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| Target and Pathway |
Top |
| Target(s) |
cAMP-dependent chloride channel (CFTR) |
Target Info
|
Regulator |
[3] |
| References |
Top |
| REF 1 |
URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7481).
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| REF 2 |
ClinicalTrials.gov (NCT00865904) Study of VX-809 in Cystic Fibrosis Subjects With the 508-CFTR Gene Mutation. U.S. National Institutes of Health.
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| REF 3 |
A CFTR corrector (lumacaftor) and a CFTR potentiator (ivacaftor) for treatment of patients with cystic fibrosis who have a phe508del CFTR mutation: a phase 2 randomised controlled trial. Lancet Respir Med. 2014 Jul;2(7):527-38.
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