| Drug General Information |
| Drug ID |
D01GMJ
|
| Former ID |
DNC002534
|
| Drug Name |
1,4-Dithiothreitol
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C4H10O2S2
|
| Canonical SMILES |
C(C(C(CS)O)O)S
|
| InChI |
1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2
|
| InChIKey |
VHJLVAABSRFDPM-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
603421, 3181634, 6852578, 8164181, 10519598, 14717142, 14717909, 16935602, 22389421, 29286623, 49747403, 49747404, 49747405, 49895758, 49895759, 49965679, 53788743, 56313414, 57330250, 76462155, 85085700, 85085701, 85085705, 87350420, 87560306, 87567636, 91010121, 103228142, 104346692, 109457234, 117613454, 125336023, 125536823, 125537278, 125665942, 126672542, 126674461, 127263983, 127263984, 127263985, 127263986, 127263987, 127263988, 127263989, 127263990, 127263991, 127263992, 127263993, 127263994, 127263995
|
| Target and Pathway |
| Target(s) |
Thymidylate synthase |
Target Info |
Inhibitor |
[1]
|
|---|
| Peptidyl-prolyl cis-trans isomerase B |
Target Info |
Inhibitor |
[1]
|
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Pyrimidine deoxyribonucleotides biosynthesis from CTP
|
|
Pyrimidine deoxyribonucleotides de novo biosynthesis
|
|
Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
|
|
Superpathway of pyrimidine deoxyribonucleoside salvage
|
|
DTMP de novo biosynthesis (mitochondrial)
|
|
Pyrimidine deoxyribonucleosides salvagePWY-5910:Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
|
|
Superpathway of cholesterol biosynthesis
|
|
Mevalonate pathway
|
|
KEGG Pathway
|
Pyrimidine metabolism
|
|
One carbon pool by folate
|
|
Metabolic pathwayshsa00900:Terpenoid backbone biosynthesis
|
|
Metabolic pathways
|
|
Biosynthesis of antibiotics
|
|
AMPK signaling pathway
|
|
Bile secretion
|
|
NetPath Pathway
|
IL5 Signaling Pathway
|
|
TGF_beta_Receptor Signaling Pathway
|
|
TSH Signaling Pathway
|
|
PANTHER Pathway
|
De novo pyrimidine deoxyribonucleotide biosynthesis
|
|
Formyltetrahydroformate biosynthesisP00014:Cholesterol biosynthesis
|
|
Pathway Interaction Database
|
E2F transcription factor networksyndecan_1_pathway:Syndecan-1-mediated signaling events
|
|
PathWhiz Pathway
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Pyrimidine MetabolismPW000164:Retinol MetabolismPW000050:Steroid Biosynthesis
|
|
Reactome
|
E2F mediated regulation of DNA replication
|
|
Pyrimidine biosynthesis
|
|
G1/S-Specific TranscriptionR-HSA-1650814:Collagen biosynthesis and modifying enzymes
|
|
WikiPathways
|
Trans-sulfuration and one carbon metabolism
|
|
Retinoblastoma (RB) in Cancer
|
|
One Carbon Metabolism
|
|
Integrated Pancreatic Cancer Pathway
|
|
miR-targeted genes in muscle cell - TarBase
|
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miR-targeted genes in lymphocytes - TarBase
|
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miR-targeted genes in leukocytes - TarBase
|
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miR-targeted genes in epithelium - TarBase
|
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Metabolism of nucleotides
|
|
Fluoropyrimidine ActivityWP2725:Collagen biosynthesis and modifying enzymes
|
|
miR-targeted genes in epithelium - TarBaseWP430:Statin Pathway
|
|
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
|
|
Activation of Gene Expression by SREBP (SREBF)
|
|
SREBF and miR33 in cholesterol and lipid homeostasis
|
|
Integrated Breast Cancer Pathway
|
|
SREBP signalling
|
|
Cholesterol Biosynthesis
|
| References |
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. |
|---|
