Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T33455 Target Info
Target Name Insulin-like growth factor-binding protein 3 (IGFBP3)
Synonyms IGFBP-3; IGF-binding protein 3; IBP3; IBP-3
Target Type Clinical trial Target
Gene Name IGFBP3
Biochemical Class Insulin-like growth factor binding
UniProt ID
IBP3_HUMAN 
Target Interacting Proteins  Top
Other proteins [+] 2 Other proteins +
Interacting Target Name Fibronectin (FN1) Clinical trial Target Interacting Protein Info
UniProt ID
FINC_HUMAN 
Synonyms Ugl-Y3; Ugl-Y2; Ugl-Y1; FN; Cold-insoluble globulin; CIG
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
3 Reconstituted Complex [1]
4 Yeast two hybrid [1]
Interacting Target Name Insulin-like growth factor-I (IGF1) Clinical trial Target Interacting Protein Info
UniProt ID
IGF1_HUMAN 
Synonyms Somatomedin-C; SomatomedinC; Mechano growth factor; Insulin-like growth factor I; IGF-I; IGFI
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [4]
3 Reconstituted Complex [3]
4 Reconstituted Complex [5]
References  Top
REF 1 Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) binds to fibronectin (FN): demonstration of IGF-I/IGFBP-3/fn ternary complexes in human plasma. J Clin Endocrinol Metab. 2001 May;86(5):2104-10.
REF 2 Co-localization of insulin-like growth factor binding protein 3 and fibronectin in human articular cartilage. Osteoarthritis Cartilage. 2002 Jul;10(7):556-63.
REF 3 Mutation of three critical amino acids of the N-terminal domain of IGF-binding protein-3 essential for high affinity IGF binding. J Clin Endocrinol Metab. 2001 Oct;86(10):4943-50.
REF 4 Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma. J Clin Endocrinol Metab. 1992 Oct;75(4):1046-53.
REF 5 Structural determinants of ligand and cell surface binding of insulin-like growth factor-binding protein-3. J Biol Chem. 1998 Jan 30;273(5):2631-8.

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