TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T99041	HUMAN dipeptidyl peptidase 4	D0N5HJ	Enalaprilat	Approved	5462501	C18H24N2O5	348.4	C[C@@H](C(=O)N1CCC[C@H]1C(=O)O)N[C@@H](CCC2=CC=CC=C2)C(=O)O	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	D0R9YR	BETULINIC ACID	Phase 1	64971	C30H48O3	456.7	CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)C(=O)O	IC50 = 55820 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	D05FMP	BDBM50382283	Patented	66561557	C18H15F2N3O2	343.3	C1[C@H](N(CC1(F)F)C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	D07JHU	BDBM50434165	Patented	71667377	C18H18N4O3	338.4	COC1=CC2=C(C=CN=C2C=C1)C(=O)NCC(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	D0C6NX	BDBM50434164	Patented	73356493	C17H15ClN4O2	342.8	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C=CC(=CC3=NC=C2)Cl)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	D0QX2U	CRWCYVOHVXAEMF-LBPRGKRZSA-N	Patented	71667229	C17H15FN4O2	326.32	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C=C(C=CC3=NC=C2)F)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	D0Y3DN	Flavonoid derivative 4	Patented	5280343	C15H10O7	302.23	C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O	IC50 = 130000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	D01XGX	JTP-4819	Discontinued in Phase 2	178060	C19H25N3O4	359.4	C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)NCC3=CC=CC=C3)C(=O)CO	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B02XQA	(S)-2,6-Diamino-1-(piperidin-1-yl)hexan-1-one	Investigative	10443207	C11H23N3O	213.32	C1CCN(CC1)C(=O)[C@H](CCCCN)N	IC50 = 134900 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B04DNO	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]isoquinoline-8-carboxamide	Investigative	71655627	C17H16N4O2	308.33	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=CC3=C2C=NC=C3)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B05HAY	CID 53312239	Investigative	53312239	C21H24N6O2	392.5	CN1C2=NC(=CC(=C2N(C1=O)CC3=CC=CC=C3C#N)N4CCC[C@H](C4)N)CO	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B07AOI	Isoindolin-2-yl((2S,4S)-4-(naphthalen-2-ylamino)pyrrolidin-2-yl)methanone	Investigative	44560701	C23H23N3O	357.4	C1[C@@H](CN[C@@H]1C(=O)N2CC3=CC=CC=C3C2)NC4=CC5=CC=CC=C5C=C4	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B09MZG	(2S)-2,6-Diamino-1-(2-diphenoxyphosphorylpyrrolidin-1-yl)hexan-1-one	Investigative	10320529	C22H30N3O4P	431.5	C1CC(N(C1)C(=O)[C@H](CCCCN)N)P(=O)(OC2=CC=CC=C2)OC3=CC=CC=C3	IC50 = 117000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B0CQ9W	2-[(5-Cyanopyridin-2-yl)amino]-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]acetamide	Investigative	73356495	C15H16N6O2	312.33	C1C[C@H](N(C1)C(=O)CNC(=O)CNC2=NC=C(C=C2)C#N)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B0EF5R	N-(1-Napthalenecarbonyl)-Gly-boroPro	Investigative	15951636	C17H19BN2O4	326.2	B([C@@H]1CCCN1C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32)(O)O	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B0HWB9	2-[[3-Methyl-2-oxo-7-(piperidin-4-ylamino)imidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile	Investigative	118712516	C20H22N6O	362.4	CN1C2=NC=CC(=C2N(C1=O)CC3=CC=CC=C3C#N)NC4CCNCC4	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B0I9XT	3-Amino-6-chloro-2-methyl-4-phenylisoquinolin-1-one	Investigative	56666264	C16H13ClN2O	284.74	CN1C(=C(C2=C(C1=O)C=CC(=C2)Cl)C3=CC=CC=C3)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B0IT9D	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-8-carboxamide	Investigative	71667227	C17H16N4O2	308.33	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=CC3=C2N=CC=C3)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B0KFM1	US9346814, Ref. Cmpd No 5	Investigative	78140030	C16H16N4O2	296.32	C1CC(N(C1)C(=O)CNC(=O)C2=CNC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B0KM5Z	(2S)-2-Amino-4-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]-1-(5-fluoro-1,3-dihydroisoindol-2-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid	Investigative	53474873	C31H31ClF4N4O4	635	C1CN(CCN1C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl)C(=O)C[C@@H](C(=O)N4CC5=C(C4)C=C(C=C5)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B0PVK1	(5-(Aminomethyl)-4-(4-methoxyphenyl)-6-methylpyridin-2-yl)(4-aminopiperidin-1-yl)methanone	Investigative	53326841	C20H26N4O2	354.4	CC1=C(C(=CC(=N1)C(=O)N2CCC(CC2)N)C3=CC=C(C=C3)OC)CN	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B0TKF3	(R)-(5-(Aminomethyl)-4-(4-methoxyphenyl)-6-methylpyridin-2-yl)(3-aminopyrrolidin-1-yl)methanone	Investigative	53317343	C19H24N4O2	340.4	CC1=C(C(=CC(=N1)C(=O)N2CC[C@H](C2)N)C3=CC=C(C=C3)OC)CN	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B12YCL	(2S)-2-Amino-1-piperidin-1-yl-4-(pyridin-4-ylmethylamino)butan-1-one	Investigative	11346439	C15H24N4O	276.38	C1CCN(CC1)C(=O)[C@H](CCNCC2=CC=NC=C2)N	IC50 = 125000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B16FIV	(2S)-2-Amino-1-(1,3-dihydroisoindol-2-yl)-4-[4-(9H-fluorene-9-carbonyl)piperazin-1-yl]butane-1,4-dione;2,2,2-trifluoroacetic acid	Investigative	56675277	C32H31F3N4O5	608.6	C1CN(CCN1C(=O)C[C@@H](C(=O)N2CC3=CC=CC=C3C2)N)C(=O)C4C5=CC=CC=C5C6=CC=CC=C46.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B17TSX	(2S)-2-Amino-4-[(1R,4R)-5-[bis(4-fluorophenyl)methyl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione;dihydrochloride	Investigative	90664438	C30H32Cl2F2N4O2	589.5	C1[C@@H]2CN([C@H]1CN2C(=O)C[C@@H](C(=O)N3CC4=CC=CC=C4C3)N)C(C5=CC=C(C=C5)F)C6=CC=C(C=C6)F.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B19EMK	6-Amino-5-propan-2-yl-2-sulfanylidene-5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidin-4-one	Investigative	13478499	C17H23N3O4S	365.4	CC(C)C1(C(=NC(=S)NC1=O)N)CC2=CC(=C(C(=C2)OC)OC)OC	Ki = 160000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B1AS7D	(2S)-2-Amino-1-(1,3-dihydroisoindol-2-yl)-4-(4-piperidin-1-ylpiperidin-1-yl)butane-1,4-dione;hydrochloride	Investigative	56671898	C22H33ClN4O2	421	C1CCN(CC1)C2CCN(CC2)C(=O)C[C@@H](C(=O)N3CC4=CC=CC=C4C3)N.Cl	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B1B6OU	(S)-1-((2S,4R)-4-(2-(Isoindolin-2-yl)-2-oxoethyl)-5-oxopyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile	Investigative	46916388	C20H22N4O3	366.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@@H](C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B1BC8W	N-[2-[(2S,4R)-2-Cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	90655560	C17H15FN4O2	326.32	C1[C@H](CN([C@@H]1C#N)C(=O)CNC(=O)C2=CC=NC3=CC=CC=C23)F	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B1BN9D	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-5-carboxamide	Investigative	71655625	C17H16N4O2	308.33	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C=CC=NC3=CC=C2)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B1FN5T	1-Pentanone, 2-amino-3-methyl-1-(1-piperidinyl)-, (2S,3S)-	Investigative	10821833	C11H22N2O	198.31	CC[C@H](C)[C@@H](C(=O)N1CCCCC1)N	IC50 = 67000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B1HQL8	(2S)-2-Amino-4-[(2S)-2-[4-[bis(4-fluorophenyl)methyl]piperazine-1-carbonyl]pyrrolidin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione;hydrochloride	Investigative	56658023	C34H38ClF2N5O3	638.1	C1C[C@H](N(C1)C(=O)C[C@@H](C(=O)N2CC3=CC=CC=C3C2)N)C(=O)N4CCN(CC4)C(C5=CC=C(C=C5)F)C6=CC=C(C=C6)F.Cl	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B1QB0E	N-[2-[(2S,4S)-4-Azido-2-cyanopyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide	Investigative	70693954	C18H16N6O2	348.4	C1[C@@H](CN([C@@H]1C#N)C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32)N=[N+]=[N-]	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B1T8CU	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-(4-fluorophenyl)-1H-imidazo[4,5-b]pyridine-7-carboxamide	Investigative	90655558	C20H17FN6O2	392.4	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C(=NC=C2)N=C(N3)C4=CC=C(C=C4)F)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B1TV8H	5-(Aminomethyl)-4-(4-methoxyphenyl)-6-methyl-N-(5-methylisoxazol-3-yl)picolinamide	Investigative	53325195	C19H20N4O3	352.4	CC1=CC(=NO1)NC(=O)C2=NC(=C(C(=C2)C3=CC=C(C=C3)OC)CN)C	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B1U8EA	(2R,3R,11Br)-9,10-dimethoxy-3-(4-methylpyridin-2-yl)-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-amine	Investigative	46230652	C21H27N3O2	353.5	CC1=CC(=NC=C1)[C@@H]2CN3CCC4=CC(=C(C=C4[C@H]3C[C@H]2N)OC)OC	IC50 = 53000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B1V6ZI	N-[2-[(2S,4S)-2-Cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	90655559	C17H15FN4O2	326.32	C1[C@@H](CN([C@@H]1C#N)C(=O)CNC(=O)C2=CC=NC3=CC=CC=C23)F	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B1W3SJ	6-Chloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	71667230	C17H15ClN4O2	342.8	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C=C(C=CC3=NC=C2)Cl)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B1W7KO	(2S)-1-(2-Benzamidoacetyl)-N-tert-butylpyrrolidine-2-carboxamide	Investigative	70689751	C18H25N3O3	331.4	CC(C)(C)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)C2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B1WXH8	1-[(2S,4S)-4-(4-Cyclopropyltriazol-1-yl)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one	Investigative	71451939	C24H31N5O2	421.5	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CCCC3=CC=CC=C3)N4C=C(N=N4)C5CC5	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B1WY8G	Benzamide, N-(2-oxo-2-(1-pyrrolidinyl)ethyl)-	Investigative	56877	C13H16N2O2	232.28	C1CCN(C1)C(=O)CNC(=O)C2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B23QVT	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-pyridin-4-ylacetamide	Investigative	89705045	C14H16N4O2	272.3	C1C[C@H](N(C1)C(=O)CNC(=O)CC2=CC=NC=C2)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B28IXO	2,2-Bis(4-chlorophenyl)-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]acetamide	Investigative	70693949	C21H19Cl2N3O2	416.3	C1C[C@H](N(C1)C(=O)CNC(=O)C(C2=CC=C(C=C2)Cl)C3=CC=C(C=C3)Cl)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B28JTM	(2S,4S)-1-{(2S,4S)-4-[2-(5-Chloro-1,3-dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl}-4-fluoropyrrolidine-2-carbonitrile	Investigative	46916435	C20H20ClFN4O3	418.8	C1[C@@H](CN([C@@H]1C#N)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=C(C3)C=C(C=C4)Cl)F	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B2ETL9	Chembl4205100	Investigative	145978529	C19H21N5O3	367.4	C1C[C@H](CN(C1)C2=CC(=O)N3C(=CC=N3)N2CC4=CC=C(C=C4)C(=O)O)N	IC50 = 59900 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B2GN3Q	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-N-(3-methylbutyl)quinoline-4-carboxamide	Investigative	90655544	C22H26N4O2	378.5	CC(C)CCN(CC(=O)N1CCC[C@H]1C#N)C(=O)C2=CC=NC3=CC=CC=C23	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B2H4MR	(S)-3-Amino-4-oxo-4-(pyrrolidin-1-yl)butanoic acid	Investigative	11206225	C8H14N2O3	186.21	C1CCN(C1)C(=O)[C@H](CC(=O)O)N	IC50 = 122000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B2I5KY	(2S,4R)-4-(4-Chlorobenzylamino)-2-amino-5-phenyl-1-(piperidin-1-yl)pentan-1-one	Investigative	44415944	C23H30ClN3O	400	C1CCN(CC1)C(=O)[C@H](C[C@@H](CC2=CC=CC=C2)NCC3=CC=C(C=C3)Cl)N	IC50 ~ 125000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B2J9LD	(R)-3-Amino-4-pyridin-4-yl-1-thiazolidin-3-yl-butan-1-one	Investigative	44393727	C12H17N3OS	251.35	C1CSCN1C(=O)C[C@@H](CC2=CC=NC=C2)N	IC50 = 51000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B2L4WQ	Daphnoretin	Investigative	5281406	C19H12O7	352.3	COC1=C(C=C2C(=C1)C=C(C(=O)O2)OC3=CC4=C(C=C3)C=CC(=O)O4)O	IC50 = 87100 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B2LBR3	(2S,3R)-2-Amino-1-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)-3-methylpentan-1-one;2,2,2-trifluoroacetic acid	Investigative	127045827	C13H19F3N4O3	336.31	CC[C@@H](C)[C@@H](C(=O)N1CC2=C(C1)NN=C2)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B2M8CF	(2s)-1-({(2s,4s)-4-[2-[4-(4-Chlorophenyl)-3,6-dihydropyridin-1(2h)-yl]-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile	Investigative	46916345	C23H25ClN4O3	440.9	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CCC(=CC3)C4=CC=C(C=C4)Cl)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B2SV1U	(2S)-2-Amino-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(2-methyl-4,6-dihydropyrrolo[3,4-d][1,3]thiazol-5-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid	Investigative	127046626	C29H30F5N5O4S	639.6	CC1=NC2=C(S1)CN(C2)C(=O)[C@H](CC(=O)N3CCN(CC3)C(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B2UKR4	US9346814, Cmpd No 29 Example 34	Investigative	89712285	C15H15N5O2	