 135437514 C13H11ClN2O2S 294.76 CC1=CC(=O)NC(=N1)SCC(=O)C2=CC=C(C=C2)Cl IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BJ9CU6 CID 76310313 Investigative 76310313 C20H18N2O3 334.4 CC1=NC=C(O1)C2=CC=C(C=C2)[C@@H]3[C@H]([C@H]3C(=O)NO)C4=CC=CC=C4 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BJX9M8 (2R,3S)-N-Hydroxy-2,3-diphenylcyclopropane-1-carboxamide Investigative 76332116 C16H15NO2 253.29 C1=CC=C(C=C1)[C@@H]2[C@@H](C2C(=O)NO)C3=CC=CC=C3 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BKE56B 2,2,3,3,4,4,5,5,6,6,7,7-Dodecakis(Fluoranyl)-~{n}-Oxidanyl-~{n}'-Phenyl-Octanediamide Investigative 56951447 C14H8F12N2O3 480.2 C1=CC=C(C=C1)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BL5N1X Nampt-IN-3 Investigative 137634086 C29H25N7O2 503.6 C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CN3C=C(N=N3)C4=CC=C(C=C4)C(=O)NCC5=CN=CC=C5 IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BL5RX8 2-[5-(3-Nitrophenyl)furfuryl]-1,2,3,4-tetrahydroisoquinoline-7-carbohydroximic acid Investigative 101882265 C21H19N3O5 393.4 C1CN(CC2=C1C=CC(=C2)C(=O)NO)CC3=CC=C(O3)C4=CC(=CC=C4)[N+](=O)[O-] IC50 = 67800 nM Poor binder T63816 Histone deacetylase 4 BL9F0X Hdac3-IN-T326 Investigative 71721558 C21H18N6O3S 434.5 C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(S2)C3=CN(N=N3)CCC4=CC(=CC=C4)[N+](=O)[O-] IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BLBA30 2-[(4-Hydroxy-6-methylpyrimidin-2-yl)sulfanyl]-1-(4-methoxyphenyl)ethanone Investigative 135449197 C14H14N2O3S 290.34 CC1=CC(=O)NC(=N1)SCC(=O)C2=CC=C(C=C2)OC IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BLTC81 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid hydroxyamide phenan-thren-9-ylamide Investigative 57336571 C22H12F12N2O3 580.3 C1=CC=C2C(=C1)C=C(C3=CC=CC=C23)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BM2S1I (E)-3-[5-[[Benzyl(2-phenoxyethyl)amino]methyl]furan-2-yl]-N-hydroxyprop-2-enamide Investigative 71770058 C23H24N2O4 392.4 C1=CC=C(C=C1)CN(CCOC2=CC=CC=C2)CC3=CC=C(O3)/C=C/C(=O)NO IC50 = 50560 nM Poor binder T63816 Histone deacetylase 4 BM9I8K Chembl4165684 Investigative 145953085 C25H23N3O5 445.5 C1COCCN1C2=C3C=CC=C4C3=C(C=C2)C(=O)N(C4=O)CCC5=CC=C(C=C5)C(=O)NO IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BMC98T 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-N-(4-fluorophenyl)-N'-hydroxyoctanediamide Investigative 137649646 C14H7F13N2O3 498.2 C1=CC(=CC=C1NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)F Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BMDG30 (1R,2R,3R)-N-Hydroxy-2-(2-methyl-1,3-benzothiazol-5-yl)-3-phenylcyclopropane-1-carboxamide Investigative 76313986 C18H16N2O2S 324.4 CC1=NC2=C(S1)C=CC(=C2)[C@@H]3[C@H]([C@H]3C(=O)NO)C4=CC=CC=C4 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BMH13O Ethyl 4-((2-amino-5-(thiophen-2-yl)phenyl)carbamoyl)benzylcarbamate Investigative 