| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T29130 | ||||
| Target Name | Signal transducer and activator of transcription 3 (STAT3) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Acitretin | Drug Info | Ki = 15000 nM | [2] | |
| GNF-PF-1399 | Drug Info | IC50 = 2936 nM | [1] | ||
| References | |||||
| REF 1 | In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. | ||||
| REF 2 | Drug target identification using side-effect similarity. Science. 2008 Jul 11;321(5886):263-6. | ||||
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