297.31	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=NC3=NC=CC23)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B2VIJ5	N-[2-[(2S)-2-Cyano-4-ethylpyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide	Investigative	70691905	C20H21N3O2	335.4	CCC1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B2W8VT	(2s)-1-[1-(4-Phenylbutanoyl)-L-Prolyl]pyrrolidine-2-Carbonitrile	Investigative	11198569	C20H25N3O2	339.4	C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)CCCC3=CC=CC=C3)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B2XOS3	8-Bromo-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	71667376	C17H15BrN4O2	387.2	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C=CC=C(C3=NC=C2)Br)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B2Y3TD	(2S)-2-Amino-1-(1,3-dihydroisoindol-2-yl)-4-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]butane-1,4-dione;2,2,2-trifluoroacetic acid	Investigative	56658022	C25H28F4N4O4	524.5	C1CN(CCN1CC2=CC=C(C=C2)F)C(=O)C[C@@H](C(=O)N3CC4=CC=CC=C4C3)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B2Y4HT	(5-(Aminomethyl)-4-(4-methoxyphenyl)-6-methylpyridin-2-yl)(pyrrolidin-1-yl)methanone	Investigative	53321253	C19H23N3O2	325.4	CC1=C(C(=CC(=N1)C(=O)N2CCCC2)C3=CC=C(C=C3)OC)CN	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B31VEK	(3S)-3-Amino-N-[bis(4-fluorophenyl)methyl]-4-(1,3-dihydroisoindol-2-yl)-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	56664961	C27H24F5N3O4	549.5	C1C2=CC=CC=C2CN1C(=O)[C@H](CC(=O)NC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B34XWR	3-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile	Investigative	53311142	C20H22N6O	362.4	CN1C2=NC=CC(=C2N(C1=O)CC3=CC(=CC=C3)C#N)N4CCC[C@H](C4)N	IC50 = 88000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B34ZJO	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-phenylbenzamide	Investigative	70681357	C20H19N3O2	333.4	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=CC(=C2)C3=CC=CC=C3)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B36EKS	(3-(Aminomethyl)-6-(2,4-dichlorophenyl)-2-methylpyridin-4-yl)(morpholino)methanone	Investigative	53321254	C18H19Cl2N3O2	380.3	CC1=C(C(=CC(=N1)C2=C(C=C(C=C2)Cl)Cl)C(=O)N3CCOCC3)CN	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B37HXI	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]isoquinoline-4-carboxamide	Investigative	71655624	C17H16N4O2	308.33	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CN=CC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B3A9QS	(S)-2-Amino-4-(3-nitro-pyridin-2-ylamino)-1-piperidin-1-yl-butan-1-one	Investigative	11243728	C14H21N5O3	307.35	C1CCN(CC1)C(=O)[C@H](CCNC2=C(C=CC=N2)[N+](=O)[O-])N	IC50 = 56000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B3CG1Q	(2S)-1-[2-(4-Naphthalen-1-yltriazol-1-yl)acetyl]pyrrolidine-2-carbonitrile	Investigative	90655551	C19H17N5O	331.4	C1C[C@H](N(C1)C(=O)CN2C=C(N=N2)C3=CC=CC4=CC=CC=C43)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B3DI8L	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-4-methyl-1,3-oxazole-5-carboxamide	Investigative	71667510	C12H14N4O3	262.26	CC1=C(OC=N1)C(=O)NCC(=O)N2CCC[C@H]2C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B3ERG1	Tert-butyl N-[[1-[(3R,5S)-1-(4-phenylbutanoyl)-5-(pyrrolidine-1-carbonyl)pyrrolidin-3-yl]triazol-4-yl]methyl]carbamate	Investigative	71460901	C27H38N6O4	510.6	CC(C)(C)OC(=O)NCC1=CN(N=N1)[C@@H]2C[C@H](N(C2)C(=O)CCCC3=CC=CC=C3)C(=O)N4CCCC4	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B3F5EW	Benzyl (2S,4S)-4-(4-phenyltriazol-1-yl)-2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate	Investigative	71450087	C25H27N5O3	445.5	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)OCC3=CC=CC=C3)N4C=C(N=N4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B3FTC1	Diphenyl 1-((2S,3S)-2-amino-3-methylpentanoyl)pyrrolidin-2-ylphosphonate	Investigative	10341846	C22H29N2O4P	416.4	CC[C@H](C)[C@@H](C(=O)N1CCCC1P(=O)(OC2=CC=CC=C2)OC3=CC=CC=C3)N	IC50 ~ 125000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B3M1PO	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-(4-methoxyphenyl)quinoline-4-carboxamide	Investigative	71655557	C24H22N4O3	414.5	COC1=CC=C(C=C1)C2=NC3=CC=CC=C3C(=C2)C(=O)NCC(=O)N4CCC[C@H]4C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B3OLR0	1,3-Dihydroisoindol-2-yl-[(2S,4S)-4-[(2-methoxynaphthalen-1-yl)methylamino]pyrrolidin-2-yl]methanone;dihydrochloride	Investigative	90664578	C25H29Cl2N3O2	474.4	COC1=C(C2=CC=CC=C2C=C1)CN[C@H]3C[C@H](NC3)C(=O)N4CC5=CC=CC=C5C4.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B3PU9A	(3-(Aminomethyl)-6-(4-methoxyphenyl)-2-methylpyridin-4-yl)(morpholino)methanone	Investigative	53323917	C19H23N3O3	341.4	CC1=C(C(=CC(=N1)C2=CC=C(C=C2)OC)C(=O)N3CCOCC3)CN	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B3TG9P	(2S,3R)-2-Amino-3-methyl-1-(2-methyl-4,6-dihydropyrrolo[3,4-d][1,3]thiazol-5-yl)pentan-1-one;2,2,2-trifluoroacetic acid	Investigative	127046628	C14H20F3N3O3S	367.39	CC[C@@H](C)[C@@H](C(=O)N1CC2=C(C1)SC(=N2)C)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B40LAN	(2S)-2-Amino-5-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)pentane-1,5-dione;2,2,2-trifluoroacetic acid	Investigative	56672016	C32H33F5N4O4	632.6	C1CN(CCN1C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C(=O)CC[C@@H](C(=O)N4CC5=CC=CC=C5C4)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B43PNH	5-Cyano-4-(2,4-dichlorophenyl)-N,6-dimethylpicolinamide	Investigative	53322529	C15H11Cl2N3O	320.2	CC1=C(C(=CC(=N1)C(=O)NC)C2=C(C=C(C=C2)Cl)Cl)C#N	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B46LRO	(2S)-1-({(2S,4S)-4-[2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile	Investigative	46916343	C22H26FN5O3	427.5	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CCN(CC3)C4=CC=C(C=C4)F)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B46ZFN	(2S)-2-Amino-4-[4-[(2-chloro-6-fluorophenyl)methyl]piperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid	Investigative	56658021	C25H27ClF4N4O4	559	C1CN(CCN1CC2=C(C=CC=C2Cl)F)C(=O)C[C@@H](C(=O)N3CC4=CC=CC=C4C3)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B49NGB	(2S)-2-Amino-4-[4-[2,2-bis(4-chlorophenyl)acetyl]piperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid	Investigative	56671895	C32H31Cl2F3N4O5	679.5	C1CN(CCN1C(=O)C[C@@H](C(=O)N2CC3=CC=CC=C3C2)N)C(=O)C(C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B4C1PD	(3R,4R)-3-Butyl-1-(6-methoxy-biphenyl-3-yl)-piperidin-4-ylamine	Investigative	44431757	C22H30N2O	338.5	CCCC[C@@H]1CN(CC[C@H]1N)C2=CC(=C(C=C2)OC)C3=CC=CC=C3	IC50 = 142000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B4C7UW	4-Phenyl-1-[(2S,4S)-4-[4-(piperazin-1-ylmethyl)triazol-1-yl]-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]butan-1-one	Investigative	71453723	C26H37N7O2	479.6	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CCCC3=CC=CC=C3)N4C=C(N=N4)CN5CCNCC5	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B4KFM2	(5-(Aminomethyl)-4-(4-methoxyphenyl)-6-methylpyridin-2-yl)(morpholino)methanone	Investigative	53323916	C19H23N3O3	341.4	CC1=C(C(=CC(=N1)C(=O)N2CCOCC2)C3=CC=C(C=C3)OC)CN	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B4LN3G	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-oxo-1H-quinoline-4-carboxamide	Investigative	73354936	C17H16N4O3	324.33	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC(=O)NC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B4M9AQ	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-6-(trifluoromethoxy)quinoline-4-carboxamide	Investigative	71667231	C18H15F3N4O3	392.3	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C=C(C=CC3=NC=C2)OC(F)(F)F)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B4SQ3V	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-phenylpyridine-4-carboxamide	Investigative	89705195	C19H18N4O2	334.4	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC(=NC=C2)C3=CC=CC=C3)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B4T6IR	(S)-N-(2-(2-Cyanopyrrolidine-1-yl)-2-oxoethyl)-3-hydroxyquinoline-4-carboxamide	Investigative	73347360	C17H16N4O3	324.33	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C(C=NC3=CC=CC=C32)O)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B4UD2V	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-naphthalen-1-yloxyacetamide	Investigative	73350450	C19H19N3O3	337.4	C1C[C@H](N(C1)C(=O)CNC(=O)COC2=CC=CC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B4WF7G	(2S,3S)-2-Amino-1-(5-azidoisoindolin-2-yl)-3-methylpentan-1-one	Investigative	44560554	C14H19N5O	273.33	CC[C@H](C)[C@@H](C(=O)N1CC2=C(C1)C=C(C=C2)N=[N+]=[N-])N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B4XFV9	(2S)-2-Amino-4-[(4-phenylmethoxyphenyl)methylamino]-1-piperidin-1-ylbutan-1-one	Investigative	11372458	C23H31N3O2	381.5	C1CCN(CC1)C(=O)[C@H](CCNCC2=CC=C(C=C2)OCC3=CC=CC=C3)N	IC50 = 192000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B54CZS	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-(1H-imidazol-5-yl)acetamide	Investigative	89705179	C12H15N5O2	261.279	C1C[C@H](N(C1)C(=O)CNC(=O)CC2=CN=CN2)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B56FIL	(2S)-2-Amino-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(4,6-dihydropyrrolo[3,4-c][1,2]oxazol-5-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid	Investigative	127046622	C28H28F5N5O5	609.5	C1CN(CCN1C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C(=O)C[C@@H](C(=O)N4CC5=CON=C5C4)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B5C9FK	1-[(2S,4S)-4-[4-(2-Chlorophenyl)triazol-1-yl]-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one	Investigative	71459090	C27H30ClN5O2	492	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CCCC3=CC=CC=C3)N4C=C(N=N4)C5=CC=CC=C5Cl	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B5CSO3	1-(Aminomethyl)-6,7-dimethoxy-N-propylisoquinoline-4-carboxamide;hydrochloride	Investigative	45264231	C16H22ClN3O3	339.82	CCCNC(=O)C1=CN=C(C2=CC(=C(C=C21)OC)OC)CN.Cl	IC50 = 51400 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B5HV8B	2-Amino-1-(2,3-dihydro-1H-isoindol-2-yl)-4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)butane-1,4-dione	Investigative	23646033	C23H27N3O4	409.5	COC1=C(C=C2CN(CCC2=C1)C(=O)CC(C(=O)N3CC4=CC=CC=C4C3)N)OC	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B5I7BM	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-methoxybenzenesulfonamide	Investigative	70693950	C14H17N3O4S	323.37	COC1=CC(=CC=C1)S(=O)(=O)NCC(=O)N2CCC[C@H]2C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B5JCR1	(S)-2,5-Diamino-1-(pyrrolidin-1-yl)pentan-1-one	Investigative	15036410	C9H19N3O	185.27	C1CCN(C1)C(=O)[C@H](CCCN)N	IC50 = 118000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B5JE4R	N-[2-[(2S)-2-Cyano-4-methylpyrrolidin-1-yl]-2-oxoethyl]benzamide	Investigative	70693955	C15H17N3O2	271.31	CC1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=CC=C2)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B5L4QG	(S)-1-((S)-2,4-Diamino-butyryl)-piperidine-2-carbonitrile	Investigative	11229576	C10H18N4O	210.28	C1CCN([C@@H](C1)C#N)C(=O)[C@H](CCN)N	IC50 = 151000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B5LK8Q	2-Amino-1-(3-azido-pyrrolidin-1-yl)-3-methyl-pentan-1-one	Investigative	44364457	C10H19N5O	225.29	CCC(C)C(C(=O)N1CCC(C1)N=[N+]=[N-])N	IC50 = 107000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B5NI9P	(2S,3R)-2-Amino-1-(3-ethylpyrrolidin-1-yl)-3-methylpentan-1-one;2,2,2-trifluoroacetic acid	Investigative	127047985	C14H25F3N2O3	326.35	CCC1CCN(C1)C(=O)[C@H]([C@H](C)CC)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B5NO1K	(2S)-1-[2-[Methyl(quinolin-4-ylmethyl)amino]acetyl]pyrrolidine-2-carbonitrile	Investigative	90655546	C18H20N4O	308.4	CN(CC1=CC=NC2=CC=CC=C12)CC(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B5QG4O	Ethyl 3-[1-(aminomethyl)-6,7-dimethoxyisoquinolin-4-yl]propanoate;2,2,2-trifluoroacetic acid	Investigative	44286290	C19H23F3N2O6	432.4	CCOC(=O)CCC1=CN=C(C2=CC(=C(C=C21)OC)OC)CN.C(=O)(C(F)(F)F)O	IC50 = 52600 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B5T9DR	3-Imino-1,2-diphenylpropan-1-one	Investigative	2750782	C15H13NO	223.27	C1=CC=C(C=C1)C(C=N)C(=O)C2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B5TE3A	6-(Aminomethyl)-4-(4-chlorophenyl)-2-methylnicotinamide	Investigative	53319950	C14H14ClN3O	275.73	CC1=NC(=CC(=C1C(=O)N)C2=CC=C(C=C2)Cl)CN	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B5TMR7	(S)-2-Amino-4-(4-chloro-benzylamino)-1-(3,6-dihydro-2H-pyridin-1-yl)-butan-1-one	Investigative	11289792	C16H22ClN3O	307.82	C1CN(CC=C1)C(=O)[C@H](CCNCC2=CC=C(C=C2)Cl)N	IC50 = 148000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B5TYP2	(2S,3R)-2-Amino-1-(4-fluoroisoindolin-2-yl)-3-methylpentan-1-one	Investigative	44560595	C14H19FN2O	250.31	CC[C@@H](C)[C@@H](C(=O)N1CC2=C(C1)C(=CC=C2)F)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B5US6T	(2S)-1-[(2S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile	Investigative	52946866	C20H22N4O3	366.4	C1C[C@H](N(C1)C(=O)[C@@H]2CC(C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B5X6QY	Benzyl (2S,4S)-4-[4-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]triazol-1-yl]-2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate	Investigative	71455494	C25H34N6O5	498.6	CC(C)(C)OC(=O)NCC1=CN(N=N1)[C@H]2C[C@H](N(C2)C(=O)OCC3=CC=CC=C3)C(=O)N4CCCC4	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B5XOQ9	N-[(2R)-1-[(2S)-2-Cyanopyrrolidin-1-yl]-3-hydroxy-1-oxopropan-2-yl]quinoline-4-carboxamide	Investigative	89705076	C18H18N4O3	338.4	C1C[C@H](N(C1)C(=O)[C@@H](CO)NC(=O)C2=CC=NC3=CC=CC=C23)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B5YM8H	US9346814, Cmpd No 27 Example 32	Investigative	129010652	C18H18N4O2	322.4	CC1=CC2=NC=CC(=C2C=C1)C(=O)NCC(=O)N3CCC[C@H]3[N+]#[C-]	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B60QKI	4-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]-4-oxobutanamide	Investigative	70685559	C28H31F2N5O3	523.6	C1C[C@H](N(C1)C(=O)CNC(=O)CCC(=O)N2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B62DJY	1-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]-4-(1,3-dihydroisoindol-2-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid	Investigative	56668673	C31H30F5N3O4	603.6	C1CN(CCN1C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C(=O)CCC(=O)N4CC5=CC=CC=C5C4.