TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T76846	Melanocortin receptor 3	D0H7AR	MK-51	Phase 1	70684954	C25H25N3O	383.5	C1C[C@H](N(C1)CC2=CC=CC3=CC=CC=C32)C(=O)NCC4=CNC5=CC=CC=C54	Ki = 68000 nM	Poor binder
T76846	Melanocortin receptor 3	B02RNM	N-(2-Fluorobenzyl)-4-(2-(4-hydroxybenzyl)-1H-indol-3-yl)-N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)butanamide	Investigative	44434696	C39H48FN3O2	609.8	C1CC(CCC1CC2CCC(CC2)N(CC3=CC=CC=C3F)C(=O)CCCC4=C(NC5=CC=CC=C54)CC6=CC=C(C=C6)O)N	Ki = 55000 nM	Poor binder
T76846	Melanocortin receptor 3	B0BM4I	N-(2-Aminoethyl)-N-cinnamyl-3-(1H-indol-3-yl)propanamide	Investigative	44434570	C22H25N3O	347.5	C1=CC=C(C=C1)/C=C/CN(CCN)C(=O)CCC2=CNC3=CC=CC=C32	Ki = 51000 nM	Poor binder
T76846	Melanocortin receptor 3	B0HN7X	N-(3-Aminopropyl)-1H-indole-3-methanamine	Investigative	44265489	C12H17N3	203.28	C1=CC=C2C(=C1)C(=CN2)CNCCCN	Ki = 145000 nM	Poor binder
T76846	Melanocortin receptor 3	B0WQS2	N-{4-[(4-Aminocyclohexyl)methyl]cyclohexyl}-4-{2-[(4-hydroxyphenyl)methyl]-1H-indol-3-yl}-N-[(3-methylphenyl)methyl]butanamide	Investigative	44434702	C40H51N3O2	605.9	CC1=CC(=CC=C1)CN(C2CCC(CC2)CC3CCC(CC3)N)C(=O)CCCC4=C(NC5=CC=CC=C54)CC6=CC=C(C=C6)O	Ki = 78000 nM	Poor binder
T76846	Melanocortin receptor 3	B1KU8L	(R)-2-Amino-N-(5-aminopentyl)-N-benzyl-3-(4-nitrophenyl)propanamide	Investigative	44434659	C21H28N4O3	384.5	C1=CC=C(C=C1)CN(CCCCCN)C(=O)[C@@H](CC2=CC=C(C=C2)[N+](=O)[O-])N	Ki = 162000 nM	Poor binder
T76846	Melanocortin receptor 3	B2TNJ4	N-[(2R)-3-(4-Chlorophenyl)-1-(4-cyclohexyl-4-oxidopiperazin-4-ium-1-yl)-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide	Investigative	44393430	C29H37ClN4O3	525.1	C1CCC(CC1)[N+]2(CCN(CC2)C(=O)[C@@H](CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)[O-]	Ki = 114000 nM	Poor binder
T76846	Melanocortin receptor 3	B2ZLW1	N-(4-Guanidino-butyl)-2-(1H-indol-3-yl)-N-naphthalen-2-ylmethyl-acetamide	Investigative	44434828	C26H29N5O	427.5	C1=CC=C2C=C(C=CC2=C1)CN(CCCCN=C(N)N)C(=O)CC3=CNC4=CC=CC=C43	Ki = 137000 nM	Poor binder
T76846	Melanocortin receptor 3	B3AQ9G	N-(3-Aminopropyl)-N-(1-(benzo[b]thiophen-3-yl)ethyl)-4-(1H-indol-3-yl)butanamide	Investigative	44434595	C25H29N3OS	419.6	CC(C1=CSC2=CC=CC=C21)N(CCCN)C(=O)CCCC3=CNC4=CC=CC=C43	Ki = 104000 nM	Poor binder
T76846	Melanocortin receptor 3	B3B6WF	2-(1H-Indol-3-yl)-N-(naphthalen-2-ylmethyl)ethanamine	Investigative	2852098	C21H20N2	300.4	C1=CC=C2C=C(C=CC2=C1)CNCCC3=CNC4=CC=CC=C43	Ki = 59000 nM	Poor binder
T76846	Melanocortin receptor 3	B3C0MX	Nalpha-(2-Naphthylmethyl)-L-Arg-L-Trp-NH2	Investigative	44265589	C28H33N7O2	499.6	C1=CC=C2C=C(C=CC2=C1)CN[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N	Ki = 107000 nM	Poor binder
