TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T77365	Adenosine A2a receptor	D09AMZ	Enprofylline	Approved	1676	C8H10N4O2	194.19	CCCN1C2=C(C(=O)NC1=O)NC=N2	Ki = 81300 nM	Poor binder
T77365	Adenosine A2a receptor	D0M3IN	Xanthine	Phase 1	1188	C5H4N4O2	152.11	C1=NC2=C(N1)C(=O)NC(=O)N2	EC50 ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	D00YSJ	Tecadenoson	Discontinued in Phase 3	158795	C14H19N5O5	337.33	C1COC[C@@H]1NC2=C3C(=NC=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B01FQP	2-N-(4-Chlorophenyl)-7-N,7-N-dimethyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine	Investigative	76313641	C13H12ClN5S	305.79	CN(C)C1=C2C(=NC=N1)SC(=N2)NC3=CC=C(C=C3)Cl	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B01LHR	1-(4-Methoxyphenyl)-3-[11-methyl-4-(4-phenylphenyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]urea	Investigative	56664888	C27H22N8O2	490.5	CN1C=C2C(=N1)N=C(N3C2=NC(=N3)C4=CC=C(C=C4)C5=CC=CC=C5)NC(=O)NC6=CC=C(C=C6)OC	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B09ZWJ	7-(2-Hydroxypropyl)-7H-adenine	Investigative	44572472	C8H11N5O	193.21	CC(CN1C=NC2=NC=NC(=C21)N)O	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B0HPC6	Ethyl 6-(dibenzoylamino)-2-methylpyrazolo[3,4-d]pyrimidine-4-carboxylate	Investigative	118732301	C23H19N5O4	429.4	CCOC(=O)C1=NC(=NC2=NN(C=C12)C)N(C(=O)C3=CC=CC=C3)C(=O)C4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B0KJ9Q	2-Amino-3-formyl-6,7-dimethylchromone	Investigative	591132	C12H11NO3	217.22	CC1=CC2=C(C=C1C)OC(=C(C2=O)C=O)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B12YXK	N-[5-(5,6-Dimethyl-4-oxo-3H-thieno[2,3-d]pyrimidin-2-yl)-4-phenyl-1,3-thiazol-2-yl]furan-2-carboxamide	Investigative	72197884	C22H16N4O3S2	448.5	CC1=C(SC2=C1C(=O)NC(=N2)C3=C(N=C(S3)NC(=O)C4=CC=CO4)C5=CC=CC=C5)C	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B14MCR	(R)-Tert-butyl 3-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-9H-purin-6-ylamino)pyrrolidine-1-carboxylate	Investigative	44435354	C19H28N6O6	436.5	CC(C)(C)OC(=O)N1CC[C@H](C1)NC2=C3C(=NC=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B1EH2P	1-Ethyl-3,7-dihydro-1H-purine-2,6-dione	Investigative	15931307	C7H8N4O2	180.16	CCN1C(=O)C2=C(NC1=O)N=CN2	EC50 = 96200 nM	Poor binder
T77365	Adenosine A2a receptor	B1EVP7	6-(([1,2,4]Triazolo[4,3-a]pyridin-3-ylthio)methyl)-N2-(4-fluorophenyl)-1,3,5-triazine-2,4-diamine	Investigative	16344477	C16H13FN8S	368.4	C1=CC2=NN=C(N2C=C1)SCC3=NC(=NC(=N3)NC4=CC=C(C=C4)F)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B1FUH7	6-Hydroxy-5,7,9-trimethyl-beta-carboline	Investigative	44567439	C14H14N2O	226.27	CC1=CC2=C(C(=C1O)C)C3=C(N2C)C=NC=C3	Ki = 80600 nM	Poor binder
T77365	Adenosine A2a receptor	B1O3KS	Ethyl 6-[bis(3,4-difluorobenzoyl)amino]-2-methylpyrazolo[3,4-d]pyrimidine-4-carboxylate	Investigative	118732303	C23H15F4N5O4	501.4	CCOC(=O)C1=NC(=NC2=NN(C=C12)C)N(C(=O)C3=CC(=C(C=C3)F)F)C(=O)C4=CC(=C(C=C4)F)F	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B26UCT	2,5,7-Trimethyl-9H-pyrido[3,4-b]indol-2-ium-6-ol;iodide	Investigative	45266426	C14H15IN2O	354.19	CC1=CC2=C(C(=C1O)C)C3=C(N2)C=[N+](C=C3)C.[I-]	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B2FS4I	3-Amino-N-(2-chlorophenyl)thieno[2,3-b]pyridine-2-carboxamide	Investigative	41316339	C14H10ClN3OS	303.8	C1=CC=C(C(=C1)NC(=O)C2=C(C3=C(S2)N=CC=C3)N)Cl	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B2UB0D	(2R,3R,4S,5R)-2-[6-Amino-2-(4-butyl-3,5-dimethyl-pyrazol-1-yl)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol	Investigative	44330735	C19H27N7O4	417.5	CCCCC1=C(N(N=C1C)C2=NC(=C3C(=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)N)C	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B30WYF	N-[4-Chloro-2-(2,2-dimethylpropyl)pyrazolo[3,4-d]pyrimidin-6-yl]-4-(trifluoromethyl)benzamide	Investigative	76332279	C18H17ClF3N5O	411.8	CC(C)(C)CN1C=C2C(=N1)N=C(N=C2Cl)NC(=O)C3=CC=C(C=C3)C(F)(F)F	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B31EDL	(2R,3R,4S,5R)-2-[6-Amino-8-(2-phenylethynyl)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	Investigative	9999033	C18H17N5O4	367.4	