| Drug General Information |
| Drug ID |
D00NWF
|
| Former ID |
DNC005107
|
| Drug Name |
ZM-336372
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C23H23N3O3
|
| Canonical SMILES |
CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)N(C)C)NC(=O)C3=CC=C(C<br />=C3)O
|
| InChI |
1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28)
|
| InChIKey |
PYEFPDQFAZNXLI-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Lck tyrosine kinase |
Target Info |
Inhibitor |
[1]
|
|---|
| Mitogen-activated protein kinase 14 |
Target Info |
Inhibitor |
[2]
|
| mRNA of RAF proto-oncogene serine/threonine-protein kinase |
Target Info |
Inhibitor |
[1]
|
| mRNA of B-Raf |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
MAP kinase cascade
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KEGG Pathway
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NF-kappa B signaling pathway
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Osteoclast differentiation
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Natural killer cell mediated cytotoxicity
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T cell receptor signaling pathway
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HTLV-I infection
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Primary immunodeficiencyhsa04010:MAPK signaling pathway
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Rap1 signaling pathway
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FoxO signaling pathway
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Sphingolipid signaling pathway
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Adrenergic signaling in cardiomyocytes
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VEGF signaling pathway
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Signaling pathways regulating pluripotency of stem cells
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Platelet activation
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Toll-like receptor signaling pathway
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NOD-like receptor signaling pathway
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RIG-I-like receptor signaling pathway
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Fc epsilon RI signaling pathway
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TNF signaling pathway
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Leukocyte transendothelial migration
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Neurotrophin signaling pathway
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Retrograde endocannabinoid signaling
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Dopaminergic synapse
|
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Inflammatory mediator regulation of TRP channels
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GnRH signaling pathway
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Progesterone-mediated oocyte maturation
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Prolactin signaling pathway
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Amyotrophic lateral sclerosis (ALS)
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Epithelial cell signaling in Helicobacter pylori infection
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Shigellosis
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Salmonella infection
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Pertussis
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Leishmaniasis
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Chagas disease (American trypanosomiasis)
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Toxoplasmosis
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Tuberculosis
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Hepatitis C
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Influenza A
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Epstein-Barr virus infection
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Proteoglycans in cancerhsa04010:MAPK signaling pathway
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ErbB signaling pathway
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Ras signaling pathway
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cGMP-PKG signaling pathway
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cAMP signaling pathway
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Chemokine signaling pathway
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PI3K-Akt signaling pathway
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Vascular smooth muscle contraction
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Focal adhesion
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Gap junction
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B cell receptor signaling pathway
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Fc gamma R-mediated phagocytosis
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Long-term potentiation
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Serotonergic synapse
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Long-term depression
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Regulation of actin cytoskeleton
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Insulin signaling pathway
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Estrogen signaling pathway
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Melanogenesis
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Thyroid hormone signaling pathway
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Oxytocin signaling pathway
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Alcoholism
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Hepatitis B
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Pathways in cancer
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Proteoglycans in cancer
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MicroRNAs in cancer
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Colorectal cancer
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Renal cell carcinoma
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Pancreatic cancer
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Endometrial cancer
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Glioma
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Prostate cancer
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Melanoma
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Bladder cancer
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Chronic myeloid leukemia
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Acute myeloid leukemia
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Non-small cell lung cancer
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Central carbon metabolism in cancer
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Choline metabolism in cancerhsa04010:MAPK signaling pathway
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mTOR signaling pathway
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Thyroid cancer
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NetPath Pathway
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TCR Signaling Pathway
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IL2 Signaling PathwayNetPath_17:IL5 Signaling Pathway
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FSH Signaling Pathway
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TCR Signaling PathwayNetPath_17:IL5 Signaling Pathway