T76846	Melanocortin receptor 3	B3FGY4	N-(2-Aminoethyl)-3-(1H-indol-3-yl)-N-(3-phenylpropyl)propanamide	Investigative	9946358	C22H27N3O	349.5	C1=CC=C(C=C1)CCCN(CCN)C(=O)CCC2=CNC3=CC=CC=C32	Ki = 127000 nM	Poor binder
T76846	Melanocortin receptor 3	B3FQ0J	N-(4-Aminobutyl)-N2-(2-naphthylmethyl)-N6-(1H-indole-3-ylmethyl)-L-lysinamide	Investigative	44265315	C30H39N5O	485.7	C1=CC=C2C=C(C=CC2=C1)CN[C@@H](CCCCNCC3=CNC4=CC=CC=C43)C(=O)NCCCCN	Ki = 167000 nM	Poor binder
T76846	Melanocortin receptor 3	B41TQM	N-(4-Aminobutyl)-N-cinnamyl-3-(1H-indol-3-yl)propanamide	Investigative	44434632	C24H29N3O	375.5	C1=CC=C(C=C1)/C=C/CN(CCCCN)C(=O)CCC2=CNC3=CC=CC=C32	Ki = 67000 nM	Poor binder
T76846	Melanocortin receptor 3	B4KSN6	N-(4-Aminobutyl)-N-isopropyl-1H-indole-3-carboxamide	Investigative	44434625	C16H23N3O	273.37	CC(C)N(CCCCN)C(=O)C1=CNC2=CC=CC=C21	Ki = 112000 nM	Poor binder
T76846	Melanocortin receptor 3	B4UD2E	CID 137639140	Investigative	137639140	C165H268N52O51S6	3989	C[C@H]([C@@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N)NC(=O)CNC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CO)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)CNC(=O)CNC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC6=CC=C(C=C6)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(=O)O)N)O	EC50 ~ 100000 nM	Poor binder
T76846	Melanocortin receptor 3	B4X5MI	(2R,5R)-5-Acetamido-N-[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1-(methylamino)-3-naphthalen-2-yl-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]-2-[(4-fluorophenyl)methyl]-6-phenylhexanamide	Investigative	44409339	C41H50FN7O4	723.9	CC(=O)N[C@H](CC[C@H](CC1=CC=C(C=C1)F)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC2=CC3=CC=CC=C3C=C2)C(=O)NC)CC4=CC=CC=C4	Ki = 55474 nM	Poor binder
T76846	Melanocortin receptor 3	B56ERM	N-(3-Amino-propyl)-3-[(1H-indol-3-ylmethyl)-amino]-2-[(naphthalen-2-ylmethyl)-amino]-propionamide	Investigative	10025669	C26H31N5O	429.6	C1=CC=C2C=C(C=CC2=C1)CN[C@@H](CNCC3=CNC4=CC=CC=C43)C(=O)NCCCN	Ki = 50118.72 nM	Poor binder
T76846	Melanocortin receptor 3	B5BML7	N-(2-Carbamimidamidoethyl)-3-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)propanamide	Investigative	44434794	C25H27N5O	413.5	C1=CC=C2C=C(C=CC2=C1)CN(CCN=C(N)N)C(=O)CCC3=CNC4=CC=CC=C43	Ki = 65000 nM	Poor binder
T76846	Melanocortin receptor 3	B5BNZ4	N-((1r,4r)-4-Aminocyclohexyl)-N-benzyl-4-(1H-indol-3-yl)butanamide	Investigative	44434861	C25H31N3O	389.5	C1CC(CCC1N)N(CC2=CC=CC=C2)C(=O)CCCC3=CNC4=CC=CC=C43	Ki = 50000 nM	Poor binder
T76846	Melanocortin receptor 3	B5UK7N	(E)-N-(3-Aminopropyl)-N-(2-methyl-3-phenylallyl)-4-(thiophen-2-yl)butanamide	Investigative	44434605	C21H28N2OS	356.5	C/C(=C\\C1=CC=CC=C1)/CN(CCCN)C(=O)CCCC2=CC=CS2	Ki = 63000 nM	Poor binder
