Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T25462 Target Info
Target Name Mixed-lineage leukemia protein (MLL)
Synonyms p320; p180; Zinc finger protein HRX; Trithoraxlike protein; Trithorax-like protein; Myeloid/lymphoid or mixed-lineage leukemia protein 1; Myeloid/lymphoid or mixed-lineage leukemia; MLL1; MLL cleavage product C180; Lysine Nmethyltransferase 2A; Lysine N-methyltransferase 2A; Histonelysine Nmethyltransferase MLL; Histone-lysine N-methyltransferase 2A; HTRX; HRX; CXXCtype zinc finger protein 7; CXXC7; CXXC-type zinc finger protein 7; ALL1; ALL-1
Target Type Literature-reported Target
Gene Name KMT2A
Biochemical Class Methyltransferase
UniProt ID
KMT2A_HUMAN 
Target Interacting Proteins  Top
Beta-transducin repeats [+] 1 Beta-transducin repeats +
Interacting Target Name WD repeat-containing protein 5 (WDR5) Literature-reported Target Interacting Protein Info
UniProt ID
WDR5_HUMAN 
Synonyms BMP2-induced 3-kb gene protein; BIG3
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Co-purification [1]
6 Co-purification [5]
7 Protein-peptide [3]
8 Reconstituted Complex [6]
9 Reconstituted Complex [5]
10 Reconstituted Complex [7]
11 Reconstituted Complex [8]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Affinity Capture-Western [10]
3 Reconstituted Complex [9]
Histones [+] 1 Histones +
Interacting Protein Name Histone H3.1 (H31) Interacting Protein Interacting Protein Info
UniProt ID
H31_HUMAN 
Synonyms H3/A; H3FA
Evidence Score (E-score) 5 Experimental Evidences +
1 Biochemical Activity [8]
2 Biochemical Activity [11]
3 Biochemical Activity [10]
4 Co-crystal Structure [12]
5 Reconstituted Complex [13]
Isomerases [+] 1 Isomerases +
Interacting Protein Name Peptidyl-prolyl cis-trans isomerase E (PPIE) Interacting Protein Interacting Protein Info
UniProt ID
PPIE_HUMAN 
Synonyms CYP.33; CYP33
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Affinity Capture-Western [15]
3 Co-crystal Structure [12]
4 Yeast two hybrid [14]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [16]
2 Reconstituted Complex [17]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Co-crystal Structure [19]
3 Reconstituted Complex [19]
4 Yeast two hybrid [18]
Other proteins [+] 8 Other proteins +
Interacting Protein Name Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2L) Interacting Protein Interacting Protein Info
UniProt ID
ASH2L_HUMAN 
Synonyms ASH2; ASH2L1; ASH2L2; Bre2
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Biochemical Activity [11]
5 Co-purification [1]
6 Co-purification [5]
7 Reconstituted Complex [7]
8 Reconstituted Complex [5]
Interacting Protein Name Menin (MEN1) Interacting Protein Interacting Protein Info
UniProt ID
MEN1_HUMAN 
Synonyms MEAI; SCG2
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [20]
3 Affinity Capture-Western [21]
4 Affinity Capture-Western [22]
5 Affinity Capture-Western [23]
6 Co-localization [22]
7 Co-purification [1]
8 Reconstituted Complex [21]
Interacting Protein Name Retinoblastoma-binding protein 5 (RBBP5) Interacting Protein Interacting Protein Info
UniProt ID
RBBP5_HUMAN 
Synonyms RBQ3; SWD1
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [24]
5 Co-purification [1]
6 Co-purification [5]
7 Reconstituted Complex [7]
8 Reconstituted Complex [5]
Interacting Protein Name Host cell factor 1 (HCFC1) Interacting Protein Interacting Protein Info
UniProt ID
HCFC1_HUMAN 
Synonyms CFF; HCF; HCF.1; HCF1; HFC1; MRX3; PPP1R89; VCAF
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Co-purification [1]
Interacting Target Name Beta-catenin (CTNNB1) Successful Target Interacting Protein Info
UniProt ID
CTNB1_HUMAN 
Synonyms Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [25]
2 Reconstituted Complex [25]
Interacting Protein Name Paired amphipathic helix protein Sin3a (SIN3A) Interacting Protein Interacting Protein Info
UniProt ID
SIN3A_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [26]
2 Affinity Capture-Western [10]
Interacting Protein Name Transcription initiation factor TFIID subunit 6 (TAF6) Interacting Protein Interacting Protein Info
UniProt ID
TAF6_HUMAN 
Synonyms MGC:8964; TAF(II)70; TAF(II)80; TAF2E; TAFII.70; TAFII.80; TAFII70; TAFII80; TAFII85
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Co-fractionation [27]
Interacting Protein Name Transcription initiation factor TFIID subunit 9 (TAF9) Interacting Protein Interacting Protein Info
UniProt ID
TAF9_HUMAN 
Synonyms MGC:5067; STAF31/32; TAF2G; TAFII.31; TAFII.32; TAFII31; TAFII32; TAFIID32
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Reconstituted Complex [28]
References  Top
REF 1 Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Mol Cell Biol. 2004 Jul;24(13):5639-49.