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IL2 Signaling Pathway
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EGFR1 Signaling PathwayNetPath_19:IL-7 Signaling Pathway
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PANTHER Pathway
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Parkinson disease
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T cell activationP00003:Alzheimer disease-amyloid secretase pathway
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Angiogenesis
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B cell activation
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EGF receptor signaling pathway
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FGF signaling pathway
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Interferon-gamma signaling pathway
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Oxidative stress response
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TGF-beta signaling pathway
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Toll receptor signaling pathway
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VEGF signaling pathway
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Ras Pathway
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p53 pathway feedback loops 2
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p38 MAPK pathway
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CCKR signaling map STP00005:Angiogenesis
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Endothelin signaling pathway
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Inflammation mediated by chemokine and cytokine signaling pathway
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Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
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Integrin signalling pathway
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Interleukin signaling pathway
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PDGF signaling pathway
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T cell activation
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Angiotensin II-stimulated signaling through G proteins and beta-arrestin
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CCKR signaling map ST
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Pathway Interaction Database
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Atypical NF-kappaB pathway
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Glypican 1 network
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TCR signaling in naï
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Signaling events mediated by PTP1B
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IL12-mediated signaling events
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Regulation of p38-alpha and p38-beta
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TCR signaling in naï
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Thromboxane A2 receptor signaling
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SHP2 signaling
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IL2-mediated signaling events
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CXCR4-mediated signaling events
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Class I PI3K signaling events
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IL2 signaling events mediated by PI3K
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amb2 Integrin signaling
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EPHA forward signaling
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PDGFR-beta signaling pathway
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IL2 signaling events mediated by STAT5
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Ephrin B reverse signaling
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Alpha-synuclein signalingendothelinpathway:Endothelins
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BCR signaling pathway
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p73 transcription factor network
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p38 MAPK signaling pathway
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IL4-mediated signaling events
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CD40/CD40L signaling
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CDC42 signaling events
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Angiopoietin receptor Tie2-mediated signaling
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FAS (CD95) signaling pathway
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
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Glucocorticoid receptor regulatory network
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Rapid glucocorticoid signaling
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Regulation of Androgen receptor activity
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ATF-2 transcription factor network
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IL6-mediated signaling events
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p38 signaling mediated by MAPKAP kinases
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Retinoic acid receptors-mediated signaling
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CXCR3-mediated signaling events
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Signaling mediated by p38-alpha and p38-beta
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EPO signaling pathway
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Signaling events mediated by VEGFR1 and VEGFR2
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p53 pathway
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S1P2 pathway
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Trk receptor signaling mediated by the MAPK pathway
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VEGFR3 signaling in lymphatic endothelium
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FGF signaling pathway
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RAC1 signaling pathway
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Regulation of retinoblastoma proteinfcer1pathway:Fc-epsilon receptor I signaling in mast cells
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Endothelins
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GMCSF-mediated signaling events
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
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mTOR signaling pathway
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IGF1 pathway
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Ras signaling in the CD4+ TCR pathway
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Ceramide signaling pathway
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ErbB1 downstream signaling
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ErbB2/ErbB3 signaling events
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Nongenotropic Androgen signaling
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Internalization of ErbB1
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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Class I PI3K signaling events mediated by Akt
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Downstream signaling in naï
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Regulation of retinoblastoma protein
|
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Signaling events mediated by focal adhesion kinasecdc42_pathway:CDC42 signaling events