T76846	Melanocortin receptor 3	B67OWJ	N-(5-Aminopentyl)-4-(1H-indol-3-yl)-N-(3-phenylpropyl)butanamide	Investigative	44434639	C26H35N3O	405.6	C1=CC=C(C=C1)CCCN(CCCCCN)C(=O)CCCC2=CNC3=CC=CC=C32	Ki = 61000 nM	Poor binder
T76846	Melanocortin receptor 3	B6Y0TA	N-(3-Aminopropyl)-N-(1,2,3,4-tetrahydronaphthalen-2-yl)-1H-indole-3-carboxamide	Investigative	10269187	C22H25N3O	347.5	C1CC2=CC=CC=C2CC1N(CCCN)C(=O)C3=CNC4=CC=CC=C43	Ki = 131000 nM	Poor binder
T76846	Melanocortin receptor 3	B7B6EH	N-(2-Aminoethyl)-N-(naphthalen-2-ylmethyl)-1H-indole-3-carboxamide	Investigative	10132207	C22H21N3O	343.4	C1=CC=C2C=C(C=CC2=C1)CN(CCN)C(=O)C3=CNC4=CC=CC=C43	Ki = 134000 nM	Poor binder
T76846	Melanocortin receptor 3	B81NMX	(Z)-N-(2-Aminoethyl)-N-(2-chloro-3-phenylallyl)-4-(1H-indol-3-yl)butanamide	Investigative	44434572	C23H26ClN3O	395.9	C1=CC=C(C=C1)/C=C(/CN(CCN)C(=O)CCCC2=CNC3=CC=CC=C32)\\Cl	Ki = 65000 nM	Poor binder
T76846	Melanocortin receptor 3	B83LOY	N-(2-Aminoethyl)-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide	Investigative	9924916	C23H23N3O	357.4	C1=CC=C2C=C(C=CC2=C1)CN(CCN)C(=O)CC3=CNC4=CC=CC=C43	Ki = 68000 nM	Poor binder
T76846	Melanocortin receptor 3	B8A4TJ	N-(3-Aminopropyl)-N-cinnamyl-3-(1H-indol-3-yl)propanamide	Investigative	44434600	C23H27N3O	361.5	C1=CC=C(C=C1)/C=C/CN(CCCN)C(=O)CCC2=CNC3=CC=CC=C32	Ki = 65000 nM	Poor binder
T76846	Melanocortin receptor 3	B8GA3H	(R)-3-(1H-Indol-3-yl)-2-[(naphthalen-2-ylmethyl)-amino]-propionamide	Investigative	44265711	C22H21N3O	343.4	C1=CC=C2C=C(C=CC2=C1)CN[C@H](CC3=CNC4=CC=CC=C43)C(=O)N	Ki = 53000 nM	Poor binder
T76846	Melanocortin receptor 3	B8NL2Y	(Z)-N-(4-((4-Amino-3-methylcyclohexyl)methyl)-2-methylcyclohexyl)-N-(2-chloro-3-phenylallyl)-4-(1H-indol-3-yl)butanamide	Investigative	44434854	C36H48ClN3O	574.2	CC1CC(CCC1N)CC2CCC(C(C2)C)N(C/C(=C/C3=CC=CC=C3)/Cl)C(=O)CCCC4=CNC5=CC=CC=C54	Ki = 64000 nM	Poor binder
T76846	Melanocortin receptor 3	B8R3MD	(Z)-N-(3-(4-(3-Aminopropyl)piperazin-1-yl)propyl)-N-(2-chloro-3-phenylallyl)-4-(1H-indol-3-yl)butanamide	Investigative	44434856	C31H42ClN5O	536.1	C1CN(CCN1CCCN)CCCN(C/C(=C/C2=CC=CC=C2)/Cl)C(=O)CCCC3=CNC4=CC=CC=C43	Ki = 78000 nM	Poor binder
T76846	Melanocortin receptor 3	B8W7IK	N-(2,6-Difluorobenzyl)-4-(2-(4-hydroxybenzyl)-1H-indol-3-yl)-N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)butanamide	Investigative	44434771	C39H47F2N3O2	627.8	C1CC(CCC1CC2CCC(CC2)N(CC3=C(C=CC=C3F)F)C(=O)CCCC4=C(NC5=CC=CC=C54)CC6=CC=C(C=C6)O)N	Ki = 65000 nM	Poor binder
T76846	Melanocortin receptor 3	BB2KP1	N-(1H-Indole-3-ylmethyl)-1-(1-naphthylmethyl)-D-prolinamide	Investigative	70682904	C25H25N3O	383.5	C1C[C@@H](N(C1)CC2=CC=CC3=CC=CC=C32)C(=O)NCC4=CNC5=CC=CC=C54	Ki = 104000 nM	Poor binder
