TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T77400	Phosphodiesterase 2A	D0Y9ZE	Milrinone	Approved	4197	C12H9N3O	211.22	CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	D0Z7ZM	Rhucin	Approved	135398744	C22H30N6O4S	474.6	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C	IC50 = 63000 nM	Poor binder
T77400	Phosphodiesterase 2A	D0T5PO	ROLIPRAM	Phase 2	5092	C16H21NO3	275.34	COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	D01RCZ	B7673	Patented	2052828	C15H16N2OS2	304.4	CCCSC1=NC2=C(C(=O)N1C3=CC=CC=C3)SCC2	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	D0SG9Q	US9388139, 12	Patented	60194756	C20H20Cl2N2O2	391.3	CC(C)(C)C1=NN(C(C1)C2=C(C=C(C=C2)Cl)Cl)C3=CC=C(C=C3)C(=O)O	IC50 ~ 50000 nM	Poor binder
T77400	Phosphodiesterase 2A	D0SH7F	BC11-28	Patented	3257208	C25H19FN4	394.4	CC1=CC=CC=C1NC2=C3C(=CN(C3=NC=N2)C4=CC=C(C=C4)F)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	D0Z7YQ	AC1M1SP5	Patented	2155273	C16H18N2O2S2	334.5	CCCSC1=NC2=C(C(=O)N1C3=CC=CC=C3OC)SCC2	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	D00YPW	ZAPRINAST	Terminated	135399235	C13H13N5O2	271.27	.	IC50 = 90200 nM	Poor binder
T77400	Phosphodiesterase 2A	B08XOB	N-[(3-Methoxyphenyl)methyl]-6-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide	Investigative	137651309	C16H16N4O2	296.32	CC1=CN2C(=C(C=N2)C(=O)NCC3=CC(=CC=C3)OC)N=C1	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	B09PFW	1-Methyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one	Investigative	15065159	C11H9N3O	199.21	CN1C2=CC3=CC=CC=C3N=C2NC1=O	IC50 = 60000 nM	Poor binder
T77400	Phosphodiesterase 2A	B0A9ID	N-(4-Methoxybenzyl)-3-(cyclopentyloxy)-4-(difluoromethoxy)benzamide	Investigative	122193679	C21H23F2NO4	391.4	COC1=CC=C(C=C1)CNC(=O)C2=CC(=C(C=C2)OC(F)F)OC3CCCC3	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	B0EK1N	N-[(2-Methoxyphenyl)methyl]-6-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide	Investigative	137653151	C16H16N4O2	296.32	CC1=CN2C(=C(C=N2)C(=O)NCC3=CC=CC=C3OC)N=C1	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	B0GXP7	6-Methyl-N-[(1S)-1-[4-(trifluoromethoxy)phenyl]propyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Investigative	137646854	C18H17F3N4O2	378.3	CC[C@@H](C1=CC=C(C=C1)OC(F)(F)F)NC(=O)C2=C3N=CC(=CN3N=C2)C	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	B0LMZ1	1-[4-Methoxy-3-(tetrahydropyran-4-yloxy)phenyl]butan-1-one	Investigative	23654252	C16H22O4	278.34	CCCC(=O)C1=CC(=C(C=C1)OC)OC2CCOCC2	IC50 ~ 50000 nM	Poor binder
T77400	Phosphodiesterase 2A	B1ANS6	Sulmazole	Investigative	5353	C14H13N3O2S	287.34	COC1=C(C=CC(=C1)S(=O)C)C2=NC3=C(N2)C=CC=N3	IC50 = 200000 nM	Poor binder
