TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T84631	Coagulation factor Xa	D07UWV	Argatroban	Approved	92722	C23H36N6O5S	508.6	C[C@@H]1CCN([C@H](C1)C(=O)O)C(=O)[C@H](CCCN=C(N)N)NS(=O)(=O)C2=CC=CC3=C2NCC(C3)C	Ki = 53000 nM	Poor binder
T84631	Coagulation factor Xa	D0I7OF	Hexamethylene amiloride	Preclinical	1794	C12H18ClN7O	311.77	C1CCCN(CC1)C2=NC(=C(N=C2Cl)C(=O)N=C(N)N)N	IC50 ~ 50000 nM	Poor binder
T84631	Coagulation factor Xa	B01VPI	N-[1-(3-Amino-5-methyl-1,2-benzoxazol-7-yl)pyrrolidin-3-yl]-2-chloro-4-(1,2,4-triazol-4-yl)benzamide	Investigative	137640248	C21H20ClN7O2	437.9	CC1=CC2=C(C(=C1)N3CCC(C3)NC(=O)C4=C(C=C(C=C4)N5C=NN=C5)Cl)ON=C2N	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	B05XVL	6-Fluoro-2-[2-hydroxy-3-((S)-2-methyl-4,4-dimethyl-cyclopentyloxy)-phenyl]-1H-benzoimidazole-5-carboxamidine	Investigative	136092212	C22H25FN4O2	396.5	C[C@H]1CC(C[C@@H]1OC2=CC=CC(=C2O)C3=NC4=C(N3)C=C(C(=C4)C(=N)N)F)(C)C	Ki = 83000 nM	Poor binder
T84631	Coagulation factor Xa	B06BIL	1-[4-[(5S)-5-[[[4-Chloro-3-(5-oxo-4H-1,2,4-oxadiazol-3-yl)benzoyl]amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid	Investigative	136224837	C25H24ClN5O7	541.9	C1CN(CCC1C(=O)O)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CC(=C(C=C4)Cl)C5=NOC(=O)N5	Ki = 89700 nM	Poor binder
T84631	Coagulation factor Xa	B08OTN	2-[3-(1H-1,3-Benzodiazol-2-yl)-4-hydroxy-5-(3-nitrophenyl)phenyl]acetic acid	Investigative	135559071	C21H15N3O5	389.4	C1=CC=C2C(=C1)NC(=N2)C3=CC(=CC(=C3O)C4=CC(=CC=C4)[N+](=O)[O-])CC(=O)O	Ki ~ 150000 nM	Poor binder
T84631	Coagulation factor Xa	B0FXR9	3-[(2S)-3-[4-(2-Aminoethyl)piperidin-1-yl]-2-(naphthalene-2-sulfonamido)-3-oxopropyl]benzene-1-carboximidamide	Investigative	11577055	C27H33N5O3S	507.6	C1CN(CCC1CCN)C(=O)[C@H](CC2=CC(=CC=C2)C(=N)N)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3	Ki = 76000 nM	Poor binder
T84631	Coagulation factor Xa	B0HX8B	{(S)-1-[(S)-2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrolidine-1-carbonyl]-4-guanidino-butyl}-carbamic acid tert-butyl ester	Investigative	44287838	C22H41N9O5	511.6	CC(C)(C)OC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NC(CCCN=C(N)N)C=O	IC50 = 60000 nM	Poor binder
T84631	Coagulation factor Xa	B0QNT2	N-[(4-Carbamimidoyl-benzylcarbamoyl)-methyl]-3-hydroxy-2-(3,4,5-triisopropyl-benzenesulfonylamino)-propionamide	Investigative	44372683	C28H41N5O5S	559.7	CC(C)C1=CC(=CC(=C1C(C)C)C(C)C)S(=O)(=O)N[C@H](CO)C(=O)NCC(=O)NCC2=CC=C(C=C2)C(=N)N	Ki = 100000 nM	Poor binder
T84631	Coagulation factor Xa	B1C9PZ	N-[3-[(4-Fluorophenyl)methoxy]phenyl]-1-pyridin-2-ylpiperidine-4-carboxamide	Investigative	72711861	C24H24FN3O2	405.5	C1CN(CCC1C(=O)NC2=CC(=CC=C2)OCC3=CC=C(C=C3)F)C4=CC=CC=N4	Ki = 78000 nM	Poor binder
T84631	Coagulation factor Xa	B1CUF3	(1-{[(4-Carbamimidoyl-benzylcarbamoyl)-methyl]-carbamoyl}-2-hydroxy-ethyl)-carbamic acid tert-butyl ester	Investigative	10293977	C18H27N5O5	393.4	CC(C)(C)OC(=O)N[C@@H](CO)C(=O)NCC(=O)NCC1=CC=C(C=C1)C(=N)N	Ki = 110000 nM	Poor binder
T84631	Coagulation factor Xa	B1FT6V	(S)-Benzyl 1-(5-(4-((2,3-dihydro-1H-inden-2-yl)carbamoyl)benzyl)-1,2,4-oxadiazol-3-yl)-6-amino-1-oxohexan-2-ylcarbamate	Investigative	44414333	C33H35N5O5	581.7	C1C(CC2=CC=CC=C21)NC(=O)C3=CC=C(C=C3)CC4=NC(=NO4)C(=O)[C@H](CCCCN)NC(=O)OCC5=CC=CC=C5	Ki = 100000 nM	Poor binder
T84631	Coagulation factor Xa	B1GZ7H	2-[6-(3-Carbamimidoylphenoxy)-3,5-difluoro-4-[[(2R)-4-phenylbutan-2-yl]amino]pyridin-2-yl]oxybenzoic acid	Investigative	44402976	C29H26F2N4O4	532.5	C[C@H](CCC1=CC=CC=C1)NC2=C(C(=NC(=C2F)OC3=CC=CC=C3C(=O)O)OC4=CC=CC(=C4)C(=N)N)F	IC50 = 51000 nM	Poor binder
T84631	Coagulation factor Xa	B1HPD6	2-[3-(2-Chloro-4-fluoro-phenylmethanesulfonylamino)-6-methyl-2-oxo-2H-pyridin-1-yl]-N-(4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl)-acetamide	Investigative	10289409	C23H25ClFN5O4S	522	CC1=CC=C(C(=O)N1CC(=O)NCC2CCC3=C(C2)C=NN3)NS(=O)(=O)CC4=C(C=C(C=C4)F)Cl	Ki = 75000 nM	Poor binder
T84631	Coagulation factor Xa	B1MA0G	Diphenyl 1-(benzyloxycarbonylamino)-2-(4-guanidinophenyl)-ethanephosphonate	Investigative	16718808	C29H29N4O5P	544.5	C1=CC=C(C=C1)COC(=O)NC(CC2=CC=C(C=C2)N=C(N)N)P(=O)(OC3=CC=CC=C3)OC4=CC=CC=C4	IC50 = 100000 nM	Poor binder
T84631	Coagulation factor Xa	B1PMC4	Chembl4217043	Investigative	135393474	C17H23N9O2	385.4	COC1=NC=C(C=N1)C2=C(N=C(C(=N2)C(=O)N=C(N)N)N)N3CCCCCC3	IC50 ~ 50000 nM	Poor binder
T84631	Coagulation factor Xa	B1PQC0	1-(5-Chlorothiophene-2-carbonyl)-6-methoxy-3-[4-(2-oxopiperidin-1-yl)phenyl]-2H-quinazolin-4-one	Investigative	137656734	C25H22ClN3O4S	496	COC1=CC2=C(C=C1)N(CN(C2=O)C3=CC=C(C=C3)N4CCCCC4=O)C(=O)C5=CC=C(S5)Cl	IC50 = 179000 nM	Poor binder
T84631	Coagulation factor Xa	B1SKE2	N-[(3R)-1-(3-Amino-4-chloro-[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-pyrimidin-5-ylbenzamide	Investigative	118457021	C21H17Cl2N7O2	470.3	C1CN(C[C@@H]1NC(=O)C2=C(C=C(C=C2)C3=CN=CN=C3)Cl)C4=NC=C(C5=C4ON=C5N)Cl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	B1U9YI	(3S)-2-(5-Chlorothiophene-2-carbonyl)-N-methyl-N-[4-(2-oxopiperidin-1-yl)phenyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide	Investigative	66573536	C27H26ClN3O3S	508	CN(C1=CC=C(C=C1)N2CCCCC2=O)C(=O)[C@@H]3CC4=CC=CC=C4CN3C(=O)C5=CC=C(S5)Cl	IC50 = 56000 nM	Poor binder
T84631	Coagulation factor Xa	B1VA4D	N-(2-Amino-4,5,6,7-tetrahydro-benzothiazol-6-yl)-2-(6-methyl-2-oxo-3-p-tolylmethanesulfonylamino-2H-pyridin-1-yl)-acetamide	Investigative	44339417	C23H27N5O4S2	501.6	CC1=CC=C(C=C1)CS(=O)(=O)NC2=CC=C(N(C2=O)CC(=O)NC3CCC4=C(C3)SC(=N4)N)C	Ki = 80000 nM	Poor binder
T84631	Coagulation factor Xa	B1WV8X	((R)-2-{(S)-2-[(2-Amino-thiazol-4-ylmethyl)-carbamoyl]-pyrrolidin-1-yl}-1-benzhydryl-2-oxo-ethyl)-carbamic acid tert-butyl ester	Investigative	10745242	C29H35N5O4S	549.7	CC(C)(C)OC(=O)N[C@H](C(C1=CC=CC=C1)C2=CC=CC=C2)C(=O)N3CCC[C@H]3C(=O)NCC4=CSC(=N4)N	Ki ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	B20QAF	(2S)-2-[[2-(4-Chlorophenyl)acetyl]amino]-N-methyl-N-[4-(2-oxopiperidin-1-yl)phenyl]-3-phenylpropanamide	Investigative	66573974	C29H30ClN3O3	504	CN(C1=CC=C(C=C1)N2CCCCC2=O)C(=O)[C@H](CC3=CC=CC=C3)NC(=O)CC4=CC=C(C=C4)Cl	IC50 = 54000 nM	Poor binder
T84631	Coagulation factor Xa	B20QPI	(2S)-1-[(2R)-2-Amino-3,3-diphenylpropanoyl]-N-[(2-amino-5,6,7,8-tetrahydroquinazolin-6-yl)methyl]pyrrolidine-2-carboxamide	Investigative	44378546	C29H34N6O2	498.6	C1C[C@H](N(C1)C(=O)[C@@H](C(C2=CC=CC=C2)C3=CC=CC=C3)N)C(=O)NCC4CCC5=NC(=NC=C5C4)N	Ki = 57600 nM	Poor binder
T84631	Coagulation factor Xa	B24INB	4-[[(2S,4S)-1-(1-Carbamimidoylpiperidine-4-carbonyl)-4-(4-methylsulfonylpiperazin-1-yl)pyrrolidine-2-carbonyl]amino]benzoic acid	Investigative	72550184	C24H35N7O6S	549.6	CS(=O)(=O)N1CCN(CC1)[C@H]2C[C@H](N(C2)C(=O)C3CCN(CC3)C(=N)N)C(=O)NC4=CC=C(C=C4)C(=O)O	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	B26LPQ	6-Fluoro-2-[2-hydroxy-3-(pyrrolidin-3-yloxy)-phenyl]-1H-benzoimidazole-5-carboxamidine	Investigative	136034781	C18H18FN5O2	355.4	C1CNCC1OC2=CC=CC(=C2O)C3=NC4=C(N3)C=C(C(=C4)C(=N)N)F	Ki = 94000 nM	Poor binder
T84631	Coagulation factor Xa	B29YTW	2-(4-Fluoro-benzenesulfonylamino)-N-(1-formyl-3-methyl-butyl)-3-methyl-butyramide	Investigative	10861643	C17H25FN2O4S	372.5	CC(C)C[C@H](C=O)NC(=O)[C@H](C(C)C)NS(=O)(=O)C1=CC=C(C=C1)F	IC50 ~ 60000 nM	Poor binder
T84631	Coagulation factor Xa	B2CB8R	1-(4-Chlorobenzoyl)-6-methoxy-3-[4-(2-oxopiperidin-1-yl)phenyl]-2H-quinazolin-4-one	Investigative	137647755	C27H24ClN3O4	489.9	COC1=CC2=C(C=C1)N(CN(C2=O)C3=CC=C(C=C3)N4CCCCC4=O)C(=O)C5=CC=C(C=C5)Cl	IC50 = 52000 nM	Poor binder
T84631	Coagulation factor Xa	B2FL3D	2-Chlorobenzenesulfonic acid 3-methyl-5-(1-amidinopiperidine-4-ylmethoxy)phenyl ester	Investigative	9910982	C20H24ClN3O4S	437.9	CC1=CC(=CC(=C1)OS(=O)(=O)C2=CC=CC=C2Cl)OCC3CCN(CC3)C(=N)N	Ki = 80000 nM	Poor binder
T84631	Coagulation factor Xa	B2HX6Q	Methyl (2S)-1-[(2S)-2-[[3-(3-aminopropanoylamino)phenyl]sulfonylamino]-3-(3-carbamimidoylphenyl)propanoyl]piperidine-2-carboxylate	Investigative	44573380	C26H34N6O6S	558.7	COC(=O)[C@@H]1CCCCN1C(=O)[C@H](CC2=CC(=CC=C2)C(=N)N)NS(=O)(=O)C3=CC=CC(=C3)NC(=O)CCN	Ki = 127000 nM	Poor binder
T84631	Coagulation factor Xa	B2I3FS	(S)-1-((R)-3-Cyclohexyl-2-phenylmethanesulfonylamino-propionyl)-pyrrolidine-2-carboxylic acid (2-amino-5,6,7,8-tetrahydro-quinazolin-6-yl)-amide	Investigative	10281431	C29H40N6O4S	568.7	C1CCC(CC1)C[C@H](C(=O)N2CCC[C@H]2C(=O)NC3CCC4=NC(=NC=C4C3)N)NS(=O)(=O)CC5=CC=CC=C5	Ki ~ 75400 nM	Poor binder
T84631	Coagulation factor Xa	B2KF1P	N-(2-Amino-4,5,6,7-tetrahydro-benzothiazol-6-yl)-2-[3-(butane-1-sulfonylamino)-6-methyl-2-oxo-2H-pyridin-1-yl]-acetamide	Investigative	44339376	C19H27N5O4S2	453.6	CCCCS(=O)(=O)NC1=CC=C(N(C1=O)CC(=O)NC2CCC3=C(C2)SC(=N3)N)C	Ki = 179000 nM	Poor binder
T84631	Coagulation factor Xa	B2MW1Z	4-[[[(6-Methoxynaphthalen-2-yl)sulfonylamino]-(4-methylpiperidine-1-carbonyl)amino]methyl]benzenecarboximidamide	Investigative	11420832	C26H31N5O4S	509.6	CC1CCN(CC1)C(=O)N(CC2=CC=C(C=C2)C(=N)N)NS(=O)(=O)C3=CC4=C(C=C3)C=C(C=C4)OC	Ki ~ 75000 nM	Poor binder
T84631	Coagulation factor Xa	B2NC1J	2-(1H-Benzo[d]imidazol-2-yl)-1H-benzo[d]imidazole-5-carboxamidine	Investigative	44407625	C15H12N6	276.3	C1=CC=C2C(=C1)NC(=N2)C3=NC4=C(N3)C=C(C=C4)C(=N)N	Ki = 72000 nM	Poor binder