T76846	Melanocortin receptor 3	BCPY81	N-(4-((4-Aminocyclohexyl)methyl)cyclohexyl)-4-(1H-indol-3-yl)-N-(pyridin-4-ylmethyl)butanamide	Investigative	44434759	C31H42N4O	486.7	C1CC(CCC1CC2CCC(CC2)N(CC3=CC=NC=C3)C(=O)CCCC4=CNC5=CC=CC=C54)N	Ki = 172000 nM	Poor binder
T76846	Melanocortin receptor 3	BCW5O2	N-(2-Bromobenzyl)-N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)-4-(1H-indol-3-yl)butanamide	Investigative	44434709	C32H42BrN3O	564.6	C1CC(CCC1CC2CCC(CC2)N(CC3=CC=CC=C3Br)C(=O)CCCC4=CNC5=CC=CC=C54)N	Ki = 80000 nM	Poor binder
T76846	Melanocortin receptor 3	BD23CF	(S)-5-Guanidino-2-[(1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-amino]-pentanoic acid amide	Investigative	44265590	C17H27N5O	317.4	C1CC2=CC=CC=C2CC1CN[C@@H](CCCN=C(N)N)C(=O)N	Ki = 155000 nM	Poor binder
T76846	Melanocortin receptor 3	BD40RE	N-(4-Aminobutyl)-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide	Investigative	10200110	C25H27N3O	385.5	C1=CC=C2C=C(C=CC2=C1)CN(CCCCN)C(=O)CC3=CNC4=CC=CC=C43	Ki = 63000 nM	Poor binder
T76846	Melanocortin receptor 3	BDH0P9	N-(2,6-Difluorobenzyl)-N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)-4-(1H-indol-3-yl)butanamide	Investigative	44434770	C32H41F2N3O	521.7	C1CC(CCC1CC2CCC(CC2)N(CC3=C(C=CC=C3F)F)C(=O)CCCC4=CNC5=CC=CC=C54)N	Ki = 52000 nM	Poor binder
T76846	Melanocortin receptor 3	BE46XJ	2-[(1R,4S,7S,13S,16S,19S,22S,25S,28R,31S,37S,40S,46S)-19,46-Dibenzyl-4-[(2S)-butan-2-yl]-16,31-bis(3-carbamimidamidopropyl)-25-[(1R)-1-hydroxyethyl]-22-(1H-imidazol-5-ylmethyl)-13-(1H-indol-3-ylmethyl)-3,6,12,15,18,21,24,27,30,33,36,39,45,48-tetradecaoxo-50,51-dithia-2,5,11,14,17,20,23,26,29,32,35,38,44,47-tetradecazatetracyclo[26.20.4.07,11.040,44]dopentacontan-37-yl]acetic acid	Investigative	137645567	C79H107N23O17S2	1715	CC[C@H](C)[C@H]1C(=O)N[C@H]2CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N3CCC[C@H]3C(=O)N1)CC4=CNC5=CC=CC=C54)CCCNC(=N)N)CC6=CC=CC=C6)CC7=CN=CN7)[C@@H](C)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H]8CCCN8C(=O)[C@@H](NC2=O)CC9=CC=CC=C9)CC(=O)O)CCCNC(=N)N	Ki ~ 100000 nM	Poor binder
T76846	Melanocortin receptor 3	BE83VC	N-(2-Guanidino-ethyl)-2-(1H-indol-3-yl)-N-naphthalen-2-ylmethyl-acetamide	Investigative	44434790	C24H25N5O	399.5	C1=CC=C2C=C(C=CC2=C1)CN(CCN=C(N)N)C(=O)CC3=CNC4=CC=CC=C43	Ki = 57000 nM	Poor binder
T76846	Melanocortin receptor 3	BE8J1C	1-(3-Aminocyclohexyl)-3-(3-(N-benzyl-4-(1H-indol-3-yl)butanamido)cyclohexyl)urea	Investigative	44434867	C32H43N5O2	529.7	C1CC(CC(C1)NC(=O)NC2CCCC(C2)N(CC3=CC=CC=C3)C(=O)CCCC4=CNC5=CC=CC=C54)N	Ki = 57000 nM	Poor binder
