Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T57291 | Target Info | |||
| Target Name | PP2A B subunit isoform R5-alpha (PPP2R5A) | ||||
| Synonyms | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; Protein phosphatase-2A; PR61alpha; PP2A, B subunit, R5 alpha isoform; PP2A, B subunit, PR61 alpha isoform; PP2A, B subunit, B56 alpha isoform; PP2A, B subunit, B' alpha isoform; PP2A B subunit isoform PR61-alpha; PP2A B subunit isoform B56-alpha; PP2A B subunit isoform B'-alpha | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | PPP2R5A | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Ester hydrolases | [+] 3 Ester hydrolases | + | |||
| Interacting Target Name | Serine/threonine PP2A-alpha (PPP2CA) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; RP-C; Replication protein C; PP2A-alpha | ||||
| Evidence Score (E-score) | 5 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| 3 | Affinity Capture-Western | [3] | |||
| 4 | Affinity Capture-Western | [4] | |||
| 5 | Co-fractionation | [2] | |||
| Interacting Protein Name | PP2A subunit A isoform PR65-beta (PPP2R1B) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | PP2A.Abeta; PR65B | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| 3 | Co-fractionation | [2] | |||
| Interacting Protein Name | PP2A subunit A isoform PR65-alpha (PPP2R1A) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | PP2A.Aalpha; PP2AAALPHA; PR65A | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Affinity Capture-Western | [3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Mol Cell Proteomics. 2009 Jan;8(1):157-71. | ||||
| REF 2 | The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. J Biol Chem. 1996 Sep 6;271(36):22081-9. | ||||
| REF 3 | Protein phosphatase 2A (PP2A) holoenzymes regulate death-associated protein kinase (DAPK) in ceramide-induced anoikis. J Biol Chem. 2010 Apr 30;285(18):13827-38. | ||||
| REF 4 | Control of APC/C-dependent ubiquitin chain elongation by reversible phosphorylation. Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):1540-5. | ||||
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