Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04OWX
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| Former ID |
DNC006836
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| Drug Name |
1-(cyclopropyl)methyl-5'-O-tritylinosine
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| Synonyms |
CHEMBL379981; BDBM50194179
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C33H32N4O5
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| Canonical SMILES |
C1CC1CN2C=NC3=C(C2=O)N=CN3C4C(C(C(O4)COC(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)O)O
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| InChI |
1S/C33H32N4O5/c38-28-26(42-32(29(28)39)37-21-34-27-30(37)35-20-36(31(27)40)18-22-16-17-22)19-41-33(23-10-4-1-5-11-23,24-12-6-2-7-13-24)25-14-8-3-9-15-25/h1-15,20-22,26,28-29,32,38-39H,16-19H2/t26-,28-,29-,32-/m1/s1
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| InChIKey |
UTXUWUTZGDAURC-DWCTZGTLSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Thymidine phosphorylase (TYMP) | Target Info | Inhibitor | [1] |
| BioCyc | Pyrimidine deoxyribonucleosides degradation | |||
| KEGG Pathway | Pyrimidine metabolism | |||
| Drug metabolism - other enzymes | ||||
| Metabolic pathways | ||||
| Bladder cancer | ||||
| NetPath Pathway | TSH Signaling Pathway | |||
| Pathwhiz Pathway | Pyrimidine Metabolism | |||
| WikiPathways | Bladder Cancer | |||
| Metabolism of nucleotides | ||||
| Fluoropyrimidine Activity | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 5'-O-tritylinosine and analogues as allosteric inhibitors of human thymidine phosphorylase. J Med Chem. 2006 Sep 7;49(18):5562-70. | |||
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