T76846	Melanocortin receptor 3	BF2CN7	N-(4-Guanidino-butyl)-3-(1H-indol-3-yl)-N-naphthalen-2-ylmethyl-propionamide	Investigative	44434839	C27H31N5O	441.6	C1=CC=C2C=C(C=CC2=C1)CN(CCCCN=C(N)N)C(=O)CCC3=CNC4=CC=CC=C43	Ki = 50000 nM	Poor binder
T76846	Melanocortin receptor 3	BFHT83	N-{4-[(4-Aminocyclohexyl)methyl]cyclohexyl}-4-{2-[(4-hydroxyphenyl)methyl]-1H-indol-3-yl}-N-[(4-methylphenyl)methyl]butanamide	Investigative	44434707	C40H51N3O2	605.9	CC1=CC=C(C=C1)CN(C2CCC(CC2)CC3CCC(CC3)N)C(=O)CCCC4=C(NC5=CC=CC=C54)CC6=CC=C(C=C6)O	Ki = 147000 nM	Poor binder
T76846	Melanocortin receptor 3	BFR29T	N-(3-Guanidinopropyl)-1-(2-naphthylmethyl)-4alpha-hydroxy-L-prolinamide	Investigative	44265681	C20H27N5O2	369.5	C1[C@@H](CN([C@@H]1C(=O)NCCCN=C(N)N)CC2=CC3=CC=CC=C3C=C2)O	Ki = 82000 nM	Poor binder
T76846	Melanocortin receptor 3	BFR4T7	N-(2-Bromo-4,5-dimethoxycinnamyl)-4-(2-(4-hydroxybenzyl)-1H-indol-3-yl)-N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)butanamide	Investigative	44434758	C43H54BrN3O4	756.8	COC1=C(C=C(C(=C1)/C=C/CN(C2CCC(CC2)CC3CCC(CC3)N)C(=O)CCCC4=C(NC5=CC=CC=C54)CC6=CC=C(C=C6)O)Br)OC	Ki = 94000 nM	Poor binder
T76846	Melanocortin receptor 3	BH5YD6	Nalpha-(2-Naphthylmethyl)-D-Arg-L-Trp-NH2	Investigative	44265591	C28H33N7O2	499.6	C1=CC=C2C=C(C=CC2=C1)CN[C@H](CCCN=C(N)N)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N	Ki = 147000 nM	Poor binder
T76846	Melanocortin receptor 3	BH8BK5	N-(3-Aminopropyl)-N-cinnamyl-1H-indole-3-carboxamide	Investigative	44434599	C21H23N3O	333.4	C1=CC=C(C=C1)/C=C/CN(CCCN)C(=O)C2=CNC3=CC=CC=C32	Ki = 172000 nM	Poor binder
T76846	Melanocortin receptor 3	BIUL40	(2R)-2-Amino-N-[(2S)-5-(diaminomethylideneamino)-1-piperidin-1-ylpentan-2-yl]-3-(4-fluorophenyl)propanamide	Investigative	44453826	C20H33FN6O	392.5	C1CCN(CC1)C[C@H](CCCN=C(N)N)NC(=O)[C@@H](CC2=CC=C(C=C2)F)N	EC50 ~ 100000 nM	Poor binder
T76846	Melanocortin receptor 3	BJ3GQ5	N-((1R,2R)-2-Aminocyclohexyl)-N-cinnamyl-4-(1H-indol-3-yl)butanamide	Investigative	44434853	C27H33N3O	415.6	C1CC[C@H]([C@@H](C1)N)N(C/C=C/C2=CC=CC=C2)C(=O)CCCC3=CNC4=CC=CC=C43	Ki = 62000 nM	Poor binder
T76846	Melanocortin receptor 3	BK30ZL	(2R)-2-Amino-N-[(2R)-5-(diaminomethylideneamino)-1-phenylpentan-2-yl]-3-(4-fluorophenyl)propanamide	Investigative	24882666	C21H28FN5O	385.5	C1=CC=C(C=C1)C[C@@H](CCCN=C(N)N)NC(=O)[C@@H](CC2=CC=C(C=C2)F)N	EC50 ~ 100000 nM	Poor binder
T76846	Melanocortin receptor 3	BK4C7R	N-(5-Aminopentyl)-3-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)propanamide	Investigative	10158674	C27H31N3O	413.6	C1=CC=C2C=C(C=CC2=C1)CN(CCCCCN)C(=O)CCC3=CNC4=CC=CC=C43	Ki = 58000 nM	Poor binder
