TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T94912	HUMAN C5a receptor	B0CM3V	Tyr-Ser-Phe-Lys-Asp-Met-Pro-Leu-D-Ala-Arg	Investigative	10351393	C56H86N14O15S	1227.4	C[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CC=C(C=C3)O)N	EC50 = 57700 nM	Poor binder
T94912	HUMAN C5a receptor	B2G1FE	1,4-Ditosylpiperazine	Investigative	235632	C18H22N2O4S2	394.5	CC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)S(=O)(=O)C3=CC=C(C=C3)C	IC50 ~ 60000 nM	Poor binder
T94912	HUMAN C5a receptor	B2LF1D	Ac-His-lys-asp-met-gln-leu-gly-arg-OH	Investigative	131577	C42H71N15O13S	1026.2	CC(C)C[C@@H](C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC1=CN=CN1)NC(=O)C	Ki = 150000 nM	Poor binder
T94912	HUMAN C5a receptor	B5R3WQ	Tyr-Ser-Phe-Lys-Asp-Met-Pro-Leu-Phe-Arg	Investigative	10102925	C62H90N14O15S	1303.5	CC(C)C[C@@H](C(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CC=C(C=C4)O)N	EC50 = 114000 nM	Poor binder
T94912	HUMAN C5a receptor	B5YF8L	N-(2-Acetylphenyl)-N,4-dimethylbenzenesulfonamide	Investigative	12473171	C16H17NO3S	303.4	CC1=CC=C(C=C1)S(=O)(=O)N(C)C2=CC=CC=C2C(=O)C	EC50 ~ 60000 nM	Poor binder
T94912	HUMAN C5a receptor	B6XAT4	Ac-Phe-[Orn-Pro-ala-Trp-Arg]	Investigative	10463109	C41H55N11O7	813.9	C[C@@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)NCCC[C@@H](C(=O)N2CCC[C@H]2C(=O)N1)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)C)CCCN=C(N)N)CC4=CNC5=CC=CC=C54	IC50 = 55000 nM	Poor binder
T94912	HUMAN C5a receptor	B78UWM	N-(2-Benzoyl-4-chlorophenyl)-N,4-dimethylbenzenesulfonamide	Investigative	1379975	C21H18ClNO3S	399.9	CC1=CC=C(C=C1)S(=O)(=O)N(C)C2=C(C=C(C=C2)Cl)C(=O)C3=CC=CC=C3	EC50 ~ 60000 nM	Poor binder
T94912	HUMAN C5a receptor	B9NL2G	N-(2-Benzoyl-4-bromophenyl)-N,4-dimethylbenzenesulfonamide	Investigative	1351023	C21H18BrNO3S	444.3	CC1=CC=C(C=C1)S(=O)(=O)N(C)C2=C(C=C(C=C2)Br)C(=O)C3=CC=CC=C3	EC50 ~ 60000 nM	Poor binder
T94912	HUMAN C5a receptor	BAF1T3	Tyr-Ser-Phe-Lys-Asp-Ala-Pro-Leu-Ala-Arg	Investigative	10464003	C54H82N14O15	1167.3	C[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CC=C(C=C3)O)N	EC50 = 114000 nM	Poor binder
T94912	HUMAN C5a receptor	BBOI90	N,N''-(Propane-1,3-diyl)bis(4-methyl-N-phenylbenzenesulfonamide)	Investigative	46225393	C29H30N2O4S2	534.7	CC1=CC=C(C=C1)S(=O)(=O)N(CCCN(C2=CC=CC=C2)S(=O)(=O)C3=CC=C(C=C3)C)C4=CC=CC=C4	IC50 ~ 60000 nM	Poor binder
T94912	HUMAN C5a receptor	BDCR74	H-DPhe-Lys-AspMet-GIn-Leu-Gly-Arg-OH	Investigative	44353083	C43H71N13O12S	994.2	CC(C)C[C@@H](C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC1=CC=CC=C1)N	Ki = 79000 nM	Poor binder