25155956 C21H21N3O3S 395.5 CCOC(=O)NCC1=CC=C(C=C1)C(=O)NC2=C(C=CC(=C2)C3=CC=CS3)N IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BMN7R5 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid hydroxyamide (4-phenylthiazol-2-yl)amide Investigative 56951446 C17H9F12N3O3S 563.3 C1=CC=C(C=C1)C2=CSC(=N2)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BMZ5H3 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-N-hydroxy-N'-(4-methoxyphenyl)octanediamide Investigative 137652670 C15H10F12N2O4 510.23 COC1=CC=C(C=C1)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BN3E0R 3beta-Cyclopentyl-2alpha-phenylcyclopropane-1alpha-carbohydroxamic acid Investigative 60148645 C15H19NO2 245.32 C1CCC(C1)[C@@H]2[C@H]([C@H]2C(=O)NO)C3=CC=CC=C3 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BN50FX (E)-5-(4-(Dimethylamino)styryl)-N-hydroxyfuran-2-carboxamide Investigative 44562079 C15H16N2O3 272.3 CN(C)C1=CC=C(C=C1)/C=C/C2=CC=C(O2)C(=O)NO IC50 = 50580 nM Poor binder T63816 Histone deacetylase 4 BN7MF9 Methyl 4-((2-amino-5-(thiophen-2-yl)phenyl)carbamoyl)benzylcarbamate Investigative 44447194 C20H19N3O3S 381.4 COC(=O)NCC1=CC=C(C=C1)C(=O)NC2=C(C=CC(=C2)C3=CC=CS3)N IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BNC7H0 (1R,2R,3R)-N-Hydroxy-2-phenyl-3-pyrimidin-5-ylcyclopropane-1-carboxamide Investigative 60148647 C14H13N3O2 255.27 C1=CC=C(C=C1)[C@@H]2[C@H]([C@@H]2C(=O)NO)C3=CN=CN=C3 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BNI3M0 CID 57336570 Investigative 57336570 C22H12F12N2O3 580.3 C1=CC=C2C=C3C=C(C=CC3=CC2=C1)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BNJI96 (7R)-N-Hydroxy-7-[(4-pyridin-3-ylpyrimidin-2-yl)amino]-5,6,7,8-tetrahydronaphthalene-2-carboxamide Investigative 92045024 C20H19N5O2 361.4 C1CC2=C(C[C@@H]1NC3=NC=CC(=N3)C4=CN=CC=C4)C=C(C=C2)C(=O)NO IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BNP3Y7 N-(2-Aminophenyl)-4-[1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl]benzamide Investigative 71721946 C21H19N5OS 389.5 C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)C3=CN(N=N3)CCC4=CSC=C4 IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BO3E9R 3beta-(Imidazo[1,2-a]pyridine-2-yl)-2alpha-phenylcyclopropane-1alpha-carbohydroxamic acid Investigative 76321252 C17H15N3O2 293.32 C1=CC=C(C=C1)[C@@H]2[C@H]([C@@H]2C(=O)NO)C3=CN4C=CC=CC4=N3 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BO3G4S (2R)-2-[(1-Hydroxy-6-sulfanylidenepyridine-2-carbonyl)amino]propanoic acid Investigative 86294741 C9H10N2O4S 242.25 C[C@H](C(=O)O)NC(=O)C1=CC=CC(=S)N1O IC50 = 100000 nM Poor binder T63816 Histone deacetylase 4 BO5I0U N-[4-[2-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)oxy]acetyl]phenyl]acetamide Investigative 136086924 C15H15N3O4 301.3 CC1=CC(=O)NC(=N1)OCC(=O)C2=CC=C(C=C2)NC(=O)C IC50 = 54200 nM Poor binder T63816 Histone deacetylase 4 BP25QZ 