TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T65783	Apelin receptor	B02TEJ	6-(((4-Methylpyrimidin-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 5-chloro-2-nitrobenzoate	Investigative	18572335	C18H12ClN3O6S	433.8	CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=C(C=CC(=C3)Cl)[N+](=O)[O-]	IC50 = 58800 nM	Poor binder
T65783	Apelin receptor	B0LZQ5	[6-[(4,6-Dimethylpyrimidin-2-yl)sulfanylmethyl]-4-oxopyran-3-yl] 4-nitrobenzenesulfonate	Investigative	49787115	C18H15N3O7S2	449.5	CC1=CC(=NC(=N1)SCC2=CC(=O)C(=CO2)OS(=O)(=O)C3=CC=C(C=C3)[N+](=O)[O-])C	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	B0UMG3	5-Hydroxy-2-((phenylthio)methyl)-4H-pyran-4-one	Investigative	44726831	C12H10O3S	234.27	C1=CC=C(C=C1)SCC2=CC(=O)C(=CO2)O	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	B1JN3L	6-(((4-Methylpyrimidin-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 4-chlorobenzoate	Investigative	7217922	C18H13ClN2O4S	388.8	CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)Cl	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	B2WEA3	4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-chlorobenzoate	Investigative	7217921	C17H11ClN2O4S	374.8	C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)Cl	IC50 = 54500 nM	Poor binder
T65783	Apelin receptor	B3MF2O	4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-ethoxybenzoate	Investigative	7217884	C19H16N2O5S	384.4	CCOC1=CC=C(C=C1)C(=O)OC2=COC(=CC2=O)CSC3=NC=CC=N3	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	B3R4UN	[6-[(4-Methylpyrimidin-2-yl)sulfanylmethyl]-4-oxopyran-3-yl] 3-cyanobenzoate	Investigative	49787120	C19H13N3O4S	379.4	CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=CC(=C3)C#N	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	B40KWY	4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-butoxybenzoate	Investigative	7217891	C21H20N2O5S	412.5	CCCCOC1=CC=C(C=C1)C(=O)OC2=COC(=CC2=O)CSC3=NC=CC=N3	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	B43AZJ	4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-methylbenzoate	Investigative	7217861	C18H14N2O4S	354.4	CC1=CC=C(C=C1)C(=O)OC2=COC(=CC2=O)CSC3=NC=CC=N3	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	B48YBW	4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-isopropoxybenzoate	Investigative	7217887	C20H18N2O5S	398.4	CC(C)OC1=CC=C(C=C1)C(=O)OC2=COC(=CC2=O)CSC3=NC=CC=N3	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	B4FE7N	5-Hydroxy-2-((pyrimidin-2-ylthio)methyl)-4H-pyran-4-one	Investigative	42281625	C10H8N2O3S	236.25	C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)O	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	B4HY9T	4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 2-methyl-3-nitrobenzoate	Investigative	7217944	C18H13N3O6S	399.4	CC1=C(C=CC=C1[N+](=O)[O-])C(=O)OC2=COC(=CC2=O)CSC3=NC=CC=N3	IC50 = 72200 nM	Poor binder
T65783	Apelin receptor	B4NW8Q	6-(((4-Methylpyrimidin-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl furan-2-carboxylate	Investigative	7218011	C16H12N2O5S	344.3	CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=CO3	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	B4VWR9	6-(((4-Methylpyrimidin-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 3-methoxybenzoate	Investigative	7217876	C19H16N2O5S	384.4	CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC(=CC=C3)OC	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	B5RSD7	6-(((4-Methylpyrimidin-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 3-chlorobenzoate	Investigative	7217919	C18H13ClN2O4S	388.8	CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC(=CC=C3)Cl	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	B69VHK	4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-(morpholinosulfonyl)benzoate	Investigative	18572382	C21H19N3O7S2	489.5	C1COCCN1S(=O)(=O)C2=CC=C(C=C2)C(=O)OC3=COC(=CC3=O)CSC4=NC=CC=N4	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	B6AOL1	4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 2-chloro-5-nitrobenzoate	Investigative	18572337	C17H10ClN3O6S	419.8	C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=C(C=CC(=C3)[N+](=O)[O-])Cl	IC50 = 51000 nM	Poor binder
