TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T70840	LIM domain kinase-1	B0RW6D	5-[6-(2-Chloro-4-ethoxyphenyl)-2-(2-fluorophenyl)pyrimidin-4-yl]-N-propan-2-yl-1,3-thiazol-2-amine	Investigative	58688403	C24H22ClFN4OS	469	CCOC1=CC(=C(C=C1)C2=CC(=NC(=N2)C3=CC=CC=C3F)C4=CN=C(S4)NC(C)C)Cl	IC50 ~ 50000 nM	Poor binder
T70840	LIM domain kinase-1	B1OFZ9	Thieno[3,2-b]pyridine-2-carboxamide, 3-amino-	Investigative	13793449	C8H7N3OS	193.23	C1=CC2=C(C(=C(S2)C(=O)N)N)N=C1	IC50 = 92000 nM	Poor binder
T70840	LIM domain kinase-1	B1WF8X	2-Methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine	Investigative	336250	C11H13N3S	219.31	CC1=NC(=C2C3=C(CCCC3)SC2=N1)N	IC50 ~ 100000 nM	Poor binder
T70840	LIM domain kinase-1	B2MRL3	N,N-Dimethyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amine	Investigative	4112641	C12H15N3S	233.33	CN(C)C1=C2C3=C(CCCC3)SC2=NC=N1	IC50 ~ 100000 nM	Poor binder
T70840	LIM domain kinase-1	B39ZXS	Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-methyl-	Investigative	65629114	C9H9N3OS	207.25	CNC(=O)C1=C(C2=C(S1)N=CC=C2)N	IC50 ~ 100000 nM	Poor binder
T70840	LIM domain kinase-1	B3ZN9C	2-(Methylsulfanyl)-6,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidin-4-amine	Investigative	2881040	C12H15N3S2	265.4	CSC1=NC(=C2C3=C(CCCCC3)SC2=N1)N	IC50 ~ 100000 nM	Poor binder
T70840	LIM domain kinase-1	B4JPX1	2-Thiophen-2-yl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-amine	Investigative	863538	C14H13N3S2	287.4	C1CCC2=C(C1)C3=C(N=C(N=C3S2)C4=CC=CS4)N	IC50 ~ 100000 nM	Poor binder
T70840	LIM domain kinase-1	B6A9NC	[(4-Amino-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-yl)sulfanyl]acetic acid	Investigative	832424	C12H13N3O2S2	295.4	C1CCC2=C(C1)C3=C(N=C(N=C3S2)SCC(=O)O)N	IC50 ~ 100000 nM	Poor binder
T70840	LIM domain kinase-1	B7ZJ1U	3-Aminothieno[2,3-b]pyridine-2-carboxylic acid	Investigative	323535	C8H6N2O2S	194.21	C1=CC2=C(N=C1)SC(=C2N)C(=O)O	IC50 ~ 100000 nM	Poor binder
T70840	LIM domain kinase-1	BAZ95E	2-(Methylthio)-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-amine	Investigative	826476	C10H11N3S2	237.3	CSC1=NC(=C2C3=C(CCC3)SC2=N1)N	IC50 ~ 100000 nM	Poor binder
T70840	LIM domain kinase-1	BB6N8Z	N-Methyl-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6-tetraen-3-amine	Investigative	676971	C11H13N3S	219.31	CNC1=C2C3=C(CCCC3)SC2=NC=N1	IC50 ~ 100000 nM	Poor binder
T70840	LIM domain kinase-1	BB6PT0	2-Phenyl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-ylamine	Investigative	337817	C16H15N3S	281.4	C1CCC2=C(C1)C3=C(N=C(N=C3S2)C4=CC=CC=C4)N	IC50 ~ 100000 nM	Poor binder
T70840	LIM domain kinase-1	BCH4P3	4-(1-Piperidinyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine	Investigative	433561	C15H19N3S	273.4	C1CCN(CC1)C2=C3C4=C(CCCC4)SC3=NC=N2	IC50 ~ 100000 nM	Poor binder
T70840	LIM domain kinase-1	BCPE08	4-Amino-6,7,8,9-tetrahydro-5H-10-thia-1,3-diaza-benzo[a]azulene-2-thiol	Investigative	3724764	C11H13N3S2	251.4	C1CCC2=C(CC1)SC3=NC(=S)NC(=C23)N	IC50 ~ 100000 nM	Poor binder
T70840	LIM domain kinase-1	BDOF54	Benzo[b]thiophene-2-carboxamide, 3-hydroxy-	Investigative	54680213	C9H7NO2S	193.22	C1=CC=C2C(=C1)C(=C(S2)C(=O)N)O	IC50 ~ 100000 nM	Poor binder
