Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D09TBA
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| Former ID |
DNC007874
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| Drug Name |
5-benzyl-6-chloropyrimidine-2,4(1H,3H)-dione
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| Synonyms |
5-benzyl-6-chloropyrimidine-2,4(1H,3H)-dione; 18493-82-8; Oprea1_007440; SCHEMBL2672214; CHEMBL394673; BDBM20060; LWRITIARHSTBLU-UHFFFAOYSA-N; 5-Substituted-6-chlorouracil, 5g; 5-benzyl-6-chloro-1H-pyrimidine-2,4-dione; SR-01000516321; SR-01000516321-1
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C11H9ClN2O2
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| Canonical SMILES |
C1=CC=C(C=C1)CC2=C(NC(=O)NC2=O)Cl
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| InChI |
1S/C11H9ClN2O2/c12-9-8(10(15)14-11(16)13-9)6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,13,14,15,16)
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| InChIKey |
LWRITIARHSTBLU-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Thymidine phosphorylase (TYMP) | Target Info | Inhibitor | [1] |
| BioCyc | Pyrimidine deoxyribonucleosides degradation | |||
| KEGG Pathway | Pyrimidine metabolism | |||
| Drug metabolism - other enzymes | ||||
| Metabolic pathways | ||||
| Bladder cancer | ||||
| NetPath Pathway | TSH Signaling Pathway | |||
| Pathwhiz Pathway | Pyrimidine Metabolism | |||
| WikiPathways | Bladder Cancer | |||
| Metabolism of nucleotides | ||||
| Fluoropyrimidine Activity | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. J Med Chem. 2007 Nov 29;50(24):6016-23. | |||
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