| Drug General Information |
| Drug ID |
D01LXG
|
| Former ID |
DIB006505
|
| Drug Name |
KC-11425
|
| Indication |
Asthma [ICD10:J45]
|
Terminated |
[1]
|
|---|
| Company |
Solvay Pharmaceuticals Inc
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Canonical SMILES |
n12c(c(c3c1c(cc(c3)CC(C)C)CCC2)CCN1CCN(c2nccc(c2)C)CC1)<br />C.Cl.Cl
|
| CAS Number |
CAS 148468-63-7
|
| Target and Pathway |
| Target(s) |
Platelet-activating factor receptor |
Target Info |
Antagonist |
[2]
|
|---|
| Arachidonate 5-lipoxygenase |
Target Info |
Antagonist |
[2]
|
|
BioCyc Pathway
|
Aspirin-triggered lipoxin biosynthesis
|
|
Resolvin D biosynthesis
|
|
Leukotriene biosynthesis
|
|
Lipoxin biosynthesis
|
|
Aspirin triggered resolvin D biosynthesis
|
|
Aspirin triggered resolvin E biosynthesis
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Staphylococcus aureus infectionhsa00590:Arachidonic acid metabolism
|
|
Metabolic pathways
|
|
Serotonergic synapse
|
|
Ovarian steroidogenesis
|
|
Toxoplasmosis
|
|
NetPath Pathway
|
IL5 Signaling Pathway
|
|
Leptin Signaling PathwayNetPath_16:IL4 Signaling Pathway
|
|
PathWhiz Pathway
|
Arachidonic Acid Metabolism
|
|
Reactome
|
Class A/1 (Rhodopsin-like receptors)
|
|
G alpha (q) signalling events
|
|
Interferon gamma signaling
|
|
WikiPathways
|
GPCRs, Class A Rhodopsin-like
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
|
Small Ligand GPCRs
|
|
Interferon gamma signaling
|
|
GPCR ligand binding
|
|
GPCR downstream signalingWP2877:Vitamin D Receptor Pathway
|
|
Arachidonic acid metabolism
|
|
Eicosanoid Synthesis
|
|
Selenium Micronutrient Network
|
| References |
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005461) |
|---|
| REF 2 | WO patent application no. 2002,01223,5, 1,4-dihydropyridines as bradykinin antagonists. |
|---|
