Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0TA4A
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| Former ID |
DIB018000
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| Drug Name |
GLPG0974
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| Synonyms |
compound 99 [PMID 25380412]
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| Drug Type |
Small molecular drug
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| Indication | Abortion [ICD-11: JA00; ICD-9: 779.6] | Phase 2 | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C25H25ClN2O4S
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| Canonical SMILES |
CC1(CCN1C(=O)C2=CSC3=CC=CC=C32)C(=O)N(CCCC(=O)O)CC4=CC(=CC=C4)Cl
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| InChI |
1S/C25H25ClN2O4S/c1-25(11-13-28(25)23(31)20-16-33-21-9-3-2-8-19(20)21)24(32)27(12-5-10-22(29)30)15-17-6-4-7-18(26)14-17/h2-4,6-9,14,16H,5,10-13,15H2,1H3,(H,29,30)/t25-/m1/s1
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| InChIKey |
MPMKMQHJHDHPBE-RUZDIDTESA-N
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| CAS Number |
CAS 1391076-61-1
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Free fatty acid receptor 2 (FFAR2) | Target Info | Antagonist | [2] |
| KEGG Pathway | cAMP signaling pathway | |||
| Reactome | G alpha (q) signalling events | |||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8417). | |||
| REF 2 | Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic. J Med Chem. 2014 Dec 11;57(23):10044-57. | |||
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