T77400	Phosphodiesterase 2A	B1J3SF	1,3-Dihydro-7-[4-oxo-4-piperidinobutoxy]-2H-imidazo[4,5-b]quinolin-2-one	Investigative	14281011	C19H22N4O3	354.4	C1CCN(CC1)C(=O)CCCOC2=CC3=CC4=C(NC(=O)N4)N=C3C=C2	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	B1O7SK	(2S)-2-[[1-(2-Chlorophenyl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N-(4-methoxyphenyl)propanamide	Investigative	136087052	C21H19ClN6O3	438.9	C[C@@H](C(=O)NC1=CC=C(C=C1)OC)NC2=NC3=C(C=NN3C4=CC=CC=C4Cl)C(=O)N2	IC50 ~ 50000 nM	Poor binder
T77400	Phosphodiesterase 2A	B1RBP9	1-Methyl-1,3-dihydro-7-[4-oxo-4-piperidinobutoxy]-2H-imidazo[4,5-b]quinolin-2-one	Investigative	14281012	C20H24N4O3	368.4	CN1C2=C(NC1=O)N=C3C=CC(=CC3=C2)OCCCC(=O)N4CCCCC4	IC50 = 60000 nM	Poor binder
T77400	Phosphodiesterase 2A	B26PIH	1-[4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyryl]-piperidine-4-carboxylic acid ethyl ester	Investigative	14281015	C22H26N4O5	426.5	CCOC(=O)C1CCN(CC1)C(=O)CCCOC2=CC3=CC4=C(NC(=O)N4)N=C3C=C2	IC50 = 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	B2DJ1U	N-(2-Chlorophenyl)-3-cyclopentyloxy-4-(difluoromethoxy)benzamide	Investigative	134129996	C19H18ClF2NO3	381.8	C1CCC(C1)OC2=C(C=CC(=C2)C(=O)NC3=CC=CC=C3Cl)OC(F)F	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	B2RH0L	1-(3-Chloro-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10650764	C29H33ClN2O8	573	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)Cl)OC)OC)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	B2ZF0G	N-[1-(4-Methoxyphenyl)propyl]-N,6-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxamide	Investigative	137652023	C19H22N4O2	338.4	CCC(C1=CC=C(C=C1)OC)N(C)C(=O)C2=C3N=CC(=CN3N=C2)C	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	B31GWV	5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-pentanoic acid methyl ester	Investigative	14280998	C16H17N3O4	315.32	COC(=O)CCCCOC1=CC2=CC3=C(NC(=O)N3)N=C2C=C1	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	B3BP5X	1,3-Dihydro-7-[3-(phenylsulfonyl)propoxy]-2H-imidazo[4,5-b]quinolin-2-one	Investigative	15005594	C19H17N3O4S	383.4	C1=CC=C(C=C1)S(=O)(=O)CCCOC2=CC3=CC4=C(NC(=O)N4)N=C3C=C2	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	B3E0YJ	N-[(4-Methoxyphenyl)methyl]-6-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide	Investigative	137658255	C16H16N4O2	296.32	CC1=CN2C(=C(C=N2)C(=O)NCC3=CC=C(C=C3)OC)N=C1	IC50 = 52000 nM	Poor binder
T77400	Phosphodiesterase 2A	B3MJU1	1-Phthalazinamine, N-(3-chlorophenyl)-4-phenyl-	Investigative	1348	C20H14ClN3	331.8	C1=CC=C(C=C1)C2=NN=C(C3=CC=CC=C32)NC4=CC(=CC=C4)Cl	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	B3YPT5	N-[5-(1H-Benzimidazol-2-yl)-1,3-thiazol-2-yl]-3-cyanobenzamide	Investigative	127041240	C18H11N5OS	345.4	C1=CC=C2C(=C1)NC(=N2)C3=CN=C(S3)NC(=O)C4=CC=CC(=C4)C#N	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	B48LUC	Chembl4206423	Investigative	145978345	C23H28N2O5S	444.5	CC(=O)NC1=CC=C(C=C1)S(=O)(=O)N2CCC3=CC(=C(C=C3C2)OC4CCCC4)OC	