TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T84133	Phosphodiesterase 10A	D01RCZ	B7673	Patented	2052828	C15H16N2OS2	304.4	CCCSC1=NC2=C(C(=O)N1C3=CC=CC=C3)SCC2	IC50 ~ 100000 nM	Poor binder
T84133	Phosphodiesterase 10A	D0SG9Q	US9388139, 12	Patented	60194756	C20H20Cl2N2O2	391.3	CC(C)(C)C1=NN(C(C1)C2=C(C=C(C=C2)Cl)Cl)C3=CC=C(C=C3)C(=O)O	IC50 ~ 50000 nM	Poor binder
T84133	Phosphodiesterase 10A	D0SH7F	BC11-28	Patented	3257208	C25H19FN4	394.4	CC1=CC=CC=C1NC2=C3C(=CN(C3=NC=N2)C4=CC=C(C=C4)F)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T84133	Phosphodiesterase 10A	B0A9ID	N-(4-Methoxybenzyl)-3-(cyclopentyloxy)-4-(difluoromethoxy)benzamide	Investigative	122193679	C21H23F2NO4	391.4	COC1=CC=C(C=C1)CNC(=O)C2=CC(=C(C=C2)OC(F)F)OC3CCCC3	IC50 ~ 100000 nM	Poor binder
T84133	Phosphodiesterase 10A	B1O7SK	(2S)-2-[[1-(2-Chlorophenyl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N-(4-methoxyphenyl)propanamide	Investigative	136087052	C21H19ClN6O3	438.9	C[C@@H](C(=O)NC1=CC=C(C=C1)OC)NC2=NC3=C(C=NN3C4=CC=CC=C4Cl)C(=O)N2	IC50 ~ 50000 nM	Poor binder
T84133	Phosphodiesterase 10A	B1YL7D	1-(3-((1-(Quinolin-2-yl)azetidin-3-yl)oxy)pyrazin-2-yl)piperidin-4-ol	Investigative	58547845	C21H23N5O2	377.4	C1CN(CCC1O)C2=NC=CN=C2OC3CN(C3)C4=NC5=CC=CC=C5C=C4	IC50 = 54000 nM	Poor binder
T84133	Phosphodiesterase 10A	B2DJ1U	N-(2-Chlorophenyl)-3-cyclopentyloxy-4-(difluoromethoxy)benzamide	Investigative	134129996	C19H18ClF2NO3	381.8	C1CCC(C1)OC2=C(C=CC(=C2)C(=O)NC3=CC=CC=C3Cl)OC(F)F	IC50 ~ 100000 nM	Poor binder
T84133	Phosphodiesterase 10A	B48LUC	Chembl4206423	Investigative	145978345	C23H28N2O5S	444.5	CC(=O)NC1=CC=C(C=C1)S(=O)(=O)N2CCC3=CC(=C(C=C3C2)OC4CCCC4)OC	IC50 ~ 100000 nM	Poor binder
T84133	Phosphodiesterase 10A	B4M7EV	2-[3-[3-[4-(Methoxymethyl)piperidin-1-yl]pyrazin-2-yl]oxyazetidin-1-yl]quinoline	Investigative	58547789	C23H27N5O2	405.5	COCC1CCN(CC1)C2=NC=CN=C2OC3CN(C3)C4=NC5=CC=CC=C5C=C4	IC50 = 147000 nM	Poor binder
T84133	Phosphodiesterase 10A	B5GSN2	Chembl4215772	Investigative	145974174	C25H26F3NO6	493.5	COC1=C(C=C2CN(C(CC2=C1)C(=O)OC)C(=O)C3=CC=C(C=C3)OC(F)(F)F)OC4CCCC4	IC50 ~ 100000 nM	Poor binder
T84133	Phosphodiesterase 10A	B85EBM	Methyl 4-(3-((1-(quinolin-2-yl)azetidin-3-yl)oxy)pyrazin-2-yl)piperidine-1-carboxylate	Investigative	58547944	C23H25N5O3	419.5	COC(=O)N1CCC(CC1)C2=NC=CN=C2OC3CN(C3)C4=NC5=CC=CC=C5C=C4	IC50 = 64000 nM	Poor binder
T84133	Phosphodiesterase 10A	B8VUQ4	3-(Cyclopropylmethoxy)-4-(difluoromethoxy)-N-pyridin-3-ylbenzamide	Investigative	134130563	C17H16F2N2O3	334.32	C1CC1COC2=C(C=CC(=C2)C(=O)NC3=CN=CC=C3)OC(F)F	IC50 ~ 100000 nM	Poor binder