T84631	Coagulation factor Xa	B2S9ZN	N-(3-Amino-2-imino-2,3,4,5,6,7-hexahydro-benzothiazol-6-yl)-2-[3-(4-fluoro-phenylmethanesulfonylamino)-6-methyl-2-oxo-2H-pyridin-1-yl]-acetamide	Investigative	44339470	C22H25FN6O4S2	520.6	CC1=CC=C(C(=O)N1CC(=O)NC2CCC3=C(C2)SC(=N)N3N)NS(=O)(=O)CC4=CC=C(C=C4)F	Ki = 131000 nM	Poor binder
T84631	Coagulation factor Xa	B2SWN5	8-Methoxy-2-oxo-N-phenylchromene-3-carboxamide	Investigative	754821	C17H13NO4	295.29	COC1=CC=CC2=C1OC(=O)C(=C2)C(=O)NC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T84631	Coagulation factor Xa	B2W7OY	3-Carboxamide-coumarin deriv., 43	Investigative	24860449	C18H13Cl2NO3	362.2	CC1=CC(=CC(=C1)NC(=O)C2=CC3=CC(=CC(=C3OC2=O)Cl)Cl)C	IC50 ~ 50000 nM	Poor binder
T84631	Coagulation factor Xa	B30NZT	N-[3-[(3,5-Dimethoxyphenyl)methoxy]phenyl]-1-pyridin-4-ylpiperidine-4-carboxamide	Investigative	72712250	C26H29N3O4	447.5	COC1=CC(=CC(=C1)COC2=CC=CC(=C2)NC(=O)C3CCN(CC3)C4=CC=NC=C4)OC	Ki = 126000 nM	Poor binder
T84631	Coagulation factor Xa	B35SFL	(2S)-N-[(6-Amino-2,4-dimethylpyridin-3-yl)methyl]-1-[(2R)-2-(benzylsulfonylamino)-3-(3,4-dichlorophenyl)propanoyl]pyrrolidine-2-carboxamide	Investigative	10841532	C29H33Cl2N5O4S	618.6	CC1=CC(=NC(=C1CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC3=CC(=C(C=C3)Cl)Cl)NS(=O)(=O)CC4=CC=CC=C4)C)N	Ki = 52000 nM	Poor binder
T84631	Coagulation factor Xa	B39FGY	3-Bromo-N-(4-guanidino-phenyl)-2-hydroxy-5-methyl-benzamide	Investigative	44304139	C15H15BrN4O2	363.21	CC1=CC(=C(C(=C1)Br)O)C(=O)NC2=CC=C(C=C2)N=C(N)N	Ki = 151000 nM	Poor binder
T84631	Coagulation factor Xa	B3C6MB	CID 10230007	Investigative	10230007	C26H31N5O5S	525.6	COC1=CC2=C(C=C1)C=C(C=C2)S(=O)(=O)NN(CC3=CC(=CC=C3)/C(=N/O)/N)C(=O)N4CCCCCC4	Ki = 103000 nM	Poor binder
T84631	Coagulation factor Xa	B3CS2P	3-Carboxamide-coumarin deriv., 46	Investigative	24860451	C18H13BrClNO3	406.7	CC1=CC(=CC(=C1)NC(=O)C2=CC3=CC(=CC(=C3OC2=O)Br)Cl)C	IC50 ~ 50000 nM	Poor binder
T84631	Coagulation factor Xa	B3M9CD	4-[[(2S,4S)-1-[4-(Aminomethyl)cyclohexanecarbonyl]-4-(4-cyclopropylsulfonylpiperazin-1-yl)pyrrolidine-2-carbonyl]amino]benzoic acid	Investigative	72550405	C27H39N5O6S	561.7	C1CC(CCC1CN)C(=O)N2C[C@H](C[C@H]2C(=O)NC3=CC=C(C=C3)C(=O)O)N4CCN(CC4)S(=O)(=O)C5CC5	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	B3OB8Q	2-Chloro-N-[3-methyl-1-(4-methyl-2-nitrophenyl)pyrrolidin-3-yl]-4-(1,2,4-triazol-4-yl)benzamide	Investigative	137638513	C21H21ClN6O3	440.9	CC1=CC(=C(C=C1)N2CCC(C2)(C)NC(=O)C3=C(C=C(C=C3)N4C=NN=C4)Cl)[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	B3RIU8	3-Amino-N-{3-[(S)-2-[4-(2-amino-ethyl)-piperidin-1-yl]-1-(3-aminomethyl-benzyl)-2-oxo-ethylsulfamoyl]-phenyl}-propionamide	Investigative	44569301	C26H38N6O4S	530.7	C1CN(CCC1CCN)C(=O)[C@H](CC2=CC(=CC=C2)CN)NS(=O)(=O)C3=CC=CC(=C3)NC(=O)CCN	Ki = 92000 nM	Poor binder
T84631	Coagulation factor Xa	B3RMB7	3-Amino-5-[1-({[(4-carbamimidoylphenyl)methyl]carbamoyl}methyl)-3-chloro-6-oxo-5-(propan-2-ylamino)-1,6-dihydropyrazin-2-yl]benzoic acid	Investigative	9936190	C24H26ClN7O4	512	CC(C)NC1=NC(=C(N(C1=O)CC(=O)NCC2=CC=C(C=C2)C(=N)N)C3=CC(=CC(=C3)N)C(=O)O)Cl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	B3SZ0P	3-Hydroxy-anthracene-2-carboxylic acid (6-guanidino-pyridin-3-yl)-amide	Investigative	44304087	C21H17N5O2	371.4	C1=CC=C2C=C3C=C(C(=CC3=CC2=C1)C(=O)NC4=CN=C(C=C4)N=C(N)N)O	Ki = 55000 nM	Poor binder
T84631	Coagulation factor Xa	B3TWQ1	(2S)-N-[[3-[3-(4-Amino-1H-pyrrolo[3,2-c]pyridin-2-yl)-2-hydroxyphenyl]phenyl]methyl]-2-hydroxy-3-phenylpropanamide	Investigative	44415581	C29H26N4O3	478.5	C1=CC=C(C=C1)C[C@@H](C(=O)NCC2=CC(=CC=C2)C3=C(C(=CC=C3)C4=CC5=C(N4)C=CN=C5N)O)O	Ki = 54000 nM	Poor binder
T84631	Coagulation factor Xa	B3XRK6	(2S)-N-[[4-[(Z)-C-Aminocarbonohydrazonoyl]thiophen-2-yl]methyl]-1-[(2R)-2-(methanesulfonamido)-3,3-diphenylpropanoyl]pyrrolidine-2-carboxamide	Investigative	44264817	C27H32N6O4S2	568.7	CS(=O)(=O)N[C@H](C(C1=CC=CC=C1)C2=CC=CC=C2)C(=O)N3CCC[C@H]3C(=O)NCC4=CC(=CS4)/C(=N/N)/N	Ki = 59000 nM	Poor binder
T84631	Coagulation factor Xa	B42FNC	Phenyl 6-(chloromethyl)-2-oxo-2H-chromene-3-carboxylate	Investigative	402499	C17H11ClO4	314.7	C1=CC=C(C=C1)OC(=O)C2=CC3=C(C=CC(=C3)CCl)OC2=O	IC50 ~ 50000 nM	Poor binder
T84631	Coagulation factor Xa	B45NTB	Ethyl 1-[4-[(5S)-5-[[(2-amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]-3-methyl-2-oxopiperidine-3-carboxylate;2,2,2-trifluoroacetic acid	Investigative	73356536	C25H28F3N5O8S	615.6	CCOC(=O)C1(CCCN(C1=O)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CN=C(S4)N)C.C(=O)(C(F)(F)F)O	Ki = 55600 nM	Poor binder
T84631	Coagulation factor Xa	B4B3OJ	N'-Hydroxy-4-[[(2-methylpiperidine-1-carbonyl)-(naphthalen-2-ylsulfonylamino)amino]methyl]benzenecarboximidamide	Investigative	44286879	C25H29N5O4S	495.6	CC1CCCCN1C(=O)N(CC2=CC=C(C=C2)/C(=N/O)/N)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3	Ki ~ 75000 nM	Poor binder
T84631	Coagulation factor Xa	B4D2JA	(2S)-1-[(2R)-2-(Benzylsulfonylamino)-3-cyclohexylpropanoyl]-N-(4,5,6,7-tetrahydro-1H-indazol-5-ylmethyl)pyrrolidine-2-carboxamide	Investigative	9872423	C29H41N5O4S	555.7	C1CCC(CC1)C[C@H](C(=O)N2CCC[C@H]2C(=O)NCC3CCC4=C(C3)C=NN4)NS(=O)(=O)CC5=CC=CC=C5	Ki ~ 75400 nM	Poor binder
T84631	Coagulation factor Xa	B4DF3A	N-[(2R)-3-(3-Aminopropylsulfanyl)-1-[4-(2-fluoroethyl)piperidin-1-yl]-1-oxopropan-2-yl]-3,3-dimethyl-2,4-dihydro-1H-quinoline-8-sulfonamide	Investigative	12047383	C24H39FN4O3S2	514.7	CC1(CC2=C(C(=CC=C2)S(=O)(=O)N[C@@H](CSCCCN)C(=O)N3CCC(CC3)CCF)NC1)C	Ki = 87000 nM	Poor binder
T84631	Coagulation factor Xa	B4QWC8	N'-Hydroxy-4-[[[(6-methoxynaphthalen-2-yl)sulfonylamino]-(4-methylpiperidine-1-carbonyl)amino]methyl]benzenecarboximidamide	Investigative	10962439	C26H31N5O5S	525.6	CC1CCN(CC1)C(=O)N(CC2=CC=C(C=C2)/C(=N/O)/N)NS(=O)(=O)C3=CC4=C(C=C3)C=C(C=C4)OC	Ki ~ 75000 nM	Poor binder
T84631	Coagulation factor Xa	B4UJA1	(2R)-2-[[(2R)-2-[[2-[[2-[[2-[[(2S)-2-[[(1R,7S,10S,13S,16S,22S,25S,28S,40R,43S,46S,49S,52S,58S,61S)-40-Acetamido-43,52-bis(2-amino-2-oxoethyl)-13-(carboxymethyl)-46-[(1R)-1-hydroxyethyl]-10,49,61-tris(1H-indol-3-ylmethyl)-16-methyl-25-(2-methylpropyl)-2,8,11,14,17,23,26,41,44,47,50,53,59,62-tetradecaoxo-30,38,65-trithia-3,9,12,15,18,24,27,42,45,48,51,54,60,63-tetradecazahexacyclo[32.29.3.132,36.03,7.018,22.054,58]heptahexaconta-32,34,36(67)-triene-28-carbonyl]amino]propanoyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoic acid	Investigative	137637214	C117H160N32O28S3	2558.9	C[C@H]1C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@H](CSCC3=CC4=CC(=C3)CSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N5CCC[C@H]5C(=O)N[C@H](C(=O)N[C@@H](CSC4)C(=O)N6CCC[C@H]6C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)O)CC7=CNC8=CC=CC=C87)CC9=CNC1=CC=CC=C19)CC(=O)N)CC1=CNC2=CC=CC=C21)[C@@H](C)O)CC(=O)N)NC(=O)C)C(=O)N[C@@H](C)C(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)O)CC(C)C	Ki ~ 50000 nM	Poor binder
T84631	Coagulation factor Xa	B4VW7Q	Chembl4203384	Investigative	9794796	C13H7FN2O2	242.2	C1=CC=C(C(=C1)C2=NC3=C(C=CN=C3)C(=O)O2)F	IC50 = 90000 nM	Poor binder
T84631	Coagulation factor Xa	B50UAL	1-[4-[(5R)-5-[[(2-Amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid;2,2,2-trifluoroacetic acid	Investigative	73348934	C22H24F3N5O7S	559.5	C1CN(CCC1C(=O)O)C2=CC=C(C=C2)N3C[C@H](OC3=O)CNC(=O)C4=CN=C(S4)N.C(=O)(C(F)(F)F)O	Ki = 88200 nM	Poor binder
T84631	Coagulation factor Xa	B57JZT	N-(2-(3-(4-(Aminomethyl)phenyl)propylamino)ethyl)-1-chloronaphthalene-2-sulfonamide	Investigative	10296435	C22H26ClN3O2S	432	C1=CC=C2C(=C1)C=CC(=C2Cl)S(=O)(=O)NCCNCCCC3=CC=C(C=C3)CN	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	B59SWA	Chembl4208878	Investigative	57404340	C24H23N5O2	413.5	C1=CC=C(C=C1)CN2C=CN=C2C[N+]3=CC=CC(=C3C(=O)NC4=CC=C(C=C4)CN)[O-]	IC50 ~ 50000 nM	Poor binder
T84631	Coagulation factor Xa	B5C8WR	3-[[4-(Diaminomethylideneamino)phenyl]methylamino]-N-(2-hydroxyethyl)imidazo[1,2-a]pyridine-7-carboxamide	Investigative	127037807	C18H21N7O2	367.4	C1=CC(=CC=C1CNC2=CN=C3N2C=CC(=C3)C(=O)NCCO)N=C(N)N	IC50 = 51580 nM	Poor binder
T84631	Coagulation factor Xa	B5DCY2	1-(2-Amino-3,3-dicyclohexyl-propionyl)-pyrrolidine-2-carboxylic acid (4-amino-cyclohexylmethyl)-amide	Investigative	10367012	C27H48N4O2	460.7	C1CCC(CC1)C(C2CCCCC2)[C@H](C(=O)N3CCC[C@H]3C(=O)NCC4CCC(CC4)N)N	Ki = 95000 nM	Poor binder
T84631	Coagulation factor Xa	B5DNX6	alpha-Ketothiazole analogue 16	Investigative	23646329	C29H42Cl2N8O4S	669.7	CCC(C)[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)C1=NC=CS1)NC(=O)[C@H](CC(C)C)NC(=O)NCC2=CC(=C(C=C2)Cl)Cl	IC50 = 85000 nM	Poor binder
T84631	Coagulation factor Xa	B5EY6C	CID 90295622	Investigative	90295622	C20H17ClN4O6	444.8	C1COCC(=O)N1C2=CC3=C(C=C2)N4[C@@H](CO3)[C@@H](OC4=O)C(=O)NC5=NC=C(C=C5)Cl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	B5F9EK	Ethyl 3-[2-(4-Carbamimidoylbenzyloxy)-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-ylamino]-3-oxo-2-phenylpropanoate	Investigative	25107507	C28H28N4O6	516.5	CCOC(=O)C(C1=CC=CC=C1)C(=O)NC2=CC3=C(C=C2)N(C(=O)C(O3)OCC4=CC=C(C=C4)C(=N)N)C	Ki = 50300 nM	Poor binder
T84631	Coagulation factor Xa	B5I2WO	N-[(3R)-1-(3-Amino-4-chloro-[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(1-methyl-5-oxo-1,2,4-triazol-4-yl)benzamide	Investigative	118456920	C20H18Cl2N8O3	489.3	CN1C(=O)N(C=N1)C2=CC(=C(C=C2)C(=O)N[C@@H]3CCN(C3)C4=NC=C(C5=C4ON=C5N)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	B5OXS4	(2S)-1-[(2R)-2-Amino-3-(3,4-dichlorophenyl)propanoyl]-N-(4,5,6,7-tetrahydro-1H-indazol-5-ylmethyl)pyrrolidine-2-carboxamide	Investigative	10165649	C22H27Cl2N5O2	464.4	C1C[C@H](N(C1)C(=O)[C@@H](CC2=CC(=C(C=C2)Cl)Cl)N)C(=O)NCC3CCC4=C(C3)C=NN4	Ki ~ 75400 nM	Poor binder