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid biphenyl-4-ylamide hydroxyamide Investigative 57336561 C20H12F12N2O3 556.3 C1=CC=C(C=C1)C2=CC=C(C=C2)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BP4CE5 (1R,2R,3R)-N-Hydroxy-2-[4-(2-oxa-6-azaspiro[3.3]heptan-6-yl)phenyl]-3-phenylcyclopropane-1-carboxamide Investigative 60148783 C21H22N2O3 350.4 C1C2(CN1C3=CC=C(C=C3)[C@@H]4[C@H]([C@H]4C(=O)NO)C5=CC=CC=C5)COC2 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BP9E6M N-Hydroxy-2-(1-methylpyrrole-2-carbonyl)-3,4-dihydro-1H-isoquinoline-6-carboxamide Investigative 49831258 C16H17N3O3 299.32 CN1C=CC=C1C(=O)N2CCC3=C(C2)C=CC(=C3)C(=O)NO IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BPRY15 Methyl 2-((4-hydroxy-6-methylpyrimidin-2-yl)thio)acetate Investigative 135412048 C8H10N2O3S 214.24 CC1=CC(=O)NC(=N1)SCC(=O)OC IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BPT31B (1R,2R,3R)-N-Hydroxy-2-phenyl-3-[5-(trifluoromethyl)pyridin-3-yl]cyclopropane-1-carboxamide Investigative 60148809 C16H13F3N2O2 322.28 C1=CC=C(C=C1)[C@@H]2[C@H]([C@@H]2C(=O)NO)C3=CC(=CN=C3)C(F)(F)F IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BPVG26 2alpha-Phenylcyclopropane-1alpha-carbohydroxamic acid Investigative 76317534 C10H11NO2 177.2 C1[C@H]([C@H]1C(=O)NO)C2=CC=CC=C2 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BQA14N N-(2-Amino-5-(thiophen-2-yl)phenyl)-6-(2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-8-yl)nicotinamide Investigative 24744325 C23H23N5O3S 449.5 C1CN(CCC12CNC(=O)O2)C3=NC=C(C=C3)C(=O)NC4=C(C=CC(=C4)C5=CC=CS5)N IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BR52IK N1-(2-Aminophenyl)-N7-phenylheptanediamide Investigative 9543539 C19H23N3O2 325.4 C1=CC=C(C=C1)NC(=O)CCCCCC(=O)NC2=CC=CC=C2N IC50 ~ 180000 nM Poor binder T63816 Histone deacetylase 4 BR6BY4 N-Hydroxy-2-[(1-methyl-1H-pyrrol-2-yl)carbonyl]isoindoline-5-carboxamide Investigative 58147189 C15H15N3O3 285.3 CN1C=CC=C1C(=O)N2CC3=C(C2)C=C(C=C3)C(=O)NO IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BR9PK4 Diethyl(4-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl)benzylamino)methylphosphonate Investigative 42601485 C23H28N3O4PS 473.5 CCOP(=O)(CNCC1=CC=C(C=C1)C(=O)NC2=C(C=CC(=C2)C3=CC=CS3)N)OCC IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BRG71V 5-(2,4-Dihydroxy-5-propan-2-ylbenzoyl)-N-[7-(hydroxyamino)-7-oxoheptyl]-6,7-dihydro-4H-[1,2]oxazolo[4,5-c]pyridine-3-carboxamide Investigative 86302594 C24H32N4O7 488.5 CC(C)C1=CC(=C(C=C1O)O)C(=O)N2CCC3=C(C2)C(=NO3)C(=O)NCCCCCCC(=O)NO IC50 = 75900 nM Poor binder T63816 Histone deacetylase 4 BRGV98 1-(3,4-Dihydroxyphenyl)-2-[(4-hydroxy-6-methylpyrimidin-2-YL)thio]ethanone Investigative 135444536 C13H12N2O4S 292.31 CC1=CC(=O)NC(=N1)SCC(=O)C2=CC(=C(C=C2)O)O IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BRH7M9 N-(2-Aminophenyl)-4-[[[(4R,5S)-4,5-diphenyl-1,3-oxazolidin-2-ylidene]amino]methyl]benzamide