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B62MNH	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-thiophen-2-ylacetamide	Investigative	70685557	C13H15N3O2S	277.34	C1C[C@H](N(C1)C(=O)CNC(=O)CC2=CC=CS2)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B62XNL	(2S)-1-[(2S,4S)-4-[2-(5,7-Dihydro-4H-thieno[2,3-c]pyridin-6-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile	Investigative	46938706	C19H22N4O3S	386.5	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CCC4=C(C3)SC=C4)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B63GSY	(2S,3S)-2-Amino-3-methyl-1-(4-methylisoindolin-2-yl)pentan-1-one	Investigative	44560397	C15H22N2O	246.35	CC[C@H](C)[C@@H](C(=O)N1CC2=CC=CC(=C2C1)C)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B67CVZ	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-4-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]-4-oxobutanamide	Investigative	70693952	C22H28FN5O3	429.5	C1C[C@H](N(C1)C(=O)CNC(=O)CCC(=O)N2CCN(CC2)CC3=CC=C(C=C3)F)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B6C4EI	1-[(2S,4S)-4-[4-(Aminomethyl)triazol-1-yl]-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one;hydrochloride	Investigative	71450088	C22H31ClN6O2	447	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CCCC3=CC=CC=C3)N4C=C(N=N4)CN.Cl	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B6EPR5	(2S)-1-[(2S,4S)-5-Oxo-4-[2-oxo-2-[2-(trifluoromethyl)-6,8-dihydro-5H-imidazo[1,2-a]pyrazin-7-yl]ethyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile	Investigative	46916384	C19H21F3N6O3	438.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CCN4C=C(N=C4C3)C(F)(F)F)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B6G9CK	4-Amino-2-(2,6-dimethylphenyl)isoindole-1,3-dione	Investigative	10333136	C16H14N2O2	266.29	CC1=C(C(=CC=C1)C)N2C(=O)C3=C(C2=O)C(=CC=C3)N	IC50 = 60100 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B6GZM1	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-naphthalen-2-yloxyacetamide	Investigative	73350449	C19H19N3O3	337.4	C1C[C@H](N(C1)C(=O)CNC(=O)COC2=CC3=CC=CC=C3C=C2)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B6HGC1	(2s)-1-({(2s,4s)-4-[2-(1,3-Dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)-4,4-difluoropyrrolidine-2-carbonitrile	Investigative	46917048	C20H20F2N4O3	402.4	C1[C@H](C(=O)N[C@@H]1C(=O)N2CC(C[C@H]2C#N)(F)F)CC(=O)N3CC4=CC=CC=C4C3	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B6TEO4	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-sulfonamide	Investigative	73353425	C17H17N3O3S	343.4	C1C[C@H](N(C1)C(=O)CNS(=O)(=O)C2=CC=CC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B70OPQ	3-Methyl-1-oxo-1-piperidin-1-ylpentan-2-aminium	Investigative	24692381	C11H22N2O	198.31	CCC(C)C(C(=O)N1CCCCC1)N	IC50 = 67000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B71MKZ	(S)-N-(2-(2-Cyanopyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide	Investigative	71655554	C17H16N4O2	308.33	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=NC3=CC=CC=C23)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B75SFI	(S)-2-Amino-1-(isoindolin-2-yl)-6-(naphthalen-2-ylamino)hexan-1-one	Investigative	44560650	C24H27N3O	373.5	C1C2=CC=CC=C2CN1C(=O)[C@H](CCCCNC3=CC4=CC=CC=C4C=C3)N	IC50 = 178000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B76RDZ	N-[2-[(2S)-2-(2-Chloroacetyl)pyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	90655562	C18H18ClN3O3	359.8	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=NC3=CC=CC=C23)C(=O)CCl	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B79LVS	7-[(3R)-3-Aminopiperidin-1-yl]-1-[(2-cyanophenyl)methyl]-3-methyl-2-oxoimidazo[4,5-b]pyridine-5-carboxamide	Investigative	118712520	C21H23N7O2	405.5	CN1C2=C(C(=CC(=N2)C(=O)N)N3CCC[C@H](C3)N)N(C1=O)CC4=CC=CC=C4C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B7CBH5	(2S,3S)-2-Amino-1-(5-fluoroisoindolin-2-yl)-3-methylpentan-1-one	Investigative	44560398	C14H19FN2O	250.31	CC[C@H](C)[C@@H](C(=O)N1CC2=C(C1)C=C(C=C2)F)N	IC50 = 80100 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B7FYL9	(2R,3S,4S,5R,6R)-2-(Hydroxymethyl)-6-[(4E,6E)-1-hydroxytetradeca-4,6-dien-8,10,12-triyn-3-yl]oxyoxane-3,4,5-triol	Investigative	118717415	C20H24O7	376.4	CC#CC#CC#C/C=C/C=C/C(CCO)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B7H4VB	2-[[7-[(3S)-3-Aminopiperidin-1-yl]-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile	Investigative	118712518	C20H22N6O	362.4	CN1C2=NC=CC(=C2N(C1=O)CC3=CC=CC=C3C#N)N4CCC[C@@H](C4)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B7J9AL	(2S)-1-Piperidino-2-amino-4-[methyl(4-chlorobenzyl)amino]-1-butanone	Investigative	10019118	C17H26ClN3O	323.9	CN(CC[C@@H](C(=O)N1CCCCC1)N)CC2=CC=C(C=C2)Cl	IC50 = 196000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B7JV8T	2-(3,4-Difluorophenyl)-1,2,3,4-tetrahydroisoquinoline	Investigative	23646029	C15H13F2N	245.27	C1CN(CC2=CC=CC=C21)C3=CC(=C(C=C3)F)F	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B7O6VW	7-But-2-ynyl-8-ethoxy-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]purine-2,6-dione	Investigative	122189865	C22H22N6O3	418.4	CCOC1=NC2=C(N1CC#CC)C(=O)N(C(=O)N2C)CC3=NC4=CC=CC=C4C(=N3)C	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B7R3FX	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-5-methylquinoline-4-carboxamide	Investigative	89705096	C18H18N4O2	322.4	CC1=C2C(=CC=NC2=CC=C1)C(=O)NCC(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B7R6DT	4-Phenyl-1-[(2S,4S)-4-(4-phenyltriazol-1-yl)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]butan-1-one	Investigative	71451900	C27H31N5O2	457.6	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CCCC3=CC=CC=C3)N4C=C(N=N4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B7T2DY	[(2-Cyclopentylamino-acetylamino)-phenyl-methyl]-phosphonic acid diphenyl ester	Investigative	11730284	C26H29N2O4P	464.5	C1CCC(C1)NCC(=O)NC(C2=CC=CC=C2)P(=O)(OC3=CC=CC=C3)OC4=CC=CC=C4	IC50 ~ 125000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B7T5LY	3-(Aminomethyl)-N-cyclopropyl-6-(2,4-dichlorophenyl)-2-methylisonicotinamide	Investigative	53326876	C17H17Cl2N3O	350.2	CC1=C(C(=CC(=N1)C2=C(C=C(C=C2)Cl)Cl)C(=O)NC3CC3)CN	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B7VEZ3	1-[(2S,4S)-4-[4-[(Dimethylamino)methyl]triazol-1-yl]-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one	Investigative	71462597	C24H34N6O2	438.6	CN(C)CC1=CN(N=N1)[C@H]2C[C@H](N(C2)C(=O)CCCC3=CC=CC=C3)C(=O)N4CCCC4	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B7XHO5	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-N-(2-methoxyethyl)quinoline-4-carboxamide	Investigative	90655543	C20H22N4O3	366.4	COCCN(CC(=O)N1CCC[C@H]1C#N)C(=O)C2=CC=NC3=CC=CC=C23	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B7ZO4N	N-[2-[(2S,4S)-4-Azido-2-cyanopyrrolidin-1-yl]-2-oxoethyl]benzamide	Investigative	70691903	C14H14N6O2	298.3	C1[C@@H](CN([C@@H]1C#N)C(=O)CNC(=O)C2=CC=CC=C2)N=[N+]=[N-]	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B82GIO	(2S)-1-[(3S)-3-Amino-4-(1,3-dihydroisoindol-2-yl)-4-oxobutanoyl]-N-[bis(4-fluorophenyl)methyl]pyrrolidine-2-carboxamide;hydrochloride	Investigative	56658025	C30H31ClF2N4O3	569	C1C[C@H](N(C1)C(=O)C[C@@H](C(=O)N2CC3=CC=CC=C3C2)N)C(=O)NC(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F.Cl	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B82JGB	(2S)-2-Amino-4-[4-[bis(4-fluorophenyl)methyl]-1,4-diazepan-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid	Investigative	56671892	C32H33F5N4O4	632.6	C1CN(CCN(C1)C(=O)C[C@@H](C(=O)N2CC3=CC=CC=C3C2)N)C(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B83VCM	N-(N-(Phenyl)butyryl-L-prolyl)pyrrolidine	Investigative	3081017	C19H26N2O2	314.4	C1CCN(C1)C(=O)[C@@H]2CCCN2C(=O)CCCC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B83YZH	(R)-1-(2-(Quinoline-4-carboxamido)acetyl)pyrrolidin-2-ylboronic acid	Investigative	89705109	C16H18BN3O4	327.1	B([C@@H]1CCCN1C(=O)CNC(=O)C2=CC=NC3=CC=CC=C23)(O)O	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B84UYE	(S)-N-(2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide	Investigative	71621488	C17H14F2N4O2	344.31	C1[C@H](N(CC1(F)F)C(=O)CNC(=O)C2=CC=NC3=CC=CC=C23)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B85INZ	CID 89705098	Investigative	89705098	C13H13N7O2	299.29	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=NC3=NC=NN23)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B89OCN	(2s)-1-({(2s,4s)-4-[2-(5-Trifluoromethyl-1,3-dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile	Investigative	46916433	C21H21F3N4O3	434.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=C(C3)C=C(C=C4)C(F)(F)F)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B89WGF	(S)-3-Amino-3-phenyl-1-thiazolidin-3-yl-propan-1-one	Investigative	44393585	C12H16N2OS	236.34	C1CSCN1C(=O)C[C@@H](C2=CC=CC=C2)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B8ADP0	2-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]acetamide	Investigative	70693951	C26H29F2N5O2	481.5	C1C[C@H](N(C1)C(=O)CNC(=O)CN2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B8C1NG	(3S)-3-Amino-N-benzhydryl-4-(1,3-dihydroisoindol-2-yl)-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	56658027	C27H26F3N3O4	513.5	C1C2=CC=CC=C2CN1C(=O)[C@H](CC(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B8CG5R	(2S,4S)-1-[(2S)-2-Amino-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-4-oxobutanoyl]-4-azidopyrrolidine-2-carbonitrile;2,2,2-trifluoroacetic acid	Investigative	127047839	C30H30F8N8O6	750.6	C1CN(CCN1C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C(=O)C[C@@H](C(=O)N4C[C@H](C[C@H]4C#N)N=[N+]=[N-])N.