T84631	Coagulation factor Xa	B5RMY2	((R)-2-{(S)-2-[(2-Amino-thiazol-4-ylmethyl)-carbamoyl]-pyrrolidin-1-yl}-1-dicyclohexylmethyl-2-oxo-ethyl)-carbamic acid tert-butyl ester	Investigative	10626722	C29H47N5O4S	561.8	CC(C)(C)OC(=O)N[C@H](C(C1CCCCC1)C2CCCCC2)C(=O)N3CCC[C@H]3C(=O)NCC4=CSC(=N4)N	Ki ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	B5S0RF	4-[[(2S,4R)-1-(3-Chloro-4-fluoro-1-methylindole-5-carbonyl)-4-(1-methylsulfonylpiperidin-4-yl)pyrrolidine-2-carbonyl]amino]benzoic acid	Investigative	72550847	C28H30ClFN4O6S	605.1	CN1C=C(C2=C1C=CC(=C2F)C(=O)N3C[C@H](C[C@H]3C(=O)NC4=CC=C(C=C4)C(=O)O)C5CCN(CC5)S(=O)(=O)C)Cl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	B5YD6I	N'-Hydroxy-4-[[(4-methylpiperidine-1-carbonyl)-(naphthalen-2-ylsulfonylamino)amino]methyl]benzenecarboximidamide	Investigative	11762766	C25H29N5O4S	495.6	CC1CCN(CC1)C(=O)N(CC2=CC=C(C=C2)/C(=N/O)/N)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3	Ki ~ 75000 nM	Poor binder
T84631	Coagulation factor Xa	B5Z1YW	6-Methoxy-1-(4-methoxybenzoyl)-3-[4-(2-oxopiperidin-1-yl)phenyl]-2H-quinazolin-4-one	Investigative	137654871	C28H27N3O5	485.5	COC1=CC=C(C=C1)C(=O)N2CN(C(=O)C3=C2C=CC(=C3)OC)C4=CC=C(C=C4)N5CCCCC5=O	IC50 = 113000 nM	Poor binder
T84631	Coagulation factor Xa	B60XYD	2-[(E)-1-[3-(Benzenesulfonamido)-5-[(E)-N-(diaminomethylideneamino)-C-methylcarbonimidoyl]phenyl]ethylideneamino]guanidine	Investigative	53322612	C18H23N9O2S	429.5	C/C(=N\\N=C(N)N)/C1=CC(=CC(=C1)NS(=O)(=O)C2=CC=CC=C2)/C(=N/N=C(N)N)/C	Ki = 80000 nM	Poor binder
T84631	Coagulation factor Xa	B61ZSK	Methyl N-[4-[2-[(2S,4R)-1-(4-carbamimidoylbenzoyl)-4-(1-methylsulfonylpiperidin-4-yl)pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]carbamate	Investigative	72550625	C29H35N7O5S	593.7	COC(=O)NC1=CC=C(C=C1)C2=CN=C(N2)[C@@H]3C[C@@H](CN3C(=O)C4=CC=C(C=C4)C(=N)N)C5CCN(CC5)S(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	B63RZJ	US8569313, Inhibitor 35	Investigative	44569359	C30H38N4O4S	550.7	COC1=CC=C(C=C1)C2=CC(=CC=C2)S(=O)(=O)NC(CC3=CC(=CC=C3)CN)C(=O)N4CCC(CC4)CCN	Ki = 55000 nM	Poor binder
T84631	Coagulation factor Xa	B65NPX	2-[6-(3-Carbamimidoylphenoxy)-3,5-difluoro-4-(4-phenylbutan-2-ylamino)pyridin-2-yl]oxy-5-[(1-hydroxy-2-methylpropan-2-yl)carbamoyl]benzoic acid;2,2,2-trifluoroacetic acid	Investigative	44403015	C36H36F5N5O8	761.7	CC(CCC1=CC=CC=C1)NC2=C(C(=NC(=C2F)OC3=C(C=C(C=C3)C(=O)NC(C)(C)CO)C(=O)O)OC4=CC=CC(=C4)C(=N)N)F.C(=O)(C(F)(F)F)O	IC50 = 59000 nM	Poor binder
T84631	Coagulation factor Xa	B6B7XI	3-((S)-2-(((Benzyloxy)carbonyl)amino)-3-methylbutanamido)-5-fluoro-4-oxopentanoic acid	Investigative	9821317	C18H23FN2O6	382.4	CC(C)[C@@H](C(=O)NC(CC(=O)O)C(=O)CF)NC(=O)OCC1=CC=CC=C1	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	B6M5LU	2-[2-(Benzenesulfonyl)-4-(benzyloxy)-5-methoxyphenyl]-N-benzyl-2-[(4-carbamimidoylphenyl)amino]acetamide	Investigative	23646463	C36H34N4O5S	634.7	COC1=C(C=C(C(=C1)C(C(=O)NCC2=CC=CC=C2)NC3=CC=C(C=C3)C(=N)N)S(=O)(=O)C4=CC=CC=C4)OCC5=CC=CC=C5	Ki ~ 74000 nM	Poor binder
T84631	Coagulation factor Xa	B6MQT3	N-(4-Amidinophenyl)-2-hydroxy-3-phenylbenzamide	Investigative	44303804	C20H17N3O2	331.4	C1=CC=C(C=C1)C2=C(C(=CC=C2)C(=O)NC3=CC=C(C=C3)C(=N)N)O	Ki = 188000 nM	Poor binder
T84631	Coagulation factor Xa	B6MVO0	n-(4-Carbamimidoyl-3-choro-phenyl)-2-hydroxy-3-iodo-5-methyl-benzamide	Investigative	4300	C15H13ClIN3O2	429.64	CC1=CC(=C(C(=C1)I)O)C(=O)NC2=CC(=C(C=C2)C(=N)N)Cl	Ki = 115000 nM	Poor binder
T84631	Coagulation factor Xa	B6NP7Z	N-(4-(Biphenyl-4-ylmethoxy)phenyl)piperidine-4-carboxamide	Investigative	25224184	C25H26N2O2	386.5	C1CNCCC1C(=O)NC2=CC=C(C=C2)OCC3=CC=C(C=C3)C4=CC=CC=C4	Ki = 126000 nM	Poor binder
T84631	Coagulation factor Xa	B6RI4S	6-Hydroxy-2-(2-hydroxy-3-biphenylyl)-1H-indole-5-carboxamidine	Investigative	135450980	C21H17N3O2	343.4	C1=CC=C(C=C1)C2=C(C(=CC=C2)C3=CC4=CC(=C(C=C4N3)O)C(=N)N)O	Ki ~ 75000 nM	Poor binder
T84631	Coagulation factor Xa	B6TGU3	1-[4-[(5S)-2-Oxo-5-[[[4-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]methylamino]methyl]-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid	Investigative	136224849	C25H27N5O6	493.5	C1CN(CCC1C(=O)O)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNCC4=CC=C(C=C4)C5=NOC(=O)N5	Ki ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	B6VC4S	5-Chloro-N-[(2S)-4-methyl-1-oxo-1-[4-(3-oxomorpholin-4-yl)anilino]pentan-2-yl]thiophene-2-carboxamide	Investigative	10411443	C21H24ClN3O4S	450	CC(C)C[C@@H](C(=O)NC1=CC=C(C=C1)N2CCOCC2=O)NC(=O)C3=CC=C(S3)Cl	IC50 = 130000 nM	Poor binder
T84631	Coagulation factor Xa	B6VSZ1	3-Hydroxy-4-methoxy-anthracene-2-carboxylic acid (6-guanidino-pyridin-3-yl)-amide	Investigative	44303935	C22H19N5O3	401.4	COC1=C(C(=CC2=CC3=CC=CC=C3C=C21)C(=O)NC4=CN=C(C=C4)N=C(N)N)O	Ki ~ 78000 nM	Poor binder
T84631	Coagulation factor Xa	B6YJ2H	NC1=NOC2=C(C=CC=C12)N1CCC(C1)NC(=O)C1=C(Cl)C=C(C=C1)N1C=NN=C1	Investigative	91972030	C20H18ClN7O2	423.9	C1CN(CC1NC(=O)C2=C(C=C(C=C2)N3C=NN=C3)Cl)C4=CC=CC5=C4ON=C5N	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	B75ANJ	(1R,3As,8bS)-1-(5-amino-5-iminopentyl)-7-[3-(diethylcarbamoyl)phenyl]-N-ethyl-2-oxo-1,3a,4,8b-tetrahydroindeno[2,1-b]pyrrole-3-carboxamide	Investigative	44290377	C30H39N5O3	517.7	CCNC(=O)N1[C@H]2CC3=C([C@@H]2[C@H](C1=O)CCCCC(=N)N)C=C(C=C3)C4=CC(=CC=C4)C(=O)N(CC)CC	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	B78ZBK	N-(4-Guanidino-phenyl)-2-hydroxy-benzamide	Investigative	44303733	C14H14N4O2	270.29	C1=CC=C(C(=C1)C(=O)NC2=CC=C(C=C2)N=C(N)N)O	Ki = 104000 nM	Poor binder
T84631	Coagulation factor Xa	B7IK6N	Chembl4208864	Investigative	9905436	C15H6F5NO2	327.2	C1=CC(=C(C(=C1)F)C2=NC3=C(C=CC(=C3)C(F)(F)F)C(=O)O2)F	IC50 = 174000 nM	Poor binder
T84631	Coagulation factor Xa	B7PGD8	((R)-1-(3,4-Dichloro-benzyl)-2-oxo-2-{(S)-2-[(4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl)-carbamoyl]-pyrrolidin-1-yl}-ethyl)-carbamic acid tert-butyl ester	Investigative	10166622	C27H35Cl2N5O4	564.5	CC(C)(C)OC(=O)N[C@H](CC1=CC(=C(C=C1)Cl)Cl)C(=O)N2CCC[C@H]2C(=O)NCC3CCC4=C(C3)C=NN4	Ki ~ 75400 nM	Poor binder
T84631	Coagulation factor Xa	B7T9PX	Ethyl 2-(benzyl{2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)-2-oxoacetate	Investigative	25107571	C29H32N4O5	516.6	CCOC(=O)C(=O)N(CC1=CC=CC=C1)C2=CC3=C(C=C2)N(CC(O3)(C)COC4=CC=C(C=C4)C(=N)N)C	Ki = 112000 nM	Poor binder
T84631	Coagulation factor Xa	B7WST0	4-{4-[5-(2,6-Dimethyl-piperidin-1-yl)-pentyl]-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl}-N-hydroxy-benzamidine	Investigative	18675209	C27H36N4O3	464.6	CC1CCCC(N1CCCCCN2C3=CC=CC=C3OC(C2=O)C4=CC=C(C=C4)/C(=N\\O)/N)C	IC50 = 66000 nM	Poor binder
T84631	Coagulation factor Xa	B83MPL	2-(6-Methyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-N-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-acetamide	Investigative	9981449	C22H25N5O4S	455.5	CC1=CC=C(C(=O)N1CC(=O)NC2CCC3=C(C2)C=NN3)NS(=O)(=O)CC4=CC=CC=C4	Ki = 99000 nM	Poor binder
T84631	Coagulation factor Xa	B8C3YI	2-[6-(3-Aminophenyl)-5-chloro-3-(cyclobutylamino)-2-oxo-1,2-dihydropyrazin-1-yl]-N-[(4-carbamimidoyl-3-hydroxyphenyl)methyl]acetamide	Investigative	136104458	C24H26ClN7O3	496	C1CC(C1)NC2=NC(=C(N(C2=O)CC(=O)NCC3=CC(=C(C=C3)C(=N)N)O)C4=CC(=CC=C4)N)Cl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	B8J6GA	N-(2-Amino-5,6,7,8-tetrahydro-quinazolin-6-ylmethyl)-2-(6-methyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-acetamide	Investigative	44337794	C24H28N6O4S	496.6	CC1=CC=C(C(=O)N1CC(=O)NCC2CCC3=NC(=NC=C3C2)N)NS(=O)(=O)CC4=CC=CC=C4	Ki = 87300 nM	Poor binder
T84631	Coagulation factor Xa	B8J7FV	5-Chloro-thiophene-2-carboxylic acid {(R)-2-methyl-1-[4-(3-oxo-morpholin-4-yl)-phenylcarbamoyl]-propyl}-amide	Investigative	10094532	C20H22ClN3O4S	435.9	CC(C)[C@H](C(=O)NC1=CC=C(C=C1)N2CCOCC2=O)NC(=O)C3=CC=C(S3)Cl	IC50 = 66000 nM	Poor binder
T84631	Coagulation factor Xa	B8MRJ0	4-[[(Naphthalen-2-ylsulfonylamino)-(piperidine-1-carbonyl)amino]methyl]benzenecarboximidamide	Investigative	44286878	C24H27N5O3S	465.6	C1CCN(CC1)C(=O)N(CC2=CC=C(C=C2)C(=N)N)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3	Ki = 66000 nM	Poor binder
T84631	Coagulation factor Xa	B8TOS5	N-[(2R)-3-(3-Aminopropylsulfanyl)-1-[4-(2-hydroxyethyl)piperidin-1-yl]-1-oxopropan-2-yl]-3,3-dimethyl-2,4-dihydro-1H-quinoline-8-sulfonamide	Investigative	12047384	C24H40N4O4S2	512.7	CC1(CC2=C(C(=CC=C2)S(=O)(=O)N[C@@H](CSCCCN)C(=O)N3CCC(CC3)CCO)NC1)C	Ki = 87000 nM	Poor binder
T84631	Coagulation factor Xa	B8WIY3	(3S)-N-Methyl-2-[2-(4-nitrophenyl)acetyl]-N-[4-(2-oxopiperidin-1-yl)phenyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide	Investigative	66573638	C30H30N4O5	526.6	CN(C1=CC=C(C=C1)N2CCCCC2=O)C(=O)[C@@H]3CC4=CC=CC=C4CN3C(=O)CC5=CC=C(C=C5)[N+](=O)[O-]	IC50 = 85000 nM	Poor binder
T84631	Coagulation factor Xa	B8YDV4	N-(2-Amino-4,5,6,7-tetrahydro-benzothiazol-6-yl)-2-[3-(2-chloro-4-fluoro-phenylmethanesulfonylamino)-6-methyl-2-oxo-2H-pyridin-1-yl]-acetamide	Investigative	44339399	C22H23ClFN5O4S2	540	CC1=CC=C(C(=O)N1CC(=O)NC2CCC3=C(C2)SC(=N3)N)NS(=O)(=O)CC4=C(C=C(C=C4)F)Cl	Ki = 69000 nM	Poor binder
