Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06BMN
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| Former ID |
DNC006837
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| Drug Name |
1-allyl-5'-O-tritylinosine
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| Synonyms |
CHEMBL213891; 1-allyl-5''-O-tritylinosine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C32H30N4O5
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| Canonical SMILES |
C=CCN1C=NC2=C(C1=O)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)O)O
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| InChI |
1S/C32H30N4O5/c1-2-18-35-20-34-29-26(30(35)39)33-21-36(29)31-28(38)27(37)25(41-31)19-40-32(22-12-6-3-7-13-22,23-14-8-4-9-15-23)24-16-10-5-11-17-24/h2-17,20-21,25,27-28,31,37-38H,1,18-19H2/t25-,27-,28-,31-/m1/s1
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| InChIKey |
WUKAFOPIIOGNJA-QWOIFIOOSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Thymidine phosphorylase (TYMP) | Target Info | Inhibitor | [1] |
| BioCyc | Pyrimidine deoxyribonucleosides degradation | |||
| KEGG Pathway | Pyrimidine metabolism | |||
| Drug metabolism - other enzymes | ||||
| Metabolic pathways | ||||
| Bladder cancer | ||||
| NetPath Pathway | TSH Signaling Pathway | |||
| Pathwhiz Pathway | Pyrimidine Metabolism | |||
| WikiPathways | Bladder Cancer | |||
| Metabolism of nucleotides | ||||
| Fluoropyrimidine Activity | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 5'-O-tritylinosine and analogues as allosteric inhibitors of human thymidine phosphorylase. J Med Chem. 2006 Sep 7;49(18):5562-70. | |||
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