T76846	Melanocortin receptor 3	BK97PM	2-[(1R,4S,7S,13S,16S,19R,22S,25S,28R,31S,37S,40S,46S)-19,46-Dibenzyl-4-[(2S)-butan-2-yl]-16,31-bis(3-carbamimidamidopropyl)-25-[(1R)-1-hydroxyethyl]-22-(1H-imidazol-5-ylmethyl)-13-(1H-indol-3-ylmethyl)-14,17-dimethyl-3,6,12,15,18,21,24,27,30,33,36,39,45,48-tetradecaoxo-50,51-dithia-2,5,11,14,17,20,23,26,29,32,35,38,44,47-tetradecazatetracyclo[26.20.4.07,11.040,44]dopentacontan-37-yl]acetic acid	Investigative	137659394	C81H111N23O17S2	1743	CC[C@H](C)[C@H]1C(=O)N[C@H]2CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N3CCC[C@H]3C(=O)N1)CC4=CNC5=CC=CC=C54)C)CCCNC(=N)N)C)CC6=CC=CC=C6)CC7=CN=CN7)[C@@H](C)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H]8CCCN8C(=O)[C@@H](NC2=O)CC9=CC=CC=C9)CC(=O)O)CCCNC(=N)N	Ki ~ 100000 nM	Poor binder
T76846	Melanocortin receptor 3	BK9Y1T	2-(1H-Indol-3-yl)-N-(1H-indol-3-ylmethyl)ethanamine	Investigative	2163781	C19H19N3	289.4	C1=CC=C2C(=C1)C(=CN2)CCNCC3=CNC4=CC=CC=C43	Ki = 86000 nM	Poor binder
T76846	Melanocortin receptor 3	BL69PQ	(2R)-2-Amino-N-[(2S)-5-(diaminomethylideneamino)-1-oxo-1-piperidin-1-ylpentan-2-yl]-3-(4-fluorophenyl)propanamide	Investigative	44453850	C20H31FN6O2	406.5	C1CCN(CC1)C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](CC2=CC=C(C=C2)F)N	Ki ~ 100000 nM	Poor binder
T76846	Melanocortin receptor 3	BLE6M1	N-(4-Guanidino-butyl)-4-(1H-indol-3-yl)-N-naphthalen-2-ylmethyl-butyramide	Investigative	44434841	C28H33N5O	455.6	C1=CC=C2C=C(C=CC2=C1)CN(CCCCN=C(N)N)C(=O)CCCC3=CNC4=CC=CC=C43	Ki = 134000 nM	Poor binder
T76846	Melanocortin receptor 3	BM0O9X	N2-(2-Naphthylmethyl)-L-ornithine allyl ester	Investigative	44265722	C19H24N2O2	312.4	C=CCOC(=O)[C@H](CCCN)NCC1=CC2=CC=CC=C2C=C1	Ki = 161000 nM	Poor binder
T76846	Melanocortin receptor 3	BMOS07	N-Benzhydryl-N-{[carbamoylmethyl-((R)-1-phenyl-ethyl)-carbamoyl]-methyl}-2-(3-guanidino-propylamino)-acetamide	Investigative	10392968	C31H39N7O3	557.7	C[C@H](C1=CC=CC=C1)N(CC(=O)N)C(=O)CN(C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)CNCCCN=C(N)N	IC50 ~ 50000 nM	Poor binder
T76846	Melanocortin receptor 3	BO2Y8T	N-(4-Hydroxy-2-methoxycinnamyl)-N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)-4-(1H-indol-3-yl)butanamide	Investigative	44434754	C35H47N3O3	557.8	COC1=C(C=CC(=C1)O)/C=C/CN(C2CCC(CC2)CC3CCC(CC3)N)C(=O)CCCC4=CNC5=CC=CC=C54	Ki = 51000 nM	Poor binder
T76846	Melanocortin receptor 3	BO7PL5	N-(2-Amino-ethyl)-2,3-bis-[(naphthalen-2-ylmethyl)-amino]-propionamide	Investigative	44265347	C27H30N4O	426.6	C1=CC=C2C=C(C=CC2=C1)CNC[C@@H](C(=O)NCCN)NCC3=CC4=CC=CC=C4C=C3	Ki = 58000 nM	Poor binder
T76846	Melanocortin receptor 3	BPD52T	N-(3-(4-(3-Aminopropyl)piperazin-1-yl)propyl)-N-benzyl-4-(1H-indol-3-yl)butanamide	Investigative	44434857	C29H41N5O	475.7	C1CN(CCN1CCCN)CCCN(CC2=CC=CC=C2)C(=O)CCCC3=CNC4=CC=CC=C43	Ki = 52000 nM	Poor binder