T84631	Coagulation factor Xa	B8YU1X	(S)-1-((R)-3-Cyclohexyl-2-phenylmethanesulfonylamino-propionyl)-pyrrolidine-2-carboxylic acid (2-amino-5,6,7,8-tetrahydro-quinazolin-6-ylmethyl)-amide	Investigative	10121049	C30H42N6O4S	582.8	C1CCC(CC1)C[C@H](C(=O)N2CCC[C@H]2C(=O)NCC3CCC4=NC(=NC=C4C3)N)NS(=O)(=O)CC5=CC=CC=C5	Ki ~ 75400 nM	Poor binder
T84631	Coagulation factor Xa	B8ZP6N	[4-(3-Aminomethylphenyl)-piperidin-1-yl]-[5-(2-fluorophenylethynyl)-furan-2-yl]-methanone trifluoroacetate	Investigative	57395169	C27H24F4N2O4	516.5	C1CN(CCC1C2=CC=CC(=C2)CN)C(=O)C3=CC=C(O3)C#CC4=CC=CC=C4F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	B94EKG	(3S)-2-[(4-Chlorophenyl)methylsulfonyl]-N-methyl-N-[4-(2-oxopiperidin-1-yl)phenyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide	Investigative	66573910	C29H30ClN3O4S	552.1	CN(C1=CC=C(C=C1)N2CCCCC2=O)C(=O)[C@@H]3CC4=CC=CC=C4CN3S(=O)(=O)CC5=CC=C(C=C5)Cl	IC50 = 151000 nM	Poor binder
T84631	Coagulation factor Xa	B94JGS	7-({[1-(3-Chloro-benzoyl)-piperidin-4-yl]-methanesulfonyl-amino}-methyl)-naphthalene-2-carboxamidine	Investigative	44429090	C25H27ClN4O3S	499	CS(=O)(=O)N(CC1=CC2=C(C=C1)C=CC(=C2)C(=N)N)C3CCN(CC3)C(=O)C4=CC(=CC=C4)Cl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	B9KR8I	CID 10165173	Investigative	10165173	C26H31N5O5S	525.6	CC1CCCCN1C(=O)N(CC2=CC(=CC=C2)/C(=N/O)/N)NS(=O)(=O)C3=CC4=C(C=C3)C=C(C=C4)OC	Ki = 111000 nM	Poor binder
T84631	Coagulation factor Xa	B9OBX0	2-Phenyl-1H-benzimidazole-5-carboxamidine	Investigative	11009950	C14H12N4	236.27	C1=CC=C(C=C1)C2=NC3=C(N2)C=C(C=C3)C(=N)N	Ki = 125000 nM	Poor binder
T84631	Coagulation factor Xa	BA12DG	CID 10117543	Investigative	10117543	C25H29N5O4S	495.6	CC1CCN(CC1)C(=O)N(CC2=CC(=CC=C2)/C(=N/O)/N)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3	Ki ~ 75000 nM	Poor binder
T84631	Coagulation factor Xa	BA4LJ3	N-[(3R)-1-(3-Amino-4-chloro-[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(1,2,4-triazol-4-yl)benzamide	Investigative	137647928	C19H16Cl2N8O2	459.3	C1CN(C[C@@H]1NC(=O)C2=C(C=C(C=C2)N3C=NN=C3)Cl)C4=NC=C(C5=C4ON=C5N)Cl	IC50 = 78000 nM	Poor binder
T84631	Coagulation factor Xa	BA4XM6	(1-{[(4-Carbamimidoyl-benzylcarbamoyl)-methyl]-carbamoyl}-2-hydroxy-ethyl)-carbamic acid benzyl ester	Investigative	44372863	C21H25N5O5	427.5	C1=CC=C(C=C1)COC(=O)N[C@H](CO)C(=O)NCC(=O)NCC2=CC=C(C=C2)C(=N)N	Ki = 140000 nM	Poor binder
T84631	Coagulation factor Xa	BA6QC9	N-(4-Carbamimidoyl-phenyl)-2-hydroxy-5-nitro-benzamide	Investigative	44303808	C14H12N4O4	300.27	C1=CC(=CC=C1C(=N)N)NC(=O)C2=C(C=CC(=C2)[N+](=O)[O-])O	Ki = 99000 nM	Poor binder
T84631	Coagulation factor Xa	BA95HB	(2S)-1-[(2R)-2-Amino-3,3-diphenylpropanoyl]-N-[1-(diaminomethylideneamino)-5,8-dioxo-8-piperidin-1-yloctan-4-yl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid	Investigative	49859964	C38H49F6N7O8	845.8	C1CCN(CC1)C(=O)CCC(=O)C(CCCN=C(N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C3=CC=CC=C3)C4=CC=CC=C4)N.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O	Ki = 149000 nM	Poor binder
T84631	Coagulation factor Xa	BAC7B2	(S)-3-{[2-(4-Carbamimidoyl-benzyloxy)-4-methyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-7-carbonyl]-amino}-3-phenyl-propionic acid ethyl ester	Investigative	11284767	C29H30N4O6	530.6	CCOC(=O)C[C@@H](C1=CC=CC=C1)NC(=O)C2=CC3=C(C=C2)N(C(=O)C(O3)OCC4=CC=C(C=C4)C(=N)N)C	Ki = 54600 nM	Poor binder
T84631	Coagulation factor Xa	BAE9Z4	4-[[(2S,4S)-1-[(E)-3-[5-Chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]-4-morpholin-4-ylpyrrolidine-2-carbonyl]amino]benzoic acid	Investigative	72550186	C26H26ClN7O5	552	C1COCCN1[C@H]2C[C@H](N(C2)C(=O)/C=C/C3=C(C=CC(=C3)Cl)N4C=NN=N4)C(=O)NC5=CC=C(C=C5)C(=O)O	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BAI39G	(2S)-1-[(2R)-2-Amino-3,3-diphenylpropanoyl]-N-(4,5,6,7-tetrahydro-1H-indazol-5-ylmethyl)pyrrolidine-2-carboxamide	Investigative	10187311	C28H33N5O2	471.6	C1C[C@H](N(C1)C(=O)[C@@H](C(C2=CC=CC=C2)C3=CC=CC=C3)N)C(=O)NCC4CCC5=C(C4)C=NN5	Ki = 82100 nM	Poor binder
T84631	Coagulation factor Xa	BAM0E8	6-Fluoro-2-[2-hydroxy-3-((S)-2-methyl-cyclohexyloxy)-phenyl]-1H-benzoimidazole-5-carboxamidine	Investigative	447540	C21H23FN4O2	382.4	C[C@@H]1CCCC[C@@H]1OC2=CC=CC(=C2O)C3=NC4=C(N3)C=C(C(=C4)C(=N)N)F	Ki = 65000 nM	Poor binder
T84631	Coagulation factor Xa	BAWP86	2-(2-Carbamimidoylbenzo[b]thiophen-4-yloxy)propionic AcidMethyl Ester	Investigative	46233364	C13H14N2O3S	278.33	CC(C(=O)OC)OC1=C2C=C(SC2=CC=C1)C(=N)N	Ki ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BAX9K5	Ethyl 1-[4-[(5S)-5-[[(2-amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylate;2,2,2-trifluoroacetic acid	Investigative	73356532	C24H28F3N5O7S	587.6	CCOC(=O)C1CCN(CC1)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CN=C(S4)N.C(=O)(C(F)(F)F)O	Ki = 54400 nM	Poor binder
T84631	Coagulation factor Xa	BAZ6W0	(2R)-N-[(2S)-4-(Benzylamino)-3,4-dioxo-1-piperidin-4-ylbutan-2-yl]-1-(3,3-diphenylpropanoyl)pyrrolidine-2-carboxamide	Investigative	44273818	C36H42N4O4	594.7	C1C[C@@H](N(C1)C(=O)CC(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)N[C@@H](CC4CCNCC4)C(=O)C(=O)NCC5=CC=CC=C5	IC50 = 54000 nM	Poor binder
T84631	Coagulation factor Xa	BB8ON6	Methyl N-[4-[5-chloro-2-[(2S,4R)-1-[4-(diaminomethylideneamino)benzoyl]-4-(1-methylsulfonylpiperidin-4-yl)pyrrolidin-2-yl]-1H-imidazol-4-yl]phenyl]carbamate	Investigative	72550626	C29H35ClN8O5S	643.2	COC(=O)NC1=CC=C(C=C1)C2=C(NC(=N2)[C@@H]3C[C@@H](CN3C(=O)C4=CC=C(C=C4)N=C(N)N)C5CCN(CC5)S(=O)(=O)C)Cl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BBG9N3	2-(6-Methyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-N-(4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl)-acetamide	Investigative	9804727	C23H27N5O4S	469.6	CC1=CC=C(C(=O)N1CC(=O)NCC2CCC3=C(C2)C=NN3)NS(=O)(=O)CC4=CC=CC=C4	Ki = 103000 nM	Poor binder
T84631	Coagulation factor Xa	BBGJ63	7-{[Methanesulfonyl-(1-methanesulfonyl-piperidin-4-yl)-amino]-methyl}-naphthalene-2-carboxamidine	Investigative	44429071	C19H26N4O4S2	438.6	CS(=O)(=O)N1CCC(CC1)N(CC2=CC3=C(C=C2)C=CC(=C3)C(=N)N)S(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BC0FA7	N-{3-[(S)-2-[4-(2-Amino-ethyl)-piperidin-1-yl]-1-(3-carbamimidoyl-benzyl)-2-oxo-ethylsulfamoyl]-phenyl}-3-hydroxy-propionamide	Investigative	44569733	C26H36N6O5S	544.7	C1CN(CCC1CCN)C(=O)[C@H](CC2=CC(=CC=C2)C(=N)N)NS(=O)(=O)C3=CC=CC(=C3)NC(=O)CCO	Ki = 61000 nM	Poor binder
T84631	Coagulation factor Xa	BC0SI7	N-[[(3S,3As)-1-oxo-7-(3-oxomorpholin-4-yl)-3a,4-dihydro-3H-[1,3]oxazolo[4,3-c][1,4]benzoxazin-3-yl]methyl]-2-(2-chloroethylsulfanyl)acetamide	Investigative	118519612	C19H22ClN3O6S	455.9	C1COCC(=O)N1C2=CC3=C(C=C2)N4[C@@H](CO3)[C@@H](OC4=O)CNC(=O)CSCCCl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BC4PZ0	4-[[(2S,4S)-1-(4-Carbamimidoylbenzoyl)-4-(4-methylsulfonylpiperazin-1-yl)pyrrolidine-2-carbonyl]amino]benzoic acid	Investigative	72550185	C25H30N6O6S	542.6	CS(=O)(=O)N1CCN(CC1)[C@H]2C[C@H](N(C2)C(=O)C3=CC=C(C=C3)C(=N)N)C(=O)NC4=CC=C(C=C4)C(=O)O	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BC81JO	N-[(3R)-1-(3-Amino-4-fluoro-1,2-benzoxazol-7-yl)pyrrolidin-3-yl]-2-chloro-4-(1,2,4-triazol-4-yl)benzamide	Investigative	118456998	C20H17ClFN7O2	441.8	C1CN(C[C@@H]1NC(=O)C2=C(C=C(C=C2)N3C=NN=C3)Cl)C4=C5C(=C(C=C4)F)C(=NO5)N	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BCA21L	1-[4-[(5R)-2-Oxo-5-[[[4-(5-oxo-4H-1,2,4-oxadiazol-3-yl)benzoyl]amino]methyl]-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid	Investigative	136224848	C25H25N5O7	507.5	C1CN(CCC1C(=O)O)C2=CC=C(C=C2)N3C[C@H](OC3=O)CNC(=O)C4=CC=C(C=C4)C5=NOC(=O)N5	Ki ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BCB10A	(2S)-1-[(2R)-2-Amino-3,3-diphenylpropanoyl]-N-[(2-amino-1,3-thiazol-4-yl)methyl]pyrrolidine-2-carboxamide	Investigative	10623402	C24H27N5O2S	449.6	C1C[C@H](N(C1)C(=O)[C@@H](C(C2=CC=CC=C2)C3=CC=CC=C3)N)C(=O)NCC4=CSC(=N4)N	Ki ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BCE68T	N-[2-(5,6-Dimethyl-1h-Benzimidazol-2-Yl)ethyl]-4-(4h-1,2,4-Triazol-4-Yl)benzamide	Investigative	46978227	C20H20N6O	360.4	CC1=CC2=C(C=C1C)N=C(N2)CCNC(=O)C3=CC=C(C=C3)N4C=NN=C4	Ki ~ 62500 nM	Poor binder
T84631	Coagulation factor Xa	BCEN75	(2S,4S)-1-[(E)-3-[5-Chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]-4-[(3S)-3-methyl-4-sulfamoylpiperazin-1-yl]-N-phenylpyrrolidine-2-carboxamide	Investigative	90033784	C26H30ClN9O4S	600.1	C[C@H]1CN(CCN1S(=O)(=O)N)[C@H]2C[C@H](N(C2)C(=O)/C=C/C3=C(C=CC(=C3)Cl)N4C=NN=N4)C(=O)NC5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BCG7X5	US10336741, Example 96	Investigative	72550850	C29H41ClN6O5S	621.2	COC(=O)NC1=CC=C(C=C1)C2=C(NC(=N2)[C@@H]3C[C@@H](CN3C(=O)C4CCC(CC4)CN)C5CCN(CC5)S(=O)(=O)C)Cl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BCI72N	3-[2-(4-Carbamimidoylbenzyloxy)-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carbonylamino]propanoic acid	Investigative	25107569	C21H22N4O6	426.4	CN1C2=C(C=C(C=C2)C(=O)NCCC(=O)O)OC(C1=O)OCC3=CC=C(C=C3)C(=N)N	Ki = 112000 nM	Poor binder
T84631	Coagulation factor Xa	BCKD46	6-Fluoro-2-[2-hydroxy-3-(piperidin-3-ylmethoxy)-phenyl]-1H-benzoimidazole-5-carboxamidine	Investigative	136092210	C20H22FN5O2	383.4	C1CC(CNC1)COC2=CC=CC(=C2O)C3=NC4=C(N3)C=C(C(=C4)C(=N)N)F	Ki = 125000 nM	Poor binder
