Drug Information
Interaction between the Drug and Microbe | Top | |||
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The Metabolism of Drug Affected by Studied Microbe(s) | ||||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
Studied Microbe: Anaerobic bacterium unspecific | [3], [4] | |||
Metabolic Reaction | Sulfoxide reduction | |||
Resulting Metabolite | Sulindac sulfide; sulinpyrzone sulfide | |||
Metabolic Effect | Increase activity | |||
Description | Sulindac can be metabolized to Sulindac sulfide and sulinpyrzone sulfide by unspecific Anaerobic bacterium through sulfoxide reduction, which results in the increase of the drug's activity. | |||
Studied Microbe: Gut microbiota unspecific | [3], [4], [5], [6] | |||
Metabolic Reaction | Sulfur oxidation | |||
Resulting Metabolite | Sulindac sulfide; sulinpyrzone sulfide | |||
Metabolic Effect | Increase activity; Increase side effect | |||
Description | Sulindac can be metabolized to Sulindac sulfide and sulinpyrzone sulfide by gut microbiota through sulfur oxidation , which results in the increase of drug's activity and side effect. |
Target and Pathway | Top | |||
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Target(s) | Aldose reductase (AKR1B1) | Target Info | Inhibitor | [7], [8] |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5425). | |||
REF 2 | New drugs in development for the treatment of endometriosis. Expert Opin Investig Drugs. 2008 Aug;17(8):1187-202. | |||
REF 3 | The influence of gut microbiota on drug metabolism and toxicity. Expert Opin Drug Metab Toxicol. 2016;12(1):31-40. | |||
REF 4 | Faecal microflora and beta-glucuronidase expression are altered in an irinotecan-induced diarrhea model in rats. Cancer Biol Ther. 2008 Dec;7(12):1919-25. | |||
REF 5 | The effect of gut microbiota on drug metabolism. Expert Opin Drug Metab Toxicol. 2013 Oct;9(10):1295-308. | |||
REF 6 | Personalized Mapping of Drug Metabolism by the Human Gut Microbiome. Cell. 2020 Jun 25;181(7):1661-1679.e22. | |||
REF 7 | Inhibition of human lens aldose reductase by flavonoids, sulindac and indomethacin. Biochem Pharmacol. 1983 Jul 1;32(13):1995-8. | |||
REF 8 | Diabetic complications in lens and nerve and their prevention by sulindac or sorbinil: two novel aldose reductase inhibitors. Invest Ophthalmol Vis Sci. 1983 Oct;24(10):1426-9. |
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