Target Validation Information
TTD ID	T78393
Target Name	MIF messenger RNA (MIF mRNA)
Type of Target	Literature-reported
Drug Potency against Target		Drug Info	IC50 = 4000 nM	[2]
		Drug Info	IC50 = 420 nM
		Drug Info	IC50 = 1500 nM	[3]
	1-(2-chlorophenyl)-3-(pyridin-2-yl)thiourea	Drug Info	IC50 = 1010 nM
	2-(4-hydroxystyryl)quinolin-8-ol	Drug Info	IC50 = 8000 nM	[2]
	3,3,3-tris(4-chlorophenyl)propanoic acid	Drug Info	IC50 = 8100 nM	[1]
	3-(1H-pyrazol-3-yl)benzoic acid	Drug Info	IC50 = 15000 nM	[2]
	3-acetyl-7-hydroxy-2H-chromen-2-one	Drug Info	Ki = 4300 nM	[2]
	3-benzyl-5-fluorobenzo[d]oxazol-2(3H)-one	Drug Info	IC50 = 1000 nM	[3]
	3-benzyl-6-methylbenzo[d]oxazol-2(3H)-one	Drug Info	IC50 = 3400 nM	[3]
	4-((pyridin-4-ylthio)methyl)benzene-1,2-diol	Drug Info	IC50 = 400 nM	[1]
	4-(4-benzyl-1H-1,2,3-triazol-1-yl)phenol	Drug Info	IC50 = 3500 nM	[4]
	6-phenylpyridazin-3-yl thiophene-2-carboxylate	Drug Info	IC50 = 50 nM
	7-hydroxy-3-phenyl-2H-chromen-2-one	Drug Info	Ki = 470 nM	[2]
	Ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate	Drug Info	Ki = 7400 nM	[2]
	N-(2-bromobenzoyloxy)-4-chlorobenzamide	Drug Info	IC50 = 4200 nM
	S-benzo[d]oxazol-2-yl O-butyl carbonothioate	Drug Info	IC50 = 150 nM
References
REF 1	Classification of chemical compounds by protein-compound docking for use in designing a focused library. J Med Chem. 2006 Jan 26;49(2):523-33.
REF 2	Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening. J Med Chem. 2009 Jan 22;52(2):416-24.
REF 3	Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF). Bioorg Med Chem Lett. 2010 Oct 1;20(19):5811-4.
REF 4	Receptor agonists of macrophage migration inhibitory factor. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7033-6.

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