T76846	Melanocortin receptor 3	BPNU43	(R)-2-Amino-N-(5-aminopentyl)-N-benzyl-3-(1H-indol-3-yl)propanamide	Investigative	44434664	C23H30N4O	378.5	C1=CC=C(C=C1)CN(CCCCCN)C(=O)[C@@H](CC2=CNC3=CC=CC=C32)N	Ki = 106000 nM	Poor binder
T76846	Melanocortin receptor 3	BQ0O5R	CID 137659949	Investigative	137659949	C167H256N48O50S6	3929	CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N3)CCC(=O)O)CO)CO)C(C)C)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@H](CC(=O)O)N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC2=O)CC6=CC=C(C=C6)O)CCCNC(=N)N)CCCCN)C)CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N)N7CCC[C@H]7C(=O)N1)C)CO)CC8=CC=C(C=C8)O)CC(C)C)[C@@H](C)O)CCC(=O)N)[C@@H](C)CC)CCCCN)[C@@H](C)O)CC9=CC=CC=C9	EC50 ~ 100000 nM	Poor binder
T76846	Melanocortin receptor 3	BR7X9O	(S)-3-(1H-Indol-3-yl)-2-[(naphthalen-2-ylmethyl)-amino]-propionamide	Investigative	44265749	C22H21N3O	343.4	C1=CC=C2C=C(C=CC2=C1)CN[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N	Ki = 56000 nM	Poor binder
T76846	Melanocortin receptor 3	BRB5Z8	N-(3-Bromo-4-methoxybenzyl)-4-(2-(4-hydroxybenzyl)-1H-indol-3-yl)-N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)butanamide	Investigative	44434753	C40H50BrN3O3	700.7	COC1=C(C=C(C=C1)CN(C2CCC(CC2)CC3CCC(CC3)N)C(=O)CCCC4=C(NC5=CC=CC=C54)CC6=CC=C(C=C6)O)Br	Ki = 132000 nM	Poor binder
T76846	Melanocortin receptor 3	BS81IW	1-((1r,4R)-4-Aminocyclohexyl)-3-((1r,4R)-4-(N-benzyl-4-(1H-indol-3-yl)butanamido)cyclohexyl)urea	Investigative	44434858	C32H43N5O2	529.7	C1CC(CCC1N)NC(=O)NC2CCC(CC2)N(CC3=CC=CC=C3)C(=O)CCCC4=CNC5=CC=CC=C54	Ki = 99000 nM	Poor binder
T76846	Melanocortin receptor 3	BV5Q0K	1-((1r,4r)-4-Aminocyclohexyl)-3-(3-(N-benzyl-4-(1H-indol-3-yl)butanamido)cyclohexyl)urea	Investigative	44434864	C32H43N5O2	529.7	C1CC(CC(C1)N(CC2=CC=CC=C2)C(=O)CCCC3=CNC4=CC=CC=C43)NC(=O)NC5CCC(CC5)N	Ki = 59000 nM	Poor binder
T76846	Melanocortin receptor 3	BV6I0Q	2-(4-Hydroxybenzyl)-N-(4-aminobutyl)-N-isopropyl-1H-indole-3-carboxamide	Investigative	44434631	C23H29N3O2	379.5	CC(C)N(CCCCN)C(=O)C1=C(NC2=CC=CC=C21)CC3=CC=C(C=C3)O	Ki = 106000 nM	Poor binder
T76846	Melanocortin receptor 3	BVBR74	N-(5-Aminopentyl)-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide	Investigative	10157774	C26H29N3O	399.5	C1=CC=C2C=C(C=CC2=C1)CN(CCCCCN)C(=O)CC3=CNC4=CC=CC=C43	Ki = 50000 nM	Poor binder
T76846	Melanocortin receptor 3	BW79MI	N-(3-Aminopropyl)-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide	Investigative	10177247	C24H25N3O	371.5	C1=CC=C2C=C(C=CC2=C1)CN(CCCN)C(=O)CC3=CNC4=CC=CC=C43	Ki = 63000 nM	Poor binder