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	B49ESZ	1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10508072	C29H33BrN2O8	617.5	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)Br)OC)OC)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	B53UJG	5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-pentanoic acid methyl ester	Investigative	14280999	C17H19N3O4	329.35	CN1C2=C(NC1=O)N=C3C=CC(=CC3=C2)OCCCCC(=O)OC	IC50 = 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	B5GSN2	Chembl4215772	Investigative	145974174	C25H26F3NO6	493.5	COC1=C(C=C2CN(C(CC2=C1)C(=O)OC)C(=O)C3=CC=C(C=C3)OC(F)(F)F)OC4CCCC4	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	B5M1ES	4-[[(1,3-Benzodioxol-5-yl)methyl]amino]quinazoline-6-carbonitrile	Investigative	9995187	C17H12N4O2	304.3	C1OC2=C(O1)C=C(C=C2)CNC3=NC=NC4=C3C=C(C=C4)C#N	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	B60LSR	1-[3-Methoxy-4-(pyridin-2-yloxy)phenyl]-1-quinolin-3-ylbutan-1-ol	Investigative	25179478	C25H24N2O3	400.5	CCCC(C1=CC(=C(C=C1)OC2=CC=CC=N2)OC)(C3=CC4=CC=CC=C4N=C3)O	IC50 ~ 50000 nM	Poor binder
T77400	Phosphodiesterase 2A	B6EV7Y	N-Cyclohexyl-4-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyramide	Investigative	14281004	C21H26N4O3	382.5	CN1C2=C(NC1=O)N=C3C=CC(=CC3=C2)OCCCC(=O)NC4CCCCC4	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	B6L8AN	Methyl 4-[(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]butanoate	Investigative	10017729	C15H15N3O4	301.3	COC(=O)CCCOC1=CC2=CC3=C(NC(=O)N3)N=C2C=C1	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	B6YDU3	1,3-Dihydro-1,8-dimethyl-2H-imidazo[4,5-b]quinolin-2-one	Investigative	15065160	C12H11N3O	213.23	CC1=C2C=C3C(=NC2=CC=C1)NC(=O)N3C	IC50 = 60000 nM	Poor binder
T77400	Phosphodiesterase 2A	B7ZGU9	N-Cyclohexyl-N-methyl-5-[(1-methyl-2-oxo-3H-imidazo[4,5-b]quinolin-7-yl)oxy]pentanamide	Investigative	14281023	C23H30N4O3	410.5	CN1C2=C(NC1=O)N=C3C=CC(=CC3=C2)OCCCCC(=O)N(C)C4CCCCC4	IC50 = 60000 nM	Poor binder
T77400	Phosphodiesterase 2A	B8NA4L	N-[5-(1H-Benzimidazol-2-yl)-1H-pyrazol-3-yl]-3-chloro-2-methylbenzamide	Investigative	137243509	C18H14ClN5O	351.8	CC1=C(C=CC=C1Cl)C(=O)NC2=NNC(=C2)C3=NC4=CC=CC=C4N3	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	B8V7GX	N-[1-(4-Methoxyphenyl)propyl]pyrazolo[1,5-a]pyridine-3-carboxamide	Investigative	137633190	C18H19N3O2	309.4	CCC(C1=CC=C(C=C1)OC)NC(=O)C2=C3C=CC=CN3N=C2	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	B8VUQ4	3-(Cyclopropylmethoxy)-4-(difluoromethoxy)-N-pyridin-3-ylbenzamide	Investigative	134130563	C17H16F2N2O3	334.32	C1CC1COC2=C(C=CC(=C2)C(=O)NC3=CN=CC=C3)OC(F)F	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	B8Y4LK	3(2H)-Pyridazinone, 5-ethyl-4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-	Investigative	13233885	C15H16N4O	268.31	CCC1CC(=O)NN=C1C2=CC=C(C=C2)N3C=CN=C3	IC50 = 71000 nM	Poor binder
