Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08EZR
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| Former ID |
DNC002831
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| Drug Name |
5-Iodouracil
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| Synonyms |
5-Iodouracil; 696-07-1; 5-iodopyrimidine-2,4(1H,3H)-dione; 2,4(1H,3H)-Pyrimidinedione, 5-iodo-; 5-iodopyrimidine-2,4-diol; Uracil, 5-iodo-; 2,4-Dihydroxy-5-iodopyrimidine; 5-iodo-1H-pyrimidine-2,4-dione; 5-iodo uracil; UNII-H59BRK500M; NSC 57848; CHEBI:43636; EINECS 211-788-2; CHEMBL1173; AI3-50390; H59BRK500M; KSNXJLQDQOIRIP-UHFFFAOYSA-N; 5-iodo-1,2,3,4-tetrahydropyrimidine-2,4-dione; NSC57848; MFCD00006020; 5-Iodouracil, 99%; 5-iodo-1,3-dihydropyrimidine-2,4-dione; IUR; 5909-21-7; 5-Iodo-uracil; 5- Iodouracil; zlchem 530
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C4H3IN2O2
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| Canonical SMILES |
C1=C(C(=O)NC(=O)N1)I
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| InChI |
1S/C4H3IN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
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| InChIKey |
KSNXJLQDQOIRIP-UHFFFAOYSA-N
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| CAS Number |
CAS 696-07-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
106724, 595839, 630496, 821031, 821038, 1582642, 3139702, 5830660, 5903128, 7868912, 7888491, 8193148, 15044327, 24888454, 43126129, 46507512, 46529921, 49834729, 50059616, 57317492, 77914273, 81065691, 85087021, 85245873, 87571594, 87793161, 88289968, 88802969, 92717671, 99583041, 103145466, 103158233, 103341945, 104016560, 104345590, 117511586, 117664335, 117773462, 117816393, 118068104, 124437990, 124550805, 125356313, 126581505, 126628772, 126653756, 126689959, 126738400, 127287426, 127287427
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| ChEBI ID |
CHEBI:43636
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dihydrothymine dehydrogenase (DPYD) | Target Info | Inhibitor | [1] |
| BioCyc | Pyrimidine ribonucleosides degradation | |||
| Thymine degradation | ||||
| Uracil degradation | ||||
| KEGG Pathway | Pyrimidine metabolism | |||
| beta-Alanine metabolism | ||||
| Pantothenate and CoA biosynthesis | ||||
| Drug metabolism - other enzymes | ||||
| Metabolic pathways | ||||
| Panther Pathway | Pyrimidine Metabolism | |||
| Pathwhiz Pathway | Beta-Alanine Metabolism | |||
| Pyrimidine Metabolism | ||||
| WikiPathways | Metabolism of nucleotides | |||
| Fluoropyrimidine Activity | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||
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