Investigative 136110961 C29H26N4O2 462.5 C1=CC=C(C=C1)[C@@H]2[C@@H](OC(=NCC3=CC=C(C=C3)C(=O)NC4=CC=CC=C4N)N2)C5=CC=CC=C5 IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BRJ7B6 (1R,2R,3R)-2-[3-Fluoro-4-(5-methyl-1H-imidazol-2-yl)phenyl]-N-hydroxy-3-phenylcyclopropane-1-carboxamide Investigative 60148950 C20H18FN3O2 351.4 CC1=CN=C(N1)C2=C(C=C(C=C2)[C@@H]3[C@H]([C@H]3C(=O)NO)C4=CC=CC=C4)F IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BS8PG9 2-(2,2-Dimethylpropanoyl)-N-hydroxy-3,4-dihydro-1H-isoquinoline-6-carboxamide Investigative 49855444 C15H20N2O3 276.33 CC(C)(C)C(=O)N1CCC2=C(C1)C=CC(=C2)C(=O)NO IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BTA14N (E)-3-[4-[3-(1-Adamantyl)-4-hydroxyphenyl]phenyl]-N-hydroxyprop-2-enamide Investigative 15986417 C25H27NO3 389.5 C1C2CC3CC1CC(C2)(C3)C4=C(C=CC(=C4)C5=CC=C(C=C5)/C=C/C(=O)NO)O IC50 = 61400 nM Poor binder T63816 Histone deacetylase 4 BTOM67 (E)-3-[5-[[2-(1,3-Benzodioxol-5-yl)ethyl-[2-(4-methylphenoxy)ethyl]amino]methyl]furan-2-yl]-N-hydroxyprop-2-enamide Investigative 71770562 C26H28N2O6 464.5 CC1=CC=C(C=C1)OCCN(CCC2=CC3=C(C=C2)OCO3)CC4=CC=C(O4)/C=C/C(=O)NO IC50 = 52450 nM Poor binder T63816 Histone deacetylase 4 BU45MK 3beta-[1-Oxo-2-(2,2,2-trifluoroethyl)isoindoline-5-yl]-2alpha-phenylcyclopropane-1alpha-carbohydroxamic acid Investigative 60148690 C20H17F3N2O3 390.4 C1C2=C(C=CC(=C2)[C@@H]3[C@H]([C@H]3C(=O)NO)C4=CC=CC=C4)C(=O)N1CC(F)(F)F IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BU4XY9 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid (3,4-dimethylphenyl)-amide hydroxyamide Investigative 57336560 C16H12F12N2O3 508.26 CC1=C(C=C(C=C1)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)C Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BU7RB5 N-Hydroxy-4-(((2-phenoxyethyl)(5-p-tolylthiazol-2-yl)amino)methyl)benzamide Investigative 45102716 C26H25N3O3S 459.6 CC1=CC=C(C=C1)C2=CN=C(S2)N(CCOC3=CC=CC=C3)CC4=CC=C(C=C4)C(=O)NO IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BUBX82 (1R,2R,3R)-2-(8-Chloro-1,2,3,4-tetrahydroquinolin-6-yl)-N-hydroxy-3-phenylcyclopropane-1-carboxamide Investigative 60148862 C19H19ClN2O2 342.8 C1CC2=C(C(=CC(=C2)[C@@H]3[C@H]([C@H]3C(=O)NO)C4=CC=CC=C4)Cl)NC1 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BULF09 N-(2-Amino-5-thiophen-2-ylphenyl)benzamide Investigative 44454144 C17H14N2OS 294.4 C1=CC=C(C=C1)C(=O)NC2=C(C=CC(=C2)C3=CC=CS3)N IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BV9UD6 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid hydroxyamide naph-thalen-1-ylamide Investigative 57336566 C18H10F12N2O3 530.3 C1=CC=C2C(=C1)C=CC=C2NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BVA69W 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-N,N'-diphenyloctanediamide Investigative 57401090 C20H12F12N2O2 540.3 