Drug Information
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Alistipes indistinctus DSM22520
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Alistipes indistinctus DSM22520 (log2FC = -8.474; p = 0.006). | |||
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Studied Microbe: Bacteroides caccae ATCC 43185
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides caccae ATCC 43185 (log2FC = -4.603; p = 0.003). | |||
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Studied Microbe: Bacteroides cellulosilyticus DSM 14838
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides cellulosilyticus DSM 14838 (log2FC = -8.405; p = 0.012). | |||
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Studied Microbe: Bacteroides coprophilus DSM 18228
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides coprophilus DSM 18228 (log2FC = -0.409; p = 0.009). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -9.84; p = 0.006). | |||
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Studied Microbe: Bacteroides eggerthii DSM20697
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides eggerthii DSM20697 (log2FC = -3.022; p = 0.0). | |||
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Studied Microbe: Bacteroides finegoldii DSM17565
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides finegoldii DSM17565 (log2FC = -1.744; p = 0.002). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -4.097; p = 0.002). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -2.818; p = 0.003). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -2.942; p = 0.006). | |||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -2.783; p = 0.016). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -3.783; p = 0.005). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -3.872; p = 0.002). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -4.353; p = 0.004). | |||
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Studied Microbe: Bacteroides intestinalis DSM 17393
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides intestinalis DSM 17393 (log2FC = -2.919; p = 0.0). | |||
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Studied Microbe: Bacteroides ovatus ATCC 8483
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides ovatus ATCC 8483 (log2FC = -6.893; p = 0.021). | |||
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Studied Microbe: Bacteroides stercoris ATCC 43183
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides stercoris ATCC 43183 (log2FC = -1.153; p = 0.007). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 3731
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -4.639; p = 0.001). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -3.397; p = 0.0). | |||
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Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -4.096; p = 0.006). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -7.225; p = 0.008). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -8.199; p = 0.01). | |||
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Studied Microbe: Bacteroides WH2
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides WH2 (log2FC = -7.95; p = 0.007). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -8.331; p = 0.007). | |||
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Studied Microbe: Odoribacter splanchnicus
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Odoribacter splanchnicus (log2FC = -1.791; p = 0.003). | |||
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Studied Microbe: Parabacteroides distasonis ATCC 8503
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -1.957; p = 0.0). | |||
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Studied Microbe: Parabacteroides johnsonii DSM 18315
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Parabacteroides johnsonii DSM 18315 (log2FC = -2.635; p = 0.006). | |||
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Studied Microbe: Parabacteroides merdae ATCC 43184
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Parabacteroides merdae ATCC 43184 (log2FC = -1.383; p = 0.005). | |||
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Studied Microbe: Pretovella copri DSM 18205
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Pretovella copri DSM 18205 (log2FC = -6.857; p = 0.049). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium longum subsp. Infantis CCUG52486
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bifidobacterium longum subsp. Infantis CCUG52486 (log2FC = -1.998; p = 0.0). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Victivallales | ||||
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Studied Microbe: Victivallis vadensis ATCC BAA-548
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Victivallis vadensis ATCC BAA-548 (log2FC = -6.554; p = 0.002). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
| Studied Microbe: Gut microbiota unspecific | [3] | |||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by gut microbiota. | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Herpes simplex virus DNA polymerase UL30 (HSV UL30) | Target Info | Inhibitor | [4] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 2 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 3 | Personalized Mapping of Drug Metabolism by the Human Gut Microbiome. Cell. 2020 Jun 25;181(7):1661-1679.e22. | |||
| REF 4 | Penciclovir cream--improved topical treatment for herpes simplex infections. Skin Pharmacol Physiol. 2004 Sep-Oct;17(5):214-8. | |||
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