T65783	Apelin receptor	B7I8OF	[6-[(4-Methylpyrimidin-2-yl)sulfanylmethyl]-4-oxopyran-3-yl] thiophene-3-carboxylate	Investigative	71462076	C16H12N2O4S2	360.4	CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CSC=C3	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	B7Y6DH	[6-[(4-Methylpyrimidin-2-yl)sulfanylmethyl]-4-oxopyran-3-yl] 1,3-oxazole-5-carboxylate	Investigative	71456693	C15H11N3O5S	345.3	CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CN=CO3	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	B8FQ5H	[6-[(4-Methylpyrimidin-2-yl)sulfanylmethyl]-4-oxopyran-3-yl] 4-(trifluoromethoxy)benzoate	Investigative	46905020	C19H13F3N2O5S	438.4	CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)OC(F)(F)F	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	B8PV4K	6-(((4-Methylpyrimidin-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 4-fluorobenzoate	Investigative	7217913	C18H13FN2O4S	372.4	CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)F	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	B9CYW7	[6-[(4,6-Dimethylpyrimidin-2-yl)sulfanylmethyl]-4-oxopyran-3-yl] benzenesulfonate	Investigative	49787117	C18H16N2O5S2	404.5	CC1=CC(=NC(=N1)SCC2=CC(=O)C(=CO2)OS(=O)(=O)C3=CC=CC=C3)C	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	B9Z5SM	4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl [1,1'-biphenyl]-4-carboxylate	Investigative	18572352	C23H16N2O4S	416.5	C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)OC3=COC(=CC3=O)CSC4=NC=CC=N4	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BAO16P	6-(((4-Methylpyrimidin-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 3-methylbenzoate	Investigative	7217859	C19H16N2O4S	368.4	CC1=CC(=CC=C1)C(=O)OC2=COC(=CC2=O)CSC3=NC=CC(=N3)C	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BC70DS	4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl benzoate	Investigative	7217852	C17H12N2O4S	340.4	C1=CC=C(C=C1)C(=O)OC2=COC(=CC2=O)CSC3=NC=CC=N3	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BCX39O	4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-(N,N-dimethylsulfamoyl)benzoate	Investigative	16194671	C19H17N3O6S2	447.5	CN(C)S(=O)(=O)C1=CC=C(C=C1)C(=O)OC2=COC(=CC2=O)CSC3=NC=CC=N3	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BE75RM	[6-[(4-Methylpyrimidin-2-yl)sulfanylmethyl]-4-oxopyran-3-yl] 5-nitrofuran-2-carboxylate	Investigative	46905022	C16H11N3O7S	389.3	CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(O3)[N+](=O)[O-]	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BEO0G5	6-(((4-Methylpyrimidin-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 2-methylbenzoate	Investigative	7217856	C19H16N2O4S	368.4	CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=CC=C3C	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BEU81N	4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 3-nitrobenzoate	Investigative	7217938	C17H11N3O6S	385.4	C1=CC(=CC(=C1)[N+](=O)[O-])C(=O)OC2=COC(=CC2=O)CSC3=NC=CC=N3	IC50 = 75700 nM	Poor binder
T65783	Apelin receptor	BF73VM	2-(((4,6-Dimethylpyrimidin-2-yl)thio)methyl)-5-hydroxy-4H-pyran-4-one	Investigative	46835120	C12H12N2O3S	264.3	CC1=CC(=NC(=N1)SCC2=CC(=O)C(=CO2)O)C	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BFE29Z	4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 3,4-dimethylbenzoate	Investigative	7217867	C19H16N2O4S	368.4	CC1=C(C=C(C=C1)C(=O)OC2=COC(=CC2=O)CSC3=NC=CC=N3)C	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BFRN42	5-[(4-Chloro-3-nitrophenyl)methoxy]-2-[(4-methylpyrimidin-2-yl)sulfanylmethyl]pyran-4-one	Investigative	46905038	C18H14ClN3O5S	419.8	CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OCC3=CC(=C(C=C3)Cl)[N+](=O)[O-]	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BFVH97	4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-fluorobenzoate	Investigative	7217912	C17H11FN2O4S	358.3	C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)F	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BGPJ87	4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-(N,N-diethylsulfamoyl)benzoate	Investigative	18572378	C21H21N3O6S2	475.5	CCN(CC)S(=O)(=O)C1=CC=C(C=C1)C(=O)OC2=COC(=CC2=O)CSC3=NC=CC=N3	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BH04BO	[6-[(4-Methylpyrimidin-2-yl)sulfanylmethyl]-4-oxopyran-3-yl] 2,2-dimethylpropanoate	Investigative	46905014	C16H18N2O4S	334.4	CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C(C)(C)C	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BHB6Y9	N-[6-[(4-Methylpyrimidin-2-yl)sulfanylmethyl]-4-oxopyran-3-yl]benzamide	Investigative	49787119	C18H15N3O3S	353.4	CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)NC(=O)C3=CC=CC=C3	