T84631	Coagulation factor Xa	BD28GB	Diphenyl 1-[(N-benzoyloxycarbonyl-D-seryl)-L-alanyl]amino-2-(4-guanidinophenyl)ethanephosphonate	Investigative	9987251	C35H39N6O8P	702.7	C[C@@H](C(=O)NC(CC1=CC=C(C=C1)N=C(N)N)P(=O)(OC2=CC=CC=C2)OC3=CC=CC=C3)NC(=O)[C@@H](CO)NC(=O)OCC4=CC=CC=C4	IC50 = 79000 nM	Poor binder
T84631	Coagulation factor Xa	BD7FT0	US9585881, Example 86	Investigative	72550627	C30H43ClN6O5S	635.2	C[C@@H](C1CCC(CC1)C(=O)N2C[C@H](C[C@H]2C3=NC(=C(N3)Cl)C4=CC=C(C=C4)NC(=O)OC)C5CCN(CC5)S(=O)(=O)C)N	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BDF37S	N-(2-Amino-4,5,6,7-tetrahydro-benzothiazol-6-yl)-2-[6-methyl-2-oxo-3-(propane-1-sulfonylamino)-2H-pyridin-1-yl]-acetamide	Investigative	44339365	C18H25N5O4S2	439.6	CCCS(=O)(=O)NC1=CC=C(N(C1=O)CC(=O)NC2CCC3=C(C2)SC(=N3)N)C	Ki = 200000 nM	Poor binder
T84631	Coagulation factor Xa	BDQI29	Pyrazinone Analog 29f	Investigative	10073864	C24H26ClN7O2	480	C1CC(C1)NC2=NC(=C(N(C2=O)CC(=O)NCC3=CC=C(C=C3)C(=N)N)C4=CC(=CC=C4)N)Cl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BDZ1X3	1-Ethanimidoyl-N-[3-[(4-fluorophenyl)methoxy]phenyl]piperidine-4-carboxamide	Investigative	72711856	C21H24FN3O2	369.4	CC(=N)N1CCC(CC1)C(=O)NC2=CC(=CC=C2)OCC3=CC=C(C=C3)F	Ki = 57300 nM	Poor binder
T84631	Coagulation factor Xa	BE0JG1	((R)-2-{(S)-2-[(6-Amino-2,4-dimethyl-pyridin-3-ylmethyl)-carbamoyl]-pyrrolidin-1-yl}-1-benzhydryl-2-oxo-ethyl)-carbamic acid tert-butyl ester	Investigative	10626893	C33H41N5O4	571.7	CC1=CC(=NC(=C1CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C3=CC=CC=C3)C4=CC=CC=C4)NC(=O)OC(C)(C)C)C)N	Ki = 160000 nM	Poor binder
T84631	Coagulation factor Xa	BE83BP	N-(2-Amino-4,5,6,7-tetrahydro-benzothiazol-6-ylmethyl)-2-(6-methyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-acetamide	Investigative	44337735	C23H27N5O4S2	501.6	CC1=CC=C(C(=O)N1CC(=O)NCC2CCC3=C(C2)SC(=N3)N)NS(=O)(=O)CC4=CC=CC=C4	Ki = 106000 nM	Poor binder
T84631	Coagulation factor Xa	BEC0I4	2-Chlorobenzenesulfonic acid 3-methyl-5-(4-guanidinobutoxy)phenyl ester	Investigative	44288029	C18H22ClN3O4S	411.9	CC1=CC(=CC(=C1)OS(=O)(=O)C2=CC=CC=C2Cl)OCCCCN=C(N)N	Ki = 110000 nM	Poor binder
T84631	Coagulation factor Xa	BEFP28	7-({Methanesulfonyl-[1-(toluene-4-sulfonyl)-piperidin-4-yl]-amino}-methyl)-naphthalene-2-carboxamidine	Investigative	44429079	C25H30N4O4S2	514.7	CC1=CC=C(C=C1)S(=O)(=O)N2CCC(CC2)N(CC3=CC4=C(C=C3)C=CC(=C4)C(=N)N)S(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BELS87	4-Cyano-2-fluoro-N-(10-hydroxy-2,7-dimethyl-3,4-dihydro-1H-pyrido[1,2-b]indazol-2-yl)benzamide	Investigative	118736125	C21H19FN4O2	378.4	CC1=CC=C(C2=C3CC(CCC3=NN12)(C)NC(=O)C4=C(C=C(C=C4)C#N)F)O	Ki ~ 62500 nM	Poor binder
T84631	Coagulation factor Xa	BF19MI	5-[(1R,3As,8bS)-2-oxo-3-(5-phenylpentyl)-1,3a,4,8b-tetrahydroindeno[2,1-b]pyrrol-1-yl]pentanimidamide	Investigative	44290502	C27H35N3O	417.6	C1[C@H]2[C@@H]([C@H](C(=O)N2CCCCCC3=CC=CC=C3)CCCCC(=N)N)C4=CC=CC=C41	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BF1V9T	4-[[(2-Methylpiperidine-1-carbonyl)-(naphthalen-2-ylsulfonylamino)amino]methyl]benzenecarboximidamide	Investigative	44286978	C25H29N5O3S	479.6	CC1CCCCN1C(=O)N(CC2=CC=C(C=C2)C(=N)N)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3	Ki = 53000 nM	Poor binder
T84631	Coagulation factor Xa	BF35VC	(2S,4S)-4-[4-(Benzenesulfonyl)piperazin-1-yl]-1-[(E)-3-[5-chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]-N-phenylpyrrolidine-2-carboxamide	Investigative	72550187	C31H31ClN8O4S	647.1	C1CN(CCN1[C@H]2C[C@H](N(C2)C(=O)/C=C/C3=C(C=CC(=C3)Cl)N4C=NN=N4)C(=O)NC5=CC=CC=C5)S(=O)(=O)C6=CC=CC=C6	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BF87QK	2-[2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl]guanidine;2,2,2-trifluoroacetic acid	Investigative	44416546	C17H25BF3N3O4	403.2	B1(OC(C(O1)(C)C)(C)C)C2=CC=C(C=C2)CCN=C(N)N.C(=O)(C(F)(F)F)O	IC50 = 175400 nM	Poor binder
T84631	Coagulation factor Xa	BFLK43	(2S)-1-[(2R)-2-Amino-3,3-diphenylpropanoyl]-N-[(6-aminopyridin-3-yl)methyl]pyrrolidine-2-carboxamide	Investigative	11797515	C26H29N5O2	443.5	C1C[C@H](N(C1)C(=O)[C@@H](C(C2=CC=CC=C2)C3=CC=CC=C3)N)C(=O)NCC4=CN=C(C=C4)N	Ki = 94000 nM	Poor binder
T84631	Coagulation factor Xa	BFQ12Y	Ethyl 1-[4-[(5R)-5-[[(3-amino-4-chlorobenzoyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylate	Investigative	71699286	C25H29ClN4O5	501	CCOC(=O)C1CCN(CC1)C2=CC=C(C=C2)N3C[C@H](OC3=O)CNC(=O)C4=CC(=C(C=C4)Cl)N	Ki = 82300 nM	Poor binder
T84631	Coagulation factor Xa	BFW1H8	Methyl N-[4-[2-[(2S,4R)-1-(1-carbamimidoylpiperidine-4-carbonyl)-4-(1-methylsulfonylpiperidin-4-yl)pyrrolidin-2-yl]-5-chloro-1H-imidazol-4-yl]phenyl]carbamate	Investigative	72551066	C28H39ClN8O5S	635.2	COC(=O)NC1=CC=C(C=C1)C2=C(NC(=N2)[C@@H]3C[C@@H](CN3C(=O)C4CCN(CC4)C(=N)N)C5CCN(CC5)S(=O)(=O)C)Cl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BGI7H5	3-Hydroxy-4-iodo-anthracene-2-carboxylic acid (6-guanidino-pyridin-3-yl)-amide	Investigative	44304084	C21H16IN5O2	497.3	C1=CC=C2C=C3C(=CC2=C1)C=C(C(=C3I)O)C(=O)NC4=CN=C(C=C4)N=C(N)N	Ki = 68000 nM	Poor binder
T84631	Coagulation factor Xa	BGI97R	2-(2-Hydroxy-3-ethoxyphenyl)-6-chloro-1H-benzimidazole-5-carboxamidine	Investigative	136092208	C16H15ClN4O2	330.77	CCOC1=CC=CC(=C1O)C2=NC3=C(N2)C=C(C(=C3)C(=N)N)Cl	Ki ~ 75000 nM	Poor binder
T84631	Coagulation factor Xa	BGLK14	6-Methyl-2-(2-hydroxy-3-biphenylyl)-1H-indole-5-carboxamidine	Investigative	10871563	C22H19N3O	341.4	CC1=CC2=C(C=C1C(=N)N)C=C(N2)C3=CC=CC(=C3O)C4=CC=CC=C4	Ki ~ 75000 nM	Poor binder
T84631	Coagulation factor Xa	BGN24E	N-{[4-(N-Aminocarbamimidoyl)phenyl]methyl}-2-[6-(3-aminophenyl)-5-chloro-3-(cyclobutylamino)-2-oxo-1,2-dihydropyrazin-1-yl]acetamide	Investigative	20802995	C24H27ClN8O2	495	C1CC(C1)NC2=NC(=C(N(C2=O)CC(=O)NCC3=CC=C(C=C3)/C(=N/N)/N)C4=CC(=CC=C4)N)Cl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BGX91W	N-[3-(1,3-Benzothiazol-2-yl)-1-(4-ethylpiperidin-1-yl)-1-oxopropan-2-yl]-3,3-dimethyl-2,4-dihydro-1H-quinoline-8-sulfonamide	Investigative	44287043	C28H36N4O3S2	540.7	CCC1CCN(CC1)C(=O)C(CC2=NC3=CC=CC=C3S2)NS(=O)(=O)C4=CC=CC5=C4NCC(C5)(C)C	Ki = 92000 nM	Poor binder
T84631	Coagulation factor Xa	BH3O5E	(2S)-1-[(2R)-2-(Benzylsulfonylamino)-3-cyclohexylpropanoyl]-N-(5,6,7,8-tetrahydroquinazolin-6-ylmethyl)pyrrolidine-2-carboxamide	Investigative	44378887	C30H41N5O4S	567.7	C1CCC(CC1)C[C@H](C(=O)N2CCC[C@H]2C(=O)NCC3CCC4=NC=NC=C4C3)NS(=O)(=O)CC5=CC=CC=C5	Ki = 111000 nM	Poor binder
T84631	Coagulation factor Xa	BH3S7T	Ethyl 1-[(4-carbamimidoylphenyl)methyl]indole-2-carboxylate	Investigative	9863579	C19H19N3O2	321.4	CCOC(=O)C1=CC2=CC=CC=C2N1CC3=CC=C(C=C3)C(=N)N	Ki = 55000 nM	Poor binder
T84631	Coagulation factor Xa	BHAG94	(7R,10S,13S,21S,24S,27S,30S,33S,36S,39S,42S,45R)-7-Acetamido-36-(3-amino-3-oxopropyl)-13-benzyl-24-(4-carbamimidamidobutyl)-39-(carboxymethyl)-10-(hydroxymethyl)-21-[(4-hydroxyphenyl)methyl]-33-(1H-imidazol-5-ylmethyl)-30-methyl-42-(2-methylpropyl)-8,11,14,19,22,25,28,34,37,40,43-undecaoxo-5,47,52-trithia-9,12,15,20,23,26,29,32,35,38,41,44-dodecazatetracyclo[25.23.3.13,49.015,18]tetrapentaconta-1,3(54),49-triene-45-carboxylic acid	Investigative	137654508	C76H105N19O19S3	1685	C[C@H]1CN[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSCC2=CC3=CC(=C2)CSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4CCC4C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](CSC3)C(=O)N1)CCCCNC(=N)N)CC5=CC=C(C=C5)O)CC6=CC=CC=C6)CO)NC(=O)C)C(=O)O)CC(C)C)CC(=O)O)CCC(=O)N)CC7=CN=CN7	Ki ~ 50000 nM	Poor binder
T84631	Coagulation factor Xa	BI3XM4	7-[(Methanesulfonyl-piperidin-4-yl-amino)-methyl]-naphthalene-2-carboxamidine	Investigative	44429069	C18H24N4O2S	360.5	CS(=O)(=O)N(CC1=CC2=C(C=C1)C=CC(=C2)C(=N)N)C3CCNCC3	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BI4G7V	1-[4-[(5R)-2-Oxo-5-[[[4-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]methylamino]methyl]-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid	Investigative	136224854	C25H27N5O6	493.5	C1CN(CCC1C(=O)O)C2=CC=C(C=C2)N3C[C@H](OC3=O)CNCC4=CC=C(C=C4)C5=NOC(=O)N5	Ki = 94800 nM	Poor binder
T84631	Coagulation factor Xa	BI75GR	N'-Hydroxy-4-[[(naphthalen-2-ylsulfonylamino)-(piperidine-1-carbonyl)amino]methyl]benzenecarboximidamide	Investigative	10906977	C24H27N5O4S	481.6	C1CCN(CC1)C(=O)N(CC2=CC=C(C=C2)/C(=N/O)/N)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3	Ki ~ 75000 nM	Poor binder
T84631	Coagulation factor Xa	BI96WP	1-[4-[(5S)-2-Oxo-5-[[[4-(5-oxo-4H-1,2,4-oxadiazol-3-yl)benzoyl]amino]methyl]-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid	Investigative	136224847	C25H25N5O7	507.5	C1CN(CCC1C(=O)O)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CC=C(C=C4)C5=NOC(=O)N5	Ki ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BIO0S5	NC1=NOC2=C(N=CC=C12)N1CCC(C1)NC(=O)C1=C(Cl)C=C(C=C1)N1C=NN=C1	Investigative	118457052	C19H17ClN8O2	424.8	C1CN(CC1NC(=O)C2=C(C=C(C=C2)N3C=NN=C3)Cl)C4=NC=CC5=C4ON=C5N	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BJ6RD2	3-[(2S)-3-[4-(3-Carbamimidamidopropanoyl)piperazin-1-yl]-2-(naphthalene-2-sulfonamido)-3-oxopropyl]benzene-1-carboximidamide	Investigative	11721188	C28H34N8O4S	578.7	C1CN(CCN1C(=O)CCN=C(N)N)C(=O)[C@H](CC2=CC(=CC=C2)C(=N)N)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3	Ki = 56000 nM	Poor binder