T94912	HUMAN C5a receptor	BE29PY	Tyr-Ser-Phe-Lys-Gly-Met-Leu-Leu-Gly-Arg	Investigative	10464012	C54H86N14O13S	1171.4	CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCSC)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CC=C(C=C2)O)N	EC50 = 70000 nM	Poor binder
T94912	HUMAN C5a receptor	BF50DU	N-(2-(Indoline-1-carbonyl)phenyl)-N,4-dimethylbenzenesulfonamide	Investigative	17615045	C23H22N2O3S	406.5	CC1=CC=C(C=C1)S(=O)(=O)N(C)C2=CC=CC=C2C(=O)N3CCC4=CC=CC=C43	EC50 ~ 60000 nM	Poor binder
T94912	HUMAN C5a receptor	BGZB76	H-His(1Me)-Lys-AspMet-GIn-Leu-Gly-Arg-OH	Investigative	44353181	C41H71N15O12S	998.2	CC(C)C[C@@H](C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC1=CN=CN1C)N	Ki = 180000 nM	Poor binder
T94912	HUMAN C5a receptor	BIQD63	Tyr-Ser-Phe-Lys-Asp-Met-Pro-Pro-Gly-Arg	Investigative	10441364	C54H80N14O15S	1197.4	CSCC[C@@H](C(=O)N1CCC[C@H]1C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CC=C(C=C4)O)N	EC50 = 50000 nM	Poor binder
T94912	HUMAN C5a receptor	BJ4W0L	N,4-Dimethyl-N-(2-(thiophene-3-carbonyl)phenyl)benzenesulfonamide	Investigative	46225413	C19H17NO3S2	371.5	CC1=CC=C(C=C1)S(=O)(=O)N(C)C2=CC=CC=C2C(=O)C3=CSC=C3	EC50 ~ 60000 nM	Poor binder
T94912	HUMAN C5a receptor	BJSW15	N-(6-Benzyloxy-4''-methoxy-biphenyl-3-yl)-N''-methyl-guanidine	Investigative	44383557	C22H23N3O2	361.4	CN=C(N)NC1=CC(=C(C=C1)OCC2=CC=CC=C2)C3=CC=C(C=C3)OC	IC50 = 54000 nM	Poor binder
T94912	HUMAN C5a receptor	BL90FC	(Tyr65,Phe67)-C5a (65-74) (human)	Investigative	10396578	C55H85N15O16S	1244.4	CC(C)C[C@@H](C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CC=C(C=C2)O)N	EC50 = 50000 nM	Poor binder
T94912	HUMAN C5a receptor	BM2N3X	Ile-Ser-Phe-Lys-Asp-Met-Gln-Leu-Gly-Arg	Investigative	10374115	C52H87N15O15S	1194.4	CC[C@H](C)[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)N	EC50 = 67700 nM	Poor binder
T94912	HUMAN C5a receptor	BMUZ29	Ac-Phe-[Orn-Pro-cha-Ala-Arg]	Investigative	44417205	C39H60N10O7	781	C[C@H]1C(=O)N[C@H](C(=O)NCCC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](C(=O)N1)CC3CCCCC3)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)C)CCCN=C(N)N	IC50 = 100000 nM	Poor binder
T94912	HUMAN C5a receptor	BN1GJ3	Methyl{2-[methyl(phenylsulfonyl)amino]phenyl}(phenylsulfonyl)amine	Investigative	1250946	C20H20N2O4S2	416.5	CN(C1=CC=CC=C1N(C)S(=O)(=O)C2=CC=CC=C2)S(=O)(=O)C3=CC=CC=C3	EC50 ~ 60000 nM	Poor binder
T94912	HUMAN C5a receptor	BPG3R2	Ac-L-Phe-L-Lys-L-Pro-3-Cyclohexyl-D-Ala-3-(9H-fluorene-9alpha-yl)-L-Ala-D-Arg-OH	Investigative	10653515	C53H72N10O8	977.2	CC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@H](CC3CCCCC3)C(=O)N[C@@H](CC4C5=CC=CC=C5C6=CC=CC=C46)C(=O)N[C@H](CCCN=C(N)N)C(=O)O	IC50 = 51000 nM	Poor binder
