Target expression details

Target's General Information
Target ID T87686
Target Name Histone-lysine N-methyltransferase (HLNM)
Synonyms Lysine N-methyltransferase 4; KMT4; KIAA1814; Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone H3-K79 methyltransferase; H3-K79-HMTase; DOT1-like protein
Target Type Clinical trial
Gene Name DOT1L
Biochemical Class Methyltransferase
UniProt ID DOT1L_HUMAN
Target's Expression Profile in Disease Related Tissue between Patients and Normal People
Disease Acute myelocytic leukemia
Example drug EPZ-5676 Phase 1 [1], [2], [3], [4]
Tissue Bone marrow
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.08
Z-score: 0.2
P-value: 7.62E-02
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data in the tissue of healthy individual
Target's Expression Profile across Various Tissues of Healthy Individual
Download the Expression Profile
References
REF 1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7019).
REF 2 ClinicalTrials.gov (NCT02141828) Dose Escalation Study of EPZ-5676 in Pediatric Patients With Leukemias Bearing a Rearrangement of the MLL Gene. U.S. National Institutes of Health.
REF 3 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
REF 4 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5.

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