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| Target and Pathway |
Top |
| Target(s) |
Nicotinamide phosphoribosyltransferase (NAMPT) |
Target Info
|
Modulator |
[1], [2] |
| References |
Top |
| REF 1 |
The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-... Mol Cell Biol. 2009 Nov;29(21):5872-88.
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| REF 2 |
Synergy between the NAMPT inhibitor GMX1777(8) and pemetrexed in non-small cell lung cancer cells is mediated by PARP activation and enhanced NAD consumption.Cancer Res.2014 Nov 1;74(21):5948-54.
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