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B8DXA4	(3-(Aminomethyl)-6-(4-fluorophenyl)-2-methylpyridin-4-yl)(pyrrolidin-1-yl)methanone	Investigative	53317345	C18H20FN3O	313.4	CC1=C(C(=CC(=N1)C2=CC=C(C=C2)F)C(=O)N3CCCC3)CN	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B8EB0N	1-[(2S,4S)-4-[4-(2,4-Difluorophenyl)triazol-1-yl]-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one	Investigative	71451901	C27H29F2N5O2	493.5	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CCCC3=CC=CC=C3)N4C=C(N=N4)C5=C(C=C(C=C5)F)F	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B8H0MY	5-Cyano-4-(2,4-dichlorophenyl)-6-methylpicolinamide	Investigative	53322742	C14H9Cl2N3O	306.1	CC1=C(C(=CC(=N1)C(=O)N)C2=C(C=C(C=C2)Cl)Cl)C#N	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B8H4KX	(S)-2-Amino-4-[bis-(4-chloro-benzyl)-amino]-1-piperidin-1-yl-butan-1-one	Investigative	11166406	C23H29Cl2N3O	434.4	C1CCN(CC1)C(=O)[C@H](CCN(CC2=CC=C(C=C2)Cl)CC3=CC=C(C=C3)Cl)N	IC50 ~ 125000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B8I2XR	(S)-2-Amino-6-(dibenzylamino)-1-(isoindolin-2-yl)hexan-1-one	Investigative	44560649	C28H33N3O	427.6	C1C2=CC=CC=C2CN1C(=O)[C@H](CCCCN(CC3=CC=CC=C3)CC4=CC=CC=C4)N	IC50 ~ 62500 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B8JN1W	2-Amino-1-(3-hydroxy-pyrrolidin-1-yl)-3-methyl-pentan-1-one	Investigative	44364210	C10H20N2O2	200.28	CCC(C)C(C(=O)N1CCC(C1)O)N	IC50 = 93000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B8JXR1	[5-Amino-1-(piperidine-1-carbonyl)-pentyl]-carbamic acid benzyl ester	Investigative	18398587	C19H29N3O3	347.5	C1CCN(CC1)C(=O)C(CCCCN)NC(=O)OCC2=CC=CC=C2	IC50 = 134900 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B8K4WN	Dihydrochelerythrine	Investigative	485077	C21H19NO4	349.4	CN1CC2=C(C=CC(=C2OC)OC)C3=C1C4=CC5=C(C=C4C=C3)OCO5	IC50 = 56230 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B8L0CX	1-[[(S)-2-Pyrrolidinyl]carbonyl]-2-pyrrolidinylphosphonic acid diphenyl ester	Investigative	10340933	C21H25N2O4P	400.4	C1C[C@H](NC1)C(=O)N2CCCC2P(=O)(OC3=CC=CC=C3)OC4=CC=CC=C4	IC50 = 55000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B8L1UF	(2S)-2-Amino-1-(1,3-dihydroisoindol-2-yl)-4-[4-(3-phenylbenzoyl)piperazin-1-yl]butane-1,4-dione;hydrochloride	Investigative	56671897	C29H31ClN4O3	519	C1CN(CCN1C(=O)C[C@@H](C(=O)N2CC3=CC=CC=C3C2)N)C(=O)C4=CC=CC(=C4)C5=CC=CC=C5.Cl	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B8NRQ4	1-[(2S,4S)-4-(4-Cyclohexyltriazol-1-yl)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one	Investigative	71453762	C27H37N5O2	463.6	C1CCC(CC1)C2=CN(N=N2)[C@H]3C[C@H](N(C3)C(=O)CCCC4=CC=CC=C4)C(=O)N5CCCC5	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B8RXS7	5-Cyano-N-[2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	90655563	C18H13F2N5O2	369.3	C1[C@H](N(CC1(F)F)C(=O)CNC(=O)C2=CC=NC3=CC=CC(=C23)C#N)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B8YJT3	(R)-1-(3,5-Difluorophenoxy)-3-(1H-indol-2-yl)propan-2-amine	Investigative	44580498	C17H16F2N2O	302.32	C1=CC=C2C(=C1)C=C(N2)C[C@H](COC3=CC(=CC(=C3)F)F)N	IC50 = 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B91XGN	7-But-2-ynyl-3-methyl-8-(3-oxopiperazin-1-yl)purine-2,6-dione	Investigative	122189875	C14H16N6O3	316.32	CC#CCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)NC2=O)C	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B93QUX	Tert-butyl N-[[1-[(3S,5S)-5-[(2S)-2-cyanopyrrolidine-1-carbonyl]-1-(4-phenylbutanoyl)pyrrolidin-3-yl]triazol-4-yl]methyl]carbamate	Investigative	71457236	C28H37N7O4	535.6	CC(C)(C)OC(=O)NCC1=CN(N=N1)[C@H]2C[C@H](N(C2)C(=O)CCCC3=CC=CC=C3)C(=O)N4CCC[C@H]4C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B94GZF	6-Chloro-3-[(dimethylamino)methyl]-2-(2-methylpropyl)-4-phenylisoquinolin-1-one	Investigative	56679836	C22H25ClN2O	368.9	CC(C)CN1C(=C(C2=C(C1=O)C=CC(=C2)Cl)C3=CC=CC=C3)CN(C)C	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B94LTU	(2S)-1-[2-[2-Methoxyethyl(quinolin-4-ylmethyl)amino]acetyl]pyrrolidine-2-carbonitrile	Investigative	90655545	C20H24N4O2	352.4	COCCN(CC1=CC=NC2=CC=CC=C12)CC(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B95THZ	(2S)-2-Amino-4-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid	Investigative	56664958	C31H32ClF3N4O4	617.1	C1CN(CCN1C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl)C(=O)C[C@@H](C(=O)N4CC5=CC=CC=C5C4)N.C(=O)(C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B97LIZ	(S)-1-((S)-2,6-Diaminohexanoyl)piperidine-2-carbonitrile	Investigative	44560928	C12H22N4O	238.33	C1CCN([C@@H](C1)C#N)C(=O)[C@H](CCCCN)N	IC50 = 51000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B9B6PJ	CID 53312243	Investigative	53312243	C22H26N6O	390.5	CCC1=CC(=C2C(=N1)N(C(=O)N2CC3=CC=CC=C3C#N)C)N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B9FUR8	2-[(3S,5S)-5-[(2S)-2-Cyanopyrrolidine-1-carbonyl]-2-oxopyrrolidin-3-yl]-N-phenylacetamide	Investigative	46916346	C18H20N4O3	340.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)NC3=CC=CC=C3)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B9GM1U	(S)-2,6-Diamino-1-(isoindolin-2-yl)hexan-1-one	Investigative	44593408	C14H21N3O	247.34	C1C2=CC=CC=C2CN1C(=O)[C@H](CCCCN)N	IC50 = 161000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B9HI5Y	Benzyl (2S,4S)-4-(4-pyridin-2-yltriazol-1-yl)-2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate	Investigative	71460903	C24H26N6O3	446.5	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)OCC3=CC=CC=C3)N4C=C(N=N4)C5=CC=CC=N5	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B9HU0F	2-[[7-[(3R)-3-Aminopiperidin-1-yl]-5-methoxy-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile	Investigative	118712519	C21H24N6O2	392.5	CN1C2=C(C(=CC(=N2)OC)N3CCC[C@H](C3)N)N(C1=O)CC4=CC=CC=C4C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B9I4LK	(2S,3R)-2-Amino-3-methyl-1-(3-methylidenepyrrolidin-1-yl)pentan-1-one;2,2,2-trifluoroacetic acid	Investigative	127046590	C13H21F3N2O3	310.31	CC[C@@H](C)[C@@H](C(=O)N1CCC(=C)C1)N.C(=O)(C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B9KAW6	US9346814, Ref. Cmpd No 4	Investigative	129010653	C16H16N4O2	296.32	C1CC(N(C1)C(=O)CNC(=O)C2=CC3=CC=CC=C3N2)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B9NAD3	(2S,4R)-4-(4-Chlorobenzylamino)-2-amino-5-methyl-1-(piperidin-1-yl)hexan-1-one	Investigative	44415906	C19H30ClN3O	351.9	CC(C)[C@@H](C[C@@H](C(=O)N1CCCCC1)N)NCC2=CC=C(C=C2)Cl	IC50 ~ 125000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B9OZE8	3,7-Dimethyl-8-(3-oxopiperazin-1-yl)purine-2,6-dione	Investigative	47370344	C11H14N6O3	278.27	CN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)NC2=O)C	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B9QBJ7	8-Chloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	71667375	C17H15ClN4O2	342.8	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C=CC=C(C3=NC=C2)Cl)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B9QW0J	(S)-2-Amino-3-hydroxy-1-(pyrrolidin-1-yl)propan-1-one	Investigative	11309656	C7H14N2O2	158.2	C1CCN(C1)C(=O)[C@H](CO)N	IC50 = 190000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B9R5WE	(2S,3S)-2-Amino-1-(4-fluoroisoindolin-2-yl)-3-methylpentan-1-one	Investigative	44560396	C14H19FN2O	250.31	CC[C@H](C)[C@@H](C(=O)N1CC2=C(C1)C(=CC=C2)F)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B9REA1	3-(Aminomethyl)-N-cyclopropyl-6-(4-methoxyphenyl)-2-methylisonicotinamide	Investigative	53320113	C18H21N3O2	311.4	CC1=C(C(=CC(=N1)C2=CC=C(C=C2)OC)C(=O)NC3CC3)CN	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B9SH1O	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-7-phenylquinoline-4-carboxamide	Investigative	89705273	C23H20N4O2	384.4	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C=CC(=CC3=NC=C2)C4=CC=CC=C4)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B9WR4C	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-4-methyl-1,3-thiazole-5-carboxamide	Investigative	71667381	C12H14N4O2S	278.33	CC1=C(SC=N1)C(=O)NCC(=O)N2CCC[C@H]2C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B9XHA8	(2S)-2-Amino-1-piperidin-1-yl-4-(piperidin-4-ylamino)butan-1-one	Investigative	9970277	C14H28N4O	268.4	C1CCN(CC1)C(=O)[C@H](CCNC2CCNCC2)N	IC50 = 64000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B9Y6PH	Tert-butyl N-[[1-[(3S,5S)-1-(4-phenylbutanoyl)-5-(pyrrolidine-1-carbonyl)pyrrolidin-3-yl]triazol-4-yl]methyl]carbamate	Investigative	71457237	C27H38N6O4	510.6	CC(C)(C)OC(=O)NCC1=CN(N=N1)[C@H]2C[C@H](N(C2)C(=O)CCCC3=CC=CC=C3)C(=O)N4CCCC4	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B9Y6WZ	2-[2,6-Bis(propan-2-yl)phenyl]-3-sulfanylidene-2,3-dihydro-1H-isoindol-1-one	Investigative	10064801	C20H21NOS	323.5	CC(C)C1=C(C(=CC=C1)C(C)C)N2C(=O)C3=CC=CC=C3C2=S	IC50 = 57800 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	B9ZK6I	4-Hydroxy-N-(2,6-dimethylphenyl)phthalimide	Investigative	477693	C16H13NO3	267.28	CC1=C(C(=CC=C1)C)N2C(=O)C3=C(C2=O)C=C(C=C3)O	IC50 = 74100 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BA10GO	(2S)-1-[2-[[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-methylamino]acetyl]pyrrolidine-2-carbonitrile	Investigative	90655547	C15H21N5O2	303.36	CN(CC(=O)N1CCC[C@H]1C#N)CC(=O)N2CCC[C@H]2C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BA2QN3	N-[2-[(2S)-2-Cyanopiperidin-1-yl]-2-oxoethyl]benzamide	Investigative	70689752	C15H17N3O2	271.31	C1CCN([C@@H](C1)C#N)C(=O)CNC(=O)C2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BA36XY	Ile-Isoindoline	Investigative	44593399	C14H20N2O	232.32	CC[C@H](C)[C@@H](C(=O)N1CC2=CC=CC=C2C1)N	IC50 = 115000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BA6CS8	N-{2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl}benzamide	Investigative	15951642	C14H15N3O2	257.29	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=CC=C2)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BA6RE2	2,6-Dichloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]benzamide	Investigative	70687705	C14H13Cl2N3O2	326.2	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C(C=CC=C2Cl)Cl)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BA93PR	N-[2-[(2S,4S)-2-Cyano-4-(trifluoromethyl)pyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide	Investigative	70691906	C19H16F3N3O2	375.3	C1[C@@H](CN([C@@H]1C#N)C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BA9RN4	(2S,3S)-2-Amino-3-methyl-1-(5-nitroisoindolin-2-yl)pentan-1-one	Investigative	44560553	C14H19N3O3	277.32	CC[C@H](C)[C@@H](C(=O)N1CC2=C(C1)C=C(C=C2)[N+](=O)[O-])N	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BAS40I	(2S,3S)-2-Amino-3-methyl-1-(5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)pentan-1-one	Investigative	44560555	C13H19N3O	233.31	CC[C@H](C)[C@@H](C(=O)N1CC2=C(C1)N=CC=C2)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BAW02X	(S)-2-Amino-4-(4-chloro-benzylamino)-1-(4-fluoro-piperidin-1-yl)-butan-1-one	Investigative	11450265	C16H23ClFN3O	327.82	C1CN(CCC1F)C(=O)[C@H](CCNCC2=CC=C(C=C2)Cl)N	IC50 = 70000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BAWY80	CID 53312238	Investigative	53312238	C21H22N6O3	406.4	CN1C2=C(C(=CC(=N2)C(=O)O)N3CCC[C@H](C3)N)N(C1=O)CC4=CC=CC=C4C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BAX78R	(2S,3R)-2-Amino-3-methyl-1-(5-(trifluoromethyl)isoindolin-2-yl)pentan-1-one	Investigative	44560597	C15H19F3N2O	300.32	CC[C@@H](C)[C@@H](C(=O)N1CC2=C(C1)C=C(C=C2)C(F)(F)F)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BAY1X6	(3S)-4-[(2S)-2-[[(2S)-1-Amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-[[(2S)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-4-oxobutanoic acid	Investigative	76309823	C25H43N9O7	581.7	CC(C)[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)N	Ki = 142000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BB16LV	US9346814, Ref Cmpd No 10	Investigative	78140064	C17H16N4O2	308.33	C1CC(N(C1)C(=O)CNC(=O)C2=CC=CC3=C2C=CN=C3)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BB5S0R	5-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-1-(4-methoxyphenyl)-6-methylpyrazolo[3,4-d]pyrimidin-4-one	Investigative	122190838	C22H16ClN5O2S	449.9	CC1=NC2=C(C=NN2C3=CC=C(C=C3)OC)C(=O)N1C4=NC(=CS4)C5=CC=C(C=C5)Cl	IC50 = 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BB7XV5	(3s,5s)-3-[2-(1,3-Dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-2-one	Investigative	46916387	C18H21N3O3S	359.4	C1CSCN1C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BBA72Y	(2S)-1-[(2R)-1-(4-Phenylbutanoyl)pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile	Investigative	70685696	C20H25N3O2	339.4	C1C[C@H](N(C1)C(=O)[C@H]2CCCN2C(=O)CCCC3=CC=CC=C3)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BBG7V2	(2S)-2-Amino-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(3-ethylpyrrolidin-1-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid	Investigative	127047761	C31H36F8N4O6	712.6	CCC1CCN(C1)C(=O)[C@H](CC(=O)N2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)N.