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BI1BH2	4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 5-chloro-2-nitrobenzoate	Investigative	18572334	C17H10ClN3O6S	419.8	C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=C(C=CC(=C3)Cl)[N+](=O)[O-]	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BIV28B	4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-(piperidin-1-ylsulfonyl)benzoate	Investigative	18572379	C22H21N3O6S2	487.6	C1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)C(=O)OC3=COC(=CC3=O)CSC4=NC=CC=N4	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BJ87PZ	6-(((4-Methylpyrimidin-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 3-nitrobenzoate	Investigative	7217939	C18H13N3O6S	399.4	CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC(=CC=C3)[N+](=O)[O-]	IC50 = 59200 nM	Poor binder
T65783	Apelin receptor	BJA4K5	6-(((4-Methylpyrimidin-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 2-chlorobenzoate	Investigative	7217916	C18H13ClN2O4S	388.8	CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=CC=C3Cl	IC50 ~ 59000 nM	Poor binder
T65783	Apelin receptor	BKU97C	4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-methoxybenzoate	Investigative	7217878	C18H14N2O5S	370.4	COC1=CC=C(C=C1)C(=O)OC2=COC(=CC2=O)CSC3=NC=CC=N3	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BL48RV	[6-[(4-Methylpyrimidin-2-yl)sulfanylmethyl]-4-oxopyran-3-yl] 2-methylpropanoate	Investigative	46905037	C15H16N2O4S	320.4	CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C(C)C	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BN7YA0	2-(((4-Fluorophenyl)thio)methyl)-5-hydroxy-4H-pyran-4-one	Investigative	351037	C12H9FO3S	252.26	C1=CC(=CC=C1F)SCC2=CC(=O)C(=CO2)O	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BNG13V	6-(((4-Methylpyrimidin-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 4-methoxybenzoate	Investigative	7217879	C19H16N2O5S	384.4	CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)OC	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BQ5IT1	N-[6-[(4-Methylpyrimidin-2-yl)sulfanylmethyl]-4-oxopyran-3-yl]-4-nitrobenzamide	Investigative	49842908	C18H14N4O5S	398.4	CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)NC(=O)C3=CC=C(C=C3)[N+](=O)[O-]	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BQM95X	[6-[(4-Methylpyrimidin-2-yl)sulfanylmethyl]-4-oxopyran-3-yl] acetate	Investigative	46905025	C13H12N2O4S	292.31	CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BS9V8A	2-[(4-Methylpyrimidin-2-yl)sulfanylmethyl]-5-phenylmethoxypyran-4-one	Investigative	46835118	C18H16N2O3S	340.4	CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OCC3=CC=CC=C3	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BSA01E	6-(((4-Methylpyrimidin-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 2-chloro-5-nitrobenzoate	Investigative	12005898	C18H12ClN3O6S	433.8	CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=C(C=CC(=C3)[N+](=O)[O-])Cl	IC50 = 74100 nM	Poor binder
T65783	Apelin receptor	BSRM25	6-(((4-Methylpyrimidin-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 4-methylbenzoate	Investigative	7217862	C19H16N2O4S	368.4	CC1=CC=C(C=C1)C(=O)OC2=COC(=CC2=O)CSC3=NC=CC(=N3)C	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BT7AO9	4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-(tert-butyl)benzoate	Investigative	7217870	C21H20N2O4S	396.5	CC(C)(C)C1=CC=C(C=C1)C(=O)OC2=COC(=CC2=O)CSC3=NC=CC=N3	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BV1TG8	4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4,5-dimethoxy-2-nitrobenzoate	Investigative	18572395	C19H15N3O8S	445.4	COC1=C(C=C(C(=C1)C(=O)OC2=COC(=CC2=O)CSC3=NC=CC=N3)[N+](=O)[O-])OC	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BVAR24	5-Hydroxy-2-(((4-methylpyrimidin-2-yl)thio)methyl)-4H-pyran-4-one	Investigative	46835124	C11H10N2O3S	250.28	CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)O	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BX15IC	6-(((4-Methylpyrimidin-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl benzoate	Investigative	7217853	C18H14N2O4S	354.4	CC1=NC(=NC=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=CC=C3	IC50 ~ 79000 nM	Poor binder
T65783	Apelin receptor	BYW32L	4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-(pyrrolidin-1-ylsulfonyl)benzoate	Investigative	16832372	C21H19N3O6S2	473.5	C1CCN(C1)S(=O)(=O)C2=CC=C(C=C2)C(=O)OC3=COC(=CC3=O)CSC4=NC=CC=N4	IC50 ~ 79000 nM	Poor binder