Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T07766 | Target Info | |||
| Target Name | PAK-2 protein kinase (PAK2) | ||||
| Synonyms | p21-activated kinase 2; Serine/threonine-protein kinase PAK 2; S6/H4 kinase; PAK65; PAK-2; Gamma-PAK | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | PAK2 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Acid anhydride hydrolases | [+] 2 Acid anhydride hydrolases | + | |||
| Interacting Target Name | Ras-related C3 botulinum toxin substrate 1 (RAC1) | Literature-reported Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | TC25; Ras-like protein TC25; p21-Rac1; MIG5; Cell migration-inducing gene5 protein; Cell migration-inducing gene 5 protein | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Reconstituted Complex | [1] | |||
| 2 | Yeast two hybrid | [2] | |||
| Interacting Protein Name | Cell division control protein 42 homolog (CDC42) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | CDC42Hs; G25K | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Protein-peptide | [3] | |||
| 2 | Reconstituted Complex | [4] | |||
| Other proteins | [+] 2 Other proteins | + | |||
| Interacting Protein Name | Rho guanine nucleotide exchange factor 7 (ARHGEF7) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | BETA.PIX; COOL.1; COOL1; Nbla10314; P50; P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [5] | |||
| 2 | Reconstituted Complex | [6] | |||
| Interacting Protein Name | Vinexin (SORBS3) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | SCAM.1; SCAM1; SH3D4 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Reconstituted Complex | [6] | |||
| 2 | Yeast two hybrid | [7] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA. J Biol Chem. 1998 Apr 10;273(15):8776-82. | ||||
| REF 2 | A human MAP kinase interactome. Nat Methods. 2010 Oct;7(10):801-5. | ||||
| REF 3 | Conformation of a Cdc42/Rac interactive binding peptide in complex with Cdc42 and analysis of the binding interface. Biochemistry. 1999 May 11;38(19):5968-75. | ||||
| REF 4 | POSH2 is a RING finger E3 ligase with Rac1 binding activity through a partial CRIB domain. FEBS Lett. 2010 Sep 24;584(18):3867-72. | ||||
| REF 5 | A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23. | ||||
| REF 6 | Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome. EMBO Rep. 2006 Feb;7(2):186-91. | ||||
| REF 7 | A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226. | ||||
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