T84631	Coagulation factor Xa	BJ98LI	N-[(2S)-6-Amino-1-[5-[[4-[2-(3,4-dichlorophenyl)ethoxy]phenyl]methyl]-1,2,4-oxadiazol-3-yl]-1-oxohexan-2-yl]-3,4-difluorobenzamide;hydrochloride	Investigative	45263389	C30H29Cl3F2N4O4	653.9	C1=CC(=CC=C1CC2=NC(=NO2)C(=O)[C@H](CCCCN)NC(=O)C3=CC(=C(C=C3)F)F)OCCC4=CC(=C(C=C4)Cl)Cl.Cl	Ki ~ 150000 nM	Poor binder
T84631	Coagulation factor Xa	BJ9F5T	N-[1-(3-Amino-5-chloro-1,2-benzoxazol-7-yl)pyrrolidin-3-yl]-2-chloro-4-(1,2,4-triazol-4-yl)benzamide	Investigative	118456935	C20H17Cl2N7O2	458.3	C1CN(CC1NC(=O)C2=C(C=C(C=C2)N3C=NN=C3)Cl)C4=CC(=CC5=C4ON=C5N)Cl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BJHL65	N-[(3R)-1-(3-Amino-4-chloro-[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(3-methyl-1,2,4-triazol-1-yl)benzamide	Investigative	118456950	C20H18Cl2N8O2	473.3	CC1=NN(C=N1)C2=CC(=C(C=C2)C(=O)N[C@@H]3CCN(C3)C4=NC=C(C5=C4ON=C5N)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BJR62Y	3-Oxo-N-phenyl-3H-benzo[f]chromene-2-carboxamide	Investigative	3123858	C20H13NO3	315.3	C1=CC=C(C=C1)NC(=O)C2=CC3=C(C=CC4=CC=CC=C43)OC2=O	IC50 ~ 50000 nM	Poor binder
T84631	Coagulation factor Xa	BJU6P3	(2S)-1-[(2R)-2-Amino-3,3-dicyclohexylpropanoyl]-N-[(6-amino-2,4-dimethylpyridin-3-yl)methyl]pyrrolidine-2-carboxamide	Investigative	10791003	C28H45N5O2	483.7	CC1=CC(=NC(=C1CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C3CCCCC3)C4CCCCC4)N)C)N	Ki = 160000 nM	Poor binder
T84631	Coagulation factor Xa	BJZL35	1-[3-(4-Carbamimidoyl-benzyl)-1-methyl-2-oxo-1,2-dihydro-quinoxalin-6-yl]-cyclopropanecarboxylic acid	Investigative	21250297	C21H20N4O3	376.4	CN1C2=C(C=C(C=C2)C3(CC3)C(=O)O)N=C(C1=O)CC4=CC=C(C=C4)C(=N)N	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BK29UD	(2R)-1-(5-Chlorothiophene-2-carbonyl)-N-methyl-N-[4-(2-oxopiperidin-1-yl)phenyl]piperidine-2-carboxamide	Investigative	66574100	C23H26ClN3O3S	460	CN(C1=CC=C(C=C1)N2CCCCC2=O)C(=O)[C@H]3CCCCN3C(=O)C4=CC=C(S4)Cl	IC50 = 99000 nM	Poor binder
T84631	Coagulation factor Xa	BK3U2S	Acetic acid;ethyl 1-[4-[(5S)-5-[[(4-carbamimidoylbenzoyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylate	Investigative	73348936	C28H35N5O7	553.6	CCOC(=O)C1CCN(CC1)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CC=C(C=C4)C(=N)N.CC(=O)O	Ki ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BK6T5D	N-[[(3S,3As)-1-oxo-7-(3-oxomorpholin-4-yl)-3a,4-dihydro-3H-[1,3]oxazolo[4,3-c][1,4]benzoxazin-3-yl]methyl]-3,6-dichloro-1-benzothiophene-2-carboxamide	Investigative	118519588	C24H19Cl2N3O6S	548.4	C1COCC(=O)N1C2=CC3=C(C=C2)N4[C@@H](CO3)[C@@H](OC4=O)CNC(=O)C5=C(C6=C(S5)C=C(C=C6)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BK78MD	Methyl N-[4-[2-[(2S,4S)-1-(1-carbamimidoylpiperidine-4-carbonyl)-4-(4-methylsulfonylpiperazin-1-yl)pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]carbamate	Investigative	72550849	C27H39N9O5S	601.7	COC(=O)NC1=CC=C(C=C1)C2=CN=C(N2)[C@@H]3C[C@@H](CN3C(=O)C4CCN(CC4)C(=N)N)N5CCN(CC5)S(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BK7N4X	2-Chlorophenyl[3-[2-[methyl(4-pyridyl)amino]ethoxy]-5-methylphenoxy] sulfone	Investigative	10094378	C21H21ClN2O4S	432.9	CC1=CC(=CC(=C1)OS(=O)(=O)C2=CC=CC=C2Cl)OCCN(C)C3=CC=NC=C3	Ki = 160000 nM	Poor binder
T84631	Coagulation factor Xa	BKR8B7	3-Amidinophenylalanine deriv., 28	Investigative	11570759	C30H38N8O4S	606.7	C1CN(CCN1C(=O)CCN=C(N)N)C(=O)[C@H](CC2=CC(=CC=C2)C(=N)N)NS(=O)(=O)CCC3=CC=CC4=CC=CC=C43	Ki = 80000 nM	Poor binder
T84631	Coagulation factor Xa	BKR8D4	3-Carboxamide-coumarin deriv., 4	Investigative	402501	C17H12ClNO3	313.7	C1=CC=C(C=C1)NC(=O)C2=CC3=C(C=CC(=C3)CCl)OC2=O	IC50 ~ 50000 nM	Poor binder
T84631	Coagulation factor Xa	BKTG92	3-(Benzyl(2-(4-carbamimidoylbenzyl)-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)amino)-3-oxopropanoic acid	Investigative	24858932	C27H26N4O5	486.5	CN1C2=C(C=C(C=C2)N(CC3=CC=CC=C3)C(=O)CC(=O)O)OC(C1=O)CC4=CC=C(C=C4)C(=N)N	Ki = 139000 nM	Poor binder
T84631	Coagulation factor Xa	BL0O2Q	N-Butyl-3-[[4-(diaminomethylideneamino)phenyl]methylamino]imidazo[1,2-a]pyridine-7-carboxamide	Investigative	127041472	C20H25N7O	379.5	CCCCNC(=O)C1=CC2=NC=C(N2C=C1)NCC3=CC=C(C=C3)N=C(N)N	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BL1B2G	(2S)-1-[(2R)-2-Amino-3,3-dicyclohexylpropanoyl]-N-[(2-amino-1,3-thiazol-4-yl)methyl]pyrrolidine-2-carboxamide	Investigative	10671702	C24H39N5O2S	461.7	C1CCC(CC1)C(C2CCCCC2)[C@H](C(=O)N3CCC[C@H]3C(=O)NCC4=CSC(=N4)N)N	Ki ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BL5HO1	3-Hydroxy-4-isopropoxy-anthracene-2-carboxylic acid (6-guanidino-pyridin-3-yl)-amide	Investigative	44303925	C24H23N5O3	429.5	CC(C)OC1=C(C(=CC2=CC3=CC=CC=C3C=C21)C(=O)NC4=CN=C(C=C4)N=C(N)N)O	Ki = 88000 nM	Poor binder
T84631	Coagulation factor Xa	BL6NQ1	CID 90295617	Investigative	90295617	C19H16ClN3O6S	449.9	C1COCC(=O)N1C2=CC3=C(C=C2)N4[C@@H](CO3)[C@@H](OC4=O)C(=O)NC5=CC=C(S5)Cl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BLKQ93	(2S)-N-[(2-Amino-1,3-thiazol-4-yl)methyl]-1-[(2R)-2-(benzylsulfonylamino)-3-(3,4-dichlorophenyl)propanoyl]pyrrolidine-2-carboxamide	Investigative	10698758	C25H27Cl2N5O4S2	596.6	C1C[C@H](N(C1)C(=O)[C@@H](CC2=CC(=C(C=C2)Cl)Cl)NS(=O)(=O)CC3=CC=CC=C3)C(=O)NCC4=CSC(=N4)N	Ki ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BM48DC	N-[[(3S,3As)-1-oxo-7-(3-oxomorpholin-4-yl)-3a,4-dihydro-3H-[1,3]oxazolo[4,3-c][1,4]benzoxazin-3-yl]methyl]-2,2-dichloroacetamide	Investigative	118519597	C17H17Cl2N3O6	430.2	C1COCC(=O)N1C2=CC3=C(C=C2)N4[C@@H](CO3)[C@@H](OC4=O)CNC(=O)C(Cl)Cl	IC50 = 52690 nM	Poor binder
T84631	Coagulation factor Xa	BM4GP8	Ethyl 1-[4-[(5R)-5-[[(2-amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylate;2,2,2-trifluoroacetic acid	Investigative	73347404	C24H28F3N5O7S	587.6	CCOC(=O)C1CCN(CC1)C2=CC=C(C=C2)N3C[C@H](OC3=O)CNC(=O)C4=CN=C(S4)N.C(=O)(C(F)(F)F)O	Ki = 111000 nM	Poor binder
T84631	Coagulation factor Xa	BMA84P	Chembl4207715	Investigative	146029523	C20H22FN7O2	411.4	C1CCCN(CC1)C2=C(N=C(C(=N2)N)C(=O)N=C(N)N)C3=CC4=C(O3)C=CC=C4F	IC50 ~ 50000 nM	Poor binder
T84631	Coagulation factor Xa	BMH7Q6	Acetic acid;1-[4-[(5S)-5-[[(4-carbamimidoylphenyl)methylamino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid	Investigative	73348937	C26H33N5O6	511.6	CC(=O)O.C1CN(CCC1C(=O)O)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNCC4=CC=C(C=C4)C(=N)N	Ki = 54100 nM	Poor binder
T84631	Coagulation factor Xa	BMI37J	(2,2-Difluoro-2-piperidin-2-yl-ethyl)-[2-(2-[1,2,4]triazol-1-yl-benzyl)-benzooxazol-4-yl]-amine	Investigative	10410866	C23H24F2N6O	438.5	C1CCNC(C1)C(CNC2=C3C(=CC=C2)OC(=N3)CC4=CC=CC=C4N5C=NC=N5)(F)F	Ki = 60000 nM	Poor binder
T84631	Coagulation factor Xa	BMJ21L	3-Amidinophenylalanine deriv., 27	Investigative	11664334	C29H36N8O4S	592.7	C1CN(CCN1C(=O)CCN=C(N)N)C(=O)[C@H](CC2=CC(=CC=C2)C(=N)N)NS(=O)(=O)CC3=CC4=CC=CC=C4C=C3	Ki = 130000 nM	Poor binder
T84631	Coagulation factor Xa	BMZC64	Sodium;[2-[(2-benzyl-3-ethoxycarbonyl-6-methoxy-1-benzofuran-5-yl)oxymethyl]-3-ethoxycarbonyl-1H-indol-5-yl] sulfate	Investigative	118723904	C31H28NNaO11S	645.6	CCOC(=O)C1=C(OC2=CC(=C(C=C21)OCC3=C(C4=C(N3)C=CC(=C4)OS(=O)(=O)[O-])C(=O)OCC)OC)CC5=CC=CC=C5.[Na+]	IC50 = 195000 nM	Poor binder
T84631	Coagulation factor Xa	BN1HJ5	Methyl N-[4-[2-[(2S,4R)-1-(4-carbamimidoylpiperazine-1-carbonyl)-4-(1-methylsulfonylpiperidin-4-yl)pyrrolidin-2-yl]-5-chloro-1H-imidazol-4-yl]phenyl]carbamate	Investigative	72550628	C27H38ClN9O5S	636.2	COC(=O)NC1=CC=C(C=C1)C2=C(NC(=N2)[C@@H]3C[C@@H](CN3C(=O)N4CCN(CC4)C(=N)N)C5CCN(CC5)S(=O)(=O)C)Cl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BN58EA	N-(2-Amino-4,5,6,7-tetrahydrobenzothiazole-6-yl)-2-oxo-3-(benzylsulfonylamino)-6-methyl-1,2-dihydropyridine-1-acetamide	Investigative	10051154	C22H25N5O4S2	487.6	CC1=CC=C(C(=O)N1CC(=O)NC2CCC3=C(C2)SC(=N3)N)NS(=O)(=O)CC4=CC=CC=C4	Ki = 92000 nM	Poor binder
T84631	Coagulation factor Xa	BN5DC1	[(1-{1-[3-(4-Carbamimidoyl-benzyl)-1-methyl-2-oxo-1,2-dihydro-quinoxalin-6-yl]-cyclopropanecarbonyl}-pyrrolidine-2-carbonyl)-amino]-acetic acid	Investigative	10256448	C28H30N6O5	530.6	CN1C2=C(C=C(C=C2)C3(CC3)C(=O)N4CCCC4C(=O)NCC(=O)O)N=C(C1=O)CC5=CC=C(C=C5)C(=N)N	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BNJ5S2	(2S,4S)-N-(2H-Benzotriazol-5-yl)-1-[(E)-3-[5-chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]-4-morpholin-4-ylpyrrolidine-2-carboxamide	Investigative	72550404	C25H25ClN10O3	549	C1COCCN1[C@H]2C[C@H](N(C2)C(=O)/C=C/C3=C(C=CC(=C3)Cl)N4C=NN=N4)C(=O)NC5=CC6=NNN=C6C=C5	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BNP02M	2-[6-(3-Aminophenyl)-5-chloro-3-(cyclobutylamino)-2-oxo-1,2-dihydropyrazin-1-yl]-N-[(4-carbamimidoyl-2,5,6-trifluoro-3-hydroxyphenyl)methyl]acetamide	Investigative	136104459	C24H23ClF3N7O3	549.9	C1CC(C1)NC2=NC(=C(N(C2=O)CC(=O)NCC3=C(C(=C(C(=C3F)F)C(=N)N)O)F)C4=CC(=CC=C4)N)Cl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BNQ63I	3-[(2S)-3-[4-(3-Aminopropyl)piperidin-1-yl]-2-(naphthalene-2-sulfonamido)-3-oxopropyl]benzene-1-carboximidamide	Investigative	11569930	C28H35N5O3S	521.7	C1CN(CCC1CCCN)C(=O)[C@H](CC2=CC(=CC=C2)C(=N)N)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3	Ki = 66000 nM	Poor binder
T84631	Coagulation factor Xa	BNT7H3	(3R)-1-(5-Chlorothiophene-2-carbonyl)-N-methyl-N-[4-(2-oxopiperidin-1-yl)phenyl]piperidine-3-carboxamide	Investigative	66574034	C23H26ClN3O3S	460	CN(C1=CC=C(C=C1)N2CCCCC2=O)C(=O)[C@@H]3CCCN(C3)C(=O)C4=CC=C(S4)Cl	IC50 = 69000 nM	Poor binder
