Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0RE9X
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| Former ID |
DNC007878
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| Drug Name |
5-butyl-6-chloropyrimidine-2,4(1H,3H)-dione
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| Synonyms |
5-butyl-6-chloropyrimidine-2,4(1H,3H)-dione; 18493-80-6; CHEMBL237996; BDBM20056; 5-Substituted-6-chlorouracil, 5c
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C8H11ClN2O2
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| Canonical SMILES |
CCCCC1=C(NC(=O)NC1=O)Cl
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| InChI |
1S/C8H11ClN2O2/c1-2-3-4-5-6(9)10-8(13)11-7(5)12/h2-4H2,1H3,(H2,10,11,12,13)
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| InChIKey |
CYNWJDGCUODOPW-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Thymidine phosphorylase (TYMP) | Target Info | Inhibitor | [1] |
| BioCyc | Pyrimidine deoxyribonucleosides degradation | |||
| KEGG Pathway | Pyrimidine metabolism | |||
| Drug metabolism - other enzymes | ||||
| Metabolic pathways | ||||
| Bladder cancer | ||||
| NetPath Pathway | TSH Signaling Pathway | |||
| Pathwhiz Pathway | Pyrimidine Metabolism | |||
| WikiPathways | Bladder Cancer | |||
| Metabolism of nucleotides | ||||
| Fluoropyrimidine Activity | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. J Med Chem. 2007 Nov 29;50(24):6016-23. | |||
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