T77400	Phosphodiesterase 2A	B9K6NZ	1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-5-chloro-2-naphthoic acid methyl ester	Investigative	10232923	C27H28BrClN2O6	591.9	COC1=C(C(=CC(=C1)C2=C3C=CC=C(C3=CC(=C2C(=O)OC)C(=O)N4CCN(CC4)CCO)Cl)Br)OC	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	B9MY0H	1-(3,4,5-Trimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10626842	C30H36N2O9	568.6	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)OC)OC)OC)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	B9V3TH	N,N-Diethyl-3-methyl-1-(2-methylphenyl)-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide	Investigative	2409032	C23H24N4OS	404.5	CCN(CC)C(=O)C1=CC(=NC2=C1C(=NN2C3=CC=CC=C3C)C)C4=CC=CS4	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	B9XEJ4	6-(4-(1H-Imidazol-1-yl)phenyl)-5-methylpyridazin-3(2H)-one	Investigative	14099446	C14H12N4O	252.27	CC1=CC(=O)NN=C1C2=CC=C(C=C2)N3C=CN=C3	IC50 = 170000 nM	Poor binder
T77400	Phosphodiesterase 2A	B9Z3AT	N-[1-(4-Methoxyphenyl)propyl]-6-methylpyrazolo[1,5-a]pyrimidine-3-sulfonamide	Investigative	137642260	C17H20N4O3S	360.4	CCC(C1=CC=C(C=C1)OC)NS(=O)(=O)C2=C3N=CC(=CN3N=C2)C	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	BA15LJ	5-(4-Imidazol-1-yl-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyridine-3-carbonitrile	Investigative	44301890	C16H14N4O	278.31	CC1=C(CC(C(=O)N1)C#N)C2=CC=C(C=C2)N3C=CN=C3	IC50 = 120000 nM	Poor binder
T77400	Phosphodiesterase 2A	BADF25	1,3-Dihydro-7-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-2H-imidazo[4,5-b]quinolin-2-one	Investigative	14281027	C21H25N7O2	407.5	C1CCC(CC1)N2C(=NN=N2)CCCCOC3=CC4=CC5=C(NC(=O)N5)N=C4C=C3	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	BAI73N	2-(Methoxymethyl)-7-methyl-5-(2-methylpropyl)-1H-imidazo[4,5-g]quinazoline-6,8-dione	Investigative	44386129	C16H20N4O3	316.35	CC(C)CN1C2=CC3=C(C=C2C(=O)N(C1=O)C)NC(=N3)COC	IC50 ~ 50000 nM	Poor binder
T77400	Phosphodiesterase 2A	BAN58F	(11R,15S)-5-Anilino-8-methyl-4-[[6-(trifluoromethyl)pyridin-3-yl]methyl]-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-one	Investigative	11989102	C24H22F3N7O	481.5	CN1C(=O)C2=C(N(N=C2N3C1=N[C@H]4[C@@H]3CCC4)CC5=CN=C(C=C5)C(F)(F)F)NC6=CC=CC=C6	Ki ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	BB1DM4	(1R,4As,6aR,6aS,6bR,8aR,10S,11R,12aR,14bS)-11-hydroxy-10-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]oxy-1,6a,6b,9,9,12a-hexamethyl-2-methylidene-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid	Investigative	127029185	C39H52O6	616.8	C[C@@H]1[C@H]2C3=CC[C@H]4[C@]([C@@]3(CC[C@]2(CCC1=C)C(=O)O)C)(CC[C@@H]5[C@@]4(C[C@H]([C@H](C5(C)C)OC(=O)/C=C/C6=CC=C(C=C6)O)O)C)C	IC50 ~ 50000 nM	Poor binder