C1=CC=C(C=C1)C#CC2=NC3=C(N=CN=C3N2[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B3I7OQ	(2R,3S,4R)-2-(Hydroxymethyl)-5-[6-[[(2S)-2-[(3-methylphenyl)methoxy]cyclopentyl]amino]purin-9-yl]oxolane-3,4-diol	Investigative	58455977	C23H29N5O5	455.5	CC1=CC(=CC=C1)CO[C@H]2CCCC2NC3=C4C(=NC=N3)N(C=N4)C5[C@@H]([C@@H]([C@H](O5)CO)O)O	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B46MKN	2-(Furan-2-yl)-5-(methylamino)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxylic acid	Investigative	118707881	C11H9N5O3	259.22	CNC1=NC=C(C2=NC(=NN21)C3=CC=CO3)C(=O)O	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B4CZV5	2-{4-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-yl]-pyrazol-1-yl}-N-methyl-acetamide	Investigative	44330671	C16H20N8O5	404.38	CNC(=O)CN1C=C(C=N1)C2=NC(=C3C(=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B4J3CY	Ethyl 6-(dibenzoylamino)-2-(2-phenylethyl)pyrazolo[3,4-d]pyrimidine-4-carboxylate	Investigative	118732305	C30H25N5O4	519.5	CCOC(=O)C1=NC(=NC2=NN(C=C12)CCC3=CC=CC=C3)N(C(=O)C4=CC=CC=C4)C(=O)C5=CC=CC=C5	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B4K3IH	N-[4-(4-Fluorophenyl)-11-methyl-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]benzamide	Investigative	46206128	C20H14FN7O	387.4	CN1C=C2C(=N1)N=C(N3C2=NC(=N3)C4=CC=C(C=C4)F)NC(=O)C5=CC=CC=C5	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B4Q1HY	N6-Cyclopentyl-9H-(2-C-methyl-5-chloro-5-deoxy-beta-D-ribofuranosyl)adenine	Investigative	42625614	C16H22ClN5O3	367.8	C[C@]1([C@@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)NC4CCCC4)CCl)O)O	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B4SA3X	Ethyl 2-[[2-(acetyloxyamino)-4-(dimethylamino)-1,3-thiazole-5-carbonyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate	Investigative	118729972	C19H24N4O5S2	452.6	CCOC(=O)C1=C(SC2=C1CCCC2)NC(=O)C3=C(N=C(S3)NOC(=O)C)N(C)C	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B4TFR7	N-(4-Acetylphenyl)-3-amino-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide	Investigative	1025219	C20H19N3O2S	365.5	CC(=O)C1=CC=C(C=C1)NC(=O)C2=C(C3=C(S2)N=C4CCCCC4=C3)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B4YG6X	Ethyl 4-[[5-[2-[4-(4-ethoxy-4-oxobutoxy)phenyl]ethylamino]-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]amino]butanoate	Investigative	71625251	C28H35N7O6	565.6	CCOC(=O)CCCNC1=NC(=NC2=NC(=NN21)C3=CC=CO3)NCCC4=CC=C(C=C4)OCCCC(=O)OCC	IC50 ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B53PFR	1-Amino-2-[(phenylimino)methyl]-9,10-anthracenedione	Investigative	2847378	C21H14N2O2	326.3	C1=CC=C(C=C1)N=CC2=C(C3=C(C=C2)C(=O)C4=CC=CC=C4C3=O)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B57HAP	[(2R,3R,4R,5R)-5-[2-Chloro-6-[[(3R)-oxolan-3-yl]amino]purin-9-yl]-3,4-dihydroxy-4-methyloxolan-2-yl]methyl N-methylcarbamate	Investigative	44447534	C17H23ClN6O6	442.9	C[C@]1([C@@H]([C@H](O[C@H]1N2C=NC3=C(N=C(N=C32)Cl)N[C@@H]4CCOC4)COC(=O)NC)O)O	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B5D2YM	(2R,3R,4S,5R)-2-[6-Amino-2-(3,5-dimethyl-4-propyl-pyrazol-1-yl)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol	Investigative	44330736	C18H25N7O4	403.4	CCCC1=C(N(N=C1C)C2=NC(=C3C(=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)N)C	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B5HGL2	8-Bromo-9-cycloheptyl-9H-adenine	Investigative	44572410	C12H16BrN5	310.19	C1CCCC(CC1)N2C3=NC=NC(=C3N=C2Br)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B5PDH0	Ethyl 6-[bis(4-bromobenzoyl)amino]-2-methylpyrazolo[3,4-d]pyrimidine-4-carboxylate	Investigative	118732302	C23H17Br2N5O4	587.2	CCOC(=O)C1=NC(=NC2=NN(C=C12)C)N(C(=O)C3=CC=C(C=C3)Br)C(=O)C4=CC=C(C=C4)Br	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B5U8YJ	N-[4-(4-Methoxyphenyl)-11-methyl-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-phenylacetamide	Investigative	46206810	C22H19N7O2	413.4	CN1C=C2C(=N1)N=C(N3C2=NC(=N3)C4=CC=C(C=C4)OC)NC(=O)CC5=CC=CC=C5	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B5WYI0	2-(6-Amino-1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-oxoethyl 2-methylquinoline-3-carboxylate	Investigative	17562147	C18H16N4O5	368.3	CC1=NC2=CC=CC=C2C=C1C(=O)OCC(=O)C3=C(N(C(=O)NC3=O)C)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B5X0ZN	2-(1-Cyclohexyl-3-methyl-4-(quinoxalin-6-yl)-1H-pyrazol-5-ylamino)-5-methoxybenzoic acid	Investigative	52941478	C26H27N5O3	457.5	CC1=NN(C(=C1C2=CC3=NC=CN=C3C=C2)NC4=C(C=C(C=C4)OC)C(=O)O)C5CCCCC5	IC50 ~ 50000 nM	Poor binder