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PathWhiz Pathway
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Fc Epsilon Receptor I Signaling in Mast CellsPW000453:Fc Epsilon Receptor I Signaling in Mast Cells
|
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Insulin SignallingPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
|
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Reactome
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GPVI-mediated activation cascade
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PIP3 activates AKT signaling
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Regulation of KIT signaling
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Phosphorylation of CD3 and TCR zeta chains
|
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Translocation of ZAP-70 to Immunological synapse
|
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Generation of second messenger molecules
|
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PECAM1 interactions
|
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Constitutive Signaling by Aberrant PI3K in Cancer
|
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DAP12 signaling
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CD28 co-stimulation
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CD28 dependent PI3K/Akt signaling
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CD28 dependent Vav1 pathway
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CTLA4 inhibitory signaling
|
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PD-1 signaling
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Interleukin-2 signalingR-HSA-168638:NOD1/2 Signaling Pathway
|
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p38MAPK events
|
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ERK/MAPK targets
|
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Activation of PPARGC1A (PGC-1alpha) by phosphorylation
|
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Oxidative Stress Induced Senescence
|
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CDO in myogenesis
|
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DSCAM interactions
|
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ADP signalling through P2Y purinoceptor 1
|
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Platelet sensitization by LDL
|
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VEGFA-VEGFR2 Pathway
|
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activated TAK1 mediates p38 MAPK activation
|
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Activation of the AP-1 family of transcription factors
|
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KSRP (KHSRP) binds and destabilizes mRNAR-HSA-2672351:Stimuli-sensing channels
|
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GP1b-IX-V activation signalling
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CREB phosphorylation through the activation of Ras
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CD209 (DC-SIGN) signaling
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RAF activation
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MAP2K and MAPK activation
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Negative feedback regulation of MAPK pathway
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Negative regulation of MAPK pathwayR-HSA-1295596:Spry regulation of FGF signaling
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Frs2-mediated activation
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ARMS-mediated activation
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Negative regulation of MAPK pathway
|
|
WikiPathways
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Notch Signaling Pathway
|
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Interferon type I signaling pathways
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IL-2 Signaling Pathway
|
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Inflammatory Response Pathway
|
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Signaling by SCF-KIT
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DAP12 interactions
|
|
Host Interactions of HIV factors
|
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PIP3 activates AKT signaling
|
|
T-Cell Receptor and Co-stimulatory Signaling
|
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B Cell Receptor Signaling Pathway
|
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TSLP Signaling Pathway
|
|
TCR signaling
|
|
Costimulation by the CD28 familyWP75:Toll-like receptor signaling pathway
|
|
Monoamine Transport
|
|
Serotonin HTR1 Group and FOS Pathway
|
|
TCR Signaling Pathway
|
|
Senescence and Autophagy in Cancer
|
|
Insulin Signaling
|
|
EGF/EGFR Signaling Pathway
|
|
MAPK Cascade
|
|
Oxidative Stress
|
|
p38 MAPK Signaling Pathway
|
|
IL-4 Signaling Pathway
|
|
MAPK Signaling Pathway
|
|
TGF beta Signaling Pathway
|
|
Kit receptor signaling pathway
|
|
Cardiac Hypertrophic Response
|
|
MAP kinase activation in TLR cascade
|
|
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
|
|
Nanoparticle-mediated activation of receptor signaling
|
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Structural Pathway of Interleukin 1 (IL-1)
|
|
JAK/STAT
|
|
Amyotrophic lateral sclerosis (ALS)
|
|
Alpha 6 Beta 4 signaling pathway
|
|
Cardiac Progenitor Differentiation
|
|
BDNF signaling pathway
|
|
Integrated Pancreatic Cancer Pathway
|
|
Oncostatin M Signaling Pathway
|
|
Parkinsons Disease Pathway
|
|
Corticotropin-releasing hormone
|
|
AGE/RAGE pathway
|
|
Prostate Cancer
|
|
TWEAK Signaling Pathway
|
|
FSH signaling pathway
|
|
Leptin signaling pathway
|
|
RANKL/RANK Signaling Pathway
|
|
miR-targeted genes in muscle cell - TarBase
|
|
miR-targeted genes in lymphocytes - TarBase
|
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miR-targeted genes in leukocytes - TarBase
|
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miR-targeted genes in epithelium - TarBase
|
|
IL-1 signaling pathway
|
|
Signal amplification
|
|
Platelet homeostasis
|
|
NGF signalling via TRKA from the plasma membrane
|
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Myogenesis
|
|
DSCAM interactions
|
|
MicroRNAs in cardiomyocyte hypertrophy
|
|
Angiogenesis
|
|
Physiological and Pathological Hypertrophy of the Heart
|
|
Regulation of toll-like receptor signaling pathwayWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
|
EPO Receptor Signaling
|
|
Regulation of Actin Cytoskeleton
|
|
Signaling of Hepatocyte Growth Factor Receptor
|
|
Extracellular vesicle-mediated signaling in recipient cells
|
|
IL-3 Signaling Pathway
|
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
|
RAF/MAP kinase cascade
|
|
Iron uptake and transport
|
|
PDGF Pathway
|
|
Retinoblastoma (RB) in Cancer
|
|
Interleukin-11 Signaling Pathway
|
|
TNF alpha Signaling Pathway
|
|
Signaling Pathways in Glioblastoma
|
|
Endothelin Pathways
|
|
Rap1 signalling
|
|
Integrin-mediated Cell Adhesion
|
|
GP1b-IX-V activation signalling
|
|
IL-5 Signaling PathwayWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
|
|
Bladder Cancer
|
|
Polycystic Kidney Disease Pathway
|
|
Integrated Breast Cancer Pathway
|
|
Signaling by FGFR
|
| References |
| REF 1 | Biochem J. 2007 Dec 15;408(3):297-315.The selectivity of protein kinase inhibitors: a further update. |
|---|
| REF 2 | Bioorg Med Chem Lett. 2004 Nov 1;14(21):5383-7.A novel series of p38 MAP kinase inhibitors for the potential treatment of rheumatoid arthritis. |
|---|