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BBI17K	2-Amino-1-(2,3-dihydro-1H-isoindol-2-yl)-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)butane-1,4-dione	Investigative	23646032	C21H23N3O2	349.4	C1CN(CC2=CC=CC=C21)C(=O)CC(C(=O)N3CC4=CC=CC=C4C3)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BBL8H4	(2R,3R,5R)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	72188904	C16H18F2N4O	320.34	C1[C@H](CO[C@@H]([C@@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BBU16R	1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-[2-(acetylamino)ethylamino]xanthine	Investigative	101887274	C24H26N8O3	474.5	CC#CCN1C2=C(N=C1NCCNC(=O)C)N(C(=O)N(C2=O)CC3=NC4=CC=CC=C4C(=N3)C)C	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BBV1F3	2-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-oxo-5-(trifluoromethyl)imidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile	Investigative	68305755	C21H21F3N6O	430.4	CN1C2=C(C(=CC(=N2)C(F)(F)F)N3CCC[C@H](C3)N)N(C1=O)CC4=CC=CC=C4C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BBZ0Y3	4-Phenyl-1-[(2S,4R)-4-(4-phenyltriazol-1-yl)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]butan-1-one	Investigative	71455456	C27H31N5O2	457.6	C1CCN(C1)C(=O)[C@@H]2C[C@H](CN2C(=O)CCCC3=CC=CC=C3)N4C=C(N=N4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BC0E1K	(S)-1-(2,4-Diamino-butyryl)-piperidine-2-carbonitrile	Investigative	44364385	C10H18N4O	210.28	C1CCN([C@@H](C1)C#N)C(=O)C(CCN)N	IC50 = 151000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BC0LG5	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-4-[(2,2,2-trifluoroacetyl)amino]benzamide	Investigative	90655557	C16H15F3N4O3	368.31	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=C(C=C2)NC(=O)C(F)(F)F)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BC0PO2	(2S)-2-Amino-4-[4-[bis(4-fluorophenyl)methyl]-3-oxopiperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione;dihydrochloride	Investigative	90664693	C29H30Cl2F2N4O3	591.5	C1CN(C(=O)CN1C(=O)C[C@@H](C(=O)N2CC3=CC=CC=C3C2)N)C(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BC2LJ5	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-methylimidazole-4-carboxamide	Investigative	89705223	C12H15N5O2	261.279	CN1C=NC=C1C(=O)NCC(=O)N2CCC[C@H]2C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BC35UT	(2s)-1-({(2s,4s)-5-Oxo-4-[2-oxo-2-(pyrrolidin-1-yl)ethyl]pyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile	Investigative	46916385	C16H22N4O3	318.37	C1CCN(C1)C(=O)C[C@@H]2C[C@H](NC2=O)C(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BCA7J5	(2S,3R)-2-Amino-3-hydroxy-1-(pyrrolidin-1-yl)butan-1-one	Investigative	44560823	C8H16N2O2	172.22	C[C@H]([C@@H](C(=O)N1CCCC1)N)O	IC50 = 98000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BCI98M	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-1H-indole-3-carboxamide	Investigative	71655555	C16H16N4O2	296.32	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CNC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BCSR15	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-1H-indole-2-carboxamide	Investigative	73350448	C16H16N4O2	296.32	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC3=CC=CC=C3N2)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BCV63Z	(S)-2-Amino-6-(benzylamino)-1-(isoindolin-2-yl)hexan-1-one	Investigative	44560648	C21H27N3O	337.5	C1C2=CC=CC=C2CN1C(=O)[C@H](CCCCNCC3=CC=CC=C3)N	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BCY75P	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2H-triazole-4-carboxamide	Investigative	89712515	C10H12N6O2	248.24	C1C[C@H](N(C1)C(=O)CNC(=O)C2=NNN=C2)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BD42AU	(2S)-2-Amino-1-(2-diphenoxyphosphorylpyrrolidin-1-yl)-3-phenyl-propan-1-one	Investigative	10456407	C25H27N2O4P	450.5	C1CC(N(C1)C(=O)[C@H](CC2=CC=CC=C2)N)P(=O)(OC3=CC=CC=C3)OC4=CC=CC=C4	IC50 = 142000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BD69UM	2-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-5-morpholin-4-yl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile	Investigative	118712522	C24H29N7O2	447.5	CN1C2=C(C(=CC(=N2)N3CCOCC3)N4CCC[C@H](C4)N)N(C1=O)CC5=CC=CC=C5C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BD7Z9M	N-[2-[(2S)-2-Cyano-4-methylidenepyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide	Investigative	70683455	C19H17N3O2	319.4	C=C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BDE0S4	(2S,4R)-1-((2S,3R)-2-Amino-3-methylpentanoyl)-4-azidopyrrolidine-2-carbonitrile	Investigative	44560989	C11H18N6O	250.3	CC[C@@H](C)[C@@H](C(=O)N1C[C@@H](C[C@H]1C#N)N=[N+]=[N-])N	IC50 = 52000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BDIV63	CID 76313540	Investigative	76313540	C143H246N50O41S4	3450.1	CC[C@H](C)[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CS)NC(=O)CNC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCSC)NC(=O)C(C(C)(C)C)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CO)N	Ki = 61000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BDQ72X	(2S,3S)-2-Amino-3-methyl-1-(5-(trifluoromethyl)isoindolin-2-yl)pentan-1-one	Investigative	44560550	C15H19F3N2O	300.32	CC[C@H](C)[C@@H](C(=O)N1CC2=C(C1)C=C(C=C2)C(F)(F)F)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BDTL57	5-Bromo-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	71655623	C17H15BrN4O2	387.2	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C(=NC=C2)C=CC=C3Br)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BDW0U7	(3-(Aminomethyl)-6-(4-chlorophenyl)-2-methylpyridin-4-yl)(pyrrolidin-1-yl)methanone	Investigative	53317346	C18H20ClN3O	329.8	CC1=C(C(=CC(=N1)C2=CC=C(C=C2)Cl)C(=O)N3CCCC3)CN	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BE1A6T	Imigliptin	Investigative	53311070	C21H24N6O	376.5	CC1=CC(=C2C(=N1)N(C(=O)N2CC3=CC=CC=C3C#N)C)N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BE34AH	(R)-1-(2-(2-Oxopyridin-1(2H)-yl)acetyl)pyrrolidin-2-ylboronic acid	Investigative	44418254	C11H15BN2O4	250.06	B([C@@H]1CCCN1C(=O)CN2C=CC=CC2=O)(O)O	Ki = 182000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BE4N7Q	2-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-oxo-5-pyrrolidin-1-ylimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile	Investigative	118712521	C24H29N7O	431.5	CN1C2=C(C(=CC(=N2)N3CCCC3)N4CCC[C@H](C4)N)N(C1=O)CC5=CC=CC=C5C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BE5W0N	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-(3,4-dimethoxyphenyl)pyridine-4-carboxamide	Investigative	71667379	C21H22N4O4	394.4	COC1=C(C=C(C=C1)C2=NC=CC(=C2)C(=O)NCC(=O)N3CCC[C@H]3C#N)OC	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BE6UQ3	1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-[2-(4-pyridylcarbonylamino)ethylamino]xanthine	Investigative	101887276	C28H27N9O3	537.6	CC#CCN1C2=C(N=C1NCCNC(=O)C3=CC=NC=C3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BE98IS	Val-trp	Investigative	168182	C16H21N3O3	303.36	CC(C)[C@@H](C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)O)N	IC50 = 65690 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BEC2Z5	Benzyl (2S,4S)-2-(pyrrolidine-1-carbonyl)-4-(4-trimethylsilyltriazol-1-yl)pyrrolidine-1-carboxylate	Investigative	71462641	C22H31N5O3Si	441.6	C[Si](C)(C)C1=CN(N=N1)[C@H]2C[C@H](N(C2)C(=O)OCC3=CC=CC=C3)C(=O)N4CCCC4	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BEF9T1	Allo-Ile-Isoindoline	Investigative	24784416	C14H20N2O	232.32	CC[C@@H](C)[C@@H](C(=O)N1CC2=CC=CC=C2C1)N	IC50 = 90000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BEG8V0	(2S)-1-[(2S,4S)-4-Azido-1-(4-phenylbutanoyl)pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile	Investigative	71462596	C20H24N6O2	380.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CCCC3=CC=CC=C3)N=[N+]=[N-])C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BEK64B	Tert-butyl 4-[[1-[(3S,5S)-1-(4-phenylbutanoyl)-5-(pyrrolidine-1-carbonyl)pyrrolidin-3-yl]triazol-4-yl]methyl]piperazine-1-carboxylate	Investigative	71451902	C31H45N7O4	579.7	CC(C)(C)OC(=O)N1CCN(CC1)CC2=CN(N=N2)[C@H]3C[C@H](N(C3)C(=O)CCCC4=CC=CC=C4)C(=O)N5CCCC5	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BEO4P7	(2S)-N-Tert-butyl-1-[(2S,4S)-4-[2-(1,3-dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide	Investigative	46938499	C24H32N4O4	440.5	CC(C)(C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BF0LN1	(2S)-1-({(2S,4S)-5-Oxo-4-[2-oxo-2-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]ethyl]pyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile	Investigative	46916386	C18H20F3N7O3	439.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CCN4C(=NN=C4C(F)(F)F)C3)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BF41BR	1-Isoleucylazetidine	Investigative	10607253	C9H18N2O	170.25	CC[C@H](C)[C@@H](C(=O)N1CCC1)N	IC50 = 50400 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BF4DX7	US9346814, Ref. Cmpd No 3 (Example 5)	Investigative	71667225	C17H16N4O2	308.33	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC3=CC=CC=C3N=C2)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BF4R7L	6-(Aminomethyl)-4-(4-methoxyphenyl)-2-methylnicotinamide	Investigative	53322575	C15H17N3O2	271.31	CC1=NC(=CC(=C1C(=O)N)C2=CC=C(C=C2)OC)CN	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BF6L8H	2-(S)-Amino-4-phenethylamino-1-piperidin-1-yl-butan-1-one	Investigative	11437726	C17H27N3O	289.4	C1CCN(CC1)C(=O)[C@H](CCNCCC2=CC=CC=C2)N	IC50 = 188000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BFAI67	(2S,3S)-2-Amino-3-methyl-1-(5-methylisoindolin-2-yl)pentan-1-one	Investigative	44560454	C15H22N2O	246.35	CC[C@H](C)[C@@H](C(=O)N1CC2=C(C1)C=C(C=C2)C)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BFE2B3	1-[(2S,4S)-4-[4-(3,4-Difluorophenyl)triazol-1-yl]-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one	Investigative	71460902	C27H29F2N5O2	493.5	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CCCC3=CC=CC=C3)N4C=C(N=N4)C5=CC(=C(C=C5)F)F	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BFO8H4	5-Bromo-N-[2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	89705152	C17H13BrF2N4O2	423.2	C1[C@H](N(CC1(F)F)C(=O)CNC(=O)C2=C3C(=NC=C2)C=CC=C3Br)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BFP0W4	3-[((S)-3-Amino-4-oxo-4-piperidin-1-yl-butylamino)-methyl]-benzonitrile	Investigative	11449442	C17H24N4O	300.4	C1CCN(CC1)C(=O)[C@H](CCNCC2=CC(=CC=C2)C#N)N	IC50 = 132000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BFQT80	(2S,3S)-2-Amino-1-(5-tert-butylisoindolin-2-yl)-3-methylpentan-1-one	Investigative	44560549	C18H28N2O	288.4	CC[C@H](C)[C@@H](C(=O)N1CC2=C(C1)C=C(C=C2)C(C)(C)C)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BFR59B	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-phenylpropanamide	Investigative	70683454	C16H19N3O2	285.34	C1C[C@H](N(C1)C(=O)CNC(=O)CCC2=CC=CC=C2)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BFZ06R	(S)-N-(2-(2-Cyanopyrrolidin-1-yl)-2-oxoethyl)-1-naphthamide	Investigative	16040457	C18H17N3O2	307.3	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BG15ST	(3-(Aminomethyl)-6-(2,4-dichlorophenyl)-2-methylpyridin-4-yl)(pyrrolidin-1-yl)methanone	Investigative	53317347	C18H19Cl2N3O	364.3	CC1=C(C(=CC(=N1)C2=C(C=C(C=C2)Cl)Cl)C(=O)N3CCCC3)CN	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BG3ES9	N-[(2S)-1-[(2S)-2-Cyanopyrrolidin-1-yl]-1-oxopropan-2-yl]quinoline-4-carboxamide	Investigative	90655538	C18H18N4O2	322.4	C[C@@H](C(=O)N1CCC[C@H]1C#N)NC(=O)C2=CC=NC3=CC=CC=C23	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BG53WY	2-(4-Cyanophenyl)-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]pyridine-4-carboxamide	Investigative	71667380	C20H17N5O2	359.4	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC(=NC=C2)C3=CC=C(C=C3)C#N)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BG5YQ6	6-Chloro-3-(methylaminomethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1-one	Investigative	56673186	C21H23ClN2O	354.9	CC(C)CN1C(=C(C2=C(C1=O)C=CC(=C2)Cl)C3=CC=CC=C3)CNC	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BG86RU	[2-Bis(4-hydroxyphenoxy)phosphorylpyrrolidin-1-yl]-pyrrolidin-2-ylmethanone;hydrochloride	Investigative	49795938	C21H26ClN2O6P	468.9	C1CC(NC1)C(=O)N2CCCC2P(=O)(OC3=CC=C(C=C3)O)OC4=CC=C(C=C4)O.Cl	IC50 = 190000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BG8CU2	Benzyl (S)-(-)-2-(1-pyrrolidinylcarbonyl)-1-pyrrolidinecarboxylate	Investigative	688304	C17H22N2O3	302.37	C1CCN(C1)C(=O)[C@@H]2CCCN2C(=O)OCC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BG9E0F	7-Anilino-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	89705100	C23H21N5O2	399.4	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C=CC(=CC3=NC=C2)NC4=CC=CC=C4)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BGE8N2	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]pyridazine-4-carboxamide	Investigative	90655555	C12H13N5O2	259.26	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CN=NC=C2)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BGH9M1	US8933056, N-(Benzyl)-Gly-boroPro	Investigative	15951541	C13H19BN2O3	262.11	B([C@@H]1CCCN1C(=O)CNCC2=CC=CC=C2)(O)O	IC50 = 69000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BGT19Y	(2S)-1-(2-Naphthalen-2-yloxyacetyl)pyrrolidine-2-carbonitrile	Investigative	73345857	C17H16N2O2	280.32	C1C[C@H](N(C1)C(=O)COC2=CC3=CC=CC=C3C=C2)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BGTC64	1-Isoleucyl-1,2,5,6-tetrahydropyridine	Investigative	10774283	C11H20N2O	196.29	CC[C@H](C)[C@@H](C(=O)N1CCC=CC1)N	IC50 = 52000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BH3UJ1	N-(2-Cyclohexylidene-2-fluoroethyl)-1-methylpiperidin-4-amine	Investigative	44387758	C14H25FN2	240.36	CN1CCC(CC1)NCC(=C2CCCCC2)F	IC50 ~ 125000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BH3WU2	2-[[7-(3-Aminoazetidin-1-yl)-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile	Investigative	53312327	C18H18N6O	334.4	CN1C2=NC=CC(=C2N(C1=O)CC3=CC=CC=C3C#N)N4CC(C4)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BH3XE8	