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| Interaction between the Drug and Microbe |
Top |
| The Metabolism of Drug Affected by Studied Microbe(s) |
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota |
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Studied Microbe: Gut microbiota unspecific
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[3] |
| Metabolic Reaction |
Reduction |
| Experimental Method |
High-throughput screening |
| Description |
Methylprednisolone can be metabolized by gut microbiota through reduction. |
| Target and Pathway |
Top |
| Target(s) |
Glucocorticoid receptor (NR3C1) |
Target Info
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Modulator |
[4] |
| References |
Top |
| REF 1 |
Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
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| REF 2 |
URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7088).
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| REF 3 |
Personalized Mapping of Drug Metabolism by the Human Gut Microbiome. Cell. 2020 Jun 25;181(7):1661-1679.e22.
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| REF 4 |
Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
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