T84631	Coagulation factor Xa	BO0Y1A	4-[[Azepane-1-carbonyl-(naphthalen-2-ylsulfonylamino)amino]methyl]benzenecarboximidamide	Investigative	44286709	C25H29N5O3S	479.6	C1CCCN(CC1)C(=O)N(CC2=CC=C(C=C2)C(=N)N)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3	Ki = 69000 nM	Poor binder
T84631	Coagulation factor Xa	BO51NX	2-(3-{5-Amino-1H-imidazo[4,5-b]pyridin-2-yl}-4-hydroxy-5-(3-nitrophenyl)phenyl)acetic acid	Investigative	135559072	C20H15N5O5	405.4	C1=CC(=CC(=C1)[N+](=O)[O-])C2=C(C(=CC(=C2)CC(=O)O)C3=NC4=C(N3)C=CC(=N4)N)O	Ki ~ 150000 nM	Poor binder
T84631	Coagulation factor Xa	BODN12	N-[(3R)-1-(3-Amino-4-chloro-[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-[3-(difluoromethyl)-1,2,4-triazol-4-yl]benzamide	Investigative	118456915	C20H16Cl2F2N8O2	509.3	C1CN(C[C@@H]1NC(=O)C2=C(C=C(C=C2)N3C=NN=C3C(F)F)Cl)C4=NC=C(C5=C4ON=C5N)Cl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BOL28Z	(S)-N-((1-Carbamimidoylpiperidin-4-yl)methyl)-5-guanidino-2-((S)-2-((S)-5-guanidino-2-(2-phenylacetamido)pentanamido)-3-methylbutanamido)pentanamide	Investigative	45486354	C32H55N13O4	685.9	CC(C)[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC1CCN(CC1)C(=N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CC2=CC=CC=C2	Ki = 123000 nM	Poor binder
T84631	Coagulation factor Xa	BOVH95	Acetic acid;ethyl 1-[4-[(5R)-5-[[(4-carbamimidoylbenzoyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylate	Investigative	73353475	C28H35N5O7	553.6	CCOC(=O)C1CCN(CC1)C2=CC=C(C=C2)N3C[C@H](OC3=O)CNC(=O)C4=CC=C(C=C4)C(=N)N.CC(=O)O	Ki ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BOY1U9	(3S)-2-[3-(4-Methoxyphenyl)propanoyl]-N-methyl-N-[4-(3-oxomorpholin-4-yl)phenyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide	Investigative	66573783	C31H33N3O5	527.6	CN(C1=CC=C(C=C1)N2CCOCC2=O)C(=O)[C@@H]3CC4=CC=CC=C4CN3C(=O)CCC5=CC=C(C=C5)OC	IC50 = 190000 nM	Poor binder
T84631	Coagulation factor Xa	BP3E4Q	N-[(3R)-1-(3-Amino-4-chloro-[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-[4-(2-hydroxyethyl)imidazol-1-yl]benzamide	Investigative	118457019	C22H21Cl2N7O3	502.3	C1CN(C[C@@H]1NC(=O)C2=C(C=C(C=C2)N3C=C(N=C3)CCO)Cl)C4=NC=C(C5=C4ON=C5N)Cl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BP56FA	3-[1-(5-Phenylethynyl-furan-2-carbonyl)-piperidin-4-yl]-benzylamine trifluoroacetate	Investigative	10228659	C27H25F3N2O4	498.5	C1CN(CCC1C2=CC=CC(=C2)CN)C(=O)C3=CC=C(O3)C#CC4=CC=CC=C4.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BP6AX3	N-[(3R)-1-(3-Amino-5-methyl-[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(1,2,4-triazol-4-yl)benzamide	Investigative	137648430	C20H19ClN8O2	438.9	CC1=CC2=C(C(=N1)N3CC[C@H](C3)NC(=O)C4=C(C=C(C=C4)N5C=NN=C5)Cl)ON=C2N	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BPE6O4	2-(2-Pyridylmethyl)-6-amidino-1H-benzoimidazole	Investigative	22628841	C14H13N5	251.29	C1=CC=NC(=C1)CC2=NC3=C(N2)C=C(C=C3)C(=N)N	Ki ~ 150000 nM	Poor binder
T84631	Coagulation factor Xa	BPK9L2	2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]guanidine;2,2,2-trifluoroacetic acid	Investigative	44416548	C15H21BF3N3O4	375.15	B1(OC(C(O1)(C)C)(C)C)C2=CC=C(C=C2)N=C(N)N.C(=O)(C(F)(F)F)O	IC50 = 129000 nM	Poor binder
T84631	Coagulation factor Xa	BPL6R7	N-[(3R)-1-(3-Amino-4-chloro-[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-pyrimidin-2-ylbenzamide	Investigative	137658233	C21H17Cl2N7O2	470.3	C1CN(C[C@@H]1NC(=O)C2=C(C=C(C=C2)C3=NC=CC=N3)Cl)C4=NC=C(C5=C4ON=C5N)Cl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BPN7X3	2-(6-Methyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-N-(2-methyl-4,5,6,7-tetrahydro-2H-indazol-5-yl)-acetamide	Investigative	44337821	C23H27N5O4S	469.6	CC1=CC=C(C(=O)N1CC(=O)NC2CCC3=NN(C=C3C2)C)NS(=O)(=O)CC4=CC=CC=C4	Ki = 90200 nM	Poor binder
T84631	Coagulation factor Xa	BPO7K0	5-Chloro-thiophene-2-carboxylic acid {(R)-1-[4-(3-oxo-morpholin-4-yl)-phenylcarbamoyl]-ethyl}-amide	Investigative	44396124	C18H18ClN3O4S	407.9	C[C@H](C(=O)NC1=CC=C(C=C1)N2CCOCC2=O)NC(=O)C3=CC=C(S3)Cl	IC50 = 59000 nM	Poor binder
T84631	Coagulation factor Xa	BQ2J3E	(3S)-2-[3-[5-(4-Chlorophenyl)-1,3-oxazol-2-yl]propanoyl]-N-methyl-N-[4-(2-oxopiperidin-1-yl)phenyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide	Investigative	66573712	C34H33ClN4O4	597.1	CN(C1=CC=C(C=C1)N2CCCCC2=O)C(=O)[C@@H]3CC4=CC=CC=C4CN3C(=O)CCC5=NC=C(O5)C6=CC=C(C=C6)Cl	IC50 = 103000 nM	Poor binder
T84631	Coagulation factor Xa	BQ3XR7	3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-5-fluoro-4-oxo-pentanoic acid methyl ester	Investigative	10318568	C19H25FN2O6	396.4	CC(C)[C@@H](C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BQ5AS6	N-[3-[(4-Fluorophenyl)methoxy]phenyl]-1-pyrimidin-2-ylpiperidine-4-carboxamide	Investigative	72711860	C23H23FN4O2	406.5	C1CN(CCC1C(=O)NC2=CC(=CC=C2)OCC3=CC=C(C=C3)F)C4=NC=CC=N4	Ki = 91600 nM	Poor binder
T84631	Coagulation factor Xa	BR0N7D	N-[[(3S,3As)-1-oxo-7-(3-oxomorpholin-4-yl)-3a,4-dihydro-3H-[1,3]oxazolo[4,3-c][1,4]benzoxazin-3-yl]methyl]-7-chloro-1-benzothiophene-2-carboxamide	Investigative	118519604	C24H20ClN3O6S	513.9	C1COCC(=O)N1C2=CC3=C(C=C2)N4[C@@H](CO3)[C@@H](OC4=O)CNC(=O)C5=CC6=C(S5)C(=CC=C6)Cl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BR2TD5	(2S)-1-[(2R)-2-Amino-3-(3,4-dichlorophenyl)propanoyl]-N-[(2-amino-5,6,7,8-tetrahydroquinazolin-6-yl)methyl]pyrrolidine-2-carboxamide	Investigative	10166616	C23H28Cl2N6O2	491.4	C1C[C@H](N(C1)C(=O)[C@@H](CC2=CC(=C(C=C2)Cl)Cl)N)C(=O)NCC3CCC4=NC(=NC=C4C3)N	Ki ~ 75400 nM	Poor binder
T84631	Coagulation factor Xa	BR8HJ7	[(R)-2-{(S)-2-[(2-Amino-5,6,7,8-tetrahydro-quinazolin-6-ylmethyl)-carbamoyl]-pyrrolidin-1-yl}-1-(3,4-dichloro-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester	Investigative	10303947	C28H36Cl2N6O4	591.5	CC(C)(C)OC(=O)N[C@H](CC1=CC(=C(C=C1)Cl)Cl)C(=O)N2CCC[C@H]2C(=O)NCC3CCC4=NC(=NC=C4C3)N	Ki ~ 75400 nM	Poor binder
T84631	Coagulation factor Xa	BRW97H	[2'-Hydroxy-3'-(1H-pyrrolo[3,2-c]pyridin-2-yl)-biphenyl-3-ylmethyl]-urea	Investigative	15942655	C21H18N4O2	358.4	C1=CC(=CC(=C1)C2=C(C(=CC=C2)C3=CC4=C(N3)C=CN=C4)O)CNC(=O)N	Ki = 125000 nM	Poor binder
T84631	Coagulation factor Xa	BS08XC	3-[(1R,3As,8bS)-1-(5-amino-5-iminopentyl)-2-oxo-3-(5-phenylpentyl)-1,3a,4,8b-tetrahydroindeno[2,1-b]pyrrol-7-yl]-N,N-diethylbenzamide	Investigative	44290518	C38H48N4O2	592.8	CCN(CC)C(=O)C1=CC=CC(=C1)C2=CC3=C(C[C@H]4[C@H]3[C@H](C(=O)N4CCCCCC5=CC=CC=C5)CCCCC(=N)N)C=C2	IC50 ~ 50000 nM	Poor binder
T84631	Coagulation factor Xa	BS2BI0	Anabaenopeptin C	Investigative	12110710	C41H60N8O9	809	C[C@H]1C(=O)N[C@H](C(=O)NCCCC[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1C)CCC2=CC=C(C=C2)O)C(C)C)NC(=O)N[C@@H](CCCCN)C(=O)O)CC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BS9F1N	7-Hydroxy-2-oxo-N-phenyl-2H-1-benzopyran-3-carboxamide	Investigative	5400404	C16H11NO4	281.26	C1=CC=C(C=C1)NC(=O)C2=CC3=C(C=C(C=C3)O)OC2=O	IC50 ~ 50000 nM	Poor binder
T84631	Coagulation factor Xa	BS9I1Q	Anabaenopeptin B	Investigative	10418061	C41H60N10O9	837	C[C@H]1C(=O)N[C@H](C(=O)NCCCC[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1C)CCC2=CC=C(C=C2)O)C(C)C)NC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)CC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BS9NB3	CID 10228506	Investigative	10228506	C25H29N5O4S	495.6	C1CCCN(CC1)C(=O)N(CC2=CC(=CC=C2)/C(=N/O)/N)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3	Ki ~ 75000 nM	Poor binder
T84631	Coagulation factor Xa	BSW8Z0	1-Carbamimidoyl-N-(3-(4-fluorobenzyloxy)phenyl)piperidine-3-carboxamide	Investigative	25222971	C20H23FN4O2	370.4	C1CC(CN(C1)C(=N)N)C(=O)NC2=CC(=CC=C2)OCC3=CC=C(C=C3)F	Ki = 57000 nM	Poor binder
T84631	Coagulation factor Xa	BTES06	6-Fluoro-2-[2-hydroxy-3-(pyrrolidin-2-ylmethoxy)-phenyl]-1H-benzoimidazole-5-carboxamidine	Investigative	136092216	C19H20FN5O2	369.4	C1C[C@@H](NC1)COC2=CC=CC(=C2O)C3=NC4=C(N3)C=C(C(=C4)C(=N)N)F	Ki = 167000 nM	Poor binder
T84631	Coagulation factor Xa	BTL6R2	2-(6-Methyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-N-(2-methyl-4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl)-acetamide	Investigative	44337785	C24H29N5O4S	483.6	CC1=CC=C(C(=O)N1CC(=O)NCC2CCC3=NN(C=C3C2)C)NS(=O)(=O)CC4=CC=CC=C4	Ki = 95000 nM	Poor binder
T84631	Coagulation factor Xa	BTO43X	1-[4-[(5R)-5-[[(3-Amino-4-chlorobenzoyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid	Investigative	71699288	C23H25ClN4O5	472.9	C1CN(CCC1C(=O)O)C2=CC=C(C=C2)N3C[C@H](OC3=O)CNC(=O)C4=CC(=C(C=C4)Cl)N	Ki = 57700 nM	Poor binder
T84631	Coagulation factor Xa	BU0AF8	2-(5-Carbamimidoyl-benzofuran-2-yl)-3-[4-((S)-pyrrolidin-3-yloxy)-phenyl]-propionic acid ethyl ester	Investigative	10047815	C24H27N3O4	421.5	CCOC(=O)C(CC1=CC=C(C=C1)O[C@H]2CCNC2)C3=CC4=C(O3)C=CC(=C4)C(=N)N	IC50 = 52000 nM	Poor binder
T84631	Coagulation factor Xa	BU2P1K	2-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-(1-methyl-3-phenyl-propylamino)-pyridin-2-yloxy]-benzoic acid	Investigative	20843251	C29H26F2N4O4	532.5	CC(CCC1=CC=CC=C1)NC2=C(C(=NC(=C2F)OC3=CC=CC=C3C(=O)O)OC4=CC=CC(=C4)C(=N)N)F	IC50 = 55000 nM	Poor binder
T84631	Coagulation factor Xa	BU2T4G	2-Chloro-benzenesulfonic acid 3-(5-guanidino-pentyloxy)-5-methyl-phenyl ester	Investigative	44287797	C19H24ClN3O4S	425.9	CC1=CC(=CC(=C1)OS(=O)(=O)C2=CC=CC=C2Cl)OCCCCCN=C(N)N	Ki = 120000 nM	Poor binder
