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| Target General Information |
Top |
| Target ID |
T85733 |
Target Info
|
| Target Name |
DNA topoisomerase II beta (TOP2B) |
| Synonyms |
Topo IIbeta; TOP2beta; TOP2B |
| Target Type |
Successful Target |
| Gene Name |
TOP2B |
| Biochemical Class |
ATP-hydrolyzing DNA topoisomerase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Isomerases |
[+] 1 Isomerases |
+ |
| Interacting Target Name |
DNA topoisomerase II alpha (TOP2A) |
Clinical trial Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
TOP2; DNA topoisomerase II, alpha isozyme; DNA topoisomerase 2-alpha; DNA topoisomerase 2alpha |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Co-fractionation |
[1] |
| 2 |
Reconstituted Complex |
[2] |
| Nuclear hormone receptors |
[+] 1 Nuclear hormone receptors |
+ |
| Interacting Target Name |
Estrogen receptor (ESR) |
Successful Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Affinity Capture-MS |
[3] |
| 2 |
Affinity Capture-Western |
[4] |
| References |
Top |
| REF 1 |
A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
|
| REF 2 |
Active heterodimers are formed from human DNA topoisomerase II alpha and II beta isoforms. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8288-93.
|
| REF 3 |
Identification of proteins associated with ligand-activated estrogen receptor in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. Proteomics. 2011 Jan;11(1):172-9.
|
| REF 4 |
A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription. Science. 2006 Jun 23;312(5781):1798-802.
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