T84133	Phosphodiesterase 10A	B97HAY	6-(3,4-Dimethoxyphenyl)-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	662965	C19H18N4O3S	382.4	COC1=C(C=C(C=C1)C2=NN3C(=NN=C3SC2)C4=CC=CC=C4OC)OC	IC50 ~ 50000 nM	Poor binder
T84133	Phosphodiesterase 10A	BA5GH9	2-[3-[3-(4-Methylpiperidin-1-yl)pyrazin-2-yl]oxyazetidin-1-yl]quinoline	Investigative	58548040	C22H25N5O	375.5	CC1CCN(CC1)C2=NC=CN=C2OC3CN(C3)C4=NC5=CC=CC=C5C=C4	IC50 = 103000 nM	Poor binder
T84133	Phosphodiesterase 10A	BA8WL4	2-[3-(3-Pyrimidin-5-ylpyrazin-2-yl)oxyazetidin-1-yl]quinoline	Investigative	58548022	C20H16N6O	356.4	C1C(CN1C2=NC3=CC=CC=C3C=C2)OC4=NC=CN=C4C5=CN=CN=C5	IC50 = 125000 nM	Poor binder
T84133	Phosphodiesterase 10A	BE0H8F	2-[3-[3-(2-Methylpyridin-3-yl)pyrazin-2-yl]oxyazetidin-1-yl]quinoline	Investigative	58548143	C22H19N5O	369.4	CC1=C(C=CC=N1)C2=NC=CN=C2OC3CN(C3)C4=NC5=CC=CC=C5C=C4	IC50 = 98000 nM	Poor binder
T84133	Phosphodiesterase 10A	BO3YQ5	2-(Butylthio)-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one	Investigative	2155145	C16H18N2OS2	318.5	CCCCSC1=NC2=C(C(=O)N1C3=CC=CC=C3)SCC2	IC50 ~ 100000 nM	Poor binder
T84133	Phosphodiesterase 10A	BQ9GF2	2-[3-[3-(1-Methylsulfonylpiperidin-4-yl)pyrazin-2-yl]oxyazetidin-1-yl]quinoline	Investigative	54671050	C22H25N5O3S	439.5	CS(=O)(=O)N1CCC(CC1)C2=NC=CN=C2OC3CN(C3)C4=NC5=CC=CC=C5C=C4	IC50 = 166000 nM	Poor binder
T84133	Phosphodiesterase 10A	BR2X7Z	2-[3-[3-(4-Methylphenyl)pyrazin-2-yl]oxyazetidin-1-yl]quinoline	Investigative	58548001	C23H20N4O	368.4	CC1=CC=C(C=C1)C2=NC=CN=C2OC3CN(C3)C4=NC5=CC=CC=C5C=C4	IC50 = 107000 nM	Poor binder
T84133	Phosphodiesterase 10A	BR5L8O	2-(Propylthio)-3-(p-tolyl)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one	Investigative	2052838	C16H18N2OS2	318.5	CCCSC1=NC2=C(C(=O)N1C3=CC=C(C=C3)C)SCC2	IC50 ~ 100000 nM	Poor binder
T84133	Phosphodiesterase 10A	BRHT84	3-Phenyl-[1,3,5]triazino[2,1-b][1,3]benzothiazole-2,4-dione	Investigative	2802078	C15H9N3O2S	295.3	C1=CC=C(C=C1)N2C(=O)N=C3N(C2=O)C4=CC=CC=C4S3	IC50 ~ 100000 nM	Poor binder
T84133	Phosphodiesterase 10A	BVA87L	2-[[1-(2-Chlorophenyl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N-(4-methoxyphenyl)propanamide	Investigative	136217455	C21H19ClN6O3	438.9	CC(C(=O)NC1=CC=C(C=C1)OC)NC2=NC3=C(C=NN3C4=CC=CC=C4Cl)C(=O)N2	IC50 ~ 50000 nM	Poor binder
T84133	Phosphodiesterase 10A	BXLO05	3-Cyclopentyloxy-4-(difluoromethoxy)-N-pyridin-3-ylbenzamide	Investigative	134130328	C18H18F2N2O3	348.3	C1CCC(C1)OC2=C(C=CC(=C2)C(=O)NC3=CN=CC=C3)OC(F)F	IC50 ~ 100000 nM	Poor binder
T84133	Phosphodiesterase 10A	BYVU78	N-(2-Chlorophenyl)-3(cyclopropylmethoxy)-4-(difluoromethoxy)benzamide	Investigative	134131162	C18H16ClF2NO3	367.8	C1CC1COC2=C(C=CC(=C2)C(=O)NC3=CC=CC=C3Cl)OC(F)F	IC50 ~ 100000 nM	Poor binder