T77365	Adenosine A2a receptor	B5ZF1R	5-(2-Amino-9H-purin-6-ylthio)pentanoic acid	Investigative	4610952	C10H13N5O2S	267.31	C1=NC2=C(N1)C(=NC(=N2)N)SCCCCC(=O)O	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B63BSM	2-Amino-6-(1-(2-chlorobenzylamino)-1-oxopropan-2-ylthio)-5-cyano-N-phenylnicotinamide	Investigative	45353990	C23H20ClN5O2S	466	CC(C(=O)NCC1=CC=CC=C1Cl)SC2=NC(=C(C=C2C#N)C(=O)NC3=CC=CC=C3)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B6QA0C	2-(3-Ethyl-4-(quinoxalin-6-yl)-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid	Investigative	52948995	C27H23N5O2	449.5	CCC1=NN(C(=C1C2=CC3=NC=CN=C3C=C2)NC4=CC=CC=C4C(=O)O)C5=CC=CC=C5C	IC50 ~ 50000 nM	Poor binder
T77365	Adenosine A2a receptor	B6TUG1	(2R,3R,4S,5R)-2-[6-Amino-2-(1-decyl-1H-pyrazol-4-yl)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol	Investigative	44330810	C23H35N7O4	473.6	CCCCCCCCCCN1C=C(C=N1)C2=NC(=C3C(=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B74AZE	7-Methyladenine	Investigative	71593	C6H7N5	149.15	CN1C=NC2=NC=NC(=C21)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B7L3BT	Chembl4294838	Investigative	145994068	C24H23N5O3S	461.5	COC1=CC=C(C=C1)N2C(=CN=C2N)C(=O)C3=C(N=C(S3)N4CCOCC4)C5=CC=CC=C5	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B7R9MW	N-(4-Chlorophenyl)-7-(4-methylpiperazin-1-yl)-[1,3]thiazolo[5,4-d]pyrimidin-2-amine	Investigative	76328082	C16H17ClN6S	360.9	CN1CCN(CC1)C2=C3C(=NC=N2)SC(=N3)NC4=CC=C(C=C4)Cl	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B7UA6T	4-[2-[(6-Amino-9-methylpurin-2-yl)amino]ethyl]phenol	Investigative	71624868	C14H16N6O	284.32	CN1C=NC2=C(N=C(N=C21)NCCC3=CC=C(C=C3)O)N	IC50 ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B7XTU0	1,3-Dimethyl-8-[3-methoxy-4-(2-morpholin-4-ylethoxy)-phenylxanthine	Investigative	42631715	C20H25N5O5	415.4	CN1C2=C(C(=O)N(C1=O)C)NC(=N2)C3=CC(=C(C=C3)OCCN4CCOCC4)OC	Ki = 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B8EI4M	Ethyl 2-propan-2-yl-6-[[4-(trifluoromethyl)benzoyl]amino]pyrazolo[3,4-d]pyrimidine-4-carboxylate	Investigative	118732292	C19H18F3N5O3	421.4	CCOC(=O)C1=NC(=NC2=NN(C=C12)C(C)C)NC(=O)C3=CC=C(C=C3)C(F)(F)F	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B8EL1S	2-Cyclopentyl-4,6-dimethyl-2,4-dihydro-[1,2,3]triazolo[4,5-d]pyrimidine-5,7-dione	Investigative	10264070	C11H15N5O2	249.27	CN1C2=NN(N=C2C(=O)N(C1=O)C)C3CCCC3	Ki = 58000 nM	Poor binder
T77365	Adenosine A2a receptor	B8GSJ7	4-[2-[[6-Amino-9-methyl-8-(triazol-1-yl)purin-2-yl]amino]ethyl]phenol	Investigative	71624867	C16H17N9O	351.37	CN1C2=NC(=NC(=C2N=C1N3C=CN=N3)N)NCCC4=CC=C(C=C4)O	IC50 = 54954.09 nM	Poor binder
T77365	Adenosine A2a receptor	B9LH0E	8-(1-Hexynyl)adenosine	Investigative	10247091	C16H21N5O4	347.37	CCCCC#CC1=NC2=C(N=CN=C2N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B9SO7Z	1-(4-Fluorophenyl)-3-[11-methyl-4-(4-phenylphenyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]urea	Investigative	56671922	C26H19FN8O	478.5	CN1C=C2C(=N1)N=C(N3C2=NC(=N3)C4=CC=C(C=C4)C5=CC=CC=C5)NC(=O)NC6=CC=C(C=C6)F	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B9X3IH	(R)-Benzyl 3-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-9H-purin-6-ylamino)pyrrolidine-1-carboxylate	Investigative	44435356	C22H26N6O6	470.5	C1CN(C[C@@H]1NC2=C3C(=NC=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)C(=O)OCC5=CC=CC=C5	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	B9Z2QD	9H-Purin-6-amine, 9-(2-methylpropyl)-	Investigative	44572353	C9H13N5	191.23	CC(C)CN1C=NC2=C(N=CN=C21)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BA24PS	7-Isobutyl-7H-adenine	Investigative	44572354	C9H13N5	191.23	CC(C)CN1C=NC2=NC=NC(=C21)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BA7TU0	Ethyl 4-amino-2-(3-amino-3-oxopropylthio)pyrimidine-5-carboxylate	Investigative	16601516	C10H14N4O3S	270.31	CCOC(=O)C1=CN=C(N=C1N)SCCC(=O)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BAL8G6	2-{4-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-yl]-pyrazol-1-yl}-N-propyl-acetamide	Investigative	44330675	C18H24N8O5	432.4	CCCNC(=O)CN1C=C(C=N1)C2=NC(=C3C(=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BANG64	2-(4-(Quinoxalin-6-yl)-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid	Investigative	46175914	C25H19N5O2	421.4	CC1=CC=CC=C1N2C(=C(C=N2)C3=CC4=NC=CN=C4C=C3)NC5=CC=CC=C5C(=O)O	IC50 ~ 50000 nM	Poor binder