T76846	Melanocortin receptor 3	BWHT72	N-{4-[(4-Aminocyclohexyl)methyl]cyclohexyl}-4-(1H-indol-3-yl)-N-[(2-methylphenyl)methyl]butanamide	Investigative	44434703	C33H45N3O	499.7	CC1=CC=CC=C1CN(C2CCC(CC2)CC3CCC(CC3)N)C(=O)CCCC4=CNC5=CC=CC=C54	Ki = 121000 nM	Poor binder
T76846	Melanocortin receptor 3	BX8DU5	N-(3-Aminopropyl)-2-naphthalenemethanamine	Investigative	44265309	C14H18N2	214.31	C1=CC=C2C=C(C=CC2=C1)CNCCCN	Ki = 57000 nM	Poor binder
T76846	Melanocortin receptor 3	BY04UD	CID 137651025	Investigative	137651025	C167H263N49O49S6	3934	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(=O)N)NC(=O)CNC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC5=CC=C(C=C5)O)NC(=O)[C@H](CC6=CN=CN6)NC(=O)[C@H](CC(=O)O)N	EC50 ~ 100000 nM	Poor binder
T76846	Melanocortin receptor 3	BYQ90O	N-(3-Guanidino-propyl)-3-(1H-indol-3-yl)-N-naphthalen-2-ylmethyl-propionamide	Investigative	23653113	C26H29N5O	427.5	C1=CC=C2C=C(C=CC2=C1)CN(CCCN=C(N)N)C(=O)CCC3=CNC4=CC=CC=C43	Ki = 53000 nM	Poor binder
T76846	Melanocortin receptor 3	BYUO85	(2S,4S)-4-Hydroxy-N-[2-(1H-imidazol-5-yl)ethyl]-1-(naphthalen-2-ylmethyl)pyrrolidine-2-carboxamide	Investigative	44265713	C21H24N4O2	364.4	C1[C@@H](CN([C@@H]1C(=O)NCCC2=CN=CN2)CC3=CC4=CC=CC=C4C=C3)O	Ki = 161000 nM	Poor binder
T76846	Melanocortin receptor 3	BYV3T9	(2R)-2-Amino-N-[3-cyclohexyl-4-(1,2,4-triazol-1-yl)butyl]-3-(4-fluorophenyl)propanamide	Investigative	44453903	C21H30FN5O	387.5	C1CCC(CC1)C(CCNC(=O)[C@@H](CC2=CC=C(C=C2)F)N)CN3C=NC=N3	EC50 ~ 50000 nM	Poor binder
T76846	Melanocortin receptor 3	BZ29WC	(Z)-N-(4-((4-Aminocyclohexyl)methyl)cyclohexyl)-N-(2-chloro-3-phenylallyl)-2-(naphthalen-2-yloxy)acetamide	Investigative	44434778	C34H41ClN2O2	545.2	C1CC(CCC1CC2CCC(CC2)N(C/C(=C/C3=CC=CC=C3)/Cl)C(=O)COC4=CC5=CC=CC=C5C=C4)N	Ki = 62000 nM	Poor binder
T76846	Melanocortin receptor 3	BZ8TO0	2-[(1R,4S,7S,13S,16S,19R,22S,25S,28R,31S,37S,40S,46S)-19,46-Dibenzyl-4-[(2S)-butan-2-yl]-16,31-bis(3-carbamimidamidopropyl)-25-[(1R)-1-hydroxyethyl]-22-(1H-imidazol-5-ylmethyl)-13-(1H-indol-3-ylmethyl)-14-methyl-3,6,12,15,18,21,24,27,30,33,36,39,45,48-tetradecaoxo-50,51-dithia-2,5,11,14,17,20,23,26,29,32,35,38,44,47-tetradecazatetracyclo[26.20.4.07,11.040,44]dopentacontan-37-yl]acetic acid	Investigative	137659790	C80H109N23O17S2	1729	CC[C@H](C)[C@H]1C(=O)N[C@H]2CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N3CCC[C@H]3C(=O)N1)CC4=CNC5=CC=CC=C54)C)CCCNC(=N)N)CC6=CC=CC=C6)CC7=CN=CN7)[C@@H](C)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H]8CCCN8C(=O)[C@@H](NC2=O)CC9=CC=CC=C9)CC(=O)O)CCCNC(=N)N	Ki = 53703.18 nM	Poor binder
T76846	Melanocortin receptor 3	BZH02D	N-(1H-Indole-3-ylmethyl)-N-(1-naphthylmethyl)-L-argininamide	Investigative	71461662	C26H30N6O	442.6	C1=CC=C2C(=C1)C=CC=C2CN(CC3=CNC4=CC=CC=C43)C(=O)[C@H](CCCN=C(N)N)N	Ki = 52000 nM	Poor binder