T77400	Phosphodiesterase 2A	BBEU89	1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-2-naphthoic acid methyl ester	Investigative	10816641	C27H29BrN2O6	557.4	COC1=C(C(=CC(=C1)C2=C(C(=CC3=CC=CC=C32)C(=O)N4CCN(CC4)CCO)C(=O)OC)Br)OC	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	BBX84M	4-(4-((8-(3-(Difluoromethoxy)phenyl)quinolin-6-yl)methoxy)phenyl)-2-methylbutan-2-ol	Investigative	46933992	C28H27F2NO3	463.5	CC(C)(CCC1=CC=C(C=C1)OCC2=CC(=C3C(=C2)C=CC=N3)C4=CC(=CC=C4)OC(F)F)O	IC50 ~ 57000 nM	Poor binder
T77400	Phosphodiesterase 2A	BC09JT	Benzo[1,3]dioxol-5-ylmethyl-(6-methyl-quinazolin-4-yl)-amine	Investigative	9994528	C17H15N3O2	293.32	CC1=CC2=C(C=C1)N=CN=C2NCC3=CC4=C(C=C3)OCO4	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	BD2YE3	1,7,8-Trimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one	Investigative	15065161	C13H13N3O	227.26	CC1=C(C2=CC3=C(NC(=O)N3C)N=C2C=C1)C	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	BE0P1Q	N-(1,3-Benzodioxol-5-ylmethyl)-6-methoxy-4-quinazolinamine	Investigative	1713	C17H15N3O3	309.32	COC1=CC2=C(C=C1)N=CN=C2NCC3=CC4=C(C=C3)OCO4	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	BE4QD5	4-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyric acid methyl ester	Investigative	14280996	C16H17N3O4	315.32	CN1C2=C(NC1=O)N=C3C=CC(=CC3=C2)OCCCC(=O)OC	IC50 = 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	BE9LP0	N-(1,3-Benzodioxol-5-ylmethyl)-6-chloro-4-quinazolinamine	Investigative	6610310	C16H12ClN3O2	313.74	C1OC2=C(O1)C=C(C=C2)CNC3=NC=NC4=C3C=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	BF7H3K	6-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-hexanoic acid methyl ester	Investigative	15005567	C17H19N3O4	329.35	COC(=O)CCCCCOC1=CC2=CC3=C(NC(=O)N3)N=C2C=C1	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	BFLR49	N-Adamantan-1-yl-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyramide	Investigative	14281001	C24H28N4O3	420.5	C1C2CC3CC1CC(C2)(C3)NC(=O)CCCOC4=CC5=CC6=C(NC(=O)N6)N=C5C=C4	IC50 = 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	BHD8G3	5-Isobutyl-7-methyl-1,5-dihydro-imidazo[4,5-g]quinazoline-6,8-dione	Investigative	44311854	C14H16N4O2	272.3	CC(C)CN1C2=CC3=C(C=C2C(=O)N(C1=O)C)NC=N3	IC50 = 89000 nM	Poor binder
T77400	Phosphodiesterase 2A	BHNB48	7-(4-(Phenylsulfonyl)butoxy)-1,3-dihydro-2H-imidazo(4,5-b)quinolin-2-one	Investigative	5492386	C20H19N3O4S	397.4	C1=CC=C(C=C1)S(=O)(=O)CCCCOC2=CC3=CC4=C(NC(=O)N4)N=C3C=C2	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	BJ8ZK6	4-(3-Chloro-4-methoxy-benzylamino)-7-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester	Investigative	44286951	C21H18ClF3N2O3	438.8	CCOC(=O)C1=CN=C2C=C(C=CC2=C1NCC3=CC(=C(C=C3)OC)Cl)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T77400	Phosphodiesterase 2A	BJA3Z5	4-[3-Methoxy-4-(pyridin-2-yloxy)phenyl]-4-quinolin-3-ylbutan-2-one	Investigative	25179287	C25H22N2O3	398.5	CC(=O)CC(C1=CC(=C(C=C1)OC2=CC=CC=N2)OC)C3=CC4=CC=CC=C4N=C3	IC50 ~ 50000 nM	Poor binder