T77365	Adenosine A2a receptor	BAP2K6	Methyl 12-[4-[4-[(E)-2-(1,3-diethyl-7-methyl-2,6-dioxopurin-8-yl)ethenyl]-2-methoxyphenoxy]butanoylamino]dodecanoate	Investigative	71625117	C36H53N5O7	667.8	CCN1C2=C(C(=O)N(C1=O)CC)N(C(=N2)/C=C/C3=CC(=C(C=C3)OCCCC(=O)NCCCCCCCCCCCC(=O)OC)OC)C	IC50 ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BB5WK1	9-Cyclohexyladenine	Investigative	95121	C11H15N5	217.27	C1CCC(CC1)N2C=NC3=C(N=CN=C32)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BB81NK	N-[4-(4-Bromophenyl)-11-methyl-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]benzamide	Investigative	46206130	C20H14BrN7O	448.3	CN1C=C2C(=N1)N=C(N3C2=NC(=N3)C4=CC=C(C=C4)Br)NC(=O)C5=CC=CC=C5	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BD49IG	{[4-Amino-5-(ethoxycarbonyl)pyrimidin-2-yl]thio}acetic acid	Investigative	747275	C9H11N3O4S	257.269	CCOC(=O)C1=CN=C(N=C1N)SCC(=O)O	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BDG8H7	2,4,6-Trimethyl-2H-[1,2,3]triazolo[4,5-d]pyrimidine-5,7(4H,6H)-dione	Investigative	12687948	C7H9N5O2	195.18	CN1C2=NN(N=C2C(=O)N(C1=O)C)C	Ki = 52800 nM	Poor binder
T77365	Adenosine A2a receptor	BE5YB9	(1S,2R,4S)-2-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid 2-bromo-benzyl ester	Investigative	44435361	C24H27BrN6O6	575.4	C1C[C@H]2[C@@H](C[C@H]1N2C(=O)OCC3=CC=CC=C3Br)NC4=C5C(=NC=N4)N(C=N5)[C@H]6[C@@H]([C@@H]([C@H](O6)CO)O)O	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BEAK01	Ethyl 2-(2,2-dimethylpropyl)-6-[[4-(trifluoromethyl)benzoyl]amino]pyrazolo[3,4-d]pyrimidine-4-carboxylate	Investigative	76335924	C21H22F3N5O3	449.4	CCOC(=O)C1=NC(=NC2=NN(C=C12)CC(C)(C)C)NC(=O)C3=CC=C(C=C3)C(F)(F)F	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BESD38	(2R,3R,4R,5S)-2-[6-(Cyclopentylamino)purin-9-yl]-5-[(2-fluorophenyl)sulfanylmethyl]-3-methyloxolane-3,4-diol	Investigative	42625691	C22H26FN5O3S	459.5	C[C@]1([C@@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)NC4CCCC4)CSC5=CC=CC=C5F)O)O	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BEU0I1	8-Amino-N-(4-fluorophenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide	Investigative	4976464	C19H17FN4OS	368.4	C1CN2CCC1C3=C2C=C4C(=C(SC4=N3)C(=O)NC5=CC=C(C=C5)F)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BF26NU	N-[11-Methyl-4-(4-nitrophenyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]benzamide	Investigative	46206132	C20H14N8O3	414.4	CN1C=C2C(=N1)N=C(N3C2=NC(=N3)C4=CC=C(C=C4)[N+](=O)[O-])NC(=O)C5=CC=CC=C5	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BF7JV1	[3-(4-Bromothiophen-2-yl)-2-oxochromen-8-yl] acetate	Investigative	127052152	C15H9BrO4S	365.2	CC(=O)OC1=CC=CC2=C1OC(=O)C(=C2)C3=CC(=CS3)Br	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BF9GX0	3-Methylxanthine	Investigative	70639	C6H6N4O2	166.14	CN1C2=C(C(=O)NC1=O)NC=N2	EC50 ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BFQS01	5-Chloro-2-(3-methyl-4-(quinoxalin-6-yl)-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid	Investigative	46175652	C26H20ClN5O2	469.9	CC1=CC=CC=C1N2C(=C(C(=N2)C)C3=CC4=NC=CN=C4C=C3)NC5=C(C=C(C=C5)Cl)C(=O)O	IC50 ~ 50000 nM	Poor binder
T77365	Adenosine A2a receptor	BFW09Q	3-(6-Amino-9H-purin-8-ylsulfanyl)-propionic acid	Investigative	785306	C8H9N5O2S	239.26	C1=NC(=C2C(=N1)N=C(N2)SCCC(=O)O)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BFZE38	6-Amino-2-(2,2-dimethylpropyl)pyrazolo[3,4-d]pyrimidine-4-carboxamide	Investigative	118732280	C11H16N6O	248.28	CC(C)(C)CN1C=C2C(=NC(=NC2=N1)N)C(=O)N	Ki ~ 80000 nM	Poor binder
