Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00CGX
|
|||
| Former ID |
DNCL001701
|
|||
| Drug Name |
DV-1179
|
|||
| Indication | Autoimmune disease [ICD-11: 4A40-4A45; ICD-9: 279] | Phase 1 | [1] | |
| Systemic lupus erythematosus [ICD-11: 4A40.0; ICD-9: 710] | Discontinued in Phase 1 | [2] | ||
| Company |
Dynavax Technologies
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Toll-like receptor 7 (TLR7) | Target Info | Modulator | [3] |
| Toll-like receptor 9 (TLR9) | Target Info | Modulator | [3] | |
| KEGG Pathway | Toll-like receptor signaling pathway | |||
| Chagas disease (American trypanosomiasis) | ||||
| African trypanosomiasis | ||||
| Malaria | ||||
| Tuberculosis | ||||
| Measles | ||||
| Herpes simplex infection | ||||
| Influenza A | ||||
| NetPath Pathway | BCR Signaling Pathway | |||
| TCR Signaling Pathway | ||||
| Panther Pathway | Toll receptor signaling pathway | |||
| Reactome | PI3K Cascade | |||
| Trafficking and processing of endosomal TLR | ||||
| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | ||||
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | ||||
| MyD88 dependent cascade initiated on endosome | ||||
| WikiPathways | Toll-like receptor signaling pathway | |||
| Toll-Like Receptors Cascades | ||||
| MyD88 dependent cascade initiated on endosome | ||||
| Trafficking and processing of endosomal TLR | ||||
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | ||||
| Regulation of toll-like receptor signaling pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800035150) | |||
| REF 3 | Company report (Dynavax) | |||
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