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-naphthalen-1-ylacetamide	Investigative	73356494	C19H19N3O2	321.4	C1C[C@H](N(C1)C(=O)CNC(=O)CC2=CC=CC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BH43EZ	4-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile	Investigative	53311143	C20H22N6O	362.4	CN1C2=NC=CC(=C2N(C1=O)CC3=CC=C(C=C3)C#N)N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BH4AD7	N'-[Bis(4-fluorophenyl)methyl]-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]butanediamide	Investigative	70687706	C24H24F2N4O3	454.5	C1C[C@H](N(C1)C(=O)CNC(=O)CCC(=O)NC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BHE45S	(S)-N-(2-(2-Cyanopyrrolidine-1-yl)-2-oxoethyl)piperidine-4-carboxamide	Investigative	89704942	C13H20N4O2	264.32	C1C[C@H](N(C1)C(=O)CNC(=O)C2CCNCC2)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BHEK84	(2S,3S)-2-Amino-1-(3-hydroxypyrrolidin-1-yl)-3-methylpentan-1-one	Investigative	10845727	C10H20N2O2	200.28	CC[C@H](C)[C@@H](C(=O)N1CCC(C1)O)N	IC50 = 93000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BHJ9V3	Pro-boroPro (PBP)	Investigative	44368735	C10H18BNO3	211.07	B([C@@H]1CCCC1C(=O)[C@@H]2CCCN2)(O)O	IC50 = 88200 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BHW27S	7-But-2-ynyl-3-methyl-8-(3-oxopiperazin-1-yl)-1-(pyridin-3-ylmethyl)purine-2,6-dione	Investigative	122189872	C20H21N7O3	407.4	CC#CCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=CN=CC=C4)C	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BI2W1C	1-((S)-2-Amino-4-benzylamino-butyryl)-piperidine-2-carbonitrile	Investigative	44330636	C17H24N4O	300.4	C1CCN(C(C1)C#N)C(=O)[C@H](CCNCC2=CC=CC=C2)N	IC50 = 68000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BI3JU6	1-(Aminomethyl)-6,7-dimethoxyisoquinoline-4-carboxylic acid;hydrochloride	Investigative	45259997	C13H15ClN2O4	298.72	COC1=C(C=C2C(=C1)C(=CN=C2CN)C(=O)O)OC.Cl	IC50 = 103000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BI3VQ6	(2S)-1-[(2S)-2-Amino-3-(furan-3-yl)propanoyl]pyrrolidine-2-carbonitrile	Investigative	76325642	C12H15N3O2	233.27	C1C[C@H](N(C1)C(=O)[C@H](CC2=COC=C2)N)C#N	IC50 = 113600 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BI4BM3	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-[4-(3,4-difluorophenyl)triazol-1-yl]acetamide	Investigative	70693953	C17H16F2N6O2	374.3	C1C[C@H](N(C1)C(=O)CNC(=O)CN2C=C(N=N2)C3=CC(=C(C=C3)F)F)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BI6AY3	Ethanone, 2-(cyclohexylamino)-1-(1-pyrrolidinyl)-	Investigative	11229581	C12H22N2O	210.32	C1CCC(CC1)NCC(=O)N2CCCC2	IC50 = 148000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BI79FX	(8S,9S)-9-Amino-4-methyl-8-(2,4,5-trifluorophenyl)-9,10-dihydro-8H-pyrano[2,3-h]chromen-2-one	Investigative	134151020	C19H14F3NO3	361.3	CC1=CC(=O)OC2=C1C=CC3=C2C[C@@H]([C@@H](O3)C4=CC(=C(C=C4F)F)F)N	IC50 = 50860 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BI9O1C	1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-(3-oxopiperazino)xanthine	Investigative	101887269	C24H24N8O3	472.5	CC#CCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BIG1T8	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-hydroxy-2-methylquinoline-4-carboxamide	Investigative	71655556	C18H18N4O3	338.4	CC1=NC2=CC=CC=C2C(=C1O)C(=O)NCC(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BIHJ42	3-(2-Aminoethyl)-6-chloro-2-methyl-4-phenylisoquinolin-1-one;hydrochloride	Investigative	56676512	C18H18Cl2N2O	349.3	CN1C(=C(C2=C(C1=O)C=CC(=C2)Cl)C3=CC=CC=C3)CCN.Cl	IC50 = 87000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BIN9Y2	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]pyridine-4-carboxamide	Investigative	71667226	C13H14N4O2	258.279	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=NC=C2)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BJ1ZB7	(2S)-1-[(2S,4S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide	Investigative	46938602	C20H24N4O4	384.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3)C(=O)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BJ76NS	(2S,3R)-2-Amino-3-methyl-1-(5-methylisoindolin-2-yl)pentan-1-one	Investigative	44560596	C15H22N2O	246.35	CC[C@@H](C)[C@@H](C(=O)N1CC2=C(C1)C=C(C=C2)C)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BJFK14	(2S)-1-[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide	Investigative	16121107	C17H24N4O4	348.4	C[C@@H](C(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CC=C(C=C2)O)N	Ki = 170000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BJFL16	Ethyl caffeate	Investigative	5317238	C11H12O4	208.21	CCOC(=O)/C=C/C1=CC(=C(C=C1)O)O	IC50 = 87720 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BJH79B	1-[(2S,4S)-4-[4-(Morpholin-4-ylmethyl)triazol-1-yl]-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one	Investigative	71457240	C26H36N6O3	480.6	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CCCC3=CC=CC=C3)N4C=C(N=N4)CN5CCOCC5	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BJMX76	1-[6-[(3R)-3-Aminopyrrolidin-1-yl]pyridin-3-yl]-4-phenylmethoxypyridin-2-one	Investigative	24963343	C21H22N4O2	362.4	C1CN(C[C@@H]1N)C2=NC=C(C=C2)N3C=CC(=CC3=O)OCC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BJU7N1	Tyr-Pro-Ala	Investigative	16121199	C17H23N3O5	349.4	C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CC=C(C=C2)O)N	Ki = 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BJV7P3	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]naphthalene-2-carboxamide	Investigative	70691901	C18H17N3O2	307.3	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC3=CC=CC=C3C=C2)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BJXK70	(2S)-1-({(2S,4S)-4-[2-(1,3-Dihydro-2H-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile	Investigative	46893990	C20H22N4O3	366.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BK01XV	(2S,3R)-2-Amino-1-(4,6-dihydropyrrolo[3,4-c][1,2]oxazol-5-yl)-3-methylpentan-1-one;2,2,2-trifluoroacetic acid	Investigative	127046624	C13H18F3N3O4	337.29	CC[C@@H](C)[C@@H](C(=O)N1CC2=CON=C2C1)N.C(=O)(C(F)(F)F)O	IC50 = 56000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BK0Q2V	5-(Aminomethyl)-2-phenyl-6-[3-(trifluoromethyl)phenyl]pyrimidin-4-amine	Investigative	23645681	C18H15F3N4	344.3	C1=CC=C(C=C1)C2=NC(=C(C(=N2)N)CN)C3=CC(=CC=C3)C(F)(F)F	IC50 = 170000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BK47RM	(2S)-2-Amino-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid	Investigative	127047762	C28H29F5N6O4	608.6	C1CN(CCN1C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C(=O)C[C@@H](C(=O)N4CC5=C(C4)NN=C5)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BK4BH8	1-[2-(1-Isopropyl-2-methyl-propylamino)-acetyl]-pyrrolidine-2-carbonitrile	Investigative	11791652	C14H25N3O	251.37	CC(C)C(C(C)C)NCC(=O)N1CCC[C@H]1C#N	IC50 = 109000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BK6NP9	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-7-methylquinoline-4-carboxamide	Investigative	89705081	C18H18N4O2	322.4	CC1=CC2=NC=CC(=C2C=C1)C(=O)NCC(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BKA5O2	N'-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-N-[(4-fluorophenyl)methyl]butanediamide	Investigative	70691902	C18H21FN4O3	360.4	C1C[C@H](N(C1)C(=O)CNC(=O)CCC(=O)NCC2=CC=C(C=C2)F)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BKAX21	2-(2,6-Diisopropylphenyl)-5-hydroxyisoindoline-1,3-dione	Investigative	11723708	C20H21NO3	323.4	CC(C)C1=C(C(=CC=C1)C(C)C)N2C(=O)C3=C(C2=O)C=C(C=C3)O	IC50 = 65900 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BKCX95	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-1,2,3,4-tetrahydroacridine-9-carboxamide	Investigative	73347359	C21H22N4O2	362.4	C1CCC2=NC3=CC=CC=C3C(=C2C1)C(=O)NCC(=O)N4CCC[C@H]4C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BKTP80	(3S,5S)-3-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-5-(pyrrolidine-1-carbonyl)pyrrolidin-2-one	Investigative	46938802	C19H23N3O3	341.4	C1CCN(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BL82NA	1-[(4-Methoxyquinazolin-2-yl)methyl]-3,7-dimethyl-8-(3-oxopiperazin-1-yl)purine-2,6-dione	Investigative	122189876	C21H22N8O4	450.5	CN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)OC)C	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BLJ32T	(2S,3S)-2-Amino-1-(3-azidopyrrolidin-1-yl)-3-methylpentan-1-one	Investigative	10799226	C10H19N5O	225.29	CC[C@H](C)[C@@H](C(=O)N1CCC(C1)N=[N+]=[N-])N	IC50 = 107000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BLO83A	7-Bromo-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	71667378	C17H15BrN4O2	387.2	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C=CC(=CC3=NC=C2)Br)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BLUG68	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-methylquinoline-4-carboxamide	Investigative	71667081	C18H18N4O2	322.4	CC1=NC2=CC=CC=C2C(=C1)C(=O)NCC(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BLV01O	2-(S)-Amino-4-(3-chloro-benzylamino)-1-piperidin-1-yl-butan-1-one	Investigative	11404106	C16H24ClN3O	309.83	C1CCN(CC1)C(=O)[C@H](CCNCC2=CC(=CC=C2)Cl)N	IC50 = 186000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BM07BP	6-(Aminomethyl)-4-(2-fluorophenyl)-2-methylnicotinamide	Investigative	53324311	C14H14FN3O	259.279	CC1=NC(=CC(=C1C(=O)N)C2=CC=CC=C2F)CN	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BM4SN0	4-Amino-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]benzamide	Investigative	90655556	C14H16N4O2	272.3	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=C(C=C2)N)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BM6YD5	[(2R)-1-[(2R)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid	Investigative	9942554	C9H19BN2O3	214.07	B([C@@H]1CCCN1C(=O)[C@@H](C(C)C)N)(O)O	IC50 = 116000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BM8N1I	(3S)-3-Amino-4-(1,3-dihydroisoindol-2-yl)-N-(3-hydroxy-1-adamantyl)-4-oxobutanamide;hydrochloride	Investigative	56658137	C22H30ClN3O3	419.9	C1C2CC3(CC1CC(C2)(C3)O)NC(=O)C[C@@H](C(=O)N4CC5=CC=CC=C5C4)N.Cl	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BMA24I	N-[2-[(2S,4S)-2-Cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide	Investigative	66561555	C18H16FN3O2	325.3	C1[C@@H](CN([C@@H]1C#N)C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32)F	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BMGB04	(2S)-2-Amino-1-(1,3-dihydroisoindol-2-yl)-5-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]pentane-1,5-dione;2,2,2-trifluoroacetic acid	Investigative	56668672	C26H30F4N4O4	538.5	C1CN(CCN1CC2=CC=C(C=C2)F)C(=O)CC[C@@H](C(=O)N3CC4=CC=CC=C4C3)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BMOE12	4-Phenyl-1-[(2S,4S)-4-[4-(phenylmethoxymethyl)triazol-1-yl]-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]butan-1-one	Investigative	71457239	C29H35N5O3	501.6	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CCCC3=CC=CC=C3)N4C=C(N=N4)COCC5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BN07TD	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-methylbutanamide	Investigative	70681470	C12H19N3O2	237.3	CC(C)CC(=O)NCC(=O)N1CCC[C@H]1C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BN2B0U	2-Chloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]pyridine-4-carboxamide	Investigative	90655552	C13H13ClN4O2	292.72	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC(=NC=C2)Cl)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BN3A9U	2-Amino-3-hydroxy-1-pyrrolidin-1-yl-propan-1-one	Investigative	21949259	C7H14N2O2	158.2	C1CCN(C1)C(=O)C(CO)N	IC50 = 190000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BN67GJ	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-1H-pyrrolo[2,3-b]pyridine-4-carboxamide	Investigative	89705136	C15H15N5O2	297.31	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C=CNC3=NC=C2)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BN6W3U	(2S,4S)-4-(4-Chlorobenzylamino)-2-amino-1-(piperidin-1-yl)hexan-1-one	Investigative	44415905	C18H28ClN3O	337.9	CC[C@@H](C[C@@H](C(=O)N1CCCCC1)N)NCC2=CC=C(C=C2)Cl	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BN9WM6	2-[[7-But-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-2,6-dioxopurin-8-yl]amino]acetamide	Investigative	122189867	C22H22N8O3	446.5	CC#CCN1C2=C(N=C1NCC(=O)N)N(C(=O)N(C2=O)CC3=NC4=CC=CC=C4C(=N3)C)C	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BNCD53	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-4-(trifluoromethoxy)benzamide	Investigative	70696068	C15H14F3N3O3	341.28	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=C(C=C2)OC(F)(F)F)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BNH8A6	[(2R)-1-[(2S)-3-Methyl-2-(pyridine-3-carbonylamino)butanoyl]pyrrolidin-2-yl]boronic acid	Investigative	71655395	C15H22BN3O4	