T77400	Phosphodiesterase 2A	BJE47N	1,8-Dimethyl-3-isobutylxanthine	Investigative	149028	C11H16N4O2	236.27	CC1=NC2=C(N1)C(=O)N(C(=O)N2CC(C)C)C	IC50 = 68000 nM	Poor binder
T77400	Phosphodiesterase 2A	BJO5E0	4,5-Dihydro-6-[4-(2-ethyl-4-methyl-1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone	Investigative	20146320	C16H18N4O	282.34	CCC1=NC(=CN1C2=CC=C(C=C2)C3=NNC(=O)CC3)C	IC50 = 92000 nM	Poor binder
T77400	Phosphodiesterase 2A	BK7VF1	Chembl4226493	Investigative	145969034	C22H22ClFN2O3S	448.9	CS(=O)(=O)C1=CC(=CC2=C1N(C3=C2CCCC3CC(=O)N)CC4=CC=C(C=C4)Cl)F	IC50 = 66879 nM	Poor binder
T77400	Phosphodiesterase 2A	BKXB96	7-(2-Hydroxy-ethoxy)-1,3-dihydro-imidazo[4,5-b]quinolin-2-one	Investigative	15005584	C12H11N3O3	245.23	C1=CC2=NC3=C(C=C2C=C1OCCO)NC(=O)N3	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	BL1W3O	8-Tert-butyl-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione	Investigative	19003750	C14H22N4O2	278.35	CC(C)CN1C2=C(C(=O)N(C1=O)C)NC(=N2)C(C)(C)C	IC50 = 58000 nM	Poor binder
T77400	Phosphodiesterase 2A	BM0B9J	2H-Imidazo[4,5-b]quinolin-2-one, 1,3-dihydro-1,7-dimethyl-	Investigative	13936986	C12H11N3O	213.23	CC1=CC2=CC3=C(NC(=O)N3C)N=C2C=C1	IC50 = 70000 nM	Poor binder
T77400	Phosphodiesterase 2A	BM2JS1	3-Oxo-N-[1-[4-(trifluoromethoxy)phenyl]propyl]-2,4-dihydroquinoxaline-1-carboxamide	Investigative	137654176	C19H18F3N3O3	393.4	CCC(C1=CC=C(C=C1)OC(F)(F)F)NC(=O)N2CC(=O)NC3=CC=CC=C32	IC50 = 70000 nM	Poor binder
T77400	Phosphodiesterase 2A	BM9H6G	3-Chloro-2-methyl-N-[5-(1-methylbenzimidazol-2-yl)-1,3-thiazol-2-yl]benzamide	Investigative	127042532	C19H15ClN4OS	382.9	CC1=C(C=CC=C1Cl)C(=O)NC2=NC=C(S2)C3=NC4=CC=CC=C4N3C	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	BN2MO7	6-[4-(1H-Imidazol-2-yl)-phenyl]-2H-pyridazin-3-one	Investigative	13887375	C13H10N4O	238.24	C1=CC(=CC=C1C2=NNC(=O)C=C2)C3=NC=CN3	IC50 = 180000 nM	Poor binder
T77400	Phosphodiesterase 2A	BNZG63	4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyramide	Investigative	15005579	C14H14N4O3	286.29	C1=CC2=NC3=C(C=C2C=C1OCCCC(=O)N)NC(=O)N3	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	BOA5R2	2-Tert-butyl-7-methyl-5-(2-methylpropyl)-1H-imidazo[4,5-g]quinazoline-6,8-dione	Investigative	44386324	C18H24N4O2	328.4	CC(C)CN1C2=CC3=C(C=C2C(=O)N(C1=O)C)NC(=N3)C(C)(C)C	IC50 ~ 50000 nM	Poor binder
T77400	Phosphodiesterase 2A	BOM09E	1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-3-(2-methylpropyl)-7-(phenylmethyl)-	Investigative	3041753	C17H20N4O2	312.37	CC(C)CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC3=CC=CC=C3	IC50 = 108000 nM	Poor binder
T77400	Phosphodiesterase 2A	BOWD63	2-(Methoxymethyl)-8-methyl-6-(2-methylpropyl)-3H-imidazo[4,5-f]quinazoline-7,9-dione	Investigative	44387117	C16H20N4O3	316.35	CC(C)CN1C2=C(C3=C(C=C2)NC(=N3)COC)C(=O)N(C1=O)C	IC50 = 66000 nM	Poor binder