REF 2 SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53. Cell. 2013 Jul 18;154(2):297-310.
REF 3 Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases. J Biol Chem. 2012 Aug 10;287(33):27275-89.
REF 4 Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells. Oncogene. 2010 Sep 9;29(36):5019-31.
REF 5 Somatic cancer mutations in the MLL1 histone methyltransferase modulate its enzymatic activity and dependence on the WDR5/RBBP5/ASH2L complex. Mol Oncol. 2017 Apr;11(4):373-387.
REF 6 WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket. J Biol Chem. 2008 Dec 12;283(50):35258-64.
REF 7 Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inh... J Biol Chem. 2016 Oct 21;291(43):22357-22372.
REF 8 A non-active-site SET domain surface crucial for the interaction of MLL1 and the RbBP5/Ash2L heterodimer within MLL family core complexes. J Mol Biol. 2014 Jun 12;426(12):2283-99.
REF 9 MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein. Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8342-7.
REF 10 ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. Mol Cell. 2002 Nov;10(5):1119-28.
REF 11 Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a "two-active site" model for multiple histone H3 lysine 4 methylation. J Biol Chem. 2014 Jan 10;289(2):868-84.
REF 12 Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Cell. 2010 Jun 25;141(7):1183-94.
REF 13 Binding of the MLL PHD3 finger to histone H3K4me3 is required for MLL-dependent gene transcription. J Mol Biol. 2010 Jul 9;400(2):137-44.
REF 14 Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells. Mol Cell Biol. 2001 May;21(10):3589-97.
REF 15 Loss of MLL PHD finger 3 is necessary for MLL-ENL-induced hematopoietic stem cell immortalization. Cancer Res. 2008 Aug 1;68(15):6199-207.
REF 16 LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. Nat Commun. 2013;4:1531.
REF 17 Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell. 2005 Jun 17;121(6):873-85.
REF 18 MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein. Mol Cell Biol. 2001 Apr;21(7):2249-58.
REF 19 Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation do... J Biol Chem. 2002 Nov 8;277(45):43168-74.
REF 20 Histone and DNA methylation defects at Hox genes in mice expressing a SET domain-truncated form of Mll. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6629-34.
REF 21 The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis. Cell. 2005 Oct 21;123(2):207-18.
REF 22 MLL associates specifically with a subset of transcriptionally active target genes. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14765-70.
REF 23 Interaction of MLL amino terminal sequences with menin is required for transformation. Cancer Res. 2007 Aug 1;67(15):7275-83.
REF 24 The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers. Mol Cell Biol. 2013 Dec;33(23):4745-54.
REF 25 The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes. Genes Dev. 2006 Mar 1;20(5):586-600.
REF 26 A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription. Cancer Cell. 2010 Feb 17;17(2):198-212.
REF 27 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 28 Divergent hTAFII31-binding motifs hidden in activation domains. J Biol Chem. 2000 May 26;275(21):15912-6.

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