319.17	B([C@@H]1CCCN1C(=O)[C@H](C(C)C)NC(=O)C2=CN=CC=C2)(O)O	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BNM78Q	2-Bromo-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]pyridine-4-carboxamide	Investigative	90655553	C13H13BrN4O2	337.17	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC(=NC=C2)Br)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BNPH45	3-Amino-4-oxo-4-pyrrolidin-1-yl-butyramide	Investigative	9855673	C8H15N3O2	185.22	C1CCN(C1)C(=O)C(CC(=O)N)N	IC50 = 188000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BNW2R8	4-Phenyl-1-[(2S,4S)-4-(4-pyridin-2-yltriazol-1-yl)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]butan-1-one	Investigative	71459091	C26H30N6O2	458.6	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CCCC3=CC=CC=C3)N4C=C(N=N4)C5=CC=CC=N5	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BNZF78	(2-Cyclohexylidene-2-fluoroethyl)({[3-(trifluoromethyl)phenyl]methyl})amine	Investigative	23646095	C16H19F4N	301.32	C1CCC(=C(CNCC2=CC(=CC=C2)C(F)(F)F)F)CC1	IC50 ~ 125000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BO3K8F	(2s,4s)-1-({(2s,4s)-4-[2-(1,3-Dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)-4-fluoropyrrolidine-2-carbonitrile	Investigative	46917047	C20H21FN4O3	384.4	C1[C@@H](CN([C@@H]1C#N)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3)F	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BO3W0D	N-[1-[(2S)-2-Cyanopyrrolidine-1-carbonyl]cyclopropyl]quinoline-4-carboxamide	Investigative	90655539	C19H18N4O2	334.4	C1C[C@H](N(C1)C(=O)C2(CC2)NC(=O)C3=CC=NC4=CC=CC=C34)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BO4R1X	US9346814, Cmpd No 37 Example 42	Investigative	89704955	C10H12N6O2	248.24	C1C[C@H](N(C1)C(=O)CNC(=O)C2=NC=NN2)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BOA5S1	6-(Aminomethyl)-4-(2,4-dichlorophenyl)-2-methylnicotinamide	Investigative	53319951	C14H13Cl2N3O	310.2	CC1=NC(=CC(=C1C(=O)N)C2=C(C=C(C=C2)Cl)Cl)CN	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BOC90L	(2S,4S)-4-(4-Chlorobenzylamino)-2-amino-5-phenyl-1-(piperidin-1-yl)pentan-1-one	Investigative	44415930	C23H30ClN3O	400	C1CCN(CC1)C(=O)[C@H](C[C@H](CC2=CC=CC=C2)NCC3=CC=C(C=C3)Cl)N	IC50 ~ 125000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BOI3X9	(2S)-2-Amino-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(5-fluoro-1,3-dihydroisoindol-2-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid	Investigative	56675536	C31H30F6N4O4	636.6	C1CN(CCN1C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C(=O)C[C@@H](C(=O)N4CC5=C(C4)C=C(C=C5)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BON0V4	4-Amino-N-(2,6-dimethylphenyl)phthalimide	Investigative	124031	C16H14N2O2	266.29	CC1=C(C(=CC=C1)C)N2C(=O)C3=C(C2=O)C=C(C=C3)N	IC50 = 87900 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BP65UJ	(2S)-1-[2-(4-Phenyltriazol-1-yl)acetyl]pyrrolidine-2-carbonitrile	Investigative	90655548	C15H15N5O	281.31	C1C[C@H](N(C1)C(=O)CN2C=C(N=N2)C3=CC=CC=C3)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BP8NB6	(2S)-1-(2-Naphthalen-1-yloxyacetyl)pyrrolidine-2-carbonitrile	Investigative	73353424	C17H16N2O2	280.32	C1C[C@H](N(C1)C(=O)COC2=CC=CC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BPA24C	2-Amino-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]pyridine-4-carboxamide	Investigative	90655554	C13H15N5O2	273.29	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC(=NC=C2)N)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BPM60Y	2-(4-Chlorophenyl)-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]acetamide	Investigative	70685558	C15H16ClN3O2	305.76	C1C[C@H](N(C1)C(=O)CNC(=O)CC2=CC=C(C=C2)Cl)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BPQZ25	2-Amino-3-[2-(2-cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-2-methyl-propionic acid	Investigative	44326630	C11H18N4O3	254.29	CC(CNCC(=O)N1CCC[C@H]1C#N)(C(=O)O)N	IC50 = 109000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BPV7D2	1-(2,6-Diamino-hexanoyl)-piperidine-2-carbonitrile	Investigative	44364405	C12H22N4O	238.33	C1CCN(C(C1)C#N)C(=O)C(CCCCN)N	IC50 = 51000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BQ13ZS	1-[(2S,4R)-4-Azido-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one	Investigative	71450086	C19H25N5O2	355.4	C1CCN(C1)C(=O)[C@@H]2C[C@H](CN2C(=O)CCCC3=CC=CC=C3)N=[N+]=[N-]	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BQ3DE2	Tert-butyl 4-[1-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-2-oxoethyl]triazol-4-yl]piperazine-1-carboxylate	Investigative	70685560	C20H30N8O4	446.5	CC(C)(C)OC(=O)N1CCN(CC1)C2=CN(N=N2)CC(=O)NCC(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BQ4PJ9	(S)-3-Amino-4-oxo-4-(pyrrolidin-1-yl)butanamide	Investigative	11229192	C8H15N3O2	185.22	C1CCN(C1)C(=O)[C@H](CC(=O)N)N	IC50 = 188000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BQ4XT6	Benzyl (S)-5-amino-6-(1-(diphenoxyphosphoryl)isoindolin-2-yl)-6-oxohexylcarbam-ate	Investigative	44435315	C34H36N3O6P	613.6	C1C2=CC=CC=C2[C@H](N1C(=O)[C@H](CCCCN)NC(=O)OCC3=CC=CC=C3)P(=O)(OC4=CC=CC=C4)OC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BQ5T3M	5-(Aminomethyl)-N-(3,4-dichlorobenzyl)-4-(4-methoxyphenyl)-6-methylpicolinamide	Investigative	53326490	C22H21Cl2N3O2	430.3	CC1=C(C(=CC(=N1)C(=O)NCC2=CC(=C(C=C2)Cl)Cl)C3=CC=C(C=C3)OC)CN	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BQ7C0M	6-Chloro-3-(hydroxymethyl)-2-methyl-4-phenylisoquinolin-1-one	Investigative	22401333	C17H14ClNO2	299.7	CN1C(=C(C2=C(C1=O)C=CC(=C2)Cl)C3=CC=CC=C3)CO	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BQ7M5N	(2S)-1-[(2S,4S)-4-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile	Investigative	46938705	C21H24N4O3	380.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CCC4=CC=CC=C4C3)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BQ8H1L	N-[(4-Chlorophenyl)methyl]-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	90655542	C24H21ClN4O2	432.9	C1C[C@H](N(C1)C(=O)CN(CC2=CC=C(C=C2)Cl)C(=O)C3=CC=NC4=CC=CC=C34)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BQ94KU	(2S)-1-[{(2S,4S)-5-Oxo-4-(2-oxo-2-(piperidin-1-yl)ethyl)pyrrolidine-2-yl}carbonyl]pyrrolidine-2-carbonitrile	Investigative	46938799	C17H24N4O3	332.4	C1CCN(CC1)C(=O)C[C@@H]2C[C@H](NC2=O)C(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BQK9T2	(2S)-1-[(2S,4S)-4-[2-(5-Fluoro-1,3-dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile	Investigative	46916389	C20H21FN4O3	384.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=C(C3)C=C(C=C4)F)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BQP1J4	Ethyl 1-(3-(aminomethyl)-6-(4-chlorophenyl)-2-methylisonicotinoyl)piperidine-4-carboxylate	Investigative	53325197	C22H26ClN3O3	415.9	CCOC(=O)C1CCN(CC1)C(=O)C2=CC(=NC(=C2CN)C)C3=CC=C(C=C3)Cl	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BQU62W	US9346814, Ref. Cmpd No 2	Investigative	73224265	C18H17N3O2	307.3	C1CC(N(C1)C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BQUC03	5-Chloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	71655622	C17H15ClN4O2	342.8	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C(=NC=C2)C=CC=C3Cl)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BQYB16	(2S)-1-[2-[4-(4-Fluorophenyl)triazol-1-yl]acetyl]pyrrolidine-2-carbonitrile	Investigative	90655549	C15H14FN5O	299.3	C1C[C@H](N(C1)C(=O)CN2C=C(N=N2)C3=CC=C(C=C3)F)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BQZ4C8	(3S)-3-Amino-N-[1-[bis(4-fluorophenyl)methyl]pyrrolidin-3-yl]-4-(1,3-dihydroisoindol-2-yl)-4-oxobutanamide;hydrochloride	Investigative	56675278	C29H31ClF2N4O2	541	C1CN(CC1NC(=O)C[C@@H](C(=O)N2CC3=CC=CC=C3C2)N)C(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F.Cl	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BR3B2S	2-Amino-1-(3,6-dihydro-2H-pyridin-1-yl)-3-methyl-pentan-1-one	Investigative	44364213	C11H20N2O	196.29	CCC(C)C(C(=O)N1CCC=CC1)N	IC50 = 52000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BR9JX7	(S)-2-Amino-2-cyclohexyl-1-(3,4-dihydroisoquinolin-2(1H)-YL)ethanone	Investigative	23646027	C17H24N2O	272.4	C1CCC(CC1)[C@@H](C(=O)N2CCC3=CC=CC=C3C2)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BR9NL3	N-(2-Oxo-2-pyrrolidin-1-ylethyl)quinoline-4-carboxamide	Investigative	90655561	C16H17N3O2	283.32	C1CCN(C1)C(=O)CNC(=O)C2=CC=NC3=CC=CC=C23	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BRD03F	2-(Adamantan-1-ylamino)-1-piperidin-1-yl-ethanone	Investigative	11000330	C17H28N2O	276.4	C1CCN(CC1)C(=O)CNC23CC4CC(C2)CC(C4)C3	IC50 = 52600 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BRF0W5	3,4-Dihydro-1H-isoquinolin-2-yl-[(2S)-pyrrolidin-2-yl]methanone	Investigative	22691359	C14H18N2O	230.31	C1C[C@H](NC1)C(=O)N2CCC3=CC=CC=C3C2	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BRIK86	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-N-cyclopropylquinoline-4-carboxamide	Investigative	90655541	C20H20N4O2	348.4	C1C[C@H](N(C1)C(=O)CN(C2CC2)C(=O)C3=CC=NC4=CC=CC=C34)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BRK80C	1-[(2S,4S)-4-Azido-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one	Investigative	71455458	C19H25N5O2	355.4	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CCCC3=CC=CC=C3)N=[N+]=[N-]	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BRSX37	5-(Aminomethyl)-4-(4-methoxyphenyl)-6-methyl-N-(2-piperazin-1-ylethyl)pyridine-2-carboxamide	Investigative	53325196	C21H29N5O2	383.5	CC1=C(C(=CC(=N1)C(=O)NCCN2CCNCC2)C3=CC=C(C=C3)OC)CN	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BRX9K5	2,5-Diamino-1-thiazolidin-3-yl-pentan-1-one	Investigative	44364297	C8H17N3OS	203.31	C1CSCN1C(=O)C(CCCN)N	IC50 = 81000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BRXF01	1-(2-Pyridylmethyl)-3-methyl-7-(2-butynyl)-8-(3-oxopiperazino)xanthine	Investigative	101887279	C20H21N7O3	407.4	CC#CCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=CC=CC=N4)C	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BS0K5C	(2R,3S,4S,5R,6R)-2-(Hydroxymethyl)-6-[(5E)-3-hydroxytrideca-1,5-dien-7,9,11-triyn-4-yl]oxyoxane-3,4,5-triol	Investigative	118717416	C19H22O7	362.4	CC#CC#CC#C/C=C/C(C(C=C)O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BS3M7R	(2S,3S)-2-Amino-1-(3-chloropyrrolidin-1-yl)-3-methylpentan-1-one	Investigative	10751333	C10H19ClN2O	218.72	CC[C@H](C)[C@@H](C(=O)N1CCC(C1)Cl)N	IC50 = 94000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BS4K0Q	(3-(Aminomethyl)-6-(4-chlorophenyl)-2-methylpyridin-4-yl)(morpholino)methanone	Investigative	53318983	C18H20ClN3O2	345.8	CC1=C(C(=CC(=N1)C2=CC=C(C=C2)Cl)C(=O)N3CCOCC3)CN	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BS74YE	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-1,7-naphthyridine-4-carboxamide	Investigative	89705103	C16H15N5O2	309.32	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C=CN=CC3=NC=C2)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BS8H6I	(2S)-2-Amino-1-(1,3-dihydroisoindol-2-yl)-4-[4-[2,4,6-tri(propan-2-yl)phenyl]sulfonylpiperazin-1-yl]butane-1,4-dione;hydrochloride	Investigative	56659162	C31H45ClN4O4S	605.2	CC(C)C1=CC(=C(C(=C1)C(C)C)S(=O)(=O)N2CCN(CC2)C(=O)C[C@@H](C(=O)N3CC4=CC=CC=C4C3)N)C(C)C.Cl	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BS9Z1T	(2S)-2-Amino-4-(naphthalen-2-ylmethylamino)-1-piperidin-1-ylbutan-1-one	Investigative	11232605	C20H27N3O	325.4	C1CCN(CC1)C(=O)[C@H](CCNCC2=CC3=CC=CC=C3C=C2)N	IC50 = 179000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BSEC19	1-[(2S,4S)-4-[4-(4-Bromophenyl)triazol-1-yl]-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one	Investigative	71457238	C27H30BrN5O2	536.5	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CCCC3=CC=CC=C3)N4C=C(N=N4)C5=CC=C(C=C5)Br	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BSG5J2	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-N-methylquinoline-4-carboxamide	Investigative	90655540	C18H18N4O2	322.4	CN(CC(=O)N1CCC[C@H]1C#N)C(=O)C2=CC=NC3=CC=CC=C23	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BSK8E6	2-Amino-1-azetidin-1-yl-3-methyl-pentan-1-one	Investigative	9964212	C9H18N2O	170.25	CCC(C)C(C(=O)N1CCC1)N	IC50 = 50400 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BSQ63I	1-[(2s,4s)-4-[4-(4-Fluorophenyl)-1,2,3-Triazol-1-Yl]-2-Pyrrolidin-1-Ylcarbonyl-Pyrrolidin-1-Yl]-4-Phenyl-Butan-1-One	Investigative	70789754	C27H30FN5O2	475.6	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CCCC3=CC=CC=C3)N4C=C(N=N4)C5=CC=C(C=C5)F	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BST0E4	(S)-N-((R)-2-Amino-1-cyclohexylethyl)-2-cyanopyrrolidine-1-carboxamide	Investigative	44580499	C14H24N4O	264.37	C1CCC(CC1)[C@H](CN)NC(=O)N2CCC[C@H]2C#N	IC50 = 180000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BSV86X	N-[2-[(2S,4R)-4-Azido-2-cyanopyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide	Investigative	70691904	C18H16N6O2	348.4	C1[C@H](CN([C@@H]1C#N)C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32)N=[N+]=[N-]	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BT1C8X	(2S)-1-[(2S)-2-Amino-4-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-4-oxobutanoyl]pyrrolidine-2-carbonitrile	Investigative	23646026	C26H29F2N5O2	481.5	C1C[C@H](N(C1)C(=O)[C@H](CC(=O)N2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)N)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BT41RH	(2s)-1-({(2s,4s)-4-[2-[4-(Pyridine-4-yl)-piperazin-1-yl]-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile	Investigative	46916347	C21H26N6O3	410.5	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CCN(CC3)C4=CC=NC=C4)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BT57CX	N-(4-Quinolinoyl)glycyl-(2-cyanopyrrolidine)	Investigative	78140029	C17H16N4O2	308.33	C1CC(N(C1)C(=O)CNC(=O)C2=CC=NC3=CC=CC=C23)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BT5Y2N	(2S)-1-[2-[4-[3-(1,3-Dihydroisoindol-2-yl)-3-oxopropyl]triazol-1-yl]acetyl]pyrrolidine-2-carbonitrile	Investigative	90655550	C20H22N6O2	378.4	C1C[C@H](N(C1)C(=O)CN2C=C(N=N2)CCC(=O)N3CC4=CC=CC=C4C3)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BT78ZL	Benzyl (2S,4S)-2-(pyrrolidine-1-carbonyl)-4-(triazol-1-yl)pyrrolidine-1-carboxylate	Investigative	71460904	C19H23N5O3	369.4	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)OCC3=CC=CC=C3)N4C=CN=N4	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BT82FY	2-(S)-Amino-4-(2-chloro-benzylamino)-1-piperidin-1-yl-butan-1-one	Investigative	11232123	C16H24ClN3O	309.83	C1CCN(CC1)C(=O)[C@H](CCNCC2=CC=CC=C2Cl)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BT8BN9	(2S,3S)-2-Amino-1-(5-iodoisoindolin-2-yl)-3-methylpentan-1-one	Investigative	44560552	C14H19IN2O	358.22	CC[C@H](C)[C@@H](C(=O)N1CC2=C(C1)C=C(C=C2)I)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BT94PM	(2S)-2-Amino-2-phenyl-1-(1,2,3,4-tetrahydroisoquinolin-2-yl)ethan-1-one	Investigative	22691666	C17H18N2O	266.34	C1CN(CC2=CC=CC=C21)C(=O)[C@H](C3=CC=CC=C3)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BTB09O	1-[2-(Cyclohexyl-methyl-amino)-acetyl]-pyrrolidine-2-carbonitrile	Investigative	10911918	C14H23N3O	249.35	CN(CC(=O)N1CCC[C@H]1C#N)C2CCCCC2	IC50 = 103000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BTB85U	(4-Methoxy-1-phenylcyclohexyl)methanamine	Investigative	69089363	C14H21NO	219.32	COC1CCC(CC1)(CN)C2=CC=CC=C2	IC50 = 60000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BTI57H	5-(Aminomethyl)-N-cyclopropyl-4-(4-methoxyphenyl)-6-methylpicolinamide	Investigative	53319949	C18H21N3O2	311.4	CC1=C(C(=CC(=N1)C(=O)NC2CC2)C3=CC=C(C=C3)OC)CN	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BU75NX	CID 89704940	Investigative	89704940	C21H20N6O3	404.4	COC1=CC=C(C=C1)C2=NC3=NC=CC(=C3N2)C(=O)NCC(=O)N4CCC[C@H]4C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BUKI39	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-methoxybenzamide	Investigative	70681469	C15H17N3O3	287.31	COC1=CC=CC(=C1)C(=O)NCC(=O)N2CCC[C@H]2C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BURK19	[(2S)-1-[(2S,3As,7aS)-2,3,3a,4,5,6,7,7a-octahydro-1H-indole-2-carbonyl]pyrrolidin-2-yl]-thiophen-2-ylmethanone	Investigative	44453520	C18H24N2O2S	332.5	C1CC[C@H]2[C@@H](C1)C[C@H](N2)C(=O)N3CCC[C@H]3C(=O)C4=CC=CS4	IC50 = 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BUS98Z	(2S,3R)-2-Amino-1-(5-fluoroisoindolin-2-yl)-3-methylpentan-1-one	Investigative	24894026	C14H19FN2O	250.31	CC[C@@H](C)[C@@H](C(=O)N1CC2=C(C1)C=C(C=C2)F)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BUTA21	1-(4-Methoxyquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-(3-oxopiperazino)xanthine	Investigative	101887272	C24H24N8O4	488.5	CC#CCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)OC)C	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BV0F1D	(2S)-2-Amino-4-[(3S)-4-[bis(4-fluorophenyl)methyl]-3-methylpiperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid	Investigative	56671893	C32H33F5N4O4	632.6	C[C@H]1CN(CCN1C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C(=O)C[C@@H](C(=O)N4CC5=CC=CC=C5C4)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BV2EX8	US9346814, Ref Cmpd No 8	Investigative	78140062	C17H16N4O2	308.33	C1CC(N(C1)C(=O)CNC(=O)C2=CN=CC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BV2UR3	(2s)-1-({(2s,4s)-4-[2-(5-Chloro-1,3-dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile	Investigative	46938704	C20H21ClN4O3	400.9	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=C(C3)C=C(C=C4)Cl)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BVA8L1	Benzyl (2S,4S)-4-azido-2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate	Investigative	71459092	C17H21N5O3	343.4	C1CCN(C1)C(=O)[C@@H]2C[C@@H](CN2C(=O)OCC3=CC=CC=C3)N=[N+]=[N-]	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BVD9U0	(2S)-2-Amino-1-(1,3-dihydroisoindol-2-yl)-4-[4-(naphthalen-2-ylmethyl)piperazin-1-yl]butane-1,4-dione;dihydrochloride	Investigative	90664579	C27H32Cl2N4O2	515.5	C1CN(CCN1CC2=CC3=CC=CC=C3C=C2)C(=O)C[C@@H](C(=O)N4CC5=CC=CC=C5C4)N.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BVJ71I	(3R)-4-[(3S)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one	Investigative	23646447	C16H20F3N3O2	343.34	C[C@@H]1C(=O)NCCCN1C(=O)C[C@H](CC2=CC(=C(C=C2F)F)F)N	IC50 = 67000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BW14UT	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-cyclopentyloxy-4-methoxybenzamide	Investigative	70689750	C20H25N3O4	371.4	COC1=C(C=C(C=C1)C(=O)NCC(=O)N2CCC[C@H]2C#N)OC3CCCC3	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BW71JF	(2S)-2-Amino-1-(2-diphenoxyphosphorylpyrrolidin-1-yl)-3-methyl-butan-1-one	Investigative	11825584	C21H27N2O4P	402.4	CC(C)[C@@H](C(=O)N1CCCC1P(=O)(OC2=CC=CC=C2)OC3=CC=CC=C3)N	IC50 = 89000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BW8RC2	Ethyl 5,7-dihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2H-chromene-8-carboxylate	Investigative	76317994	C18H18O6	330.3	CCOC(=O)C1=C(C=C(C2=C1OC(CC2)C3=CC=C(C=C3)O)O)O	IC50 = 113760 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BWYJ26	2-Amino-3-hydroxy-1-piperidin-1-yl-propan-1-one	Investigative	21949272	C8H16N2O2	172.22	C1CCN(CC1)C(=O)C(CO)N	IC50 = 67000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BWZC31	7-But-2-ynyl-3-methyl-8-(3-oxopiperazin-1-yl)-1-(pyridin-4-ylmethyl)purine-2,6-dione	Investigative	122189873	C20H21N7O3	407.4	CC#CCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=CC=NC=C4)C	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BX3O0G	2-[4-[[4-[(3S)-3-Amino-4-(1,3-dihydroisoindol-2-yl)-4-oxobutanoyl]piperazin-1-yl]methyl]phenyl]benzonitrile	Investigative	53466049	C30H31N5O2	493.6	C1CN(CCN1CC2=CC=C(C=C2)C3=CC=CC=C3C#N)C(=O)C[C@@H](C(=O)N4CC5=CC=CC=C5C4)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BX4WD0	1-[(4-Methoxyquinazolin-2-yl)methyl]-3-methyl-7-(4-methylpent-3-enyl)-8-(3-oxopiperazin-1-yl)purine-2,6-dione	Investigative	122189878	C26H30N8O4	518.6	CC(=CCCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)OC)C)C	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BXA4O7	(2S)-2-Amino-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-[3-(trifluoromethyl)pyrrolidin-1-yl]butane-1,4-dione	Investigative	127048116	C26H29F5N4O2	524.5	C1CN(CC1C(F)(F)F)C(=O)[C@H](CC(=O)N2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BXMS65	2-Amino-3-methyl-pentanoic acid ethyl-methyl-amide	Investigative	23595882	C9H20N2O	172.27	CCC(C)C(C(=O)N(C)CC)N	IC50 = 167000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BXP65Y	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[2-(trifluoromethyl)-4H,5H,6H,7H-pyrido[3,4-d][1,3]thiazol-5-yl]butan-1-one	Investigative	11269712	C17H16F5N3OS	405.4	C1CN(CC2=C1SC(=N2)C(F)(F)F)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 = 95000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BXZ1N3	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-5-methoxyquinoline-4-carboxamide	Investigative	89705244	C18H18N4O3	338.4	COC1=CC=CC2=NC=CC(=C21)C(=O)NCC(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BY3J8M	(2S)-2-Amino-4-[(3R)-4-[bis(4-fluorophenyl)methyl]-3-methylpiperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid	Investigative	53474793	C32H33F5N4O4	632.6	C[C@@H]1CN(CCN1C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C(=O)C[C@@H](C(=O)N4CC5=CC=CC=C5C4)N.C(=O)(C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BY5QC9	(S)-N-(2-(2-Cyanopyrrolidine-1-yl)-2-oxoethyl)-5-phenylquinoline-4-carboxamide	Investigative	89704970	C23H20N4O2	384.4	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=NC3=CC=CC(=C23)C4=CC=CC=C4)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BY7FR1	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]isoquinoline-5-carboxamide	Investigative	71655626	C17H16N4O2	308.33	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=CC3=C2C=CN=C3)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BY90ZF	(3S)-2-[(2S)-2-Amino-2-cyclohexylacetyl]-3,4-dihydro-1H-isoquinoline-3-carbonitrile	Investigative	24784664	C18H23N3O	297.4	C1CCC(CC1)[C@@H](C(=O)N2CC3=CC=CC=C3C[C@H]2C#N)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BY93LZ	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-fluoro-2-(trifluoromethyl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797048	C17H18F8N2O3	450.32	C[C@@H](C1=C(C=C(C=C1)F)C(F)(F)F)[C@@H](C(=O)N2CC[C@@H](C2)F)N.C(=O)(C(F)(F)F)O	IC50 = 54000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BYH35Q	5-(Aminomethyl)-6-(3-methoxyphenyl)-2-phenylpyrimidin-4-amine	Investigative	22220623	C18H18N4O	306.4	COC1=CC=CC(=C1)C2=C(C(=NC(=N2)C3=CC=CC=C3)N)CN	IC50 = 80000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BYH49E	N-[2-[(2S)-2-Cyanopiperidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide	Investigative	70693956	C19H19N3O2	321.4	C1CCN([C@@H](C1)C#N)C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BYI91W	N-[2-[(2S)-2-Cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]benzamide	Investigative	66561556	C14H13F2N3O2	293.27	C1[C@H](N(CC1(F)F)C(=O)CNC(=O)C2=CC=CC=C2)C#N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BYM81T	(2S,3S)-2-Amino-1-(5-bromoisoindolin-2-yl)-3-methylpentan-1-one	Investigative	44560551	C14H19BrN2O	311.22	CC[C@H](C)[C@@H](C(=O)N1CC2=C(C1)C=C(C=C2)Br)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BZ7I3Q	(3-(Aminomethyl)-6-(4-methoxyphenyl)-2-methylpyridin-4-yl)(pyrrolidin-1-yl)methanone	Investigative	53317348	C19H23N3O2	325.4	CC1=C(C(=CC(=N1)C2=CC=C(C=C2)OC)C(=O)N3CCCC3)CN	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BZC1J3	N-((R)-1-((S)-2-Cyanopyrrolidine-1-yl)-1-oxopropan-2-yl)quinoline-4-carboxamide	Investigative	89705242	C18H18N4O2	322.4	C[C@H](C(=O)N1CCC[C@H]1C#N)NC(=O)C2=CC=NC3=CC=CC=C23	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BZCI06	N-[(3R)-1-[1-[(2-Cyanophenyl)methyl]-3-methyl-2-oxoimidazo[4,5-b]pyridin-7-yl]piperidin-3-yl]acetamide	Investigative	118712517	C22H24N6O2	404.5	CC(=O)N[C@@H]1CCCN(C1)C2=C3C(=NC=C2)N(C(=O)N3CC4=CC=CC=C4C#N)C	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BZI1R7	7-But-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-8-piperidin-1-ylpurine-2,6-dione	Investigative	89668929	C25H27N7O2	457.5	CC#CCN1C2=C(N=C1N3CCCCC3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	BZL0X4	1-(Aminomethyl)-6,7-dimethoxyisoquinoline-4-carboxamide;hydrochloride	Investigative	45259984	C13H16ClN3O3	297.74	COC1=C(C=C2C(=C1)C(=CN=C2CN)C(=O)N)OC.Cl	IC50 = 170000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	D02RDY	PMID15664838C18	Investigative	11375559	C29H30F2N4O2	504.6	C1CN(CCN1C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C(=O)CC(C(=O)N4CC5=CC=CC=C5C4)N	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	D03DNV	ARI-3099	Investigative	71655266	C13H18BN3O4	291.11	B([C@@H]1CCCN1C(=O)[C@@H](C)NC(=O)C2=CC=NC=C2)(O)O	IC50 ~ 100000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	D09ALJ	Rutin	Investigative	5280805	C27H30O16	610.5	C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O	IC50 = 145000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	D0AU0M	P-Coumaric Acid	Investigative	637542	C9H8O3	164.16	C1=CC(=CC=C1/C=C/C(=O)O)O	IC50 = 83180 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	D0CP1J	1G244	Investigative	56658139	C29H30F2N4O2	504.6	C1CN(CCN1C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C(=O)C[C@@H](C(=O)N4CC5=CC=CC=C5C4)N	IC50 ~ 50000 nM	Poor binder
T99041	HUMAN dipeptidyl peptidase 4	D0G3TK	KAEMPFEROL	Investigative	5280863	C15H10O6	286.24	C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O	IC50 = 132000 nM	Poor binder