T77365	Adenosine A2a receptor	BGA04D	(2R,3R,4R,5S)-2-[6-(2-Bicyclo[2.2.1]heptanylamino)-2-chloropurin-9-yl]-5-[(2-fluorophenyl)sulfanylmethyl]-3-methyloxolane-3,4-diol	Investigative	44582691	C24H27ClFN5O3S	520	C[C@]1([C@@H]([C@H](O[C@H]1N2C=NC3=C(N=C(N=C32)Cl)NC4CC5CCC4C5)CSC6=CC=CC=C6F)O)O	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BGDM38	(2R,3R,4S,5R)-2-[2-Chloro-6-(4-chloro-2-fluoroanilino)purin-9-yl]-5-[(3,5-dimethylpyrazol-1-yl)methyl]oxolane-3,4-diol	Investigative	137652383	C21H20Cl2FN7O3	508.3	CC1=CC(=NN1C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=C(N=C43)Cl)NC5=C(C=C(C=C5)Cl)F)O)O)C	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BGEK52	3-(2-{3-Amino-8-thia-4,6,11-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6-tetraen-11-yl}-2-oxoethyl)-1,3-thiazolidin-4-one	Investigative	25392045	C14H15N5O2S2	349.4	C1CN(CC2=C1C3=C(N=CN=C3S2)N)C(=O)CN4CSCC4=O	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BGIZ74	1,4-Diamino-N-butyl-9,10-dioxo-9,10-dihydroanthracene-2-carboxamide	Investigative	4388935	C19H19N3O3	337.4	CCCCNC(=O)C1=CC(=C2C(=C1N)C(=O)C3=CC=CC=C3C2=O)N	Ki = 120000 nM	Poor binder
T77365	Adenosine A2a receptor	BGJ6M8	2-(1-(2-Ethylphenyl)-3-methyl-4-(quinoxalin-6-yl)-1H-pyrazol-5-ylamino)-5-methoxybenzoic acid	Investigative	46176000	C28H25N5O3	479.5	CCC1=CC=CC=C1N2C(=C(C(=N2)C)C3=CC4=NC=CN=C4C=C3)NC5=C(C=C(C=C5)OC)C(=O)O	IC50 ~ 50000 nM	Poor binder
T77365	Adenosine A2a receptor	BH23DY	2,5,7,9-Tetramethylpyrido[3,4-b]indol-2-ium-6-ol;iodide	Investigative	45266415	C15H17IN2O	368.21	CC1=CC2=C(C(=C1O)C)C3=C(N2C)C=[N+](C=C3)C.[I-]	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BH3VZ7	N-[4-(4-Chlorophenyl)-11-methyl-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]benzamide	Investigative	46206129	C20H14ClN7O	403.8	CN1C=C2C(=N1)N=C(N3C2=NC(=N3)C4=CC=C(C=C4)Cl)NC(=O)C5=CC=CC=C5	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BH3XJ1	2-(4-(Quinoxalin-6-yl)-1-o-tolyl-3-(trifluoromethyl)-1H-pyrazol-5-ylamino)benzoic acid	Investigative	52948788	C26H18F3N5O2	489.4	CC1=CC=CC=C1N2C(=C(C(=N2)C(F)(F)F)C3=CC4=NC=CN=C4C=C3)NC5=CC=CC=C5C(=O)O	IC50 ~ 50000 nM	Poor binder
T77365	Adenosine A2a receptor	BH5F7Y	Ethyl 3-(benzylthio)-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate	Investigative	2778810	C18H18O3S2	346.5	CCOC(=O)C1=C2CCCC(=O)C2=C(S1)SCC3=CC=CC=C3	Ki = 54300 nM	Poor binder
T77365	Adenosine A2a receptor	BH8X0G	{4-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-yl]-pyrazol-1-yl}-acetic acid methyl ester	Investigative	44330838	C16H19N7O6	405.37	COC(=O)CN1C=C(C=N1)C2=NC(=C3C(=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BI64EU	2-(Furan-2-yl)-5-[(4-phenylphenyl)methylamino]-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxylic acid	Investigative	118707895	C23H17N5O3	411.4	C1=CC=C(C=C1)C2=CC=C(C=C2)CNC3=NC=C(C4=NC(=NN43)C5=CC=CO5)C(=O)O	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BJ1M2X	(2R,3R,4S,5R)-2-{6-Amino-2-[1-(2-hydroxy-ethyl)-1H-pyrazol-4-yl]-purin-9-yl}-5-hydroxymethyl-tetrahydro-furan-3,4-diol	Investigative	44330651	C15H19N7O5	377.36	C1=C(C=NN1CCO)C2=NC(=C3C(=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BJ2L5X	Chembl4290655	Investigative	145987813	C21H26N6O5	442.5	CCOC(=O)C1=CN=C(N2C1=NC(=N2)C3=CC=CO3)N4CCN(CC4)C(=O)OC(C)(C)C	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BJ3I4R	Acetamide, 2-(5-amino-2-phenyl-2H-[1,2,4]triazol-3-ylsulfanyl)-N-methyl-N-phenyl-	Investigative	715162	C17H17N5OS	339.4	CN(C1=CC=CC=C1)C(=O)CSC2=NC(=NN2C3=CC=CC=C3)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BJAG93	(2R,3R,4S,5R)-2-[6-Amino-2-(5-methyl-3-phenyl-pyrazol-1-yl)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol	Investigative	44330776	C20H21N7O4	423.4	CC1=CC(=NN1C2=NC(=C3C(=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)N)C5=CC=CC=C5	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BJBH60	(1S,2R,4S)-2-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid benzyl ester	Investigative	44435359	C24H28N6O6	496.5	C1C[C@H]2[C@@H](C[C@H]1N2C(=O)OCC3=CC=CC=C3)NC4=C5C(=NC=N4)N(C=N5)[C@H]6[C@@H]([C@@H]([C@H](O6)CO)O)O	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BJC2E0	7-(Sec-Butyl)-7H-adenine	Investigative	44572294	C9H13N5	