Target Validation Information
TTD ID	T45993
Target Name	Calcium channel unspecific (CaC)
Type of Target	Successful
Drug Potency against Target		Drug Info	IC50 = 1.45 nM	[3]
		Drug Info	IC50 = 14.9 nM	[3]
	Nicardipine	Drug Info	Ki = 280 nM	[2]
	Nisoldipine	Drug Info	IC50 = 80 nM	[1]
References
REF 1	Block of cardiac delayed-rectifier and inward-rectifier K+ currents by nisoldipine. Br J Pharmacol. 2003 Nov;140(5):863-70.
REF 2	Development and validation of an in silico P450 profiler based on pharmacophore models. Curr Drug Discov Technol. 2006 Mar;3(1):1-48.
REF 3	Synthesis, biological evaluation, calcium channel antagonist activity, and anticonvulsant activity of felodipine coupled to a dihydropyridine-pyridinium salt redox chemical delivery system. J Med Chem. 1996 Nov 8;39(23):4576-82.

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