Target Validation Information
TTD ID	T22095
Target Name	Interleukin-17 (IL17)
Type of Target	Successful
Action against Disease Model	Secukinumab	Drug Info	AIN457 significantly down-regulated IL-6 production (-25+7%; p<0.05) in MM-BMSC co-culture. We also observed that AIN-457 significantly reduced adhesion of MM cells to stromal cells (27%, p=0.011). AIN457 significantly inhibited IL-6 production in h uMan fetal bone chips in the presence of MM cells within 24 hours of ex-vivo culture (control - 487+39 pg/ml; IL-17 990+27 pg/ml; p<0.01 and AIN-457 - 326+7 pg/ml; p<0.01).
References

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.