Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0X5RA
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| Former ID |
DNC005614
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| Drug Name |
6-amino-5-bromouracil
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| Synonyms |
6312-73-8; 5-Bromo-6-aminouracil; 6-Amino-5-bromouracil; 6-Amino-5-bromopyrimidine-2,4(1H,3H)-dione; 6-Amino-5-bromo-1H-pyrimidine-2,4-dione; 6-amino-5-bromo-1,2,3,4-tetrahydropyrimidine-2,4-dione; CHEMBL64909; 6-amino-5-bromopyrimidine-2,4-diol; 6-amino-5-bromo-2,4(1H,3H)-pyrimidinedione; 6-amino-5-bromo-1,3-dihydropyrimidine-2,4-dione; NSC40394; EINECS 228-638-7; NSC 27652; NSC 40394; AC1Q24DM; AC1Q50HI; AC1L2ZP9; SCHEMBL2894070; CTK5B7686; KS-00001QBO; DTXSID60212460; MolPort-000-873-593; FSLBEEVCUZFKRL-UHFFFAOYSA-N
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C4H4BrN3O2
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| Canonical SMILES |
C1(=C(NC(=O)NC1=O)N)Br
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| InChI |
1S/C4H4BrN3O2/c5-1-2(6)7-4(10)8-3(1)9/h(H4,6,7,8,9,10)
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| InChIKey |
FSLBEEVCUZFKRL-UHFFFAOYSA-N
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| CAS Number |
CAS 6312-73-8
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Thymidine phosphorylase (TYMP) | Target Info | Inhibitor | [1] |
| BioCyc | Pyrimidine deoxyribonucleosides degradation | |||
| KEGG Pathway | Pyrimidine metabolism | |||
| Drug metabolism - other enzymes | ||||
| Metabolic pathways | ||||
| Bladder cancer | ||||
| NetPath Pathway | TSH Signaling Pathway | |||
| Pathwhiz Pathway | Pyrimidine Metabolism | |||
| WikiPathways | Bladder Cancer | |||
| Metabolism of nucleotides | ||||
| Fluoropyrimidine Activity | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors. Eur J Med Chem. 2008 Jun;43(6):1248-60. | |||
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