Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06QYR
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| Former ID |
DIB020681
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| Drug Name |
PF-4800567
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| Synonyms |
PF4800567; PF 4800567
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| Drug Type |
Small molecular drug
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| Indication | Chronic lymphocytic leukaemia [ICD-11: 2A82.0; ICD-10: C83.0, C91.1] | Preclinical | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C17H18ClN5O2
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| Canonical SMILES |
C1COCCC1N2C3=NC=NC(=C3C(=N2)COC4=CC(=CC=C4)Cl)N
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| InChI |
1S/C17H18ClN5O2/c18-11-2-1-3-13(8-11)25-9-14-15-16(19)20-10-21-17(15)23(22-14)12-4-6-24-7-5-12/h1-3,8,10,12H,4-7,9H2,(H2,19,20,21)
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| InChIKey |
AUMDBEHGJRZSOO-UHFFFAOYSA-N
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| CAS Number |
CAS 1188296-52-7
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:87237
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Casein kinase I delta (CSNK1D) | Target Info | Inhibitor | [2] |
| Casein kinase I epsilon (CSNK1E) | Target Info | Inhibitor | [2] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Circadian rhythm as a therapeutic target. Nat Rev Drug Discov. 2021 Apr;20(4):287-307. | |||
| REF 2 | Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period. J Pharmacol Exp Ther. 2009 Aug;330(2):430-9. | |||
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