191.23	CCC(C)N1C=NC2=NC=NC(=C21)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BJE4L3	Ethyl 2-(furan-2-yl)-5-(morpholin-4-ylamino)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxylate	Investigative	118707878	C16H18N6O4	358.35	CCOC(=O)C1=CN=C(N2C1=NC(=N2)C3=CC=CO3)NN4CCOCC4	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BJL85G	2-Amino-6-((2-(2,4-dimethylphenyl)-2-oxoethyl)thio)-4-(thiophen-2-yl)pyridine-3,5-dicarbonitrile	Investigative	1722573	C21H16N4OS2	404.5	CC1=CC(=C(C=C1)C(=O)CSC2=C(C(=C(C(=N2)N)C#N)C3=CC=CS3)C#N)C	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BJS52H	2-(2H-1,3-Benzodioxol-5-yl)-5-imino-9-methyl-5H-chromeno[3,4-c]pyridin-4-amine	Investigative	4780194	C20H15N3O3	345.4	CC1=CC2=C(C=C1)OC(=N)C3=C(N=C(C=C23)C4=CC5=C(C=C4)OCO5)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BK18YZ	5-(Benzhydrylamino)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxylic acid	Investigative	118707896	C23H17N5O3	411.4	C1=CC=C(C=C1)C(C2=CC=CC=C2)NC3=NC=C(C4=NC(=NN43)C5=CC=CO5)C(=O)O	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BKI3A5	(2R,3R,4R,5S)-2-[6-(2-Bicyclo[2.2.1]heptanylamino)purin-9-yl]-5-[(2-fluorophenyl)sulfanylmethyl]-3-methyloxolane-3,4-diol	Investigative	44582690	C24H28FN5O3S	485.6	C[C@]1([C@@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)NC4CC5CCC4C5)CSC6=CC=CC=C6F)O)O	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BKM27T	(2R,3R,4S,5R)-2-[6-Amino-2-(1H-pyrazol-4-yl)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol	Investigative	44330819	C13H15N7O4	333.3	C1=C(C=NN1)C2=NC(=C3C(=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BLKE04	2-(4-Amino-phenyl)-1H-benzoimidazol-4-ylamine	Investigative	1084663	C13H12N4	224.26	C1=CC(=C2C(=C1)NC(=N2)C3=CC=C(C=C3)N)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BN4X1C	7-(2,3-Dihydroxypropyl)-7H-adenine	Investigative	20847387	C8H11N5O2	209.21	C1=NC(=C2C(=N1)N=CN2CC(CO)O)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BO28DC	2-(1-(2-Chlorophenyl)-3-methyl-4-(quinoxalin-6-yl)-1H-pyrazol-5-ylamino)-5-methoxybenzoic acid	Investigative	46175738	C26H20ClN5O3	485.9	CC1=NN(C(=C1C2=CC3=NC=CN=C3C=C2)NC4=C(C=C(C=C4)OC)C(=O)O)C5=CC=CC=C5Cl	IC50 ~ 50000 nM	Poor binder
T77365	Adenosine A2a receptor	BOAV40	2-(3-Methyl-4-(quinoxalin-6-yl)-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid	Investigative	46175737	C26H21N5O2	435.5	CC1=CC=CC=C1N2C(=C(C(=N2)C)C3=CC4=NC=CN=C4C=C3)NC5=CC=CC=C5C(=O)O	IC50 ~ 50000 nM	Poor binder
T77365	Adenosine A2a receptor	BOCA58	{4-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-yl]-pyrazol-1-yl}-acetic acid	Investigative	44330672	C15H17N7O6	391.34	C1=C(C=NN1CC(=O)O)C2=NC(=C3C(=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BOY0A8	5-Methyl-2-(3-methyl-4-(quinoxalin-6-yl)-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid	Investigative	46175736	C27H23N5O2	449.5	CC1=CC(=C(C=C1)NC2=C(C(=NN2C3=CC=CC=C3C)C)C4=CC5=NC=CN=C5C=C4)C(=O)O	IC50 ~ 50000 nM	Poor binder
T77365	Adenosine A2a receptor	BP4H6M	Dimethyl 2,6-diamino-4-(4-methylphenyl)furo[2,3-f][1]benzofuran-3,7-dicarboxylate	Investigative	1259943	C21H18N2O6	394.4	CC1=CC=C(C=C1)C2=C3C(=CC4=C2C(=C(O4)N)C(=O)OC)C(=C(O3)N)C(=O)OC	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BP82KX	2-(4-(8-Fluoroquinoxalin-6-yl)-3-methyl-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid	Investigative	44631910	C26H20FN5O2	453.5	CC1=CC=CC=C1N2C(=C(C(=N2)C)C3=CC4=NC=CN=C4C(=C3)F)NC5=CC=CC=C5C(=O)O	IC50 ~ 50000 nM	Poor binder
T77365	Adenosine A2a receptor	BPG15V	(2R,3R,4S,5R)-2-[6-(3-Fluoro-4-hydroxyanilino)purin-9-yl]-5-(methoxymethyl)oxolane-3,4-diol	Investigative	9843424	C17H18FN5O5	391.4	COC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)NC4=CC(=C(C=C4)O)F)O)O	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BPG1X8	5-[(4-Chlorophenyl)methylamino]-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxylic acid	Investigative	118707893	C17H12ClN5O3	369.8	C1=COC(=C1)C2=NN3C(=N2)C(=CN=C3NCC4=CC=C(C=C4)Cl)C(=O)O	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BQ2DL4	2-((4-Amino-6-(o-tolylamino)-1,3,5-triazin-2-yl)methylthio)-N-o-tolylacetamide	