Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T99989 Target Info
Target Name Casein kinase I epsilon (CSNK1E)
Synonyms Casein kinase I isoform epsilon; CKIe; CKI-epsilon
Target Type Successful Target
Gene Name CSNK1E
Biochemical Class Kinase
UniProt ID
KC1E_HUMAN 
Target Interacting Proteins  Top
FAM proteins [+] 2 FAM proteins +
Interacting Target Name Spindle protein CHICA (FAM83D) Literature-reported Target Interacting Protein Info
UniProt ID
FA83D_HUMAN 
Synonyms Spindle protein CHICA; Protein FAM83D; FAM83D
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [2]
Interacting Protein Name Family with sequence similarity 110 member C (FAM110C) Interacting Protein Interacting Protein Info
UniProt ID
F110C_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [3]
Transcription regulators [+] 3 Transcription regulators +
Interacting Protein Name Period circadian protein homolog 1 (PER1) Interacting Protein Interacting Protein Info
UniProt ID
PER1_HUMAN 
Synonyms PER; RIGUI; hPER
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [1]
4 Biochemical Activity [6]
5 Yeast two hybrid [6]
6 Yeast two hybrid [7]
Interacting Protein Name Colorectal mutant cancer protein (MCC) Interacting Protein Interacting Protein Info
UniProt ID
CRCM_HUMAN 
Synonyms MCC1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-MS [1]
3 Yeast two hybrid [2]
Interacting Protein Name Period circadian protein homolog 2 (PER2) Interacting Protein Interacting Protein Info
UniProt ID
PER2_HUMAN 
Synonyms FASPS; FASPS1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Yeast two hybrid [7]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Segment polarity protein dishevelled homolog DVL-2 (DVL2) Interacting Protein Interacting Protein Info
UniProt ID
DVL2_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [8]
References  Top
REF 1 Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Nat Methods. 2013 Apr;10(4):307-14.
REF 2 A directed protein interaction network for investigating intracellular signal transduction. Sci Signal. 2011 Sep 6;4(189):rs8.
REF 3 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 4 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 5 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 6 Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon. Mol Cell Biol. 2000 Jul;20(13):4888-99.
REF 7 Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions. PLoS Genet. 2013 Mar;9(3):e1003398.
REF 8 Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005 Oct 20;437(7062):1173-8.

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