TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T88806	Integrin alpha-5/beta-1	D0Q5LF	BIO-1211	Phase 2	9961766	C36H48N6O9	708.8	CC1=CC=CC=C1NC(=O)NC2=CC=C(C=C2)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)O	IC50 ~ 100000 nM	Poor binder
T88806	Integrin alpha-5/beta-1	B1W5NJ	2-[(2R,5S,9R)-5-Benzyl-9-[3-(diaminomethylideneamino)propyl]-3,8,11,13-tetraoxo-1,4,7,10-tetrazacyclotridec-2-yl]acetic acid	Investigative	44628055	C22H31N7O6	489.5	C1[C@@H](NC(=O)[C@H](NC(=O)CC(=O)N[C@@H](C(=O)N1)CCCN=C(N)N)CC(=O)O)CC2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T88806	Integrin alpha-5/beta-1	B38VRA	(2S)-2-[(2,6-Dichlorobenzoyl)amino]-3-[3-[4-(pyridin-2-ylamino)butoxy]phenyl]propanoic acid	Investigative	68899684	C25H25Cl2N3O4	502.4	C1=CC=NC(=C1)NCCCCOC2=CC=CC(=C2)C[C@@H](C(=O)O)NC(=O)C3=C(C=CC=C3Cl)Cl	IC50 = 83000 nM	Poor binder
T88806	Integrin alpha-5/beta-1	B5EQL9	(2S)-2-[(2,6-Dichlorobenzoyl)amino]-3-[4-[3-(1-methylazetidin-3-yl)propoxy]phenyl]propanoic acid	Investigative	70694227	C23H26Cl2N2O4	465.4	CN1CC(C1)CCCOC2=CC=C(C=C2)C[C@@H](C(=O)O)NC(=O)C3=C(C=CC=C3Cl)Cl	IC50 = 58000 nM	Poor binder
T88806	Integrin alpha-5/beta-1	B78HVP	2-[(2R,5R,9R)-5-Benzyl-9-[3-(diaminomethylideneamino)propyl]-3,8,11,13-tetraoxo-1,4,7,10-tetrazacyclotridec-2-yl]acetic acid	Investigative	44628054	C22H31N7O6	489.5	C1[C@H](NC(=O)[C@H](NC(=O)CC(=O)N[C@@H](C(=O)N1)CCCN=C(N)N)CC(=O)O)CC2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T88806	Integrin alpha-5/beta-1	B7LE1P	Grgdnp	Investigative	9895205	C23H38N10O10	614.6	C1C[C@H](N(C1)C(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)CN)C(=O)O	IC50 ~ 100000 nM	Poor binder
T88806	Integrin alpha-5/beta-1	B85FRU	(2S)-2-[[2-[[(2S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]butanedioic acid	Investigative	90645591	C21H31N7O7	493.5	C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)O)N	IC50 = 66000 nM	Poor binder
T88806	Integrin alpha-5/beta-1	B8J0YW	3-[4-(3-Guanidino-benzoylamino)-phenylsulfanyl]-3-pyridin-3-yl-propionic acid	Investigative	9828979	C22H21N5O3S	435.5	C1=CC(=CC(=C1)N=C(N)N)C(=O)NC2=CC=C(C=C2)SC(CC(=O)O)C3=CN=CC=C3	EC50 ~ 100000 nM	Poor binder
T88806	Integrin alpha-5/beta-1	B9AL6N	2-[(5Z)-3-[[4-[(2-Aminoacetyl)amino]phenyl]methyl]-5-ethylidene-2,6-dioxo-4-propan-2-yl-1,3-diazinan-1-yl]acetic acid	Investigative	72204878	C20H26N4O5	402.4	C/C=C\\1/C(N(C(=O)N(C1=O)CC(=O)O)CC2=CC=C(C=C2)NC(=O)CN)C(C)C	IC50 ~ 100000 nM	Poor binder