T77400	Phosphodiesterase 2A	BPC5O6	1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6-ethoxy-7-methoxy-2-naphthoic acid methyl ester	Investigative	10579873	C30H35BrN2O8	631.5	CCOC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)Br)OC)OC)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	BR5D0B	1H-Imidazo(4,5-b)pyridine, 2-(2,4-dimethoxyphenyl)-	Investigative	156890	C14H13N3O2	255.27	COC1=CC(=C(C=C1)C2=NC3=C(N2)C=CC=N3)OC	IC50 = 57000 nM	Poor binder
T77400	Phosphodiesterase 2A	BR5L8O	2-(Propylthio)-3-(p-tolyl)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one	Investigative	2052838	C16H18N2OS2	318.5	CCCSC1=NC2=C(C(=O)N1C3=CC=C(C=C3)C)SCC2	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	BRHT84	3-Phenyl-[1,3,5]triazino[2,1-b][1,3]benzothiazole-2,4-dione	Investigative	2802078	C15H9N3O2S	295.3	C1=CC=C(C=C1)N2C(=O)N=C3N(C2=O)C4=CC=CC=C4S3	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	BS76JD	7-(3-Hydroxy-propoxy)-1,3-dihydro-imidazo[4,5-b]quinolin-2-one	Investigative	14281033	C13H13N3O3	259.26	C1=CC2=NC3=C(C=C2C=C1OCCCO)NC(=O)N3	IC50 = 50000 nM	Poor binder
T77400	Phosphodiesterase 2A	BSD2W8	4-(4-Imidazol-1-yl-phenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one	Investigative	44279839	C17H18N4O	294.35	C1CCC2C(C1)C(=NNC2=O)C3=CC=C(C=C3)N4C=CN=C4	IC50 = 130000 nM	Poor binder
T77400	Phosphodiesterase 2A	BSR18M	4-Amino-6-(4-imidazol-1-ylphenyl)-2H-pyridazin-3-one	Investigative	14099449	C13H11N5O	253.26	C1=CC(=CC=C1C2=NNC(=O)C(=C2)N)N3C=CN=C3	IC50 = 88000 nM	Poor binder
T77400	Phosphodiesterase 2A	BT0HP4	1-(4-Methoxyphenyl)-N-[(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]propan-1-amine	Investigative	137653345	C18H22N4O	310.4	CCC(C1=CC=C(C=C1)OC)NCC2=C3N=CC(=CN3N=C2)C	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	BTE2I1	Acetic acid, [(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]-	Investigative	14280992	C12H9N3O4	259.22	C1=CC2=NC3=C(C=C2C=C1OCC(=O)O)NC(=O)N3	IC50 = 50000 nM	Poor binder
T77400	Phosphodiesterase 2A	BV8A6B	1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6-methoxy-2-naphthoic acid methyl ester	Investigative	10674875	C28H31BrN2O7	587.5	COC1=CC2=CC(=C(C(=C2C=C1)C3=CC(=C(C(=C3)Br)OC)OC)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	BVA87L	2-[[1-(2-Chlorophenyl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N-(4-methoxyphenyl)propanamide	Investigative	136217455	C21H19ClN6O3	438.9	CC(C(=O)NC1=CC=C(C=C1)OC)NC2=NC3=C(C=NN3C4=CC=CC=C4Cl)C(=O)N2	IC50 ~ 50000 nM	Poor binder
T77400	Phosphodiesterase 2A	BX47WE	1-[4-(Difluoromethoxy)-3-(oxolan-3-yloxy)phenyl]-3-methylbutan-1-one	Investigative	25147798	C16H20F2O4	314.32	CC(C)CC(=O)C1=CC(=C(C=C1)OC(F)F)OC2CCOC2	IC50 ~ 50000 nM	Poor binder
