Resistance mutation info of target
| Target General Information | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Target ID | T96311 | ||||||||||||
| Target Name | NEDD8-activating enzyme E1 catalytic subunit (UBA3) | ||||||||||||
| Gene Name | UBA3 | ||||||||||||
| Species | Homo sapiens | ||||||||||||
| UniProt ID | UBA3_HUMAN | ||||||||||||
| Sequence |
MADGEEPEKKRRRIEELLAEKMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPST ESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI GRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLI SLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIA SMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYR LTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAER KENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTS IEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS [Homo sapiens] |
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| Drug and Corresponding Resistance Mutations | |||||||||||||
| Mutation Info | Missense: I310N | ||||||||||||
| Drugs |
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| Mutation Info | Missense: Y352H | ||||||||||||
| Drugs |
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| References | |||||||||||||
| REF 1 | Mutations in UBA3 confer resistance to the NEDD8-activating enzyme inhibitor MLN4924 in human leukemic cells.PLoS One.2014 Apr 1;9(4):e93530. | ||||||||||||
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