C1=CC=C(C=C1)NC(=O)C(C(C(C(C(C(C(=O)NC2=CC=CC=C2)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BVLJ94 N-Hydroxy-4-(((2-(p-tolyloxy)ethyl)(5-p-tolylthiazol-2-yl)amino)methyl)benzamide Investigative 45102721 C27H27N3O3S 473.6 CC1=CC=C(C=C1)C2=CN=C(S2)N(CCOC3=CC=C(C=C3)C)CC4=CC=C(C=C4)C(=O)NO IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BVSP75 6-[2-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetyl]-1,3-dihydroindol-2-one Investigative 136086921 C15H13N3O3S 315.3 CC1=CC(=O)NC(=N1)SCC(=O)C2=CC3=C(CC(=O)N3)C=C2 IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BW4IX7 Azumamide A Investigative 16095102 C27H39N5O5 513.6 C[C@H]1[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC1=O)C(C)C)C)CC2=CC=CC=C2)C/C=C\\CCC(=O)N IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BW4PZ5 (1r,2r,3r)-2-[4-(1,3-Oxazol-5-Yl)phenyl]-N-Oxidanyl-3-Phenyl-Cyclopropane-1-Carboxamide Investigative 60148693 C19H16N2O3 320.3 C1=CC=C(C=C1)[C@@H]2[C@H]([C@@H]2C(=O)NO)C3=CC=C(C=C3)C4=CN=CO4 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BW53QM N-[4-[2-(4-Methoxy-6-methylpyrimidin-2-yl)sulfanylacetyl]phenyl]acetamide Investigative 56673234 C16H17N3O3S 331.4 CC1=CC(=NC(=N1)SCC(=O)C2=CC=C(C=C2)NC(=O)C)OC IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BW7C9A 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-N-hydroxy-N'-(3-methylphenyl)octanediamide Investigative 137658785 C15H10F12N2O3 494.23 CC1=CC(=CC=C1)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BX18GK Ethyl 4-[(4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-3-oxobutanoate Investigative 136086922 C11H14N2O4S 270.31 CCOC(=O)CC(=O)CSC1=NC(=CC(=O)N1)C IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BX62ZD 6-Methyl-2-{[2-oxo-2-(thiophen-2-yl)ethyl]sulfanyl}-3,4-dihydropyrimidin-4-one Investigative 135407493 C11H10N2O2S2 266.3 CC1=CC(=O)NC(=N1)SCC(=O)C2=CC=CS2 IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BX6S7Z (1R,2R,3R)-N-Hydroxy-2-phenyl-3-pyridazin-4-ylcyclopropane-1-carboxamide Investigative 60148666 C14H13N3O2 255.27 C1=CC=C(C=C1)[C@@H]2[C@H]([C@@H]2C(=O)NO)C3=CN=NC=C3 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BX8AF0 N-[4-[2-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetyl]phenyl]benzamide Investigative 136025837 C20H17N3O3S 379.4 CC1=CC(=O)NC(=N1)SCC(=O)C2=CC=C(C=C2)NC(=O)C3=CC=CC=C3 IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BXK72U Thailandepsin A Investigative 56602459 C23H37N3O6S3 547.8 CC[C@H](C)[C@@H]1[C@H](CC(=O)O[C@H]\\2CC(=O)N[C@@H](C(=O)N[C@H](CSSCC/C=C2)C(=O)N1)CCSC)O IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BY4SD8 (1R,2S,3R)-N-Hydroxy-2-phenyl-3-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-2-yl]cyclopropane-1-carboxamide Investigative 76321253 C16H12F3N3O2S 367.3 C1=CC=C(C=C1)[C@@H]2[C@H]([C@@H]2C(=O)NO)C3=CN4C=C(N=C4S3)C(F)(F)F IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BY54PI (1R,14S,17R,23S)-23-Methyl-4-oxa-7,8-dithia-15,21,24,26-tetrazatricyclo[12.11.2.017,21]heptacosane-16,22,25,27-tetrone Investigative 118706557 C21H34N4O5S2 486.7 C[C@H]1C(=O)N2CCC[C@@H]2C(=O)N[C@H]3CCCCCSSCCOCC[C@H](C(=O)N1)NC3=O IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 BYW3G5 (E)-N-Hydroxy-5-(4-hydroxystyryl)furan-2-carboxamide Investigative 44562039 C13H11NO4 245.23 C1=CC(=CC=C1/C=C/C2=CC=C(O2)C(=O)NO)O IC50 = 57060 nM Poor binder T63816 Histone deacetylase 4 BYW6V2 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid hydroxyamide 4-methyl-phenylamide Investigative 57336554 C15H10F12N2O3 494.23 CC1=CC=C(C=C1)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BZ0IU3 (1r,2r,3r)-2-[4-(5-Fluoranylpyrimidin-2-Yl)phenyl]-N-Oxidanyl-3-Phenyl-Cyclopropane-1-Carboxamide Investigative 60148711 C20H16FN3O2 349.4 C1=CC=C(C=C1)[C@@H]2[C@H]([C@@H]2C(=O)NO)C3=CC=C(C=C3)C4=NC=C(C=N4)F IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BZ0O7G 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid anthracen-1-ylamide hydroxyamide Investigative 57336572 C22H12F12N2O3 580.3 C1=CC=C2C=C3C(=CC2=C1)C=CC=C3NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Ki ~ 50000 nM Poor binder T63816 Histone deacetylase 4 BZU80T (1R,2R,3R)-2-[3-(5-Fluoropyrimidin-2-yl)phenyl]-N-hydroxy-3-phenylcyclopropane-1-carboxamide Investigative 60148712 C20H16FN3O2 349.4 C1=CC=C(C=C1)[C@@H]2[C@H]([C@@H]2C(=O)NO)C3=CC=CC(=C3)C4=NC=C(C=N4)F IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 D02NWS 4-Phenylbutyrohydroxamic acid Investigative 279980 C10H13NO2 179.22 C1=CC=C(C=C1)CCCC(=O)NO IC50 = 140000 nM Poor binder T63816 Histone deacetylase 4 D04UVL N-(2-aminophenyl)nicotinamide Investigative 1133083 C12H11N3O 213.23 C1=CC=C(C(=C1)N)NC(=O)C2=CN=CC=C2 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 D0E0TA N-(4-hydroxybiphenyl-3-yl)benzamide Investigative 44454650 C19H15NO2 289.3 C1=CC=C(C=C1)C2=CC(=C(C=C2)O)NC(=O)C3=CC=CC=C3 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 D0M9LJ N-(4-aminobiphenyl-3-yl)nicotinamide Investigative 44454415 C18H15N3O 289.3 C1=CC=C(C=C1)C2=CC(=C(C=C2)N)NC(=O)C3=CN=CC=C3 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 D0MD7H N-(4-aminobiphenyl-3-yl)benzamide Investigative 44454143 C19H16N2O 288.3 C1=CC=C(C=C1)C2=CC(=C(C=C2)N)NC(=O)C3=CC=CC=C3 IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 D0Q2GM N-(2-amino-5-(thiophen-2-yl)phenyl)nicotinamide Investigative 44454416 C16H13N3OS 295.4 C1=CC(=CN=C1)C(=O)NC2=C(C=CC(=C2)C3=CC=CS3)N IC50 ~ 50000 nM Poor binder T63816 Histone deacetylase 4 D0Q5MC PCI-34051 Investigative 24753719 C17H16N2O3 296.32 COC1=CC=C(C=C1)CN2C=CC3=C2C=C(C=C3)C(=O)NO IC50 ~ 100000 nM Poor binder T63816 Histone deacetylase 4 D0U8FC N-(2-aminophenyl)benzamide Investigative 759408 C13H12N2O 212.25 C1=CC=C(C=C1)C(=O)NC2=CC=CC=C2N IC50 ~ 50000 nM Poor binder