Target Information

Target General Infomation
Target ID
T53892
Former ID
TTDI03463
Target Name
phosphomevalonate kinase
Gene Name
PMVK
Synonyms
PMVK
Target Type
Research
UniProt ID
Q15126
Sequence
MAPLGGAPRLVLLFSGKRKSGKDFVTEALQSRLGADVCAVLRLSGPLKEQYAQEHGLNFQ
RLLDTSTYKEAFRKDMIRWGEEKRQADPGFFCRKIVEGISQPIWLVSDTRRVSDIQWFRE
AYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHGVEQRLEEQ
LENLIEFIRSRL
Inhibitor (R)-5-diphosphomevalonate Drug Info [529070]
3-hydroxy-3-methyl-6-phosphohexanoic acid Drug Info [543907]
cinnamic acid Drug Info [531912]
isoferulic acid Drug Info [531912]
References
Ref 529070Functional evaluation of conserved basic residues in human phosphomevalonate kinase. Biochemistry. 2007 Oct 23;46(42):11780-8. Epub 2007 Sep 29.
Ref 531912Inhibition of rat liver mevalonate pyrophosphate decarboxylase and mevalonate phosphate kinase by phenyl and phenolic compounds. Biochem J. 1979 Jul 1;181(1):143-51.
Ref 543907(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 641).

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