T88806	Integrin alpha-5/beta-1	BD41MY	2-[(2R,5S,9S)-5-Benzyl-9-[3-(diaminomethylideneamino)propyl]-3,8,11,13-tetraoxo-1,4,7,10-tetrazacyclotridec-2-yl]acetic acid	Investigative	44628053	C22H31N7O6	489.5	C1[C@@H](NC(=O)[C@H](NC(=O)CC(=O)N[C@H](C(=O)N1)CCCN=C(N)N)CC(=O)O)CC2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T88806	Integrin alpha-5/beta-1	BM40CG	(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[4-(3-o-tolyl-ureido)-phenyl]-acetylamino}-pentanoylamino)-propionylamino]-3-methyl-butyric acid	Investigative	9851886	C31H41N5O8	611.7	CC1=CC=CC=C1NC(=O)NC2=CC=C(C=C2)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)O	IC50 ~ 100000 nM	Poor binder
T88806	Integrin alpha-5/beta-1	BN30XQ	2-[(2S,5R,9R)-5-Benzyl-9-[3-(diaminomethylideneamino)propyl]-3,8,11,13-tetraoxo-1,4,7,10-tetrazacyclotridec-2-yl]acetic acid	Investigative	44626483	C22H31N7O6	489.5	C1[C@H](NC(=O)[C@@H](NC(=O)CC(=O)N[C@@H](C(=O)N1)CCCN=C(N)N)CC(=O)O)CC2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T88806	Integrin alpha-5/beta-1	BO5AJ1	(2S)-2-[(4-Fluoro-2-methoxybenzoyl)amino]-3-[4-[2-[6-(methylamino)pyridin-2-yl]ethoxy]phenyl]propanoic acid	Investigative	70689988	C25H26FN3O5	467.5	CNC1=CC=CC(=N1)CCOC2=CC=C(C=C2)C[C@@H](C(=O)O)NC(=O)C3=C(C=C(C=C3)F)OC	IC50 ~ 100000 nM	Poor binder
T88806	Integrin alpha-5/beta-1	BOE7H8	3-[[2-[3-(4-Carbamimidoylphenyl)-4,5-dihydro-1,2-oxazol-5-yl]acetyl]amino]propanoic acid;2,2,2-trifluoroacetic acid	Investigative	44359644	C17H19F3N4O6	432.4	C1C(ON=C1C2=CC=C(C=C2)C(=N)N)CC(=O)NCCC(=O)O.C(=O)(C(F)(F)F)O	IC50 = 180000 nM	Poor binder
T88806	Integrin alpha-5/beta-1	BRQ28U	(R)-3-[(S)-5-(3-Guanidino-propylcarbamoyl)-2-oxo-1-aza-bicyclo[5.2.0]non-8-yl]-propionic acid	Investigative	44286652	C16H27N5O4	353.42	C1CC(=O)N2C[C@@H]([C@H]2C[C@H]1C(=O)NCCCN=C(N)N)CCC(=O)O	IC50 = 65000 nM	Poor binder
T88806	Integrin alpha-5/beta-1	BV35KH	3-{2-[(Z)-4-Carbamimidoyl-benzoylimino]-3,4-dimethyl-2,3-dihydro-thiazol-5-yl}-propionic acid	Investigative	9863046	C16H18N4O3S	346.4	CC1=C(SC(=NC(=O)C2=CC=C(C=C2)C(=N)N)N1C)CCC(=O)O	IC50 ~ 100000 nM	Poor binder
T88806	Integrin alpha-5/beta-1	BV3Z5S	(S)-2-((S)-4-Methyl-2-{2-[4-(3-o-tolyl-ureido)-phenyl]-acetylamino}-pentanoylamino)-succinic acid	Investigative	11799915	C26H32N4O7	512.6	CC1=CC=CC=C1NC(=O)NC2=CC=C(C=C2)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)O	IC50 ~ 100000 nM	Poor binder
T88806	Integrin alpha-5/beta-1	BWYS25	Cyclo(-Arg-Ala-Asp-D-Phe-Val)	Investigative	10461016	C27H40N8O7	588.7	C[C@H]1C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCN=C(N)N)C(C)C)CC2=CC=CC=C2)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T88806	Integrin alpha-5/beta-1	BZVL27	3-[[2-[5-(Diaminomethylideneamino)pentanoylamino]acetyl]amino]-3-pyridin-3-ylpropanoic acid	Investigative	9907082	C16H24N6O4	364.4	C1=CC(=CN=C1)C(CC(=O)O)NC(=O)CNC(=O)CCCCN=C(N)N	IC50 = 70000 nM	Poor binder