Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T00933 Target Info
Target Name Histone lysine demethylase PHF8 (PHF8)
Synonyms ZNF422; PHD finger protein 8; KIAA1111
Target Type Literature-reported Target
Gene Name PHF8
Biochemical Class Paired donor oxygen oxidoreductase
UniProt ID
PHF8_HUMAN 
Target Interacting Proteins  Top
Histones [+] 1 Histones +
Interacting Protein Name Histone H3.1 (H31) Interacting Protein Interacting Protein Info
UniProt ID
H31_HUMAN 
Synonyms H3/A; H3FA
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [2]
3 Biochemical Activity [1]
4 Biochemical Activity [3]
5 Biochemical Activity [4]
6 Biochemical Activity [5]
7 Biochemical Activity [6]
8 Reconstituted Complex [3]
9 Reconstituted Complex [1]
10 Reconstituted Complex [6]
References  Top
REF 1 The X-linked mental retardation gene PHF8 is a histone demethylase involved in neuronal differentiation. Cell Res. 2010 Aug;20(8):908-18.
REF 2 PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation. Nat Struct Mol Biol. 2010 Apr;17(4):445-50.
REF 3 A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation. Mol Cell. 2010 Apr 23;38(2):165-78.
REF 4 Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development. Nature. 2010 Jul 22;466(7305):503-7.
REF 5 PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis. Cell Res. 2010 Jul;20(7):794-801.
REF 6 PHF8 targets histone methylation and RNA polymerase II to activate transcription. Mol Cell Biol. 2010 Jul;30(13):3286-98.

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