| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T14908 | ||||
| Target Name | Ceramide glucosyltransferase (UGCG) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Miglustat | Drug Info | IC50 = 50000 nM | [2] | |
| N-butylgalactonojirimycin | Drug Info | IC50 = 5300 nM | [1] | ||
| References | |||||
| REF 1 | Accumulation of glucosylceramide in murine testis, caused by inhibition of beta-glucosidase 2: implications for spermatogenesis. J Biol Chem. 2007 Nov 9;282(45):32655-64. | ||||
| REF 2 | Novel oral treatment of Gaucher's disease with N-butyldeoxynojirimycin (OGT 918) to decrease substrate biosynthesis. Lancet. 2000 Apr 29;355(9214):1481-5. | ||||
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