Investigative	2079368	C20H22N6OS	394.5	CC1=CC=CC=C1NC2=NC(=NC(=N2)N)CSCC(=O)NC3=CC=CC=C3C	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BQ69BH	Chembl4167197	Investigative	145954995	C18H19N5O2	337.4	CN1C(=NC2=C(N=CN=C21)NC3CCCC3)C4=CC=C(C=C4)C(=O)O	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BQ6KV9	(1S,2S,3R,4R,5S)-1-(6-Aminopurin-9-yl)-4-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol	Investigative	71450842	C12H15N5O3	277.28	C1[C@@H]2[C@@]1([C@@H]([C@@H]([C@H]2CO)O)O)N3C=NC4=C(N=CN=C43)N	Ki = 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BR4WS1	2-[(3-Amino-2-oxo-2H-chromen-4-yl)amino]benzoic acid	Investigative	767064	C16H12N2O4	296.28	C1=CC=C2C(=C1)C(=C(C(=O)O2)N)NC3=CC=CC=C3C(=O)O	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BR9B2Y	N-Phenyl-7-(4-piperidin-1-ylpiperidin-1-yl)-[1,3]thiazolo[5,4-d]pyrimidin-2-amine	Investigative	76313640	C21H26N6S	394.5	C1CCN(CC1)C2CCN(CC2)C3=C4C(=NC=N3)SC(=N4)NC5=CC=CC=C5	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BS0Y3E	3-Ethylxanthine	Investigative	350737	C7H8N4O2	180.16	CCN1C2=C(C(=O)NC1=O)NC=N2	EC50 = 69200 nM	Poor binder
T77365	Adenosine A2a receptor	BS4K1U	2-{4-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-yl]-pyrazol-1-yl}-N-ethyl-acetamide	Investigative	44330685	C17H22N8O5	418.4	CCNC(=O)CN1C=C(C=N1)C2=NC(=C3C(=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BS72CT	2-Neopentyl-6-(4-methylbenzoylamino)-2H-pyrazolo[3,4-d]pyrimidine-4-carboxylic acid ethyl ester	Investigative	76328600	C21H25N5O3	395.5	CCOC(=O)C1=NC(=NC2=NN(C=C12)CC(C)(C)C)NC(=O)C3=CC=C(C=C3)C	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BSK0J5	(1S,2R,4S)-2-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid 2-chloro-benzyl ester	Investigative	44435360	C24H27ClN6O6	531	C1C[C@H]2[C@@H](C[C@H]1N2C(=O)OCC3=CC=CC=C3Cl)NC4=C5C(=NC=N4)N(C=N5)[C@H]6[C@@H]([C@@H]([C@H](O6)CO)O)O	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BT35HL	(2R,3R,4R,5S)-2-[2-Chloro-6-(cyclopentylamino)purin-9-yl]-5-[(2-fluorophenyl)sulfanylmethyl]-3-methyloxolane-3,4-diol	Investigative	42625767	C22H25ClFN5O3S	494	C[C@]1([C@@H]([C@H](O[C@H]1N2C=NC3=C(N=C(N=C32)Cl)NC4CCCC4)CSC5=CC=CC=C5F)O)O	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BT7B2M	N-[4-(4-Methoxyphenyl)-11-methyl-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]benzamide	Investigative	46206131	C21H17N7O2	399.4	CN1C=C2C(=N1)N=C(N3C2=NC(=N3)C4=CC=C(C=C4)OC)NC(=O)C5=CC=CC=C5	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BTP6M5	(10As)-2-benzyl-1,5,10,10a-tetrahydroimidazo[1,5-b]isoquinolin-3-imine;hydrochloride	Investigative	127037758	C18H20ClN3	313.8	C1[C@H]2CN(C(=N)N2CC3=CC=CC=C31)CC4=CC=CC=C4.Cl	Ki = 64000 nM	Poor binder
T77365	Adenosine A2a receptor	BU2P3Q	N-[4-(4-Bromophenyl)-11-methyl-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-phenylacetamide	Investigative	46206809	C21H16BrN7O	462.3	CN1C=C2C(=N1)N=C(N3C2=NC(=N3)C4=CC=C(C=C4)Br)NC(=O)CC5=CC=CC=C5	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BU4MS2	1-(4-Methoxyphenyl)-3-[11-methyl-4-[4-(trifluoromethyl)phenyl]-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]urea	Investigative	56675199	C22H17F3N8O2	482.4	CN1C=C2C(=N1)N=C(N3C2=NC(=N3)C4=CC=C(C=C4)C(F)(F)F)NC(=O)NC5=CC=C(C=C5)OC	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BU7D8Z	N-[4-(4-Bromophenyl)-11-(2-phenylethyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]benzamide	Investigative	46206466	C27H20BrN7O	538.4	C1=CC=C(C=C1)CCN2C=C3C(=N2)N=C(N4C3=NC(=N4)C5=CC=C(C=C5)Br)NC(=O)C6=CC=CC=C6	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BU9ZG4	Ethyl 6-(dibenzoylamino)-2-propan-2-ylpyrazolo[3,4-d]pyrimidine-4-carboxylate	Investigative	118732304	C25H23N5O4	457.5	CCOC(=O)C1=NC(=NC2=NN(C=C12)C(C)C)N(C(=O)C3=CC=CC=C3)C(=O)C4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BUG08W	Ethyl 1-amino-3-bromo-6-(4-bromophenyl)benzo[c]thiophene-4-carboxylate	Investigative	46232972	C17H13Br2NO2S	455.2	CCOC(=O)C1=CC(=CC2=C(SC(=C12)Br)N)C3=CC=C(C=C3)Br	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BURH65	7-(3-Hydroxypropyl)-7H-adenine	Investigative	44572470	C8H11N5O	