Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T01851 | Target Info | |||
| Target Name | Integrin beta-1 (ITGB1) | ||||
| Synonyms | VLA-4 subunit beta; MSK12; MDF2; Integrin VLA-4 beta subunit; Glycoprotein IIa; GPIIA; Fibronectin receptor subunit beta; Fibronectin receptor beta subunit; FNRB; CD29 antigen; CD29; Beta(1) integrin | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | ITGB1 | ||||
| Biochemical Class | Integrin | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Auxiliary transporters | [+] 1 Auxiliary transporters | + | |||
| Interacting Target Name | Integrin alpha-V (ITGAV) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | VTNR; VNRA; Vitronectin receptor subunit alpha; Vitronectin receptor alpha subunit; Vitronectin receptor; MSK8; CD51 antigen; CD51 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Co-fractionation | [1] | |||
| 2 | Co-localization | [2] | |||
| Integrins | [+] 1 Integrins | + | |||
| Interacting Target Name | Integrin alpha-5 (ITGA5) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | VLA-5; Integrin alpha-F; Integrin alpha-5 light chain; Integrin alpha-5 heavy chain; FNRA; Fibronectin receptor subunit alpha; CD49e antigen; CD49e; CD49 antigen-like family member E | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [3] | |||
| 2 | Co-fractionation | [1] | |||
| Other proteins | [+] 2 Other proteins | + | |||
| Interacting Target Name | Fibronectin (FN1) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Ugl-Y3; Ugl-Y2; Ugl-Y1; FN; Cold-insoluble globulin; CIG | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [4] | |||
| 2 | Affinity Capture-Western | [4] | |||
| 3 | Reconstituted Complex | [5] | |||
| Interacting Target Name | Angiopoietin-2 (ANGPT2) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | ANG-2 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [6] | |||
| 2 | Reconstituted Complex | [7] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44. | ||||
| REF 2 | COMP-Ang1 Potentiates EPC Treatment of Ischemic Brain Injury by Enhancing Angiogenesis Through Activating AKT-mTOR Pathway and Promoting Vascular Migration Through Activating Tie2-FAK Pathway. Exp Neurobiol. 2015 Mar;24(1):55-70. | ||||
| REF 3 | Ubiquitination of alpha 5 beta 1 integrin controls fibroblast migration through lysosomal degradation of fibronectin-integrin complexes. Dev Cell. 2010 Jul 20;19(1):148-59. | ||||
| REF 4 | Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Sci Signal. 2009 Sep 8;2(87):ra51. | ||||
| REF 5 | Interplay of Endosomal pH and Ligand Occupancy in Integrin 51Ubiquitination, Endocytic Sorting, and Cell Migration. Cell Rep. 2015 Oct 20;13(3):599-609. | ||||
| REF 6 | Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the alphavbeta1 integrin and focal adhesion kinase signaling pathway. Cancer Res. 2006 Jan 15;66(2):775-83. | ||||
| REF 7 | Gln-362 of angiopoietin-2 mediates migration of tumor and endothelial cells through association with 51 integrin. J Biol Chem. 2014 Nov 7;289(45):31330-40. | ||||
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