T70840	LIM domain kinase-1	BH37ID	4-Amino-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidine-2-thiol	Investigative	738893	C10H11N3S2	237.3	C1CCC2=C(C1)C3=C(NC(=S)N=C3S2)N	IC50 ~ 100000 nM	Poor binder
T70840	LIM domain kinase-1	BJE3W8	3-Amino-1-benzothiophene-2-carboxylic acid	Investigative	2736849	C9H7NO2S	193.22	C1=CC=C2C(=C1)C(=C(S2)C(=O)O)N	IC50 ~ 100000 nM	Poor binder
T70840	LIM domain kinase-1	BJH08V	3-Aminobenzofuran-2-carboxamide	Investigative	600546	C9H8N2O2	176.17	C1=CC=C2C(=C1)C(=C(O2)C(=O)N)N	IC50 ~ 100000 nM	Poor binder
T70840	LIM domain kinase-1	BJS73U	N-(2-Phenylethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine	Investigative	830964	C18H19N3S	309.4	C1CCC2=C(C1)C3=C(N=CN=C3S2)NCCC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T70840	LIM domain kinase-1	BK38HJ	N'-(5,6,7,8-Tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)ethane-1,2-diamine	Investigative	3161284	C12H16N4S	248.35	C1CCC2=C(C1)C3=C(N=CN=C3S2)NCCN	IC50 ~ 100000 nM	Poor binder
T70840	LIM domain kinase-1	BK9S3V	Ethyl 3-aminobenzo[b]thiophene-2-carboxylate	Investigative	731510	C11H11NO2S	221.28	CCOC(=O)C1=C(C2=CC=CC=C2S1)N	IC50 ~ 100000 nM	Poor binder
T70840	LIM domain kinase-1	BLC2I5	4-Phenyl-8-thia-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-6-amine	Investigative	90666100	C15H10N4S	278.3	C1=CC=C(C=C1)C2=NC3=C(C(=N2)N)SC4=C3C=CC=N4	IC50 ~ 50000 nM	Poor binder
T70840	LIM domain kinase-1	BM6K1C	3-Aminothieno[2,3-b]pyridine-2-carbohydrazide	Investigative	8027126	C8H8N4OS	208.24	C1=CC2=C(N=C1)SC(=C2N)C(=O)NN	IC50 ~ 100000 nM	Poor binder
T70840	LIM domain kinase-1	BMH2P9	2-(5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-ylamino)ethanol	Investigative	1641261	C12H15N3OS	249.33	C1CCC2=C(C1)C3=C(N=CN=C3S2)NCCO	IC50 ~ 100000 nM	Poor binder
T70840	LIM domain kinase-1	BMSK67	2-(Methylsulfanyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-ylamine	Investigative	2270285	C11H13N3S2	251.4	CSC1=NC(=C2C3=C(CCCC3)SC2=N1)N	IC50 ~ 100000 nM	Poor binder
T70840	LIM domain kinase-1	BNJS38	Pyrazino[1,2]thieno[3,4-d]pyrimidin-4-amine	Investigative	71451313	C8H5N5S	203.23	C1=CN=C2C(=N1)C3=C(S2)C(=NC=N3)N	IC50 ~ 100000 nM	Poor binder
T70840	LIM domain kinase-1	BT47FE	3-Amino-6-methylthieno[2,3-b]pyridine-2-carboxamide	Investigative	765847	C9H9N3OS	207.25	CC1=NC2=C(C=C1)C(=C(S2)C(=O)N)N	IC50 = 56000 nM	Poor binder
T70840	LIM domain kinase-1	BX0R3T	3-Amino-N,N-dimethylthieno[2,3-b]pyridine-2-carboxamide	Investigative	41316396	C10H11N3OS	221.28	CN(C)C(=O)C1=C(C2=C(S1)N=CC=C2)N	IC50 ~ 100000 nM	Poor binder
T70840	LIM domain kinase-1	BYFO49	Benzo[b]thiophene-2-carboxamide	Investigative	237073	C9H7NOS	177.22	C1=CC=C2C(=C1)C=C(S2)C(=O)N	IC50 ~ 100000 nM	Poor binder
T70840	LIM domain kinase-1	BZ7W5F	N-(4-Methoxyphenyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine	Investigative	723159	C17H17N3OS	311.4	COC1=CC=C(C=C1)NC2=C3C4=C(CCCC4)SC3=NC=N2	IC50 ~ 100000 nM	Poor binder
T70840	LIM domain kinase-1	BZPR07	N-(1-Phenylethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine	Investigative	2791276	C18H19N3S	309.4	CC(C1=CC=CC=C1)NC2=C3C4=C(CCCC4)SC3=NC=N2	IC50 ~ 100000 nM	Poor binder