T94912	HUMAN C5a receptor	BR6A5E	2-[2-(2-{2-[2-(2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-6-amino-hexanoylamino}-3-carboxy-propionylamino)-4-methylsulfanyl-butyrylamino]-4-carbamoyl-butyrylamino}-4-methyl-pentanoylamino)-acetylamino]-5-guanidino-pentanoic acid	Investigative	73354472	C42H71N15O13S	1026.2	CC(C)C[C@@H](C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC1=CN=CN1)NC(=O)C	Ki = 150000 nM	Poor binder
T94912	HUMAN C5a receptor	BT03FR	N-(6-Benzyloxy-4''-chloro-biphenyl-3-yl)-N''-methyl-guanidine	Investigative	44383043	C21H20ClN3O	365.9	CN=C(N)NC1=CC(=C(C=C1)OCC2=CC=CC=C2)C3=CC=C(C=C3)Cl	IC50 = 50000 nM	Poor binder
T94912	HUMAN C5a receptor	BT8NA6	N-(3,4-Bis-benzyloxy-phenyl)-guanidine	Investigative	12253728	C21H21N3O2	347.4	C1=CC=C(C=C1)COC2=C(C=C(C=C2)N=C(N)N)OCC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T94912	HUMAN C5a receptor	BUS3G6	Ac-Ile-Ser-His-Lys-Asp-Met-Gln-Leu-Arg-Gly-Arg	Investigative	44305625	C57H99N21O17S	1382.6	CC[C@H](C)[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)C	Ki = 100000 nM	Poor binder
T94912	HUMAN C5a receptor	BV9M2U	(S)-2-[(S)-2-[(S)-2-({(S)-1-[(S)-6-Amino-2-((S)-2-methylamino-3-phenyl-propionylamino)-hexanoyl]-pyrrolidine-2-carbonyl}-amino)-4-methyl-pentanoylamino]-3-(1H-indol-3-yl)-propionylamino]-5-guanidino-pentanoic acid	Investigative	10557548	C44H65N11O7	860.1	CC(C)C[C@@H](C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CC=CC=C4)NC	IC50 = 144000 nM	Poor binder
T94912	HUMAN C5a receptor	BVD13P	Tyr-Ser-Phe-Lys-Asp-Met-Pro-Leu-Gly-Arg	Investigative	10441383	C55H84N14O15S	1213.4	CC(C)C[C@@H](C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CC=C(C=C3)O)N	EC50 = 80000 nM	Poor binder
T94912	HUMAN C5a receptor	BVR7U1	5,12-Ditosyl-5,6,11,12-tetrahydrodibenzo[b,f][1,4]diazocine	Investigative	46225392	C28H26N2O4S2	518.7	CC1=CC=C(C=C1)S(=O)(=O)N2CC3=CC=CC=C3CN(C4=CC=CC=C42)S(=O)(=O)C5=CC=C(C=C5)C	IC50 ~ 60000 nM	Poor binder
T94912	HUMAN C5a receptor	BW3FE1	1,4-Ditosyl-1,2,3,4-tetrahydroquinoxaline	Investigative	46225376	C22H22N2O4S2	442.6	CC1=CC=C(C=C1)S(=O)(=O)N2CCN(C3=CC=CC=C32)S(=O)(=O)C4=CC=C(C=C4)C	EC50 ~ 60000 nM	Poor binder
T94912	HUMAN C5a receptor	BWZ3I1	[(4-Methylphenyl)sulfonyl](2-{[(4-methylphenyl)sulfonyl]prop-2-enylamino}pheny l)prop-2-enylamine	Investigative	3453336	C26H28N2O4S2	496.6	CC1=CC=C(C=C1)S(=O)(=O)N(CC=C)C2=CC=CC=C2N(CC=C)S(=O)(=O)C3=CC=C(C=C3)C	EC50 ~ 60000 nM	Poor binder
T94912	HUMAN C5a receptor	BZA14G	n,n'-1,2-Phenylenebis(n,4-dimethylbenzenesulfonamide)	Investigative	265219	C22H24N2O4S2	444.6	CC1=CC=C(C=C1)S(=O)(=O)N(C)C2=CC=CC=C2N(C)S(=O)(=O)C3=CC=C(C=C3)C	EC50 ~ 60000 nM	Poor binder