Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T83585 Target Info
Target Name Wiskott-Aldrich syndrome protein (WAS)
Synonyms WASp; IMD2
Target Type Clinical trial Target
Gene Name WAS
UniProt ID
WASP_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: (S)-Wiskostatin Ligand Info
Structure Description Solution structure of the Wiskott-Aldrich Syndrome Protein (WASP) autoinhibited core domain complexed with (S)-wiskostatin, a small molecule inhibitor PDB:1T84
Method Solution NMR Resolution N.A. Mutation No [1]
PDB Sequence
SGFKHVSHVG
10
WDPQNGFDVN
20
NLDPDLRSLF
30
SRAGISEAQL
40
TDAETSKLIY
50

DFIEDQGGLE
60
AVRQEMRRQG
70
GSGGSQSSEG
80
LVGALMHVMQ
90
KRSRAIHSSD
100

EGEDQAG
Residue
Distance (Å)
LYS4
4.407
VAL6
1.604
HIS8
2.474
VAL9
1.640
GLY10
2.486
TRP11
2.352
PHE17
3.127
PHE30
4.795
SER46
3.679
ILE49
4.217
TYR50
1.803
Residue
Distance (Å)
ASP51
3.738
PHE52
4.221
ILE53
2.349
GLU54
1.620
ASP55
4.388
GLY57
2.751
GLY58
1.877
LEU59
2.474
GLU60
2.497
ALA61
4.574
References  Top
REF 1 Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nat Struct Mol Biol. 2004 Aug;11(8):747-55.

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