Drug Information
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides coprophilus DSM 18228
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Glipizide can be metabolized by Bacteroides coprophilus DSM 18228 (log2FC = -0.335; p = 0.019). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Glipizide can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -0.778; p = 0.022). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Glipizide can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -0.801; p = 0.016). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Glipizide can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -0.77; p = 0.011). | |||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Glipizide can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -0.751; p = 0.035). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Glipizide can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -0.62; p = 0.019). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Glipizide can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -0.693; p = 0.03). | |||
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Studied Microbe: Odoribacter splanchnicus
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Glipizide can be metabolized by Odoribacter splanchnicus (log2FC = -0.555; p = 0.03). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Eubacterium biforme DSM 3989
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Glipizide can be metabolized by Eubacterium biforme DSM 3989 (log2FC = -0.461; p = 0.027). | |||
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides eggerthii
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Bacteroides eggerthii was increased by Glipizide (pre abundance: 1.56E-02; post abundance: 9.04E-03; p = 3.82E-02; q = 9.70E-01). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Veillonellales | ||||
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Studied Microbe: Megasphaera elsdenii
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Megasphaera elsdenii was decreased by Glipizide (pre abundance: 6.43E-04; post abundance: 2.93E-04; p = 1.43E-02; q = 9.70E-01). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Inward rectifier potassium channel Kir1.2 (KCNJ10) | Target Info | Blocker | [5] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6821). | |||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 074223. | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 4 | Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment. Nat Commun. 2017 Nov 27;8(1):1785. | |||
| REF 5 | Triggering and amplification of insulin secretion by dimethyl alpha-ketoglutarate, a membrane permeable alpha-ketoglutarate analogue. Eur J Pharmacol. 2009 Apr 1;607(1-3):41-6. | |||
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