Target Validation Information
TTD ID	T77548
Target Name	Metabotropic glutamate receptor 8 (mGluR8)
Type of Target	Literature-reported
Drug Potency against Target		Drug Info	Ki = 3400 nM	[2]
	2-Amino-4-phosphono-butyric acid	Drug Info	IC50 = 5.1 nM	[1]
	L-AP4	Drug Info	Ki = 1900 nM	[2]
	[3H]quisqualate	Drug Info	IC50 = 25 nM	[3]
References
REF 1	(2S,1'S,2'R,3'R)-2(2'-Carboxy-3'-hydroxymethylcyclopropyl)glycine-[3H], a potent and selective radioligand for labeling group 2 and 3 metabotropic ... Bioorg Med Chem Lett. 2005 Jan 17;15(2):349-51.
REF 2	Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first clas... Bioorg Med Chem. 2007 May 1;15(9):3161-70.
REF 3	Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)... J Med Chem. 1998 Mar 12;41(6):930-9.

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