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| Target General Information |
Top |
| Target ID |
T80454 |
Target Info
|
| Target Name |
T-lymphoma invasion and metastasis 1 (TIAM1) |
| Synonyms |
TIAM-1; T-lymphoma invasion and metastasis-inducing protein 1 |
| Target Type |
Literature-reported Target |
| Gene Name |
TIAM1 |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Acid anhydride hydrolases |
[+] 1 Acid anhydride hydrolases |
+ |
| Interacting Target Name |
Ras-related C3 botulinum toxin substrate 1 (RAC1) |
Literature-reported Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
TC25; Ras-like protein TC25; p21-Rac1; MIG5; Cell migration-inducing gene5 protein; Cell migration-inducing gene 5 protein |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Co-crystal Structure |
[1] |
| 2 |
Reconstituted Complex |
[2] |
| References |
Top |
| REF 1 |
Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1. Nature. 2000 Dec 7;408(6813):682-8.
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| REF 2 |
Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors. J Biol Chem. 2001 Dec 14;276(50):47530-41.
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