T84631	Coagulation factor Xa	BUCM18	Methyl N-[4-[2-[(2S,4S)-1-(4-carbamimidoylcyclohexanecarbonyl)-4-(4-methylsulfonylpiperazin-1-yl)pyrrolidin-2-yl]-5-chloro-1H-imidazol-4-yl]phenyl]carbamate	Investigative	129012579	C28H39ClN8O5S	635.2	COC(=O)NC1=CC=C(C=C1)C2=C(NC(=N2)[C@@H]3C[C@@H](CN3C(=O)C4CCC(CC4)C(=N)N)N5CCN(CC5)S(=O)(=O)C)Cl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BUG5A8	N-[[(3S,3As)-1-oxo-7-(3-oxomorpholin-4-yl)-3a,4-dihydro-3H-[1,3]oxazolo[4,3-c][1,4]benzoxazin-3-yl]methyl]-4-chloro-1-benzothiophene-2-carboxamide	Investigative	118519581	C24H20ClN3O6S	513.9	C1COCC(=O)N1C2=CC3=C(C=C2)N4[C@@H](CO3)[C@@H](OC4=O)CNC(=O)C5=CC6=C(S5)C=CC=C6Cl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BUK51W	3-Azanyl-5-(azepan-1-yl)-6-(1-benzofuran-2-yl)-Ncarbamimidoyl-pyrazine-2-carboxamide	Investigative	135393470	C20H23N7O2	393.4	C1CCCN(CC1)C2=C(N=C(C(=N2)N)C(=O)N=C(N)N)C3=CC4=CC=CC=C4O3	IC50 ~ 50000 nM	Poor binder
T84631	Coagulation factor Xa	BV0YT5	(2S)-1-[(2R)-2-(Benzylsulfonylamino)-3-cyclohexylpropanoyl]-N-(4,5,6,7-tetrahydro-1H-indazol-5-yl)pyrrolidine-2-carboxamide	Investigative	10209142	C28H39N5O4S	541.7	C1CCC(CC1)C[C@H](C(=O)N2CCC[C@H]2C(=O)NC3CCC4=C(C3)C=NN4)NS(=O)(=O)CC5=CC=CC=C5	Ki ~ 75400 nM	Poor binder
T84631	Coagulation factor Xa	BV15DG	Acetic acid;1-[4-[(5R)-5-[[(4-carbamimidoylbenzoyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid	Investigative	73356537	C26H31N5O7	525.6	CC(=O)O.C1CN(CCC1C(=O)O)C2=CC=C(C=C2)N3C[C@H](OC3=O)CNC(=O)C4=CC=C(C=C4)C(=N)N	Ki = 62900 nM	Poor binder
T84631	Coagulation factor Xa	BV2K9G	Methyl N-[4-[2-[(2S,4R)-1-(1-carbamimidoylpiperidine-4-carbonyl)-4-(1-methylsulfonylpiperidin-4-yl)pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]carbamate	Investigative	72550407	C28H40N8O5S	600.7	COC(=O)NC1=CC=C(C=C1)C2=CN=C(N2)[C@@H]3C[C@@H](CN3C(=O)C4CCN(CC4)C(=N)N)C5CCN(CC5)S(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BV5SL9	((R)-1-Benzhydryl-2-oxo-2-{(S)-2-[(4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl)-carbamoyl]-pyrrolidin-1-yl}-ethyl)-carbamic acid tert-butyl ester	Investigative	10231661	C33H41N5O4	571.7	CC(C)(C)OC(=O)N[C@H](C(C1=CC=CC=C1)C2=CC=CC=C2)C(=O)N3CCC[C@H]3C(=O)NCC4CCC5=C(C4)C=NN5	Ki = 85200 nM	Poor binder
T84631	Coagulation factor Xa	BV65UX	Chembl4213790	Investigative	10447733	C14H6F2N2O4	304.2	C1=CC(=C(C(=C1)F)C2=NC3=C(C=CC(=C3)[N+](=O)[O-])C(=O)O2)F	IC50 = 112000 nM	Poor binder
T84631	Coagulation factor Xa	BV8DX9	Ethyl 4-{2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-ylamino}-4-oxobutanoate acetate	Investigative	25107772	C24H30N4O5	454.5	CCOC(=O)CCC(=O)NC1=CC2=C(C=C1)N(CC(O2)(C)COC3=CC=C(C=C3)C(=N)N)C	Ki = 74700 nM	Poor binder
T84631	Coagulation factor Xa	BVCQ30	(2S)-N-[[5-(Aminomethyl)thiophen-3-yl]methyl]-1-[(2R)-2-(methanesulfonamido)-3,3-diphenylpropanoyl]pyrrolidine-2-carboxamide	Investigative	44264834	C27H32N4O4S2	540.7	CS(=O)(=O)N[C@H](C(C1=CC=CC=C1)C2=CC=CC=C2)C(=O)N3CCC[C@H]3C(=O)NCC4=CSC(=C4)CN	Ki = 100000 nM	Poor binder
T84631	Coagulation factor Xa	BVGP86	N-(2-Amino-4,5,6,7-tetrahydro-1,3-benzothiazol-5-yl)-2-[3-(benzylsulfonylamino)-6-methyl-2-oxopyridin-1-yl]acetamide	Investigative	44337751	C22H25N5O4S2	487.6	CC1=CC=C(C(=O)N1CC(=O)NC2CCC3=C(C2)N=C(S3)N)NS(=O)(=O)CC4=CC=CC=C4	Ki = 92000 nM	Poor binder
T84631	Coagulation factor Xa	BVRL15	Methyl 2-benzyl-3-(2-(4-carbamimidoylbenzyl)-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-ylamino)-3-oxopropanoate	Investigative	24858931	C28H28N4O5	500.5	CN1C2=C(C=C(C=C2)NC(=O)C(CC3=CC=CC=C3)C(=O)OC)OC(C1=O)CC4=CC=C(C=C4)C(=N)N	Ki = 58700 nM	Poor binder
T84631	Coagulation factor Xa	BVS94L	N-((S)-2-Amino-4,5,6,7-tetrahydro-benzothiazol-6-yl)-2-[3-(4-fluoro-phenylmethanesulfonylamino)-6-methyl-2-oxo-2H-pyridin-1-yl]-acetamide	Investigative	44339464	C22H24FN5O4S2	505.6	CC1=CC=C(C(=O)N1CC(=O)N[C@H]2CCC3=C(C2)SC(=N3)N)NS(=O)(=O)CC4=CC=C(C=C4)F	Ki = 176400 nM	Poor binder
T84631	Coagulation factor Xa	BW05HT	7-({[1-(3-Cyano-benzoyl)-piperidin-4-yl]-methanesulfonyl-amino}-methyl)-naphthalene-2-carboxamidine	Investigative	44429092	C26H27N5O3S	489.6	CS(=O)(=O)N(CC1=CC2=C(C=C1)C=CC(=C2)C(=N)N)C3CCN(CC3)C(=O)C4=CC=CC(=C4)C#N	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BW17DK	{2-[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrolidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester	Investigative	44337899	C24H38N6O4	474.6	CC(C)(C)OC(=O)N[C@@H](CN1CCC[C@H]1C(=O)NC(CCCN=C(N)N)C=O)C2=CC=CC=C2	IC50 = 190000 nM	Poor binder
T84631	Coagulation factor Xa	BWP07F	1-(4-Aminophenyl)-N-[3-[(4-fluorophenyl)methoxy]phenyl]piperidine-4-carboxamide	Investigative	72711863	C25H26FN3O2	419.5	C1CN(CCC1C(=O)NC2=CC(=CC=C2)OCC3=CC=C(C=C3)F)C4=CC=C(C=C4)N	Ki = 63500 nM	Poor binder
T84631	Coagulation factor Xa	BX26EM	Ethyl {(1S)-5-amino-1-[(5-{4-[(2,3-dihydro-1H-inden-2-ylamino)carbonyl]benzyl}-1,2,4-oxadiazol-3-YL)carbonyl]pentyl}carbamate	Investigative	6857707	C28H33N5O5	519.6	CCOC(=O)N[C@@H](CCCCN)C(=O)C1=NOC(=N1)CC2=CC=C(C=C2)C(=O)NC3CC4=CC=CC=C4C3	Ki = 140000 nM	Poor binder
T84631	Coagulation factor Xa	BXNG21	Boc-D-Ser-Gly-(4-Amidinobenzyl)NH2	Investigative	44372738	C18H27N5O5	393.4	CC(C)(C)OC(=O)N[C@H](CO)C(=O)NCC(=O)NCC1=CC=C(C=C1)C(=N)N	Ki = 140000 nM	Poor binder
T84631	Coagulation factor Xa	BXNZ19	(2S)-N-[(5-Aminothiophen-3-yl)methyl]-1-[(2R)-2-(benzylsulfonylamino)-3-(3,4-dichlorophenyl)propanoyl]pyrrolidine-2-carboxamide	Investigative	10651120	C26H28Cl2N4O4S2	595.6	C1C[C@H](N(C1)C(=O)[C@@H](CC2=CC(=C(C=C2)Cl)Cl)NS(=O)(=O)CC3=CC=CC=C3)C(=O)NCC4=CSC(=C4)N	Ki ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BY4ZB6	4-[[Azepane-1-carbonyl-(naphthalen-2-ylsulfonylamino)amino]methyl]-N'-hydroxybenzenecarboximidamide	Investigative	10368538	C25H29N5O4S	495.6	C1CCCN(CC1)C(=O)N(CC2=CC=C(C=C2)/C(=N/O)/N)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3	Ki ~ 75000 nM	Poor binder
T84631	Coagulation factor Xa	BYR42B	2-[[(2R)-1-[[1-[(4-Carbamimidoylphenyl)methylamino]-1-oxo-4-piperidin-4-ylbutan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acid	Investigative	76332426	C28H44N6O4	528.7	C1CCC(CC1)C[C@H](C(=O)NC(CCC2CCNCC2)C(=O)NCC3=CC=C(C=C3)C(=N)N)NCC(=O)O	IC50 ~ 130000 nM	Poor binder
T84631	Coagulation factor Xa	BYSM86	7-Methoxy-2-oxo-N-phenyl-2H-chromene-3-carboxamide	Investigative	3162843	C17H13NO4	295.29	COC1=CC2=C(C=C1)C=C(C(=O)O2)C(=O)NC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T84631	Coagulation factor Xa	BZ1DI5	Benzyl (R)-1-((S)-1-(1-(diphenoxyphosphoryl)-4-guanidinobutylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-oxopropan-2-ylcarbamate	Investigative	11158066	C31H39N6O8P	654.6	C[C@@H](C(=O)NC(CCCN=C(N)N)P(=O)(OC1=CC=CC=C1)OC2=CC=CC=C2)NC(=O)[C@@H](CO)NC(=O)OCC3=CC=CC=C3	IC50 = 65000 nM	Poor binder
T84631	Coagulation factor Xa	BZ3G8D	Benzyl N-[1-bis(4-acetamidophenoxy)phosphoryl-2-[4-(diaminomethylideneamino)phenyl]ethyl]carbamate	Investigative	24749175	C33H35N6O7P	658.6	CC(=O)NC1=CC=C(C=C1)OP(=O)(C(CC2=CC=C(C=C2)N=C(N)N)NC(=O)OCC3=CC=CC=C3)OC4=CC=C(C=C4)NC(=O)C	IC50 = 100000 nM	Poor binder
T84631	Coagulation factor Xa	BZ42FM	(S)-5-Guanidino-N-((S)-1-((S)-5-guanidino-1-(3-guanidinopropylamino)-1-oxopentan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-2-(2-phenylacetamido)pentanamide	Investigative	45486346	C30H53N13O4	659.8	CC(C)[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CC1=CC=CC=C1	Ki = 83000 nM	Poor binder
T84631	Coagulation factor Xa	BZ4U7A	(2S)-N-[5-(Diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(2R)-2-phenylpropanoyl]pyrrolidine-2-carboxamide	Investigative	44337925	C20H29N5O3	387.5	C[C@H](C1=CC=CC=C1)C(=O)N2CCC[C@H]2C(=O)NC(CCCN=C(N)N)C=O	IC50 = 81000 nM	Poor binder
T84631	Coagulation factor Xa	BZ62OY	(3S)-2-(4-Chlorobenzoyl)-N-methyl-N-[4-(2-oxopiperidin-1-yl)phenyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide	Investigative	66573637	C29H28ClN3O3	502	CN(C1=CC=C(C=C1)N2CCCCC2=O)C(=O)[C@@H]3CC4=CC=CC=C4CN3C(=O)C5=CC=C(C=C5)Cl	IC50 = 197000 nM	Poor binder
T84631	Coagulation factor Xa	BZ78RA	N-[(3R)-1-(3-Amino-4-chloro-[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-4-(benzimidazol-1-yl)-2-chlorobenzamide	Investigative	118456946	C24H19Cl2N7O2	508.4	C1CN(C[C@@H]1NC(=O)C2=C(C=C(C=C2)N3C=NC4=CC=CC=C43)Cl)C5=NC=C(C6=C5ON=C6N)Cl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BZ97ND	7-({[1-(2,6-Dichloro-benzenesulfonyl)-piperidin-4-yl]-methanesulfonyl-amino}-methyl)-naphthalene-2-carboxamidine	Investigative	44429093	C24H26Cl2N4O4S2	569.5	CS(=O)(=O)N(CC1=CC2=C(C=C1)C=CC(=C2)C(=N)N)C3CCN(CC3)S(=O)(=O)C4=C(C=CC=C4Cl)Cl	IC50 ~ 100000 nM	Poor binder
T84631	Coagulation factor Xa	BZI6A2	((R)-1-Cyclohexylmethyl-2-oxo-2-{(S)-2-[(4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl)-carbamoyl]-pyrrolidin-1-yl}-ethylamino)-acetic acid	Investigative	9828470	C24H37N5O4	459.6	C1CCC(CC1)C[C@H](C(=O)N2CCC[C@H]2C(=O)NCC3CCC4=C(C3)C=NN4)NCC(=O)O	Ki = 84800 nM	Poor binder
T84631	Coagulation factor Xa	BZP1X5	N-(2-Amino-4,5,6,7-tetrahydro-benzothiazol-6-yl)-2-[6-methyl-2-oxo-3-(3-trifluoromethyl-phenylmethanesulfonylamino)-2H-pyridin-1-yl]-acetamide	Investigative	44339443	C23H24F3N5O4S2	555.6	CC1=CC=C(C(=O)N1CC(=O)NC2CCC3=C(C2)SC(=N3)N)NS(=O)(=O)CC4=CC(=CC=C4)C(F)(F)F	Ki = 81000 nM	Poor binder
T84631	Coagulation factor Xa	D0P7NY	PF-429242	Investigative	23661637	C25H35N3O2	409.6	CCN(CC)CC1=CC=C(C=C1)C(=O)N(CCC2=CC=CC=C2OC)[C@@H]3CCNC3	IC50 = 100000 nM	Poor binder