TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T96235	Glutamate receptor AMPA 4	D03DHQ	CX-516	Phase 2/3	148184	C14H15N3O	241.29	C1CCN(CC1)C(=O)C2=CC3=NC=CN=C3C=C2	EC50 = 156000 nM	Poor binder
T96235	Glutamate receptor AMPA 4	D0B0NQ	LY293558	Phase 2	127894	C13H21N5O2	279.34	C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1CCC3=NNN=N3)C(=O)O	Ki = 50000 nM	Poor binder
T96235	Glutamate receptor AMPA 4	B3Z4CI	(RS)-2-amino-3-[3-hydroxy-5-(2-propyl-2H-5-tetrazolyl)-4-isoxazolyl]propionic acid	Investigative	11219775	C10H14N6O4	282.26	CCCN1N=C(N=N1)C2=C(C(=O)NO2)CC(C(=O)O)N	EC50 = 79000 nM	Poor binder
T96235	Glutamate receptor AMPA 4	B7SB9O	(RS)-2-amino-3-[3-hydroxy-5-(2-benzyl-2H-5-tetrazolyl)-4-isoxazolyl]propionic acid	Investigative	16659202	C14H14N6O4	330.3	C1=CC=C(C=C1)CN2N=C(N=N2)C3=C(C(=O)NO3)CC(C(=O)O)N	EC50 = 75000 nM	Poor binder
T96235	Glutamate receptor AMPA 4	B8OER9	2-[4-(2-Fluorophenyl)phenyl]propan-1-amine	Investigative	10680928	C15H16FN	229.29	CC(CN)C1=CC=C(C=C1)C2=CC=CC=C2F	EC50 ~ 100000 nM	Poor binder
T96235	Glutamate receptor AMPA 4	B95TLY	2-Amino-3-(3-hydroxy-5-(2-isopropyl-2H-tetrazol-5-yl)isoxazol-4-yl)propanoic acid	Investigative	11818375	C10H14N6O4	282.26	CC(C)N1N=C(N=N1)C2=C(C(=O)NO2)CC(C(=O)O)N	EC50 = 160000 nM	Poor binder
T96235	Glutamate receptor AMPA 4	B9P0KJ	N-[2-(2'-Fluoro-4-biphenylyl)propyl]-1-butanesulfonamide	Investigative	10617783	C19H24FNO2S	349.5	CCCCS(=O)(=O)NCC(C)C1=CC=C(C=C1)C2=CC=CC=C2F	EC50 ~ 100000 nM	Poor binder
T96235	Glutamate receptor AMPA 4	B9XN7B	N-(beta-Phenethyl-4-tert-butylphenethyl)-2-propanesulfonamide	Investigative	10620266	C23H33NO2S	387.6	CC(C)S(=O)(=O)NCC(CCC1=CC=CC=C1)C2=CC=C(C=C2)C(C)(C)C	EC50 ~ 100000 nM	Poor binder
T96235	Glutamate receptor AMPA 4	BD41BU	4-Chloro-2-(naphthalen-2-ylcarbamoylamino)benzoic Acid	Investigative	10132082	C18H13ClN2O3	340.8	C1=CC=C2C=C(C=CC2=C1)NC(=O)NC3=C(C=CC(=C3)Cl)C(=O)O	IC50 ~ 100000 nM	Poor binder
T96235	Glutamate receptor AMPA 4	BE7YH0	N-[2-(2'-Fluoro-4-biphenylyl)propyl]phenylmethanesulfonamide	Investigative	10547998	C22H22FNO2S	383.5	CC(CNS(=O)(=O)CC1=CC=CC=C1)C2=CC=C(C=C2)C3=CC=CC=C3F	EC50 ~ 100000 nM	Poor binder
T96235	Glutamate receptor AMPA 4	BP54NT	N-(beta-Benzyl-4-tert-butylphenethyl)-2-propanesulfonamide	Investigative	10571414	C22H31NO2S	373.6	CC(C)S(=O)(=O)NCC(CC1=CC=CC=C1)C2=CC=C(C=C2)C(C)(C)C	EC50 ~ 100000 nM	Poor binder
T96235	Glutamate receptor AMPA 4	BU46IP	N-[2-[4-(2-Fluorophenyl)phenyl]propyl]benzenesulfonamide	Investigative	10737832	C21H20FNO2S	369.5	CC(CNS(=O)(=O)C1=CC=CC=C1)C2=CC=C(C=C2)C3=CC=CC=C3F	EC50 = 62500 nM	Poor binder
T96235	Glutamate receptor AMPA 4	D0N1CL	2-(3-(3-bromophenyl)ureido)-4-chlorobenzoic acid	Investigative	9799478	C14H10BrClN2O3	369.6	C1=CC(=CC(=C1)Br)NC(=O)NC2=C(C=CC(=C2)Cl)C(=O)O	IC50 ~ 100000 nM	Poor binder