T77400	Phosphodiesterase 2A	BX6Z7J	2,7-Dimethyl-5-(2-methylpropyl)-1H-imidazo[4,5-g]quinazoline-6,8-dione	Investigative	44386000	C15H18N4O2	286.33	CC1=NC2=C(N1)C=C3C(=C2)N(C(=O)N(C3=O)C)CC(C)C	IC50 ~ 50000 nM	Poor binder
T77400	Phosphodiesterase 2A	BX8D0H	9-[(2-Fluorophenyl)methyl]-N-methylpurin-6-amine;methanesulfonic acid	Investigative	44295018	C14H16FN5O3S	353.37	CNC1=C2C(=NC=N1)N(C=N2)CC3=CC=CC=C3F.CS(=O)(=O)O	Ki = 122000 nM	Poor binder
T77400	Phosphodiesterase 2A	BXLO05	3-Cyclopentyloxy-4-(difluoromethoxy)-N-pyridin-3-ylbenzamide	Investigative	134130328	C18H18F2N2O3	348.3	C1CCC(C1)OC2=C(C=CC(=C2)C(=O)NC3=CN=CC=C3)OC(F)F	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	BYVU78	N-(2-Chlorophenyl)-3(cyclopropylmethoxy)-4-(difluoromethoxy)benzamide	Investigative	134131162	C18H16ClF2NO3	367.8	C1CC1COC2=C(C=CC(=C2)C(=O)NC3=CC=CC=C3Cl)OC(F)F	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	BYW6B1	6-(4-Imidazol-1-yl-phenyl)-2H-pyridazin-3-one	Investigative	13059432	C13H10N4O	238.24	C1=CC(=CC=C1C2=NNC(=O)C=C2)N3C=CN=C3	IC50 = 190000 nM	Poor binder
T77400	Phosphodiesterase 2A	BZ21LT	N-Cyclohexyl-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyramide	Investigative	9999105	C20H24N4O3	368.4	C1CCC(CC1)NC(=O)CCCOC2=CC3=CC4=C(NC(=O)N4)N=C3C=C2	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	BZ5W4G	Benzo[1,3]dioxol-5-ylmethyl-(6-methylsulfanyl-quinazolin-4-yl)-amine	Investigative	10471556	C17H15N3O2S	325.4	CSC1=CC2=C(C=C1)N=CN=C2NCC3=CC4=C(C=C3)OCO4	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	BZT5M6	CCC(NC(=O)N1CC(=O)Nc2cccnc12)c1ccc(OC(F)(F)F)cc1	Investigative	117949009	C18H17F3N4O3	394.3	CCC(C1=CC=C(C=C1)OC(F)(F)F)NC(=O)N2CC(=O)NC3=C2N=CC=C3	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	D05HFD	7-Methyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one	Investigative	13936971	C11H9N3O	199.21	CC1=CC2=CC3=C(NC(=O)N3)N=C2C=C1	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	D09GTN	7-Fluoro-1,3-dihydro-imidazo[4,5-b]quinolin-2-one	Investigative	13936969	C10H6FN3O	203.17	C1=CC2=NC3=C(C=C2C=C1F)NC(=O)N3	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	D0N6MR	1,3-Dihydro-imidazo[4,5-b]quinolin-2-one	Investigative	10867033	C10H7N3O	185.18	C1=CC=C2C(=C1)C=C3C(=N2)NC(=O)N3	IC50 = 80000 nM	Poor binder
T77400	Phosphodiesterase 2A	D0NI4Z	7-Chloro-1,3-dihydro-imidazo[4,5-b]quinolin-2-one	Investigative	13936972	C10H6ClN3O	219.63	C1=CC2=NC3=C(C=C2C=C1Cl)NC(=O)N3	IC50 ~ 100000 nM	Poor binder
T77400	Phosphodiesterase 2A	D0RC4F	BUFROLIN	Investigative	72103	C18H16N2O6	356.3	CCCCC1=CC2=C(C3=C1NC(=CC3=O)C(=O)O)NC(=CC2=O)C(=O)O	IC50 = 80000 nM	Poor binder
T77400	Phosphodiesterase 2A	D0T3UP	1,3-Dihydro-naphtho[2,3-d]imidazol-2-one	Investigative	13724742	C11H8N2O	184.19	C1=CC=C2C=C3C(=CC2=C1)NC(=O)N3	IC50 ~ 100000 nM	Poor binder