193.21	C1=NC(=C2C(=N1)N=CN2CCCO)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BV4XH5	1-((R)-3-(9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-9H-purin-6-ylamino)pyrrolidin-1-yl)ethanone	Investigative	44435355	C16H22N6O5	378.38	CC(=O)N1CC[C@H](C1)NC2=C3C(=NC=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BVO1B6	N-Benzoyl-N-[4-chloro-2-(2,2-dimethylpropyl)pyrazolo[3,4-d]pyrimidin-6-yl]benzamide	Investigative	76317723	C24H22ClN5O2	447.9	CC(C)(C)CN1C=C2C(=N1)N=C(N=C2Cl)N(C(=O)C3=CC=CC=C3)C(=O)C4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BVW7J6	2-((4-Amino-6-(p-tolylamino)-1,3,5-triazin-2-yl)methylthio)-N-cyclopropylacetamide	Investigative	17544645	C16H20N6OS	344.4	CC1=CC=C(C=C1)NC2=NC(=NC(=N2)N)CSCC(=O)NC3CC3	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BW26SF	7-Chloro-N-(2-morpholin-4-ylethyl)-[1,3]thiazolo[5,4-d]pyrimidin-2-amine	Investigative	127045166	C11H14ClN5OS	299.78	C1COCCN1CCNC2=NC3=C(S2)N=CN=C3Cl	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BWDN12	5-Methoxy-2-(3-methyl-4-(quinoxalin-6-yl)-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid	Investigative	52946211	C27H23N5O3	465.5	CC1=CC=CC=C1N2C(=C(C(=N2)C)C3=CC4=NC=CN=C4C=C3)NC5=C(C=C(C=C5)OC)C(=O)O	IC50 ~ 50000 nM	Poor binder
T77365	Adenosine A2a receptor	BWN7U3	8-Hydroxy-3-(4-bromo-2-thienyl)-2H-1-benzopyran-2-one	Investigative	127051231	C13H7BrO3S	323.16	C1=CC2=C(C(=C1)O)OC(=O)C(=C2)C3=CC(=CS3)Br	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BWZ0E8	[8-Acetyloxy-3-(4-bromothiophen-2-yl)-2-oxochromen-7-yl] acetate	Investigative	23371944	C17H11BrO6S	423.2	CC(=O)OC1=C(C2=C(C=C1)C=C(C(=O)O2)C3=CC(=CS3)Br)OC(=O)C	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BX2Z3K	(2R,3R,4S,5R)-2-[6-Amino-2-(1-methyl-1H-pyrazol-4-yl)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol	Investigative	21054078	C14H17N7O4	347.33	CN1C=C(C=N1)C2=NC(=C3C(=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BXU0P8	7-(2-Hydroxyethyl)adenine	Investigative	11019436	C7H9N5O	179.18	C1=NC(=C2C(=N1)N=CN2CCO)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BXU9D2	2-{4-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-yl]-pyrazol-1-yl}-N,N-dimethyl-acetamide	Investigative	44330661	C17H22N8O5	418.4	CN(C)C(=O)CN1C=C(C=N1)C2=NC(=C3C(=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)N	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BY4GM1	Ethyl 6-[(3,4-dichlorobenzoyl)amino]-2-(2-phenylethyl)pyrazolo[3,4-d]pyrimidine-4-carboxylate	Investigative	118732300	C23H19Cl2N5O3	484.3	CCOC(=O)C1=NC(=NC2=NN(C=C12)CCC3=CC=CC=C3)NC(=O)C4=CC(=C(C=C4)Cl)Cl	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BY8O7R	(8-Acetyloxy-2-oxo-3-thiophen-2-ylchromen-7-yl) acetate	Investigative	127051850	C17H12O6S	344.3	CC(=O)OC1=C(C2=C(C=C1)C=C(C(=O)O2)C3=CC=CS3)OC(=O)C	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BY96EM	Ethyl 2-methyl-6-[[4-(trifluoromethyl)benzoyl]amino]pyrazolo[3,4-d]pyrimidine-4-carboxylate	Investigative	118732288	C17H14F3N5O3	393.32	CCOC(=O)C1=NC(=NC2=NN(C=C12)C)NC(=O)C3=CC=C(C=C3)C(F)(F)F	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	BYL8X6	Tert-butyl N-[12-oxo-12-[3-[2-(2-oxo-1,3-dihydroindol-4-yl)ethyl-propylamino]propylamino]dodecyl]carbamate	Investigative	118725996	C33H56N4O4	572.8	CCCN(CCCNC(=O)CCCCCCCCCCCNC(=O)OC(C)(C)C)CCC1=C2CC(=O)NC2=CC=C1	IC50 ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	D07DOE	2'-Me-tecadenoson	Investigative	44447542	C15H21N5O5	351.36	C[C@]1([C@@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)N[C@@H]4CCOC4)CO)O)O	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	D0K5WC	6-Hydroxy-5,7-dimethyl-beta-carboline	Investigative	44567438	C13H12N2O	212.25	CC1=CC2=C(C(=C1O)C)C3=C(N2)C=NC=C3	Ki ~ 100000 nM	Poor binder
T77365	Adenosine A2a receptor	D0LD0X	1-Propyl-3,7-dihydro-purine-2,6-dione	Investigative	128525	C8H10N4O2	194.19	CCCN1C(=O)C2=C(NC1=O)N=CN2	EC50 = 62000 nM	Poor binder
T77365	Adenosine A2a receptor	D0Z1WY	2-chloro-2'-C-methyl-tecadenoson	Investigative	44447548	C15H20ClN5O5	385.8	C[C@]1([C@@H]([C@H](O[C@H]1N2C=NC3=C(N=C(N=C32)Cl)N[C@@H]4CCOC4)CO)O)O	Ki ~ 100000 nM	Poor binder