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Target and Pathway |
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Target(s) |
Aggrecanase (ADAMTS5) |
Target Info
|
Inhibitor |
[1] |
Aggrecanase-1 (ADAMTS4) |
Target Info
|
Inhibitor |
[1] |
Matrix metalloproteinase-1 (MMP-1) |
Target Info
|
Inhibitor |
[2] |
Matrix metalloproteinase-2 (MMP-2) |
Target Info
|
Inhibitor |
[2] |
Matrix metalloproteinase-3 (MMP-3) |
Target Info
|
Inhibitor |
[3] |
Matrix metalloproteinase-7 (MMP-7) |
Target Info
|
Inhibitor |
[2] |
Matrix metalloproteinase-8 (MMP-8) |
Target Info
|
Inhibitor |
[1] |
Matrix metalloproteinase-9 (MMP-9) |
Target Info
|
Inhibitor |
[1] |
References |
Top |
REF 1 |
Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivati... J Med Chem. 2001 Oct 11;44(21):3347-50.
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REF 2 |
A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers. J Med Chem. 2003 Jul 31;46(16):3514-25.
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REF 3 |
Amide surrogates of matrix metalloproteinase inhibitors: Urea and sulfonamide mimics, Bioorg. Med. Chem. Lett. 7(18):2331-2336 (1997).
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